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Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/0006-2952(83)90613-5openalex-snapshot
Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase
inferredcites →https://doi.org/10.1016/0006-8993(79)90307-xopenalex-snapshot
Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool
inferredcites →https://doi.org/10.1016/0020-711x(94)90021-3openalex-snapshot
Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems
inferredcites →https://doi.org/10.1016/j.biocel.2009.03.003openalex-snapshot
Glutamine homeostasis and mitochondrial dynamics
inferredcites →https://doi.org/10.1016/j.bpj.2011.06.063openalex-snapshot
Automated Real-Space Refinement of Protein Structures Using a Realistic Backbone Move Set
inferredcites →https://doi.org/10.1016/j.ccr.2010.08.009openalex-snapshot
Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
inferredcites →https://doi.org/10.1016/j.neuint.2009.01.008openalex-snapshot
Glutamine in neoplastic cells: Focus on the expression and roles of glutaminases
inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot
[20] Processing of X-ray diffraction data collected in oscillation mode
inferredcites →https://doi.org/10.1016/s0959-440x(98)80156-5openalex-snapshot
Validation of protein models derived from experiment
inferredcites →https://doi.org/10.1021/bi800097hopenalex-snapshot
Functional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis
inferredcites →https://doi.org/10.1038/nature07823openalex-snapshot
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
inferredcites →https://doi.org/10.1038/onc.2009.358openalex-snapshot
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
inferredcites →https://doi.org/10.1042/bj20070039openalex-snapshot
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
inferredcites →https://doi.org/10.1093/jn/131.9.2491sopenalex-snapshot
Role of Mitochondrial Glutaminase in Rat Renal Glutamine Metabolism
inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot
The CCP4 suite: programs for protein crystallography
inferredcites →https://doi.org/10.1111/j.1471-4159.1983.tb04785.xopenalex-snapshot
In Vivo Release from Cerebral Cortex of [14C]Glutamate Synthesized from [U‐14C]Glutamine
inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04594.xopenalex-snapshot
Glutamate production by HIV‐1 infected human macrophage is blocked by the inhibition of glutaminase
inferredcites →https://doi.org/10.1111/j.1471-4159.2009.05989.xopenalex-snapshot
In vitro glutaminase regulation and mechanisms of glutamate generation in HIV‐1‐infected macrophage
inferredcites →https://doi.org/10.1113/expphysiol.1985.sp002935openalex-snapshot
GLUTAMINE METABOLISM IN LYMPHOCYTES: ITS BIOCHEMICAL, PHYSIOLOGICAL AND CLINICAL IMPORTANCE
inferredcites →https://doi.org/10.1152/ajprenal.2000.278.2.f227openalex-snapshot
Differential expression and acid-base regulation of glutaminase mRNAs in gluconeogenic LLC-PK1-FBPase+cells
inferredcites →https://doi.org/10.1152/physiolgenomics.1999.1.2.51openalex-snapshot
Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing
inferredcites →https://doi.org/10.1369/jhc.2009.954008openalex-snapshot
Fixative Composition Alters Distributions of Immunoreactivity for Glutaminase and Two Markers of Nociceptive Neurons, Na v 1.8 and TRPV1, in the Rat Dorsal Root Ganglion
inferredcites →https://doi.org/10.1523/jneurosci.4241-05.2006openalex-snapshot
Mice Lacking Brain/Kidney Phosphate-Activated Glutaminase Have Impaired Glutamatergic Synaptic Transmission, Altered Breathing, Disorganized Goal-Directed Behavior and Die Shortly after Birth
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Targeting Hepatic Glutaminase 1 Ameliorates Non-Alcoholic Steatohepatitis by Restoring Disrupted Hepatic Very-Low Density Lipoproteins Triglyceride Assembly
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Identification and characterization of a novel glutaminase inhibitor
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Regulation of Renal Glutamine Metabolism During Metabolic Acidosis
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Glutamine Metabolism in Gliomas
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The pyridazine heterocycle in molecular recognition and drug discovery
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Glutamine metabolism in prostate cancer
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Glutamine metabolism targeting liposomes for synergistic chemosensitization and starvation therapy in ovarian cancer
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Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling
