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Discovery of Colchicine Aryne Cyclo-Adduct as a Potent Molecule for the Abrogation of Epithelial to Mesenchymal Transition Via Modulating Cell Cycle Regulatory Cdk-2 and Cdk-4 Kinases

https://doi.org/10.2139/ssrn.4814175
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inferredcites →https://doi.org/10.1002/cmdc.201100361openalex-extracted
The Tubulin Colchicine Domain: a Molecular Modeling Perspective
inferredcites →https://doi.org/10.1002/jbt.22487openalex-extracted
Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells—in vitro and ex vivo study
inferredcites →https://doi.org/10.1002/med.20097openalex-extracted
Anti‐mitotic activity of colchicine and the structural basis for its interaction with tubulin
inferredcites →https://doi.org/10.1002/med.21377openalex-extracted
Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates
inferredcites →https://doi.org/10.1007/128_2008_11openalex-extracted
Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin
inferredcites →https://doi.org/10.1007/s11883-021-00932-5openalex-extracted
Colchicine and Cardiovascular Outcomes: a Critical Appraisal of Recent Studies
inferredcites →https://doi.org/10.1007/s13277-016-5160-5openalex-extracted
A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells
inferredcites →https://doi.org/10.1016/j.ceb.2005.08.001openalex-extracted
Molecular requirements for epithelial–mesenchymal transition during tumor progression
inferredcites →https://doi.org/10.1016/j.ctrv.2011.11.001openalex-extracted
Epithelial–mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact
inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.055openalex-extracted
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids
inferredcites →https://doi.org/10.1016/j.lfs.2013.07.002openalex-extracted
Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.pan.2020.09.021openalex-extracted
Par-4 activation restrains EMT-induced chemoresistance in PDAC by attenuating MDM-2
inferredcites →https://doi.org/10.1016/j.tcb.2015.08.009openalex-extracted
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment
inferredcites →https://doi.org/10.1016/s1470-2045(00)00254-0openalex-extracted
Epidemiology of breast cancer
inferredcites →https://doi.org/10.1021/acs.bioconjchem.7b00670openalex-extracted
Cyclodipeptide c(Orn-Pro) Conjugate with 4-Ethylpiperic Acid Abrogates Cancer Cell Metastasis through Modulating MDM2
inferredcites →https://doi.org/10.1021/acs.jmedchem.0c00222openalex-extracted
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives
inferredcites →https://doi.org/10.1021/bi00076a022openalex-extracted
The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance
inferredcites →https://doi.org/10.1021/jm401939gopenalex-extracted
Novel Colchicine-Site Binders with a Cyclohexanedione Scaffold Identified through a Ligand-Based Virtual Screening Approach
inferredcites →https://doi.org/10.1021/jo00083a034openalex-extracted
Exploratory Synthetic Studies Involving the Tricyclo[9.3.0.02,8]tetradecane Ring System Peculiar to the Cyathins
inferredcites →https://doi.org/10.1021/jo500819wopenalex-extracted
Diels–Alder Reaction of Tropones with Arynes: Synthesis of Functionalized Benzobicyclo[3.2.2]nonatrienones
inferredcites →https://doi.org/10.1038/nrc2602openalex-extracted
Cell cycle, CDKs and cancer: a changing paradigm
inferredcites →https://doi.org/10.1038/s41419-019-1690-2openalex-extracted
Vimentin activation in early apoptotic cancer cells errands survival pathways during DNA damage inducer CPT treatment in colon carcinoma model
inferredcites →https://doi.org/10.1080/07388551.2017.1303804openalex-extracted
Biotherapeutic potential and mechanisms of action of colchicine
inferredcites →https://doi.org/10.1097/cad.0000000000000464openalex-extracted
Potential anticancer role of colchicine-based derivatives
inferredcites →https://doi.org/10.1111/bph.12704openalex-extracted
Movers and shakers: cell cytoskeleton in cancer metastasis
inferredcites →https://doi.org/10.1158/1055-9965.epi-14-0017openalex-extracted
The Potential for Markers of Epithelial–Mesenchymal Transition to Improve Colorectal Cancer Outcomes: A Systematic Review
inferredcites →https://doi.org/10.1186/s13023-019-1201-7openalex-extracted
Update on the management of colchicine resistant Familial Mediterranean Fever (FMF)
inferredcites →https://doi.org/10.1246/bcsj.64.2778openalex-extracted
Synthetic Photochemistry. LVII. Facile Photochemical Construction of Hexahydro-as-indacene Skeleton, a Carbon Framework of Ikarugamycin, from High-Pressure Diels–Alder Adducts of Tropones–Cyclopentenone
inferredcites →https://doi.org/10.1371/journal.pone.0087064openalex-extracted
Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells
inferredcites →https://doi.org/10.3389/fphar.2012.00009openalex-extracted
Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies
inferredcites →https://doi.org/10.3389/fphar.2019.01614openalex-extracted
Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice
inferredcites →https://doi.org/10.3390/ijms22136923openalex-extracted
The Influence of Cell Cycle Regulation on Chemotherapy
inferredcites →https://doi.org/10.4103/idoj.idoj_475_20openalex-extracted
Colchicine in dermatology: Rediscovering an old drug with novel uses
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