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Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

https://doi.org/10.1021/cb500917m
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cmdc.201300134openalex-snapshot
Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications
inferredcites →https://doi.org/10.1007/978-1-4757-2917-7openalex-snapshot
Model Selection and Inference
inferredcites →https://doi.org/10.1016/j.antiviral.2014.06.011openalex-snapshot
Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
inferredcites →https://doi.org/10.1016/j.bmc.2013.11.041openalex-snapshot
Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings
inferredcites →https://doi.org/10.1016/j.jinf.2012.10.002openalex-snapshot
Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?
inferredcites →https://doi.org/10.1016/j.mib.2004.06.007openalex-snapshot
Molecular biology of severe acute respiratory syndrome coronavirus
inferredcites →https://doi.org/10.1016/j.virol.2013.11.040openalex-snapshot
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities
inferredcites →https://doi.org/10.1016/s0140-6736(13)60982-4openalex-snapshot
Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission
inferredcites →https://doi.org/10.1021/jm1004489openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation
inferredcites →https://doi.org/10.1021/jm401712topenalex-snapshot
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
inferredcites →https://doi.org/10.1021/jm900611topenalex-snapshot
Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease
inferredcites →https://doi.org/10.1038/nature02145openalex-snapshot
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
inferredcites →https://doi.org/10.1038/sj.emboj.7600832openalex-snapshot
Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14
inferredcites →https://doi.org/10.1056/nejme1212300openalex-snapshot
Emerging Human Coronaviruses — Disease Potential and Preparedness
inferredcites →https://doi.org/10.1056/nejmoa1211721openalex-snapshot
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
inferredcites →https://doi.org/10.1056/nejmoa1306742openalex-snapshot
Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1073/pnas.0506735102openalex-snapshot
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
inferredcites →https://doi.org/10.1073/pnas.0510403103openalex-snapshot
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1
inferredcites →https://doi.org/10.1073/pnas.0510851103openalex-snapshot
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
inferredcites →https://doi.org/10.1073/pnas.0805240105openalex-snapshot
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
inferredcites →https://doi.org/10.1074/jbc.m114.609644openalex-snapshot
Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression
inferredcites →https://doi.org/10.1074/jbc.m310283200openalex-snapshot
Pleiotropic Effects of Ubp6 Loss on Drug Sensitivities and Yeast Prion Are Due to Depletion of the Free Ubiquitin Pool
inferredcites →https://doi.org/10.1093/emboj/16.13.3787openalex-snapshot
Crystal structure of a deubiquitinating enzyme (human UCH‐L3) at 1.8 å resolution
inferredcites →https://doi.org/10.1099/vir.0.059014-0openalex-snapshot
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease
inferredcites →https://doi.org/10.1099/vir.0.19424-0openalex-snapshot
Mechanisms and enzymes involved in SARS coronavirus genome expression
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444904023510openalex-snapshot
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
inferredcites →https://doi.org/10.1107/s0907444909047337openalex-snapshot
XDS
inferredcites →https://doi.org/10.1107/s0907444910007493openalex-snapshot
Features and development of Coot
inferredcites →https://doi.org/10.1107/s1399004713031040openalex-snapshot
Structural basis for catalysis and ubiquitin recognition by theSevere acute respiratory syndrome coronaviruspapain-like protease
inferredcites →https://doi.org/10.1111/ajt.12320openalex-snapshot
Update: Severe Respiratory Illness Associated With a Novel Coronavirus—Worldwide, 2012–2013
inferredcites →https://doi.org/10.1126/science.1118391openalex-snapshot
Bats Are Natural Reservoirs of SARS-Like Coronaviruses
inferredcites →https://doi.org/10.1128/jvi.01055-13openalex-snapshot
Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1128/jvi.01244-13openalex-snapshot
Commentary: Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
inferredcites →https://doi.org/10.1128/jvi.78.24.13600-13612.2004openalex-snapshot
Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease Activity
inferredcites →https://doi.org/10.1128/jvi.79.24.15189-15198.2005openalex-snapshot
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
inferredcites →https://doi.org/10.1128/mbio.00473-12openalex-snapshot
Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
inferredcites →https://doi.org/10.1128/mbio.00515-12openalex-snapshot
Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capability in Mammalian Cell Lines
inferredcites →https://doi.org/10.1186/1743-422x-10-66openalex-snapshot
A novel coronavirus capable of lethal human infections: an emerging picture
inferredcites →https://doi.org/10.1371/journal.ppat.1004113openalex-snapshot
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
inferredcites →https://doi.org/10.2174/138161206779010369openalex-snapshot
Drug Design Targeting the Main Protease, the Achilles Heel of Coronaviruses
