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Long-Term Stabilization of Maleimide–Thiol Conjugates
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.bmcl.2007.09.002openalex-snapshot
Catalysis of imido group hydrolysis in a maleimide conjugate
inferredcites →https://doi.org/10.1016/j.jconrel.2008.05.010openalex-snapshot
Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
inferredcites →https://doi.org/10.1016/j.progpolymsci.2007.05.008openalex-snapshot
Polymer–drug conjugation, recent achievements and general strategies
inferredcites →https://doi.org/10.1021/bc200148vopenalex-snapshot
Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments
inferredcites →https://doi.org/10.1021/bc500276mopenalex-snapshot
Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers
inferredcites →https://doi.org/10.1021/bc500357nopenalex-snapshot
Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy
inferredcites →https://doi.org/10.1021/bc7004329openalex-snapshot
Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates
inferredcites →https://doi.org/10.1021/bi00467a014openalex-snapshot
Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase
inferredcites →https://doi.org/10.1038/nbt.2108openalex-snapshot
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
inferredcites →https://doi.org/10.1038/nbt.2968openalex-snapshot
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates
inferredcites →https://doi.org/10.1039/b910239fopenalex-snapshot
Boiling water-catalyzed neutral and selective N-Boc deprotection
inferredcites →https://doi.org/10.1039/c1cc11114kopenalex-snapshot
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis
inferredcites →https://doi.org/10.1039/p29780001277openalex-snapshot
Hydrolysis of some N-alkylmaleimides
inferredcites →https://doi.org/10.1073/pnas.1117147109openalex-snapshot
Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates
inferredcites →https://doi.org/10.1073/pnas.1215498110openalex-snapshot
Hydrogel drug delivery system with predictable and tunable drug release and degradation rates
inferredcites →https://doi.org/10.1073/pnas.1217203110openalex-snapshot
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1
inferredcites →https://doi.org/10.1139/v70-082openalex-snapshot
Kinetics of the reaction of glycine with N-ethylmaleimide
inferredcites →https://doi.org/10.1371/journal.pone.0083865openalex-snapshot
In Vitro and In Vivo Evaluation of Cysteine and Site Specific Conjugated Herceptin Antibody-Drug Conjugates
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inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.03.002openalex-snapshot
Insights into maleimide-thiol conjugation chemistry: Conditions for efficient surface functionalization of nanoparticles for receptor targeting
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.08.040openalex-snapshot
Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors
inferred← citeshttps://doi.org/10.1016/j.jconrel.2019.06.005openalex-snapshot
Crossing biological barriers with nanogels to improve drug delivery performance
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.09.016openalex-snapshot
Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.10.014openalex-snapshot
The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.113705openalex-snapshot
Glycogen-inspired trimannosylated serum albumin nanocarriers for targeted delivery of toll-like receptor 7/8 agonists to immune cells and liver
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.113876openalex-snapshot
Antibody polymer drug conjugates with increased drug to antibody ratio: CD38-targeting nanomedicines for innovative therapy of relapsed lymphomas
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115427openalex-snapshot
Structural DNA nanotechnology-guided spatially-ordered arrangement of aptamers on natural killer cells for solid tumor immunotherapy
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102481openalex-snapshot
Doxorubicin-loaded chitosan-alginate nanoparticles with dual mucoadhesive functionalities for intravesical chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jddst.2026.108761openalex-snapshot
Betulinic acid-loaded polymeric nanoparticles: synthesis, characterization and tumor-targeting potential
inferred← citeshttps://doi.org/10.1016/j.jpba.2018.11.009openalex-snapshot
Multi-arm PEG-maleimide conjugation intermediate characterization and hydrolysis study by a selective HPLC method
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113434openalex-snapshot
Development of a rapid reversed-phase liquid chromatographic method for total free thiol quantitation in protein therapeutics
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116455openalex-snapshot
