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https://doi.org/10.2139/ssrn.5399844
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/aic.18595openalex-extracted
Impinging jet mixers: A review of their mixing characteristics, performance considerations, and applications
inferredcites →https://doi.org/10.1002/biot.202400473openalex-extracted
An Experimental and Modeling Approach to Study Tangential Flow Filtration Performance for mRNA Drug Substance Purification
inferredcites →https://doi.org/10.1002/bit.25695openalex-extracted
Continuous downstream processing for high value biological products: A Review
inferredcites →https://doi.org/10.1002/bit.27232openalex-extracted
Improved protein A resin for antibody capture in a continuous countercurrent tangential chromatography system
inferredcites →https://doi.org/10.1002/bit.27690openalex-extracted
A common framework for integrated and continuous biomanufacturing
inferredcites →https://doi.org/10.1002/bit.28200openalex-extracted
Pressure‐dependent fouling behavior during sterile filtration of mRNA‐containing lipid nanoparticles
inferredcites →https://doi.org/10.1002/bit.28525openalex-extracted
Continuous precipitation‐filtration process for initial capture of a monoclonal antibody product using a four‐stage countercurrent hollow fiber membrane washing step
inferredcites →https://doi.org/10.1002/bit.28699openalex-extracted
Mechanistic modeling of in vitro transcription incorporating effects of magnesium pyrophosphate crystallization
inferredcites →https://doi.org/10.1002/btpr.2250openalex-extracted
Performance optimization of continuous countercurrent tangential chromatography for antibody capture
inferredcites →https://doi.org/10.1002/btpr.3316openalex-extracted
Mechanistic modeling, simulation, and optimization of mixed‐mode chromatography for an antibody polishing step
inferredcites →https://doi.org/10.1002/btpr.3353openalex-extracted
Predictive modeling of single pass tangential flow filtration for continuous biomanufacturing
inferredcites →https://doi.org/10.1002/smll.202405618openalex-extracted
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning
inferredcites →https://doi.org/10.1007/978-3-319-16145-7openalex-extracted
Mathematical Modeling and Scale-Up of Liquid Chromatography : With Application Examples
inferredcites →https://doi.org/10.1007/s13206-022-00052-5openalex-extracted
Advances in Nanoparticles for Effective Delivery of RNA Therapeutics
inferredcites →https://doi.org/10.1016/j.bbamem.2021.183627openalex-extracted
Acidic pH-induced changes in lipid nanoparticle membrane packing
inferredcites →https://doi.org/10.1016/j.biotechadv.2025.108643openalex-extracted
Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics
inferredcites →https://doi.org/10.1016/j.bpj.2011.12.014openalex-extracted
A Multiphysics Model of In Vitro Transcription Coupling Enzymatic Reaction and Precipitation Formation
inferredcites →https://doi.org/10.1016/j.cherd.2007.10.007openalex-extracted
Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions
inferredcites →https://doi.org/10.1016/j.chroma.2017.06.018openalex-extracted
Continuous countercurrent tangential chromatography for mixed mode post-capture operations in monoclonal antibody purification
inferredcites →https://doi.org/10.1016/j.coche.2021.100702openalex-extracted
Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing
inferredcites →https://doi.org/10.1016/j.copbio.2022.102768openalex-extracted
Current research approaches in downstream processing of pharmaceutically relevant proteins
inferredcites →https://doi.org/10.1016/j.ijheatmasstransfer.2023.125023openalex-extracted
Mechanistic modeling and analysis of thermal radiation in conventional, microwave-assisted, and hybrid freeze drying for biopharmaceutical manufacturing
inferredcites →https://doi.org/10.1016/j.ijpharm.2016.10.038openalex-extracted
Advancing pharmaceutical quality: An overview of science and research in the U.S. FDA’s Office of Pharmaceutical Quality
inferredcites →https://doi.org/10.1016/j.ijpharm.2024.125114openalex-extracted
Understanding the self-assembly and molecular structure of mRNA lipid nanoparticles at real size: Insights from the ultra-large-scale simulation
inferredcites →https://doi.org/10.1016/j.jbiotec.2015.02.026openalex-extracted
Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography
inferredcites →https://doi.org/10.1016/j.jconrel.2022.02.017openalex-extracted
Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
inferredcites →https://doi.org/10.1016/j.jconrel.2023.03.039openalex-extracted
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
inferredcites →https://doi.org/10.1016/j.jmsy.2021.05.011openalex-extracted
Digital twins-based smart manufacturing system design in Industry 4.0: A review
inferredcites →https://doi.org/10.1016/j.memsci.2025.123730openalex-extracted
