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The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/bf00762962openalex-snapshot
Binding protein-dependent transport systems
inferredcites →https://doi.org/10.1016/0006-291x(89)90830-9openalex-snapshot
Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine
inferredcites →https://doi.org/10.1016/0092-8674(86)90594-5openalex-snapshot
Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
inferredcites →https://doi.org/10.1016/0092-8674(86)90595-7openalex-snapshot
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
inferredcites →https://doi.org/10.1016/0092-8674(88)90568-5openalex-snapshot
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene
inferredcites →https://doi.org/10.1016/0378-1119(88)90057-1openalex-snapshot
Sequence of mdr3 cDNA encoding a human P-glycoprotein
inferredcites →https://doi.org/10.1016/s0021-9258(18)54771-2openalex-snapshot
Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.
inferredcites →https://doi.org/10.1016/s0021-9258(18)71619-0openalex-snapshot
Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies
inferredcites →https://doi.org/10.1016/s0021-9258(19)39690-5openalex-snapshot
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.
inferredcites →https://doi.org/10.1016/s0021-9258(19)84855-xopenalex-snapshot
Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine
inferredcites →https://doi.org/10.1016/s0026-895x(25)13330-0openalex-snapshot
Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
inferredcites →https://doi.org/10.1021/bi00122a014openalex-snapshot
Lipophilic cations: a group of model substrates for the multidrug-resistance transporter
inferredcites →https://doi.org/10.1021/bi00122a020openalex-snapshot
Effect of B-ring substituents on absorption and circular dichroic spectra of colchicine analogs
inferredcites →https://doi.org/10.1021/bi00141a021openalex-snapshot
Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles
inferredcites →https://doi.org/10.1021/bi00852a043openalex-snapshot
Colchicine-binding protein of mammalian brain and its relation to microtubules
inferredcites →https://doi.org/10.1021/ja00200a015openalex-snapshot
Analysis of the near-ultraviolet absorption band of colchicine and the effect of tubulin binding
inferredcites →https://doi.org/10.1021/ja01171a045openalex-snapshot
The Microwave Spectra of CH3NCS and CH3SCN
inferredcites →https://doi.org/10.1021/jm00169a014openalex-snapshot
Structure-activity relationships of antineoplastic agents in multidrug resistance
inferredcites →https://doi.org/10.1021/jm00171a001openalex-snapshot
Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine
inferredcites →https://doi.org/10.1021/jm00211a010openalex-snapshot
Use of distribution coefficients in quantitative structure-activity relations
inferredcites →https://doi.org/10.1021/jm00243a001openalex-snapshot
Calculation of hydrophobic constant (log P) from .pi. and f constants
inferredcites →https://doi.org/10.1073/pnas.83.7.2052openalex-snapshot
B ring regulation of colchicine binding kinetics and fluorescence.
inferredcites →https://doi.org/10.1073/pnas.86.13.5128openalex-snapshot
Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.
inferredcites →https://doi.org/10.1073/pnas.87.18.7225openalex-snapshot
Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
inferredcites →https://doi.org/10.1073/pnas.88.16.7289openalex-snapshot
A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.
inferredcites →https://doi.org/10.1073/pnas.89.10.4564openalex-snapshot
Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.
inferredcites →https://doi.org/10.1128/mcb.10.4.1652openalex-snapshot
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
inferredcites →https://doi.org/10.1128/mcb.10.7.3596openalex-snapshot
Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells
inferredcites →https://doi.org/10.1128/mcb.11.2.595openalex-snapshot
Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.
inferredcites →https://doi.org/10.1128/mcb.8.7.2770openalex-snapshot
Cloning and characterization of a second member of the mouse mdr gene family.
