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Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease

https://doi.org/10.1021/acsinfecdis.0c00168
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Proteases and protease inhibitors in infectious diseases
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Coronaviruses: An Overview of Their Replication and Pathogenesis
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Protein Structure Modeling with MODELLER
inferredcites →https://doi.org/10.1007/978-1-60327-058-8_8openalex-snapshot
Protein Structure Modeling with MODELLER
inferredcites →https://doi.org/10.1016/j.antiviral.2014.12.015openalex-snapshot
The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
inferredcites →https://doi.org/10.1016/j.antiviral.2019.104661openalex-snapshot
Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease
inferredcites →https://doi.org/10.1016/j.celrep.2017.08.040openalex-snapshot
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease
inferredcites →https://doi.org/10.1016/j.chom.2007.09.014openalex-snapshot
Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses
inferredcites →https://doi.org/10.1016/j.jmb.2017.04.011openalex-snapshot
Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species
inferredcites →https://doi.org/10.1016/j.jmb.2019.03.013openalex-snapshot
ISG15: It's Complicated
inferredcites →https://doi.org/10.1016/j.jviromet.2012.05.030openalex-snapshot
Development and optimization of a direct plaque assay for human and avian metapneumoviruses
inferredcites →https://doi.org/10.1016/j.molcel.2016.04.016openalex-snapshot
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
inferredcites →https://doi.org/10.1016/j.virol.2014.02.026openalex-snapshot
The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference
inferredcites →https://doi.org/10.1016/j.virol.2015.02.033openalex-snapshot
Ubiquitination in the antiviral immune response
inferredcites →https://doi.org/10.1021/cb500917mopenalex-snapshot
Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV
inferredcites →https://doi.org/10.1021/jm401712topenalex-snapshot
X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases
inferredcites →https://doi.org/10.1021/jm900611topenalex-snapshot
Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease
inferredcites →https://doi.org/10.1038/ncomms12754openalex-snapshot
Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
inferredcites →https://doi.org/10.1038/nmeth.1649openalex-snapshot
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
inferredcites →https://doi.org/10.1038/nri2314openalex-snapshot
Interferon-inducible antiviral effectors
inferredcites →https://doi.org/10.1038/s41564-020-0695-zopenalex-snapshot
The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
inferredcites →https://doi.org/10.1073/pnas.0504754102openalex-snapshot
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways
inferredcites →https://doi.org/10.1073/pnas.0510851103openalex-snapshot
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
inferredcites →https://doi.org/10.1073/pnas.0805240105openalex-snapshot
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
inferredcites →https://doi.org/10.1073/pnas.1218464110openalex-snapshot
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
inferredcites →https://doi.org/10.1074/jbc.c109.095703openalex-snapshot
Species Specificity of the NS1 Protein of Influenza B Virus
inferredcites →https://doi.org/10.1074/jbc.m114.609644openalex-snapshot
Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression
inferredcites →https://doi.org/10.1074/jbc.m115.662130openalex-snapshot
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
inferredcites →https://doi.org/10.1074/jbc.m704870200openalex-snapshot
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1107/s2059798318015322openalex-snapshot
Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement
inferredcites →https://doi.org/10.1128/jvi.00338-15openalex-snapshot
Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis
inferredcites →https://doi.org/10.1128/jvi.00975-16openalex-snapshot
Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species
inferredcites →https://doi.org/10.1128/jvi.01067-17openalex-snapshot
Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1128/jvi.01294-14openalex-snapshot
Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1128/jvi.01734-19openalex-snapshot
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
inferredcites →https://doi.org/10.1128/jvi.02220-08openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling
inferredcites →https://doi.org/10.1128/jvi.02395-09openalex-snapshot
Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein
inferredcites →https://doi.org/10.1128/jvi.03252-12openalex-snapshot
Diversity of Ubiquitin and ISG15 Specificity among Nairoviruses' Viral Ovarian Tumor Domain Proteases
inferredcites →https://doi.org/10.1128/jvi.79.24.15189-15198.2005openalex-snapshot
The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity
inferredcites →https://doi.org/10.1371/journal.pone.0226415openalex-snapshot
Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases
inferredcites →https://doi.org/10.1371/journal.ppat.1004113openalex-snapshot
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
inferredcites →https://doi.org/10.1371/journal.ppat.1005531openalex-snapshot
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
inferredcites →https://doi.org/10.1371/journal.ppat.1007515openalex-snapshot
Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
inferredcites →https://doi.org/10.2305/iucn.uk.2019-3.rlts.t136250a22003049.enopenalex-snapshot
Myotis davidii: Jiang, T.L. & Feng, J.