Single-pass tangential flow filtration (SPTFF) for continuous mRNA concentration and purification
inferredcites →https://doi.org/10.1016/j.omtn.2024.102333openalex-extracted
Quality by design for mRNA platform purification based on continuous oligo-dT chromatography
inferredcites →https://doi.org/10.1016/j.seppur.2022.120776openalex-extracted
Defining the optimal operating conditions and configuration of a single-pass tangential flow filtration (SPTFF) system via CFD modelling
inferredcites →https://doi.org/10.1016/j.seppur.2022.120949openalex-extracted
Single pass tangential flow filtration: Critical operational variables, fouling, and main current applications
inferredcites →https://doi.org/10.1016/j.seppur.2025.132179openalex-extracted
Vibration-assisted ultrafiltration dramatically improves mRNA purification
inferredcites →https://doi.org/10.1016/j.trsl.2021.11.009openalex-extracted
Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials
inferredcites →https://doi.org/10.1016/j.vaccine.2021.03.038openalex-extracted
mRNA vaccines manufacturing: Challenges and bottlenecks
inferredcites →https://doi.org/10.1016/j.xphs.2023.05.007openalex-extracted
A New Model-Based Approach for the Development of Freeze-Drying Cycles Using a Small-Scale Freeze-Dryer
inferredcites →https://doi.org/10.1016/j.ymthe.2022.02.001openalex-extracted
Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
inferredcites →https://doi.org/10.1016/s0958-1669(00)00201-9openalex-extracted
Membrane separations in biotechnology
inferredcites →https://doi.org/10.1021/acs.biochem.9b00049openalex-extracted
RNA Polymerase: Step-by-Step Kinetics and Mechanism of Transcription Initiation
inferredcites →https://doi.org/10.1021/acs.oprd.2c00291openalex-extracted
A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry
inferredcites →https://doi.org/10.1021/acsomega.4c04985openalex-extracted
Digital Twin for Continuous Production of Virus-like Particles toward Autonomous Operation
inferredcites →https://doi.org/10.1021/bp970094popenalex-extracted
Application of Solution Equilibrium Analysis to in Vitro RNA Transcription
inferredcites →https://doi.org/10.1038/s41565-021-00898-0openalex-extracted
The current landscape of nucleic acid therapeutics
inferredcites →https://doi.org/10.1038/s41598-022-13112-5openalex-extracted
Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer
inferredcites →https://doi.org/10.1039/d0ra08826aopenalex-extracted
Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production
inferredcites →https://doi.org/10.1039/d2bm02031aopenalex-extracted
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
inferredcites →https://doi.org/10.1080/00401706.1991.10484804openalex-extracted
Factorial Sampling Plans for Preliminary Computational Experiments
inferredcites →https://doi.org/10.1080/01496395.2013.767837openalex-extracted
Continuous Countercurrent Tangential Chromatography for Monoclonal Antibody Purification
inferredcites →https://doi.org/10.1089/nat.2018.0721openalex-extracted
Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility
inferredcites →https://doi.org/10.1093/nar/15.21.8783openalex-extracted
Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
inferredcites →https://doi.org/10.1248/bpb.b21-01016openalex-extracted
Importance of Process Parameters Influencing the Mean Diameters of siRNA-Containing Lipid Nanoparticles (LNPs) on the in Vitro Activity of Prepared LNPs
inferredcites →https://doi.org/10.1371/journal.pone.0187962openalex-extracted
Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers
inferredcites →https://doi.org/10.18609/cgti.2021.073openalex-extracted
Supporting development of mRNA-based therapies by addressing large-scale purification challenges
inferredcites →https://doi.org/10.2139/ssrn.5233946openalex-extracted
Mechanistic Modeling of Lipid Nanoparticle(Lnp) Precipitation Via Population Balance Equations (Pbes)
inferredcites →https://doi.org/10.3389/fceng.2023.1182817openalex-extracted
Deep neural network for prediction and control of permeability decline in single pass tangential flow ultrafiltration in continuous processing of monoclonal antibodies
inferredcites →https://doi.org/10.3389/fmolb.2023.1291045openalex-extracted
Formation of dsRNA by-products during in vitro transcription can be reduced by using low steady-state levels of UTP
inferredcites →https://doi.org/10.3390/membranes13040433openalex-extracted
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications
inferredcites →https://doi.org/10.3390/pr9050748openalex-extracted
Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing
inferredcites →https://doi.org/10.3390/pr9111967openalex-extracted
Digital Twins for Continuous mRNA Production
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1101/2025.10.18.683252openalex-snapshot
Thermodynamic Modeling of mRNA with the Addition of Precipitants
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