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inferred← citeshttps://doi.org/10.1016/j.bbi.2020.11.038openalex-snapshot
Glutaminase in microglia: A novel regulator of neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.06.110openalex-snapshot
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
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Reprogramming the impact of glutamine metabolism on controlling the immunoinflammatory milieu in psoriasis
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Glutaminase 1 inhibitors: Therapeutic potential, mechanisms of action, and clinical perspectives
inferred← citeshttps://doi.org/10.1016/j.biochi.2012.11.016openalex-snapshot
Bmcc1s interacts with the phosphate-activated glutaminase in the brain
inferred← citeshttps://doi.org/10.1016/j.biochi.2021.03.009openalex-snapshot
Structure and activation mechanism of the human liver-type glutaminase GLS2
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113585openalex-snapshot
Structure-based virtual screening discovers novel kidney-type glutaminase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bj.2024.100714openalex-snapshot
Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.03.009openalex-snapshot
Design and evaluation of novel glutaminase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115698openalex-snapshot
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.04.032openalex-snapshot
Design and synthesis of novel tellurodibenzoic acid compounds as kidney-type glutaminase (KGA) inhibitors
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Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.126632openalex-snapshot
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency
inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130595openalex-snapshot
Design, synthesis and biological evaluation of symmetric thiadiazole carboxamide derivative as glutaminase inhibitor
inferred← citeshttps://doi.org/10.1016/j.cbpa.2021.01.006openalex-snapshot
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment
inferred← citeshttps://doi.org/10.1016/j.cbpb.2012.05.010openalex-snapshot
Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate
inferred← citeshttps://doi.org/10.1016/j.cdc.2023.101044openalex-snapshot
Molecular docking/dynamics simulations, MEP analysis, and pharmacokinetics prediction of some withangulatin A derivatives as allosteric glutaminase C inhibitors in breast cancer
inferred← citeshttps://doi.org/10.1016/j.cell.2018.08.038openalex-snapshot
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117975openalex-snapshot
Mitochondrial Raf1 regulates glutamine catabolism
inferred← citeshttps://doi.org/10.1016/j.chembiol.2014.08.007openalex-snapshot
Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell Metabolism
inferred← citeshttps://doi.org/10.1016/j.cmet.2011.12.009openalex-snapshot
Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.01.013openalex-snapshot
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2022.105669openalex-snapshot
Discovery of novel Glutaminase allosteric inhibitors through drug repurposing and comparative MMGB/PBSA and molecular dynamics simulation
inferred← citeshttps://doi.org/10.1016/j.coph.2014.07.001openalex-snapshot
Emerging approaches to target tumor metabolism
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.10.008openalex-snapshot
Glutaminase regulation in cancer cells: a druggable chain of events
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112980openalex-snapshot
Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114686openalex-snapshot
Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115306openalex-snapshot
Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112405openalex-snapshot
Dynamic crosstalk between amino acid metabolism and cancer drug efficacy: From mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101535openalex-snapshot
New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113091openalex-snapshot
Structure and enzymology of glutaminase S482C and H461L variants associated with excess brain glutamate and neurological disease
inferred← citeshttps://doi.org/10.1016/j.jpha.2025.101292openalex-snapshot
Recent insights into the roles and therapeutic potentials of GLS1 in inflammatory diseases
inferred← citeshttps://doi.org/10.1016/j.metabol.2012.07.007openalex-snapshot
Ammonium metabolism in humans
inferred← citeshttps://doi.org/10.1016/j.molcel.2012.10.024openalex-snapshot
Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome
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Rho GTPases and their roles in cancer metabolism
