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Long‐Term in Vitro Function of Adult Hepatocytes in a Collagen Sandwich Configuration
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1 of the 43 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1073/pnas.86.20.7928 (notice 1992-08-15).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/bf02623304openalex-snapshotUse of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations
inferredcites →https://doi.org/10.1016/0014-4827(87)90292-8openalex-snapshotCell contact but not junctional communication (dye coupling) with biliary epithelial cells is required for hepatocytes to maintain differentiated functions
inferredcites →https://doi.org/10.1073/pnas.85.7.2161openalex-snapshotCell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.
inferredcites →https://doi.org/10.1083/jcb.105.5.2417openalex-snapshotRat hepatocytes in serum-free primary culture elaborate an extensive extracellular matrix containing fibrin and fibronectin.
inferredcites →https://doi.org/10.1083/jcb.91.1.157openalex-snapshotInfluence of collagen gel on the orientation of epithelial cell polarity: follicle formation from isolated thyroid cells and from preformed monolayers.
inferredcites →https://doi.org/10.1172/jci112887openalex-snapshotSupport of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.
inferredcites →https://doi.org/10.1242/dev.106.2.407openalex-snapshotDifferential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/adfm.200601237openalex-snapshotPrimary Neuron/Astrocyte Co‐Culture on Polyelectrolyte Multilayer Films: A Template for Studying Astrocyte‐Mediated Oxidative Stress in Neurons
inferred← citeshttps://doi.org/10.1002/bdd.2262openalex-snapshotHepatic transporter‐mediated pharmacokinetic drug–drug interactions: Recent studies and regulatory recommendations
inferred← citeshttps://doi.org/10.1002/bit.10041openalex-snapshotFunctional engineering of hepatocytes via heterocellular presentation of a homoadhesive molecule, E‐cadherin
inferred← citeshttps://doi.org/10.1002/bit.10275openalex-snapshotMetabolic pre‐conditioning of cultured cells in physiological levels of insulin: Generating resistance to the lipid‐accumulating effects of plasma in hepatocytes
inferred← citeshttps://doi.org/10.1002/bit.1071openalex-snapshotEffects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat‐plate bioreactor
inferred← citeshttps://doi.org/10.1002/bit.20328openalex-snapshotEngineering hepatocellular morphogenesis and function via ligand‐presenting hydrogels with graded mechanical compliance
inferred← citeshttps://doi.org/10.1002/bit.20535openalex-snapshotIdentification of neutrophil gelatinase‐associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte‐secreted protein response to IL‐1β: a proteomic analysis
inferred← citeshttps://doi.org/10.1002/bit.21089openalex-snapshotDevelopment and characterization of a small‐scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings
inferred← citeshttps://doi.org/10.1002/bit.23025openalex-snapshotUse of three‐dimensional spheroids of hepatocyte‐derived reporter cells to study the effects of intracellular fat accumulation and subsequent cytokine exposure
inferred← citeshttps://doi.org/10.1002/bit.260400214openalex-snapshotThe importance of proline on long‐term hepatocyte function in a collagen gel sandwich configuration: Regulation of protein secretion
inferred← citeshttps://doi.org/10.1002/bit.26986openalex-snapshotA thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions
inferred← citeshttps://doi.org/10.1002/bit.27225openalex-snapshotProgressive hypoxia‐on‐a‐chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease
inferred← citeshttps://doi.org/10.1002/bit.27328openalex-snapshotOptimization of 3D hydrogel microenvironment for enhanced hepatic functionality of primary human hepatocytes
inferred← citeshttps://doi.org/10.1002/bit.28485openalex-snapshotOptimization of physical microenvironment to maintain the quiescence of human induced pluripotent stem cell‐derived hepatic stellate cells
inferred← citeshttps://doi.org/10.1002/em.21700openalex-snapshotProliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro
inferred← citeshttps://doi.org/10.1002/hep.20351openalex-snapshotExploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
inferred← citeshttps://doi.org/10.1002/hep.21016openalex-snapshotLiver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes
inferred← citeshttps://doi.org/10.1002/hep.510290328openalex-snapshotA Histone Deacetylase Inhibitor, Trichostatin A, Suppresses Myofibroblastic Differentiation of Rat Hepatic Stellate Cells in Primary Culture