inferredcites →https://doi.org/10.3201/eid2606.200516openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States
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SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus)

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inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.130366openalex-snapshot
Unmasking of crucial structural fragments for coronavirus protease inhibitors and its implications in COVID-19 drug discovery
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.132915openalex-snapshot
Synthesis, spectroscopic characterization of novel phthalimides derivatives bearing a 1,2,3-triazole unit and examination as potential SARS-CoV-2 inhibitors via in silico studies
inferred← citeshttps://doi.org/10.1016/j.pep.2023.106267openalex-snapshot
Preparation and characterization of nanobodies targeting SARS-CoV-2 papain-like protease
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154324openalex-snapshot
A review on computational approaches that support the researches on traditional Chinese medicines (TCM) against COVID-19
inferred← citeshttps://doi.org/10.1016/j.phyplu.2022.100402openalex-snapshot
Therapeutic potential of green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) in SARS-CoV-2 infection: Major interactions with host/virus proteases
inferred← citeshttps://doi.org/10.1016/j.phytol.2025.103010openalex-snapshot
Isolation and computational characterization of a novel cyanogenic glucoside from Centaurea microcarpa with antiviral potential against SARS-CoV-2: DFT, ADMET, and molecular docking analysis
inferred← citeshttps://doi.org/10.1016/j.rechem.2025.102851openalex-snapshot
Identification of selective protease inhibitors by using virtual screening, molecular dynamics simulation for SARS CoV-2 papain-like protease
inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.09.028openalex-snapshot
Analyzing the effect of mutations in SARS-CoV2 papain-like protease from Saudi isolates on protein structure and drug-protein binding: Molecular modelling and dynamics studies
inferred← citeshttps://doi.org/10.1016/j.slast.2026.100409openalex-snapshot
Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination
inferred← citeshttps://doi.org/10.1016/j.tips.2022.08.008openalex-snapshot
Targeting SARS-CoV-2 papain-like protease in the postvaccine era
inferred← citeshttps://doi.org/10.1016/j.virol.2023.02.011openalex-snapshot
Genetic conservation across SARS-CoV-2 non-structural proteins – Insights into possible targets for treatment of future viral outbreaks
inferred← citeshttps://doi.org/10.1016/j.virs.2023.04.008openalex-snapshot
Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase
inferred← citeshttps://doi.org/10.1016/j.virusres.2024.199368openalex-snapshot
Viral deubiquitinating proteases and the promising strategies of their inhibition
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01140openalex-snapshot
Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00566openalex-snapshot
Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01307openalex-snapshot
Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00303openalex-snapshot
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00378openalex-snapshot
Non-Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease (PLpro): In Vitro and In Vivo Antiviral Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00534openalex-snapshot
Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c03846openalex-snapshot
Discovery of the SARS-CoV-2 Papain-Like Protease Inhibitor MR1–114: From Structure-Based Design to In Vivo Antiviral Efficacy
inferred← citeshttps://doi.org/10.1021/acs.jpcb.1c07060openalex-snapshot
In Silico Elucidation of Potent Inhibitors and Rational Drug Design against SARS-CoV-2 Papain-like Protease
inferred← citeshttps://doi.org/10.1021/acs.jpclett.1c00831openalex-snapshot
Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein
inferred← citeshttps://doi.org/10.1021/acs.jproteome.0c00779openalex-snapshot
Molecular Basis of SARS-CoV‑2 Infection and Rational Design of Potential Antiviral Agents: Modeling and Simulation Approaches
inferred← citeshttps://doi.org/10.1021/acs.jproteome.5c01277openalex-snapshot