inferredcites →https://doi.org/10.1146/annurev.bi.58.070189.001033openalex-snapshot
THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4814175openalex-extracted
Discovery of Colchicine Aryne Cyclo-Adduct as a Potent Molecule for the Abrogation of Epithelial to Mesenchymal Transition Via Modulating Cell Cycle Regulatory Cdk-2 and Cdk-4 Kinases
inferred← citeshttps://doi.org/10.1002/cbf.3166openalex-snapshot
A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT‐116 colon cancer cells
inferred← citeshttps://doi.org/10.1002/cmdc.201800641openalex-snapshot
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1‐Activated Prodrugs as Antiviral Agents
inferred← citeshttps://doi.org/10.1002/ijc.2910620413openalex-snapshot
Comparison of solutol HS 15, cremophor EL and novel ethoxylated fatty acid surfactants as multidrug resistance modification agents
inferred← citeshttps://doi.org/10.1007/978-1-4613-1143-0_13openalex-snapshot
Multidrug Resistance Transporter
inferred← citeshttps://doi.org/10.1007/978-3-642-41787-0_10openalex-snapshot
Plant Compounds Acting on the Cytoskeleton
inferred← citeshttps://doi.org/10.1007/bf02110325openalex-snapshot
Using purified P-glycoprotein to understand multidrug resistance
inferred← citeshttps://doi.org/10.1007/s00018-002-8424-8openalex-snapshot
Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters
inferred← citeshttps://doi.org/10.1016/0098-2997(94)00040-aopenalex-snapshot
P-glycoprotein-mediated multidrug resistance in tumor cells: Biochemistry, clinical relevance and modulation
inferred← citeshttps://doi.org/10.1016/0304-4157(95)00006-dopenalex-snapshot
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport
inferred← citeshttps://doi.org/10.1016/0960-894x(95)00300-iopenalex-snapshot
Hydroxylation at C-3′ of doxorubicin alters the selected phenotype of cellular drug resistance
inferred← citeshttps://doi.org/10.1016/b978-012352551-2/50006-8openalex-snapshot
SUBSTRATE-BINDING SITES IN ABC TRANSPORTERS
inferred← citeshttps://doi.org/10.1016/j.addr.2022.114138openalex-snapshot
Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107581openalex-snapshot
Discovery of colchicine aryne cycloadduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases in breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.108098openalex-snapshot
Design, synthesis, biological evaluation and multi spectroscopic studies of novel 2-styrylquinoline-carboxamide derivatives as potential DNA intercalating anticancer agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.09.104openalex-snapshot
Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation
inferred← citeshttps://doi.org/10.1016/j.drup.2023.100951openalex-snapshot
Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance
inferred← citeshttps://doi.org/10.1016/j.ejphar.2005.11.038openalex-snapshot
Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?
inferred← citeshttps://doi.org/10.1016/j.ejps.2005.09.009openalex-snapshot
Interactions between the dopamine agonist, bromocriptine and the efflux protein, P-glycoprotein at the blood–brain barrier in the mouse
inferred← citeshttps://doi.org/10.1016/j.febslet.2005.12.009openalex-snapshot
ABC transporters involved in the transport of plant secondary metabolites
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2004.07.686openalex-snapshot
Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113320openalex-snapshot
Distinct nuclear localization signals confer differential microtubule dependence among ZFTA fusion oncoproteins
inferred← citeshttps://doi.org/10.1016/s0014-5793(97)00899-5openalex-snapshot
Amino acid substitutions in the first transmembrane domain (TM1) of P‐glycoprotein that alter substrate specificity
inferred← citeshttps://doi.org/10.1016/s0026-895x(24)12139-6openalex-snapshot
Functional Analysis of a Tryptophan-Less P-glycoprotein: A Tool for Tryptophan Insertion and Fluorescence Spectroscopy
inferred← citeshttps://doi.org/10.1016/s0065-2490(96)80005-0openalex-snapshot
Multidrug resistance of cancer cells
inferred← citeshttps://doi.org/10.1016/s0076-6879(98)92032-8openalex-snapshot
[30] Mutational analysis of P-glycoprotein in yeast Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1016/s0169-409x(97)00498-5openalex-snapshot
Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters
inferred← citeshttps://doi.org/10.1016/s0925-4439(97)00026-4openalex-snapshot
Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity
inferred← citeshttps://doi.org/10.1016/s0928-0987(00)00177-9openalex-snapshot
Structure–activity relationship of P-glycoprotein substrates and modifiers
inferred← citeshttps://doi.org/10.1016/s0968-0004(99)01514-5openalex-snapshot
A structure-based mechanism for drug binding by multidrug transporters
inferred← citeshttps://doi.org/10.1016/s1383-8121(96)80048-0openalex-snapshot
