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An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation
Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system
Transgene Expression and Transposition Efficiency of Two-Component Sleeping Beauty Transposon Vector Systems Utilizing Plasmid or mRNA Encoding the Transposase
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
The importance of vaccine stockpiling to respond to epidemics and remediate global supply shortages affecting immunization: strategic challenges and risks identified by manufacturers
Biophysical characterization of influenza virus subpopulations using field flow fractionation and multiangle light scattering: Correlation of particle counts, size distribution and infectivity
Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors
Artificial Neural Network for Fast and Versatile Model Parameter Adjustment Utilizing PAT Signals of Chromatography Processes for Process Control under Production Conditions
Toward a Distinct and Quantitative Validation Method for Predictive Process Modelling—On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts
Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable without a Digital-Twin?
Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing
Fast and Flexible mRNA Vaccine Manufacturing as a Solution to Pandemic Situations by Adopting Chemical Engineering Good Practice—Continuous Autonomous Operation in Stainless Steel Equipment Concepts
Size and Beyond: A Comparative and Prospective Analysis on Asymmetric Flow Field-Flow Fractionation and Size-Exclusion Chromatography in Nanopharmaceutical Characterization
From Observability to Intervention in Purification: A Critical Framework for Digital Twins, Chemometrics, and Control Across Membranes, Adsorption, and Chromatography
Product Twins, Process Twins, Patient Twins, and Regulatory Twins in Pharmaceutical Digital Twin Systems
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