inferredcites →https://doi.org/10.2807/ese.18.07.20404-enopenalex-snapshot
Early estimates of influenza vaccine effectiveness in Navarre, Spain: 2012/13 mid-season analysis
inferredcites →https://doi.org/10.2807/ese.18.24.20502-enopenalex-snapshot
First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Structural and biochemical characterization of SADS‐CoV papain‐like protease 2
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Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes
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Crystal structure of SARS-CoV-2 papain-like protease
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Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
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The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING
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The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression
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GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
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Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro
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Synonymous and Biased Codon Usage by MERS CoV Papain-Like and 3CL-Proteases
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Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity
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Starting Anti-COVID-19 Drug Discovery with Natural Products
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Molecular Dynamics and Inhibition of MERS CoV Papain-like Protease by Small Molecule Imidazole and Aminopurine Derivatives
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Properties and Reactivities of Niclosamide in Different Media, a Potential Antiviral to Treatment of COVID-19 by Using DFT Calculations and Molecular Docking
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Virucidal Activities of Zinc-Finger Antiviral Proteins and Zinc-Binding Domains for Virus Entry, DNA/RNA Replication and Spread
inferred← citeshttps://doi.org/10.3389/fchem.2020.592289openalex-snapshot
Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking
inferred← citeshttps://doi.org/10.3389/fchem.2020.623971openalex-snapshot
Identification of Small Molecule Inhibitors of the Deubiquitinating Activity of the SARS-CoV-2 Papain-Like Protease: in silico Molecular Docking Studies and in vitro Enzymatic Activity Assay
inferred← citeshttps://doi.org/10.3389/fchem.2022.861209openalex-snapshot
Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
inferred← citeshttps://doi.org/10.3389/fchem.2022.876212openalex-snapshot
Inhibitors of SARS-CoV-2 PLpro
inferred← citeshttps://doi.org/10.3389/fmolb.2020.00174openalex-snapshot
Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease
inferred← citeshttps://doi.org/10.3390/ijms21051783openalex-snapshot
UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity
inferred← citeshttps://doi.org/10.3390/ijms24054397openalex-snapshot
Identifying Drug Candidates for COVID-19 with Large-Scale Drug Screening
inferred← citeshttps://doi.org/10.3390/ijms26041481openalex-snapshot
Potential Broad-Spectrum Antiviral Agents: A Key Arsenal Against Newly Emerging and Reemerging Respiratory RNA Viruses
inferred← citeshttps://doi.org/10.3390/ijms26115254openalex-snapshot
Inhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants
inferred← citeshttps://doi.org/10.3390/molecules26030727openalex-snapshot
COVID-19 Prophylaxis Efforts Based on Natural Antiviral Plant Extracts and Their Compounds
inferred← citeshttps://doi.org/10.3390/molecules26041134openalex-snapshot
Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease
inferred← citeshttps://doi.org/10.3390/molecules27217553openalex-snapshot
Identification of Doxorubicin as Repurposing Inhibitory Drug for MERS-CoV PLpro
inferred← citeshttps://doi.org/10.3390/ph13100277openalex-snapshot
Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and Limitations
inferred← citeshttps://doi.org/10.3390/ph18060798openalex-snapshot
Structure-Based Design and In-Silico Evaluation of Computationally Proposed Curcumin Derivatives as Potential Inhibitors of the Coronaviral PLpro Enzymes
inferred← citeshttps://doi.org/10.3390/v10120721openalex-snapshot
Development of Small-Molecule MERS-CoV Inhibitors
inferred← citeshttps://doi.org/10.37341/interest.v9i2.218openalex-snapshot
Pilihan Terapi Infeksi Covid-19 Pada Anak
inferred← citeshttps://doi.org/10.37489/0235-2990-2024-69-11-12-49-58openalex-snapshot
Antiviral Activity of 5-chloropyridin-3-yl-1h-indole-4-carboxylate (AMND) Against COVID-19
inferred← citeshttps://doi.org/10.4014/jmb.2602.02038openalex-snapshot
Modulation of Host Innate Immune Response by Highly Pathogenic Human Coronaviruses during Viral Infection
inferred← citeshttps://doi.org/10.4172/2161-0444.1000287openalex-snapshot
Middle East Respiratory Syndrome-Coronavirus (MERS-CoV): An Updated Overview and Pharmacotherapeutics
inferred← citeshttps://doi.org/10.7287/peerj.9965v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.9965v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.9965v0.1/reviews/3openalex-snapshot
Peer Review #3 of "Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs (v0.1)"
inferred← citeshttps://doi.org/10.7717/peerj.9965openalex-snapshot
Potential COVID-19 papain-like protease PL pro inhibitors: repurposing FDA-approved drugs
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.