Determination of degradation for sulfo-SIAB, SM(PEG)2, and sulfo-GMBS by RPLC-UV analysis
inferred← citeshttps://doi.org/10.1016/j.jpet.2025.103724openalex-snapshot
Half-life extension of therapeutics: Applications and mechanisms
inferred← citeshttps://doi.org/10.1016/j.jpha.2026.101740openalex-snapshot
Charged-tagging ion-exchange chromatography enables rapid, accurate and comprehensive (RAC) profiling of free thiols and charge heterogeneity in mAbs
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118674openalex-snapshot
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.121121openalex-snapshot
Rational designing of peptide-ligand conjugates-based immunotherapy for the treatment of complicated malaria
inferred← citeshttps://doi.org/10.1016/j.matt.2019.11.011openalex-snapshot
Site-Selective Protein Modification: From Functionalized Proteins to Functional Biomaterials
inferred← citeshttps://doi.org/10.1016/j.mex.2026.103809openalex-snapshot
Protocol for the synthesis of N-Alkyl bromomaleimide linkers
inferred← citeshttps://doi.org/10.1016/j.microc.2024.111025openalex-snapshot
On the utility of the extracted ion chromatograms for assigning the conjugation sites and side reactions in bioconjugates synthesized by the maleimide-thiol chemistry
inferred← citeshttps://doi.org/10.1016/j.molstruc.2016.07.015openalex-snapshot
Hydrolytic degradation of N , N ′-ethylenedimaleimide: Crystal structures of key intermediates and proposed mechanisms
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.147306openalex-snapshot
A biomimetic β-cyclodextrin-imidazole supramolecular system for selective conversion of L-cystine to L-cysteine toward cystine nephrolithiasis management
inferred← citeshttps://doi.org/10.1016/j.mtbio.2026.102908openalex-snapshot
Modulating cell surface chemistry through mild reduction reinforces extracellular-to-intracellular transmission forces and mechano-signaling
inferred← citeshttps://doi.org/10.1016/j.mtbio.2026.103334openalex-snapshot
Delivering the future of immunotherapy: A state-of-the-art review of gene editing in immune cells with lipid nanoparticles
inferred← citeshttps://doi.org/10.1016/j.mtchem.2017.02.007openalex-snapshot
Bioactive peptides grafted silicone dressings: A simple and specific method
inferred← citeshttps://doi.org/10.1016/j.nano.2017.07.004openalex-snapshot
Rationally designed peptide nanosponges for cell-based cancer therapy
inferred← citeshttps://doi.org/10.1016/j.polymer.2023.125884openalex-snapshot
Beyond Diels-Alder: Domino reactions in furan-maleimide click networks
inferred← citeshttps://doi.org/10.1016/j.procbio.2016.09.029openalex-snapshot
Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins
inferred← citeshttps://doi.org/10.1016/j.reactfunctpolym.2021.104932openalex-snapshot
Low-melting phthalonitrile monomers containing maleimide group: Synthesis, dual-curing behavior, thermal and mechanical properties
inferred← citeshttps://doi.org/10.1016/j.synbio.2021.01.001openalex-snapshot
Chemical modifications of proteins and their applications in metalloenzyme studies
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118179openalex-snapshot
Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets
inferred← citeshttps://doi.org/10.1016/j.ultrasmedbio.2026.03.013openalex-snapshot
Antibody Conjugation Strategies for Ultrasound Microbubbles: A Review of Bioconjugation Chemistry and Clinical Translation
inferred← citeshttps://doi.org/10.1016/j.xcrm.2026.102749openalex-snapshot
Debio 1562M CD37-targeting ADC is highly active and well tolerated in preclinical models of AML and MDS
inferred← citeshttps://doi.org/10.1016/j.xphs.2015.11.037openalex-snapshot
Physical and Chemical Stability of Antibody Drug Conjugates: Current Status
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.10.063openalex-snapshot
Characterization of Ring-Opening Reaction of Succinimide Linkers in ADCs
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.12.003openalex-snapshot
Agitation-Induced Aggregation of Lysine- And Interchain Cysteine-Linked Antibody-Drug Conjugates
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.08.021openalex-snapshot
Developing analytical ion exchange chromatography methods for antibody drug conjugates containing the hydrolysis-prone succinimide-thioether conjugation chemistry
inferred← citeshttps://doi.org/10.1016/j.ymeth.2025.07.010openalex-snapshot
Development of capillary electrophoresis method to measure albumin thiol oxidation in dystrophic humans and animal models of Duchenne muscular dystrophy
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c04025openalex-snapshot
Site-Specific Conjugation Quantitation of a Cysteine-Conjugated Antibody–Drug Conjugate Using Stable Isotope Labeling Peptide Mapping LC–MS/MS Analysis