Computationally Efficient Bayesian Estimation of Graphical Networks for Omics Data
inferred← citeshttps://doi.org/10.1021/acscentsci.1c00519openalex-snapshot
Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00815openalex-snapshot
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00866openalex-snapshot
The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease
inferred← citeshttps://doi.org/10.1021/acsinfecdis.1c00631openalex-snapshot
Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses
inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00458openalex-snapshot
Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00444openalex-snapshot
Native Mass Spectrometry Reveals Binding Interactions of SARS-CoV-2 PLpro with Inhibitors and Cellular Targets
inferred← citeshttps://doi.org/10.1021/acsomega.2c06675openalex-snapshot
Investigating Derivatives of Tanshinone IIA Sulfonate Sodium and Chloroxine for Their Inhibition Activities against the SARS-CoV-2 Papain-like Protease
inferred← citeshttps://doi.org/10.1021/acsomega.4c02392openalex-snapshot
Systematic Studies on the Anti-SARS-CoV-2 Mechanisms of Tea Polyphenol-Related Natural Products
inferred← citeshttps://doi.org/10.1021/acsptsci.0c00130openalex-snapshot
Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV‑2 Main Protease Inhibitors
inferred← citeshttps://doi.org/10.1021/acsptsci.1c00099openalex-snapshot
Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir
inferred← citeshttps://doi.org/10.1021/acsptsci.1c00240openalex-snapshot
Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors
inferred← citeshttps://doi.org/10.1038/s41467-020-20718-8openalex-snapshot
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
inferred← citeshttps://doi.org/10.1038/s41467-023-37254-wopenalex-snapshot
Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41580-022-00543-1openalex-snapshot
An expanded lexicon for the ubiquitin code
inferred← citeshttps://doi.org/10.1038/s41586-020-2601-5openalex-snapshot
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
inferred← citeshttps://doi.org/10.1038/s41598-021-84782-wopenalex-snapshot
The in-vitro effect of famotidine on SARS-CoV-2 proteases and virus replication
inferred← citeshttps://doi.org/10.1038/s41598-022-18676-wopenalex-snapshot
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts
inferred← citeshttps://doi.org/10.1038/s41598-023-35907-wopenalex-snapshot
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
inferred← citeshttps://doi.org/10.1038/s41598-025-01425-0openalex-snapshot
Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
inferred← citeshttps://doi.org/10.1039/d1ra05976aopenalex-snapshot
Dietary stigmastane-type saponins as promising dual-target directed inhibitors of SARS-CoV-2 proteases: a structure-based screening
inferred← citeshttps://doi.org/10.1039/d1ra07092dopenalex-snapshot
One-pot synthesis of new alkyl 1-naphthoates bearing quinoline, pyranone and cyclohexenone moieties via metal-free sequential addition/oxidation reactions
inferred← citeshttps://doi.org/10.1039/d1ra08752eopenalex-snapshot
Insights into the binding and covalent inhibition mechanism of PF-07321332 to SARS-CoV-2 M pro
inferred← citeshttps://doi.org/10.1039/d2cp04476eopenalex-snapshot
Characterizing the ligand-binding affinity toward SARS-CoV-2 Mpro via physics- and knowledge-based approaches
inferred← citeshttps://doi.org/10.1039/d3cb00128hopenalex-snapshot
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein
inferred← citeshttps://doi.org/10.1039/d3ra01915bopenalex-snapshot
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication
inferred← citeshttps://doi.org/10.1039/d3sc00166kopenalex-snapshot
Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches
inferred← citeshttps://doi.org/10.1042/bcj20200514openalex-snapshot
The role of chemical biology in the fight against SARS-CoV-2
inferred← citeshttps://doi.org/10.1042/bcj20210197openalex-snapshot
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
inferred← citeshttps://doi.org/10.1042/bcj20210244openalex-snapshot
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
inferred← citeshttps://doi.org/10.1042/bst20200396openalex-snapshot