Chapter 7 The P-glycoprotein family and multidrug resistance: An overview
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00222openalex-snapshot
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives
inferred← citeshttps://doi.org/10.1021/bi00013a032openalex-snapshot
Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3
inferred← citeshttps://doi.org/10.1021/bi00183a006openalex-snapshot
Structurally Distinct MDR Modulators Show Specific Patterns of Reversal Against P-Glycoproteins Bearing Unique Mutations at Serine939/941
inferred← citeshttps://doi.org/10.1021/jm010126mopenalex-snapshot
C-7 Analogues of Progesterone as Potent Inhibitors of the P-Glycoprotein Efflux Pump
inferred← citeshttps://doi.org/10.1021/jm301151topenalex-snapshot
Synthesis and Biological Evaluation of Colchicine B-Ring Analogues Tethered with Halogenated Benzyl Moieties
inferred← citeshttps://doi.org/10.1021/mp400450mopenalex-snapshot
ADMET Evaluation in Drug Discovery. 13. Development ofin SilicoPrediction Models for P-Glycoprotein Substrates
inferred← citeshttps://doi.org/10.1023/a:1006022811895openalex-snapshot
Vinflunine (20′,20′-difluoro- 3′,4′-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro
inferred← citeshttps://doi.org/10.1046/j.1432-1327.2000.01046.xopenalex-snapshot
Analysis of the tangled relationships between P‐glycoprotein‐mediated multidrug resistance and the lipid phase of the cell membrane
inferred← citeshttps://doi.org/10.1074/jbc.270.29.17159openalex-snapshot
Functional Dissection of P-glycoprotein Nucleotide-binding Domains in Chimeric and Mutant Proteins
inferred← citeshttps://doi.org/10.1074/jbc.270.39.22859openalex-snapshot
Characterization of Prenylcysteines That Interact with P-glycoprotein and Inhibit Drug Transport in Tumor Cells
inferred← citeshttps://doi.org/10.1074/jbc.271.16.9240openalex-snapshot
Transmembrane Organization of Mouse P-glycoprotein Determined by Epitope Insertion and Immunofluorescence
inferred← citeshttps://doi.org/10.1074/jbc.272.42.26479openalex-snapshot
Topology Mapping of the Amino-terminal Half of Multidrug Resistance-associated Protein by Epitope Insertion and Immunofluorescence
inferred← citeshttps://doi.org/10.1097/00126334-200406010-00001openalex-snapshot
Transport of HIV Protease Inhibitors Through the Blood-Brain Barrier and Interactions With the Efflux Proteins, P-Glycoprotein and Multidrug Resistance Proteins
inferred← citeshttps://doi.org/10.1097/cad.0000000000000464openalex-snapshot
Potential anticancer role of colchicine-based derivatives
inferred← citeshttps://doi.org/10.1101/2024.11.26.625308openalex-snapshot
Inhibition of microtubule polymerization and dynein impairs the nuclear localization of the ependymoma-associated ZFTA-RELA fusion protein and NF-κB activation
inferred← citeshttps://doi.org/10.1124/mol.52.2.323openalex-snapshot
Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents
inferred← citeshttps://doi.org/10.1128/aac.39.8.1696openalex-snapshot
Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata
inferred← citeshttps://doi.org/10.1146/annurev.pharmtox.39.1.361openalex-snapshot
BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER
inferred← citeshttps://doi.org/10.1152/physrev.00037.2005openalex-snapshot
Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System
inferred← citeshttps://doi.org/10.1271/bbb.100325openalex-snapshot
Increased ABCB1 Expression in TP-110-Resistant RPMI-8226 Cells
inferred← citeshttps://doi.org/10.1517/17425247.2.4.683openalex-snapshot
Role of efflux pumps and metabolising enzymes in drug delivery
inferred← citeshttps://doi.org/10.1590/s0100-879x1999000800001openalex-snapshot
P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships
inferred← citeshttps://doi.org/10.1645/ge-1418.1openalex-snapshot
cGMP Secreted From the Tapeworm Hymenolepis diminuta Is a Signal Molecule to the Host Intestine
inferred← citeshttps://doi.org/10.2165/00003088-200342010-00003openalex-snapshot
Role of P-Glycoprotein in Pharmacokinetics
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-rs3lhopenalex-snapshot
Silicon-tethered colchicine aryne cyclo-adduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases
inferred← citeshttps://doi.org/10.3390/molecules21101375openalex-snapshot
Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site
inferred← citeshttps://doi.org/10.5451/unibas-004517459openalex-snapshot
"In silico" prediction of blood-brain barrier permeation and P-glycoprotein activity
inferred← citeshttps://doi.org/10.59761/rcr5125openalex-snapshot
The chemistry of heterocycles in the 21st century
inferred← citeshttps://doi.org/10.70675/baa8a399z3cefz452bza32eza8a0f2d45eefopenalex-snapshot
Caractérisation d’un transporteur ABC d’antibiotiques de Streptococcus pneumoniae, PatA-PatB
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