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c05594openalex-snapshot
Stable Immobilization of DNA to Silica Surfaces by Sequential Michael Addition Reactions Developed with Insights from Confocal Raman Microscopy
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00411openalex-snapshot
LC/MS/MS Bioanalysis of Protein–Drug Conjugates—The Importance of Incorporating Succinimide Hydrolysis Products
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00694openalex-snapshot
A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine–Maleimide-Based Antibody Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01287openalex-snapshot
Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b05134openalex-snapshot
Reductive Desulfuration as an Important Tool in Detection of Small Molecule Modifications to Payload of Antibody Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00279openalex-snapshot
Monitoring Protein–Protein Interactions in the Cyanobacterial Circadian Clock in Real Time via Electron Paramagnetic Resonance Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00545openalex-snapshot
Reaction of Human Cd7metallothionein and N-Ethylmaleimide: Kinetic and Structural Insights from Electrospray Ionization Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00257openalex-snapshot
Dynamic Nuclear Polarization Nuclear Magnetic Resonance in Human Cells Using Fluorescent Polarizing Agents
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00143openalex-snapshot
Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00256openalex-snapshot
Chemoselective Methionine Bioconjugation: Site-Selective Fluorine-18 Labeling of Proteins and Peptides
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00121openalex-snapshot
Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00561openalex-snapshot
Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00144openalex-snapshot
Preparation of Maleimide-Modified Oligonucleotides from the Corresponding Amines Using N-Methoxycarbonylmaleimide
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00354openalex-snapshot
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00374openalex-snapshot
The Evolving Landscape of Antibody–Drug Conjugates: In Depth Analysis of Recent Research Progress
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.4c00162openalex-snapshot
Facile Access to Branched Multispecific Proteins
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.4c00275openalex-snapshot
Facile Rebridging Conjugation Approach to Attain Monoclonal Antibody-Targeted Nanoparticles with Enhanced Antigen Binding and Payload Delivery
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.4c00588openalex-snapshot
In Silico-Driven THIOMAB Approach for Stable PROTAC Conjugates by Docking Payloads in Antibody Cavities
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00224openalex-snapshot
Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00260openalex-snapshot
Antibody–Drug Conjugates for Tumor Targeting—Novel Conjugation Chemistries and the Promise of non-IgG Binding Proteins
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00355openalex-snapshot
Hydrolytically Stable Site-Specific Conjugation at the N-Terminus of an Engineered Antibody
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00420openalex-snapshot
Conjugation Approach To Produce a Staphylococcus aureus Synbody with Activity in Serum
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00024openalex-snapshot
Indium-111-Labeled Single-Domain Antibody for In Vivo CXCR4 Imaging Using Single-Photon Emission Computed Tomography
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00135openalex-snapshot
FlexTORCH: An Improved Flexible Fluorophore–Linker–Quencher Molecule Enlightening ADC Research
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00175openalex-snapshot
Impact of Conjugation Chemistry on the Pharmacokinetics of Peptide–Polymer Conjugates in a Model of Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00578openalex-snapshot
Fluorogenic Imaging Enables the Identification of Phosphoramidate Antibody–Drug Conjugate Linkers
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00117openalex-snapshot
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00133openalex-snapshot
One-Step Conjugation Method for Site-Specific Antibody–Drug Conjugates through Reactive Cysteine-Engineered Antibodies
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6c00140openalex-snapshot
A Case Study on the Impact of Thermal Hydrolysis and Lactone Ring Opening of Linker-Payload on Drug-to-Antibody Ratio Determination in a Topoisomerase I Inhibitor-Based ADC
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