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Targeting Hepatic Glutaminase 1 Ameliorates Non-Alcoholic Steatohepatitis by Restoring Disrupted Hepatic Very-Low Density Lipoproteins Triglyceride Assembly

https://doi.org/10.2139/ssrn.3219265

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.23094openalex-extracted

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis # †

inferredcites →https://doi.org/10.1002/hep.23314openalex-extracted

Decreased Survival of Subjects With Elevated Liver Function Tests During A 28-Year Follow-Up

inferredcites →https://doi.org/10.1002/hep.23527openalex-extracted

the Incidence and Risk Factors of Hepatocellular Carcinoma in Patients With Nonalcoholic Steatohepatitis

inferredcites →https://doi.org/10.1002/hep.24607openalex-extracted

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

inferredcites →https://doi.org/10.1002/hep.24795openalex-extracted

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

inferredcites →https://doi.org/10.1002/hep.28431openalex-extracted

Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes

inferredcites →https://doi.org/10.1002/hep4.1107openalex-extracted

Role of aramchol in steatohepatitis and fibrosis in mice

inferredcites →https://doi.org/10.1007/978-1-60761-688-7_6openalex-extracted

Hepatocyte Differentiation

inferredcites →https://doi.org/10.1016/j.bbalip.2014.11.006openalex-extracted

Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice

inferredcites →https://doi.org/10.1016/j.bbrc.2013.06.110openalex-extracted

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors

inferredcites →https://doi.org/10.1016/j.ccr.2010.08.009openalex-extracted

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

inferredcites →https://doi.org/10.1016/j.cmet.2011.12.015openalex-extracted

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

inferredcites →https://doi.org/10.1016/j.cmet.2015.04.004openalex-extracted

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

inferredcites →https://doi.org/10.1016/j.molcel.2015.12.014openalex-extracted

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

inferredcites →https://doi.org/10.1016/s0005-2760(97)00137-9openalex-extracted

Phosphatidylserine synthase I and II of mammalian cells

inferredcites →https://doi.org/10.1016/s0021-9258(18)64849-5openalex-extracted

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

inferredcites →https://doi.org/10.1016/s0022-2275(20)33317-4openalex-extracted

Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase concentrations

inferredcites →https://doi.org/10.1016/s0022-2275(20)37430-7openalex-extracted

Quantification in the subnanomolar range of phospholipids and neutral lipids by monodimensional thin-layer chromatography and image analysis

inferredcites →https://doi.org/10.1016/s0022-2275(20)40584-xopenalex-extracted

Very low density lipoprotein. Fate of phospholipids, cholesterol, and apolipoprotein C during lipolysis in vitro.

inferredcites →https://doi.org/10.1016/s1665-2681(19)31355-9openalex-extracted

S-adenosylmethionine metabolism and liver disease

inferredcites →https://doi.org/10.1021/bi201613dopenalex-extracted

Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

inferredcites →https://doi.org/10.1021/jm301191popenalex-extracted

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

inferredcites →https://doi.org/10.1021/pr200047copenalex-extracted

A Proton Nuclear Magnetic Resonance Metabonomics Approach for Biomarker Discovery in Nonalcoholic Fatty Liver Disease

inferredcites →https://doi.org/10.1021/pr201223popenalex-extracted

Obesity-Dependent Metabolic Signatures Associated with Nonalcoholic Fatty Liver Disease Progression

inferredcites →https://doi.org/10.1038/cddis.2014.513openalex-extracted

Redox control of glutamine utilization in cancer

inferredcites →https://doi.org/10.1038/labinvest.3700489openalex-extracted

Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARγ agonist pioglitazone

inferredcites →https://doi.org/10.1038/nature07823openalex-extracted

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

inferredcites →https://doi.org/10.1038/nature08778openalex-extracted

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

inferredcites →https://doi.org/10.1038/ncomms15111openalex-extracted

Hepatic p63 regulates steatosis via IKKβ/ER stress

inferredcites →https://doi.org/10.1038/nrd.2016.188openalex-extracted

Nonalcoholic steatohepatitis (NASH) drugs market

inferredcites →https://doi.org/10.1053/j.gastro.2010.05.039openalex-extracted

Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals

inferredcites →https://doi.org/10.1053/j.gastro.2017.01.015openalex-extracted

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

inferredcites →https://doi.org/10.1073/pnas.1112495109openalex-extracted

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

inferredcites →https://doi.org/10.1073/pnas.1116573109openalex-extracted

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

inferredcites →https://doi.org/10.1073/pnas.1312570111openalex-extracted

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α

inferredcites →https://doi.org/10.1073/pnas.1611406113openalex-extracted

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

inferredcites →https://doi.org/10.1074/jbc.272.31.19133openalex-extracted

Cloning of a Chinese Hamster Ovary (CHO) cDNA Encoding Phosphatidylserine Synthase (PSS) II, Overexpression of Which Suppresses the Phosphatidylserine Biosynthetic Defect of a PSS I-lacking Mutant of CHO-K1 Cells

inferredcites →https://doi.org/10.1074/jbc.m109.099333openalex-extracted

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

inferredcites →https://doi.org/10.1074/jbc.m204542200openalex-extracted

An Unexpected Requirement for PhosphatidylethanolamineN-Methyltransferase in the Secretion of Very Low Density Lipoproteins

inferredcites →https://doi.org/10.1096/fj.09-143651openalex-extracted

Regulation of homocysteine metabolism and methylation in human and mouse tissues

inferredcites →https://doi.org/10.1152/ajpgi.00042.2009openalex-extracted

Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion

inferredcites →https://doi.org/10.1152/ajpgi.00360.2005openalex-extracted

Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium

inferredcites →https://doi.org/10.1161/atvbaha.109.188672openalex-extracted

Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

inferredcites →https://doi.org/10.1172/jci107593openalex-extracted

Splanchnic glucose and amino acid metabolism in obesity.

inferredcites →https://doi.org/10.1172/jci74382openalex-extracted

Splicing regulator SLU7 is essential for maintaining liver homeostasis

inferredcites →https://doi.org/10.1172/jci75836openalex-extracted

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

inferredcites →https://doi.org/10.1172/jci82204openalex-extracted

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

inferredcites →https://doi.org/10.1186/2049-3002-2-s1-p78openalex-extracted

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

inferredcites →https://doi.org/10.1194/jlr.d500019-jlr200openalex-extracted

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339

inferredcites →https://doi.org/10.1194/jlr.m017277openalex-extracted

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites

inferredcites →https://doi.org/10.1194/jlr.m600198-jlr200openalex-extracted

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1

inferredcites →https://doi.org/10.1194/jlr.m800633-jlr200openalex-extracted

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis

inferredcites →https://doi.org/10.1371/journal.pone.0112620openalex-extracted

The E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice

inferredcites →https://doi.org/10.18632/oncotarget.1958openalex-extracted

Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells

inferredcites →https://doi.org/10.18632/oncotarget.3196openalex-extracted

Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

inferredcites →https://doi.org/10.2174/1566524011313040005openalex-extracted

Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress Against Cancer

inferredcites →https://doi.org/10.2337/db11-1437openalex-extracted

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

inferredcites →https://doi.org/10.3109/07853890.2014.931100openalex-extracted

Microsomal transfer protein (MTP) inhibition—a novel approach to the treatment of homozygous hypercholesterolemia

inferredcites →https://doi.org/10.3945/jn.115.215517openalex-extracted

Oral Glutamine Supplementation Protects Female Mice from Nonalcoholic Steatohepatitis

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inferred← citeshttps://doi.org/10.3350/cmh.2020.0173openalex-snapshot

Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases

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