inferred← citeshttps://doi.org/10.1016/j.molstruc.2017.04.020openalex-snapshot
First report on the structural exploration and prediction of new BPTES analogs as glutaminase inhibitors
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.142985openalex-snapshot
Allosteric inhibitors for the treatment of cancers (2021-): A review from medicinal chemistry perspectives
inferred← citeshttps://doi.org/10.1016/j.neuint.2014.11.004openalex-snapshot
Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype
inferred← citeshttps://doi.org/10.1016/j.neuint.2014.12.003openalex-snapshot
Effect of lysine to alanine mutations on the phosphate activation and BPTES inhibition of glutaminase
inferred← citeshttps://doi.org/10.1016/j.rechem.2023.100842openalex-snapshot
Discovery of aminothiazole derivatives as a chemical scaffold for glutaminase inhibition
inferred← citeshttps://doi.org/10.1016/j.ymgme.2026.109906openalex-snapshot
Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity
inferred← citeshttps://doi.org/10.1016/s0021-9258(17)49889-9openalex-snapshot
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
inferred← citeshttps://doi.org/10.1017/erm.2019.4openalex-snapshot
Warburg and Krebs and related effects in cancer
inferred← citeshttps://doi.org/10.1021/acs.analchem.6b03849openalex-snapshot
Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.jcim.5b00177openalex-snapshot
Intermolecular Sulfur···Oxygen Interactions: Theoretical and Statistical Investigations
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c02044openalex-snapshot
Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00282openalex-snapshot
Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00327openalex-snapshot
Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00961openalex-snapshot
Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01198openalex-snapshot
Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00260openalex-snapshot
Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.3c00375openalex-snapshot
Targeting the Subpocket Enables the Discovery of Thiadiazole–Pyridazine Derivatives as Glutaminase C Inhibitors
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.6b00060openalex-snapshot
Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold
inferred← citeshttps://doi.org/10.1021/jm301191popenalex-snapshot
Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors
inferred← citeshttps://doi.org/10.1021/mp500405hopenalex-snapshot
Simultaneously Targeting Tissue Transglutaminase and Kidney Type Glutaminase Sensitizes Cancer Cells to Acid Toxicity and Offers New Opportunities for Therapeutic Intervention
inferred← citeshttps://doi.org/10.1038/nature12040openalex-snapshot
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
inferred← citeshttps://doi.org/10.1038/nrc.2016.71openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41418-022-01022-yopenalex-snapshot
Targeting mitochondrial metabolism for precision medicine in cancer
inferred← citeshttps://doi.org/10.1038/s41422-023-00886-0openalex-snapshot
Structural basis for activation and filamentation of glutaminase
inferred← citeshttps://doi.org/10.1038/s41422-024-00985-6openalex-snapshot
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
inferred← citeshttps://doi.org/10.1038/s41467-020-14374-1openalex-snapshot
Targeting glutamine metabolism slows soft tissue sarcoma growth
inferred← citeshttps://doi.org/10.1038/s41467-024-46351-3openalex-snapshot
Filament formation drives catalysis by glutaminase enzymes important in cancer progression
inferred← citeshttps://doi.org/10.1038/srep03827openalex-snapshot
Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)
inferred← citeshttps://doi.org/10.1039/c6mb00231eopenalex-snapshot
Small-molecule binding sites to explore protein–protein interactions in the cancer proteome
inferred← citeshttps://doi.org/10.1039/d3cc00487bopenalex-snapshot
Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy
inferred← citeshttps://doi.org/10.1039/d5np00039dopenalex-snapshot
Natural products targeting the metabolism of amino acids: from discovery to synthetic development
inferred← citeshttps://doi.org/10.1073/pnas.1116573109openalex-snapshot
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
inferred← citeshttps://doi.org/10.1073/pnas.1402012111openalex-snapshot
Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter
inferred← citeshttps://doi.org/10.1073/pnas.1414056112openalex-snapshot
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells
inferred← citeshttps://doi.org/10.1073/pnas.1507228112openalex-snapshot
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