A pocket guide on how to structure SARS-CoV-2 drugs and therapies
inferred← citeshttps://doi.org/10.1080/07391102.2020.1823887openalex-snapshot
The potential role of procyanidin as a therapeutic agent against SARS-CoV-2: a text mining, molecular docking and molecular dynamics simulation approach
inferred← citeshttps://doi.org/10.1080/07391102.2021.1953601openalex-snapshot
Protein degradation: a novel computational approach to design protein degrader probes for main protease of SARS-CoV-2
inferred← citeshttps://doi.org/10.1080/07391102.2021.1958700openalex-snapshot
Quantitative structure-activity relationships, molecular docking and molecular dynamics simulations reveal drug repurposing candidates as potent SARS-CoV-2 main protease inhibitors
inferred← citeshttps://doi.org/10.1080/07391102.2023.2173297openalex-snapshot
Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins
inferred← citeshttps://doi.org/10.1080/07391102.2023.2240424openalex-snapshot
Reconstruction of the unbinding pathways of new inhibitors of the SARS-CoV-2 papain-like protease using molecular dynamics simulation
inferred← citeshttps://doi.org/10.1080/0889311x.2022.2098281openalex-snapshot
The Swiss army knife of SARS-CoV-2: the structures and functions of NSP3
inferred← citeshttps://doi.org/10.1080/08927022.2021.1957884openalex-snapshot
An in silico molecular dynamics simulation study on the inhibitors of SARS-CoV-2 proteases (3CLpro and PLpro) to combat COVID-19
inferred← citeshttps://doi.org/10.1080/1062936x.2021.1960601openalex-snapshot
Molecular modelling on SARS-CoV-2 papain-like protease: an integrated study with homology modelling, molecular docking, and molecular dynamics simulations
inferred← citeshttps://doi.org/10.1080/10826068.2025.2456940openalex-snapshot
Improving soluble recombinant SARS-CoV-2 papain-like protease production in Escherichia coli through chaperonin and maltose-binding protein tag: purification and kinetic characterization
inferred← citeshttps://doi.org/10.1080/13543776.2021.1857726openalex-snapshot
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses
inferred← citeshttps://doi.org/10.1080/14756366.2024.2301772openalex-snapshot
Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis
inferred← citeshttps://doi.org/10.1080/15548627.2024.2442849openalex-snapshot
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase
inferred← citeshttps://doi.org/10.1083/jcb.202006159openalex-snapshot
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
inferred← citeshttps://doi.org/10.1093/bib/bbaa422openalex-snapshot
Ligand-based approach for predicting drug targets and for virtual screening against COVID-19
inferred← citeshttps://doi.org/10.1093/nar/gkaa861openalex-snapshot
DockCoV2: a drug database against SARS-CoV-2
inferred← citeshttps://doi.org/10.1093/nar/gkad944openalex-snapshot
The IUPHAR/BPS Guide to PHARMACOLOGY in 2024
inferred← citeshttps://doi.org/10.1093/procel/pwac016openalex-snapshot
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
inferred← citeshttps://doi.org/10.1098/rsos.211480openalex-snapshot
Unbinding ligands from SARS-CoV-2 Mpro via umbrella sampling simulations
inferred← citeshttps://doi.org/10.1101/2020.08.30.273979openalex-snapshot
Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PL pro and M pro in in vitro studies
inferred← citeshttps://doi.org/10.1101/2020.12.27.424507openalex-snapshot
Losartan promotes cell survival following SARS-CoV-2 infection in vitro
inferred← citeshttps://doi.org/10.1101/2021.03.02.433434openalex-snapshot
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
inferred← citeshttps://doi.org/10.1101/2022.03.30.486313openalex-snapshot
Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease
inferred← citeshttps://doi.org/10.1101/2023.03.23.533924openalex-snapshot
Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic function
inferred← citeshttps://doi.org/10.1107/s205979832100509xopenalex-snapshot
Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin
inferred← citeshttps://doi.org/10.1111/cbdd.14115openalex-snapshot
Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain‐Like cysteine proteases of SARS‐CoV‐2
