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Mechanistic Analysis of a Suicide Inactivator of Histone Demethylase LSD1

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzymes
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions
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Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
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lysine‐specific demethylase
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Observation of Two Different Chromophores in the Resting State of Monoamine Oxidase B by Fluorescence Spectroscopy
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Determination of Hα,Hβ and Hβ,C′ coupling constants in13C-labeled proteins
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Resolution enhancement and spectral editing of uniformly 13C-enriched proteins by homonuclear broadband 13C decoupling
inferredcites →https://doi.org/10.1016/0076-6879(95)49038-8openalex-snapshot
[10] Mechanism-based enzyme inactivators
inferredcites →https://doi.org/10.1016/j.cell.2004.12.012openalex-snapshot
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
inferredcites →https://doi.org/10.1016/j.cell.2006.03.028openalex-snapshot
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
inferredcites →https://doi.org/10.1016/j.chembiol.2006.05.004openalex-snapshot
Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications
inferredcites →https://doi.org/10.1016/j.molcel.2005.08.027openalex-snapshot
Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors
inferredcites →https://doi.org/10.1016/j.molcel.2006.07.012openalex-snapshot
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
inferredcites →https://doi.org/10.1016/j.molcel.2006.12.010openalex-snapshot
Dynamic Regulation of Histone Lysine Methylation by Demethylases
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Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase
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Mitochondrial Monoamine Oxidase
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Suicide inactivation of monoamine oxidase by trans-phenylcyclopropylamine.
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Signaling Network Model of Chromatin
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Conformation of Valine Side Chains in Ribonuclease T1 Determined by NMR Studies of Homonuclear and Heteronuclear 3J Coupling Constants
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The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase
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Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate]2-hydroxy-3-butynoate
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Human liver mitochondrial monoamine oxidase. III. Kinetic studies concerning time-dependent inhibitions
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Spectrometric Evidence for the Flavin−1-Phenylcyclopropylamine Inactivator Adduct with Monoamine Oxidase N
inferredcites →https://doi.org/10.1021/bi0618621openalex-snapshot
trans-2-Phenylcyclopropylamine Is a Mechanism-Based Inactivator of the Histone Demethylase LSD1
inferredcites →https://doi.org/10.1021/ja0602748openalex-snapshot
A Mechanism-Based Inactivator for Histone Demethylase LSD1
inferredcites →https://doi.org/10.1021/ja0656907openalex-snapshot
Activity-Based Protein Profiling Reagents for Protein Arginine Deiminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe
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Inactivation of Purified Human Recombinant Monoamine Oxidases A and B by Rasagiline and Its Analogues
inferredcites →https://doi.org/10.1021/jm0506266openalex-snapshot
Binding of Rasagiline-Related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis
inferredcites →https://doi.org/10.1038/nature04021openalex-snapshot
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
inferredcites →https://doi.org/10.1038/nature04433openalex-snapshot
Histone demethylation by a family of JmjC domain-containing proteins
inferredcites →https://doi.org/10.1038/nchembio728openalex-snapshot
Dynamic imaging of protease activity with fluorescently quenched activity-based probes
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Proteomic profiling of metalloprotease activities with cocktails of active-site probes
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Chromatin history: our view from the bridge
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Can transcription factors function as cell–cell signalling molecules?
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The diverse functions of histone lysine methylation
inferredcites →https://doi.org/10.1038/nsmb1113openalex-snapshot
Crystal structure and mechanism of human lysine-specific demethylase-1
inferredcites →https://doi.org/10.1046/j.1432-1327.1998.2530270.xopenalex-snapshot
Isolation and characterization of an evolutionary precursor of human monoamine oxidases A and B
inferredcites →https://doi.org/10.1073/pnas.0402323101openalex-snapshot
Activity-based probes for protein tyrosine phosphatases
inferredcites →https://doi.org/10.1073/pnas.0606381103openalex-snapshot
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
inferredcites →https://doi.org/10.1073/pnas.95.12.6705openalex-snapshot
Expressed protein ligation: A general method for protein engineering
inferredcites →https://doi.org/10.1074/jbc.m509549200openalex-snapshot
Human Histone Demethylase LSD1 Reads the Histone Code
inferredcites →https://doi.org/10.1074/jbc.m607411200openalex-snapshot
A Highly Specific Mechanism of Histone H3-K4 Recognition by Histone Demethylase LSD1
inferredcites →https://doi.org/10.1074/jbc.r200005200openalex-snapshot
Structure-Function Relationships in Flavoenzyme-dependent Amine Oxidations
inferredcites →https://doi.org/10.1111/j.1432-1033.1976.tb10223.xopenalex-snapshot
Structure of Flavin Adducts with Acetylenic Substrates
inferredcites →https://doi.org/10.1126/science.1060077openalex-snapshot
Expanding the Genetic Code of Escherichia coli
inferredcites →https://doi.org/10.1126/science.1063127openalex-snapshot
Translating the Histone Code
inferredcites →https://doi.org/10.1146/annurev.bi.53.070184.002425openalex-snapshot
SUICIDE SUBSTRATES, MECHANISM-BASED ENZYME INACTIVATORS: RECENT DEVELOPMENTS
inferredcites →https://doi.org/10.1159/000479439openalex-snapshot
Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling
inferredcites →https://doi.org/10.2174/0929867043364784openalex-snapshot
Structure and Mechanism of Monoamine Oxidase
inferredcites →https://doi.org/10.5860/choice.38-3881openalex-snapshot
Enzymes: a practical introduction to structure, mechanism, and data analysis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Probing the MAO Enzymes with a Novel Family of Quaternary Propargylamine Derivatives
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Epigenetic Proteins as Emerging Drug Targets
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Histone Demethylases
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KDM1 class flavin‐dependent protein lysine demethylases
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Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy
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Epigenetic Targets and Cancer Drug Discovery
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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region
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Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents
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Acetylene Group, Friend or Foe in Medicinal Chemistry
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Lysine-Specific Demethylase 1 (LSD1) Inhibitors: Peptides as an Emerging Class of Therapeutics
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Structural Basis for the Inhibition of the LSD1 Histone Demethylase by the Antidepressant trans-2-Phenylcyclopropylamine,
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cis‐cyclopropylamines as mechanism‐based inhibitors of monoamine oxidases
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Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
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Data from DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
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Data from DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
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Targeting Histone Demethylases: A New Avenue for the Fight against Cancer
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Epigenetic assays for chemical biology and drug discovery
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Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
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Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor
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A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1
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Computational Methods for De novo Protein Design and its Applications to the Human Immunodeficiency Virus 1, Purine Nucleoside Phosphorylase, Ubiquitin Specific Protease 7, and Histone Demethylases
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TCPs: Privileged Scaffolds for Identifying Potent LSD1 Inhibitors for Cancer Therapy
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Epigenomics of leukemia: from mechanisms to therapeutic applications
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Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism
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Jumonji C Demethylases in Cellular Senescence
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Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures
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Are Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed
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Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
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MassSQUIRM
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Additional file 1 of Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
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Additional file 2 of Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
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Additional file 3 of Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
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