inferred← citeshttps://doi.org/10.1073/pnas.1611406113openalex-snapshot
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
inferred← citeshttps://doi.org/10.1073/pnas.2310479121openalex-snapshot
Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1074/jbc.m113.501346openalex-snapshot
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
inferred← citeshttps://doi.org/10.1074/jbc.m116.720268openalex-snapshot
Mechanistic Basis of Glutaminase Activation
inferred← citeshttps://doi.org/10.1074/jbc.m116.758219openalex-snapshot
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators
inferred← citeshttps://doi.org/10.1074/jbc.m117.787291openalex-snapshot
The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats
inferred← citeshttps://doi.org/10.1074/jbc.m117.810101openalex-snapshot
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010314openalex-snapshot
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
inferred← citeshttps://doi.org/10.1080/13543776.2018.1530759openalex-snapshot
Glutaminase inhibitors: a patent review
inferred← citeshttps://doi.org/10.1080/14728222.2019.1615438openalex-snapshot
The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension
inferred← citeshttps://doi.org/10.1080/14756366.2023.2290911openalex-snapshot
Glutaminase inhibition as potential cancer therapeutics: current status and future applications
inferred← citeshttps://doi.org/10.1093/ndt/gfx349openalex-snapshot
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease
inferred← citeshttps://doi.org/10.1101/2021.09.20.461106openalex-snapshot
New Insights into the Mechanisms Used by Inhibitors Targeting Glutamine Metabolism in Cancer Cells
inferred← citeshttps://doi.org/10.1101/2023.03.30.534948openalex-snapshot
Structural basis for activation of glutaminase
inferred← citeshttps://doi.org/10.1101/2023.07.20.548338openalex-snapshot
AMPK targets PDZD8 to trigger carbon source shift to glutamine
inferred← citeshttps://doi.org/10.1101/2025.09.14.674662openalex-snapshot
Structure and enzymology of glutaminase mutants that disrupt glutamine-glutamate homeostasis and cause neurological disease
inferred← citeshttps://doi.org/10.1101/gad.189365.112openalex-snapshot
Links between metabolism and cancer
inferred← citeshttps://doi.org/10.1107/s1600576715023195openalex-snapshot
Reduction of lattice disorder in protein crystals by high-pressure cryocooling
inferred← citeshttps://doi.org/10.1146/annurev-med-092012-112344openalex-snapshot
Targeting Metabolic Changes in Cancer: Novel Therapeutic Approaches
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-11-0942openalex-snapshot
Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-13-0870openalex-snapshot
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.11606/t.76.2018.tde-25022021-104637openalex-snapshot
Uma visão estrutural sobre componentes do processo de adaptação metabólica de tumores
inferred← citeshttps://doi.org/10.11606/t.95.2016.tde-04012016-152835openalex-snapshot
Implementação de uma abordagem híbrida utilizando modelagem comparativa e ab initio para predição de estruturas tridimensionais de proteínas contendo múltiplos domínios com conectores flexíveis
inferred← citeshttps://doi.org/10.1172/jci75836openalex-snapshot
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
inferred← citeshttps://doi.org/10.1186/s12915-016-0313-yopenalex-snapshot
Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia
inferred← citeshttps://doi.org/10.1186/s12943-026-02571-3openalex-snapshot
Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects
inferred← citeshttps://doi.org/10.1186/s12976-019-0109-1openalex-snapshot
Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism
inferred← citeshttps://doi.org/10.1186/s40035-017-0080-xopenalex-snapshot
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration
inferred← citeshttps://doi.org/10.13023/etd.2021.303openalex-snapshot
DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS
inferred← citeshttps://doi.org/10.1371/journal.pone.0115144openalex-snapshot
Mesenchymal Phenotype Predisposes Lung Cancer Cells to Impaired Proliferation and Redox Stress in Response to Glutaminase Inhibition
inferred← citeshttps://doi.org/10.1371/journal.pone.0160291openalex-snapshot
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions
inferred← citeshttps://doi.org/10.1371/journal.pone.0185092openalex-snapshot
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition
inferred← citeshttps://doi.org/10.1590/s2175-97902026e24897openalex-snapshot
Novel 3-thio-1,2,4- and 1,2,3-triazole derivatives as allosteric glutaminase inhibitors
inferred← citeshttps://doi.org/10.18632/oncotarget.10579openalex-snapshot
Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells
inferred← citeshttps://doi.org/10.18632/oncotarget.10791openalex-snapshot
Structural basis for exploring the allosteric inhibition of human kidney type glutaminase
inferred← citeshttps://doi.org/10.18632/oncotarget.12944openalex-snapshot
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
inferred← citeshttps://doi.org/10.18632/oncotarget.14188openalex-snapshot
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway
inferred← citeshttps://doi.org/10.18632/oncotarget.2173openalex-snapshot
Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells
inferred← citeshttps://doi.org/10.18632/oncotarget.5150openalex-snapshot
Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy
inferred← citeshttps://doi.org/10.18632/oncotarget.6311openalex-snapshot
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
inferred← citeshttps://doi.org/10.20517/cdr.2018.004openalex-snapshot
Glutaminase inhibition in renal cell carcinoma therapy
inferred← citeshttps://doi.org/10.21037/tcr.2016.09.02openalex-snapshot
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
inferred← citeshttps://doi.org/10.2174/1568026618666180523111351openalex-snapshot
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer
inferred← citeshttps://doi.org/10.2174/1570159x14666160509123042openalex-snapshot
Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain Pathways
inferred← citeshttps://doi.org/10.3109/10409238.2013.844093openalex-snapshot
Stress eating and tuning out: Cancer cells re-wire metabolism to counter stress
inferred← citeshttps://doi.org/10.3233/kca-180043openalex-snapshot
The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1610255openalex-snapshot
Metabolism in the tumor microenvironment: implications for pathogenesis and therapeutics
inferred← citeshttps://doi.org/10.3389/fonc.2020.00276openalex-snapshot
Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2025.1673513openalex-snapshot
Ammonium metabolism rewiring in the prostate cancer microenvironment: Mechanisms and clinical prospects
inferred← citeshttps://doi.org/10.3389/fphys.2017.00217openalex-snapshot
Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer
inferred← citeshttps://doi.org/10.3390/cancers11111628openalex-snapshot
Glutamine Metabolism in Brain Tumors
inferred← citeshttps://doi.org/10.3390/fermentation12010036openalex-snapshot
Rhodotorula mucilaginosa Growth on Glutamine Is Sensitive to Mammalian-Glutaminase Inhibitors
inferred← citeshttps://doi.org/10.3390/foods11010067openalex-snapshot
Mechanistic Insights into Biological Activities of Polyphenolic Compounds from Rosemary Obtained by Inverse Molecular Docking
inferred← citeshttps://doi.org/10.3390/ijms160922830openalex-snapshot
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
inferred← citeshttps://doi.org/10.3390/ijms232012695openalex-snapshot
Role of Glycolysis and Fatty Acid Synthesis in the Activation and T Cell-Modulating Potential of Dendritic Cells Stimulated with a TLR5-Ligand Allergen Fusion Protein
inferred← citeshttps://doi.org/10.3390/ijms232315296openalex-snapshot
Therapeutic Targeting of Glutaminolysis as a Novel Strategy to Combat Cancer Stem Cells
inferred← citeshttps://doi.org/10.3390/molecules30173457openalex-snapshot
Metabolism, a Blossoming Target for Small-Molecule Anticancer Drugs
inferred← citeshttps://doi.org/10.3390/v18030326openalex-snapshot
Host Cell Central Carbon Metabolism and Cellular NAD+ Pool Regulate Efficient Replication of Vesicular Stomatitis Virus
inferred← citeshttps://doi.org/10.37796/2211-8039.1445openalex-snapshot
Glutaminase - A potential target for cancer treatment
inferred← citeshttps://doi.org/10.4155/fdd-2022-0011openalex-snapshot
Alone and Together: Current Approaches to Targeting Glutaminase Enzymes As Part of Anti-Cancer Therapies
inferred← citeshttps://doi.org/10.4155/fmc-2016-0190openalex-snapshot
A Tale of Two Glutaminases: Homologous Enzymes with Distinct Roles in Tumorigenesis
inferred← citeshttps://doi.org/10.4155/fmc.13.130openalex-snapshot
Therapeutic Strategies Impacting Cancer Cell Glutamine Metabolism
inferred← citeshttps://doi.org/10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0openalex-snapshot
Biochemical characterization of mTORC1 regulation by glutamine metabolism
inferred← citeshttps://doi.org/10.7497/j.issn.2095-3941.2014.01.001openalex-snapshot
Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies.
inferred← citeshttps://doi.org/10.9758/cpn.2017.15.2.115openalex-snapshot
In SilicoModel-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology
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