inferred← citeshttps://doi.org/10.1111/sji.13044openalex-snapshot
Interactions between SARS coronavirus 2 papain‐like protease and immune system: A potential drug target for the treatment of COVID‐19
inferred← citeshttps://doi.org/10.1126/sciadv.abd4596openalex-snapshot
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
inferred← citeshttps://doi.org/10.1126/sciadv.ado4288openalex-snapshot
Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model
inferred← citeshttps://doi.org/10.1126/scisignal.add0082openalex-snapshot
The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING
inferred← citeshttps://doi.org/10.1126/scisignal.ade1985openalex-snapshot
The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression
inferred← citeshttps://doi.org/10.1128/aac.02577-20openalex-snapshot
Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2
inferred← citeshttps://doi.org/10.1128/jvi.00857-26openalex-snapshot
A chimeric murine coronavirus with altered deISGylase and proteolytic activities exhibits attenuated viral pathogenesis
inferred← citeshttps://doi.org/10.1128/jvi.01734-19openalex-snapshot
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
inferred← citeshttps://doi.org/10.1128/spectrum.00744-22openalex-snapshot
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected Cells
inferred← citeshttps://doi.org/10.1134/s0006350922060082openalex-snapshot
SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein–Protein Interactions
inferred← citeshttps://doi.org/10.11606/d.60.2021.tde-22032022-092001openalex-snapshot
Explorando a diversidade química de fungos fitoparasitas de frutos e avaliação de seus potenciais inibitórios de papaína
inferred← citeshttps://doi.org/10.1172/jci161453openalex-snapshot
Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure
inferred← citeshttps://doi.org/10.1177/2472555220960428openalex-snapshot
Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3
inferred← citeshttps://doi.org/10.1177/2472555220963667openalex-snapshot
High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2
inferred← citeshttps://doi.org/10.1186/s12863-022-01044-yopenalex-snapshot
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
inferred← citeshttps://doi.org/10.1186/s40816-022-00347-yopenalex-snapshot
Pharmacoinformatic study of inhibitory potentials of selected flavonoids against papain-like protease and 3-chymotrypsin-like protease of SARS-CoV-2
inferred← citeshttps://doi.org/10.1186/s43141-021-00152-zopenalex-snapshot
Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics
inferred← citeshttps://doi.org/10.1246/bcsj.20220179openalex-snapshot
Molecular Mechanisms of the Medicines for COVID-19
inferred← citeshttps://doi.org/10.1248/cpb.c23-00622openalex-snapshot
In Silico Identification of Inhibitory Compounds for SARS-Cov-2 Papain-Like Protease
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1010667openalex-snapshot
Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding
inferred← citeshttps://doi.org/10.1371/journal.pone.0253364openalex-snapshot
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
inferred← citeshttps://doi.org/10.1371/journal.pone.0309305openalex-snapshot
A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals
inferred← citeshttps://doi.org/10.1371/journal.ppat.1009013openalex-snapshot
The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012100openalex-snapshot
Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo
inferred← citeshttps://doi.org/10.1515/pac-2026-0807openalex-snapshot
Development of SARS-CoV-2 papain-like protease inhibitors with a thiadiazole and oxadiazole linker
inferred← citeshttps://doi.org/10.15252/embj.2020106275openalex-snapshot
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
inferred← citeshttps://doi.org/10.1590/0074-02760210127openalex-snapshot
The adaptation of SARS-CoV-2 to humans
inferred← citeshttps://doi.org/10.18004/anales/2020.053.03.131openalex-snapshot
Potential therapeutic agents against COVID-19 based on blocking and inhibition of the viral life cycle and the cytokine storm syndrome
inferred← citeshttps://doi.org/10.18433/jpps31931openalex-snapshot
Losartan Inhibits SARS-CoV-2 Replication in Vitro
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