inferred← citeshttps://doi.org/10.1002/jat.3189openalex-snapshotCytochrome P450 induction response in tethered spheroids as a three‐dimensional human hepatocyte in vitro model
inferred← citeshttps://doi.org/10.1002/jbm.1224openalex-snapshotPerfusion culture of hepatocytes within galactose‐derivatized biodegradable poly(lactide‐co‐glycolide) scaffolds prepared by gas foaming of effervescent salts
inferred← citeshttps://doi.org/10.1002/jbm.a.30306openalex-snapshotThe viability and function of primary rat hepatocytes cultured on polymeric membranes developed for hybrid artificial liver devices
inferred← citeshttps://doi.org/10.1002/jbm.a.35910openalex-snapshotEffect of amine content and chemistry on long‐term, three‐dimensional hepatocyte spheroid culture atop aminated elastin‐like polypeptide coatings
inferred← citeshttps://doi.org/10.1002/jbm.a.36072openalex-snapshotLong‐term liver‐specific functions of hepatocytes in electrospun chitosan nanofiber scaffolds coated with fibronectin
inferred← citeshttps://doi.org/10.1002/jcb.25962openalex-snapshotMetabolic Oscillations in Co‐Cultures of Hepatocytes and Mesenchymal Stem Cells: Effects of Seeding Arrangement and Culture Mixing
inferred← citeshttps://doi.org/10.1002/lt.23905openalex-snapshotElevated sensitivity of macrosteatotic hepatocytes to hypoxia/reoxygenation stress is reversed by a novel defatting protocol
inferred← citeshttps://doi.org/10.1002/stem.170295openalex-snapshotMaintenance of CD34 Expression During Proliferation of CD34 + Cord Blood Cells on Glycosaminoglycan Surfaces
inferred← citeshttps://doi.org/10.1002/term.393openalex-snapshotHepatogenic engineering from human bone marrow mesenchymal stem cells in porous polylactic glycolic acid scaffolds under perfusion culture
inferred← citeshttps://doi.org/10.1006/abbi.1999.1688openalex-snapshotSandwich Configuration of Type I Collagen Suppresses Progesterone Production in Primary Cultured Porcine Granulosa Cells by Reducing Gene Expression of Cytochrome P450 Cholesterol Side-Chain Cleavage Enzyme
inferred← citeshttps://doi.org/10.1007/10_012openalex-snapshotTissue Assembly Guided via Substrate Biophysics: Applications to Hepatocellular Engineering
inferred← citeshttps://doi.org/10.1007/bf00365347openalex-snapshotQuantitative comparison of rat hepatocyte functions in two improved culture systems with or without rat liver epithelial cell line
inferred← citeshttps://doi.org/10.1007/bf00749872openalex-snapshotLong-term culture of primary rat hepatocytes with high albumin secretion using membrane-supported collagen sandwich
inferred← citeshttps://doi.org/10.1007/bf02577575openalex-snapshotOptimization of culture conditions for determining hepatobiliary disposition of taurocholate in sandwich-cultured rat hepatocytes
inferred← citeshttps://doi.org/10.1007/s00204-013-1078-5openalex-snapshotRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
inferred← citeshttps://doi.org/10.1007/s00204-016-1758-zopenalex-snapshotBile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition
inferred← citeshttps://doi.org/10.1007/s004410100429openalex-snapshotRegulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions.
inferred← citeshttps://doi.org/10.1007/s10544-014-9877-xopenalex-snapshotMicrophysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes
inferred← citeshttps://doi.org/10.1007/s10856-013-4867-8openalex-snapshotEffect of solid freeform fabrication-based polycaprolactone/poly(lactic-co-glycolic acid)/collagen scaffolds on cellular activities of human adipose-derived stem cells and rat primary hepatocytes
inferred← citeshttps://doi.org/10.1007/s11095-010-0203-xopenalex-snapshotEvaluation of 99mTechnetium-Mebrofenin and 99mTechnetium-Sestamibi as Specific Probes for Hepatic Transport Protein Function in Rat and Human Hepatocytes
inferred← citeshttps://doi.org/10.1007/s11160-010-9181-7openalex-snapshotExpression of a highly differentiated phenotype and hepatic functionality markers in gilthead seabream (Sparus aurata L.) long-cultured hepatocytes: first morphological and functional in vitro characterization
inferred← citeshttps://doi.org/10.1007/s12274-023-5940-3openalex-snapshotLong-term functional maintenance of primary hepatocytes in vitro using macroporous hydrogels engineered through liquid-liquid phase separation
inferred← citeshttps://doi.org/10.1007/s13346-022-01147-0openalex-snapshotThree-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
inferred← citeshttps://doi.org/10.1016/0168-8278(95)80069-7openalex-snapshotThe influence of medium composition on the maintenance of cytochrome P-450, glutathione content and urea synthesis: a comparison of rat and sheep primary hepatocyte cultures
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