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The Reemergence of Cocrystals: The Crystal Clear Writing Is on the WallIntroduction to Virtual Special Issue on Pharmaceutical Cocrystals
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.addr.2007.05.011openalex-snapshot
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
inferredcites →https://doi.org/10.1016/j.drudis.2008.03.004openalex-snapshot
The role of cocrystals in pharmaceutical science
inferredcites →https://doi.org/10.1016/s0065-7743(08)00022-5openalex-snapshot
The Emerging Utility of Co-Crystals in Drug Discovery and Development
inferredcites →https://doi.org/10.1021/cg070569copenalex-snapshot
Cocrystal of Urea and Imidazolidone: Formation of an Unexpected 1-D Substructure in a Plausibly Predictable Cocrystal
inferredcites →https://doi.org/10.1021/cg701024copenalex-snapshot
Controlling the Formation of Benzoic Acid: Isonicotinamide Molecular Complexes
inferredcites →https://doi.org/10.1021/cg800173dopenalex-snapshot
Physicochemical Properties of Pharmaceutical Co-Crystals: A Case Study of Ten AMG 517 Co-Crystals
inferredcites →https://doi.org/10.1021/cg800454ropenalex-snapshot
Continuously Substituted Solid Solutions of Organic Co-Crystals
inferredcites →https://doi.org/10.1021/cg8005019openalex-snapshot
Drug Substance and Former Structure Property Relationships in 15 Diverse Pharmaceutical Co-Crystals
inferredcites →https://doi.org/10.1021/cg800565aopenalex-snapshot
Hierarchy of Supramolecular Synthons: Persistent Carboxylic Acid···Pyridine Hydrogen Bonds in Cocrystals That also Contain a Hydroxyl Moiety
inferredcites →https://doi.org/10.1021/cg800585dopenalex-snapshot
The Role of π-Stacking in the Composition of Phloroglucinol and Phenazine Cocrystals
inferredcites →https://doi.org/10.1021/cg800632ropenalex-snapshot
Role of Cocrystal and Solution Chemistry on the Formation and Stability of Cocrystals with Different Stoichiometry
inferredcites →https://doi.org/10.1021/cg8006712openalex-snapshot
Supramolecular Synthesis Based on a Combination of Hydrogen and Halogen Bonds
inferredcites →https://doi.org/10.1021/cg800685zopenalex-snapshot
Can the Formation of Pharmaceutical Cocrystals Be Computationally Predicted? I. Comparison of Lattice Energies
inferredcites →https://doi.org/10.1021/cg8007014openalex-snapshot
Solid-State NMR Analysis of Organic Cocrystals and Complexes
inferredcites →https://doi.org/10.1021/cg8007359openalex-snapshot
Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine
inferredcites →https://doi.org/10.1021/cg800764nopenalex-snapshot
Recent Advances in Understanding the Mechanism of Cocrystal Formation via Grinding
inferredcites →https://doi.org/10.1021/cg800861mopenalex-snapshot
Cambridge Structural Database Analysis of Molecular Complementarity in Cocrystals
inferredcites →https://doi.org/10.1021/cg8008893openalex-snapshot
Testing the Sensitivity of Terahertz Spectroscopy to Changes in Molecular and Supramolecular Structure: A Study of Structurally Similar Cocrystals
inferredcites →https://doi.org/10.1021/cg8009089openalex-snapshot
Designing Co-Crystals of Pharmaceutically Relevant Compounds That Crystallize with Z′ > 1
inferredcites →https://doi.org/10.1021/cg800936dopenalex-snapshot
Synthesis and Structural Characterization of Cocrystals and Pharmaceutical Cocrystals: Mechanochemistry vs Slow Evaporation from Solution
inferredcites →https://doi.org/10.1021/cg800942nopenalex-snapshot
Piracetam Co-Crystals with OH-Group Functionalized Carboxylic Acids
inferredcites →https://doi.org/10.1021/cg801019dopenalex-snapshot
Cocrystal Formation in Solution: In Situ Solute Concentration Monitoring of the Two Components and Kinetic Pathways
inferredcites →https://doi.org/10.1021/cg801039jopenalex-snapshot
Solubility Advantage of Pharmaceutical Cocrystals
inferredcites →https://doi.org/10.1021/cg801056copenalex-snapshot
Analysis of 50 Crystal Structures Containing Carbamazepine Using the Materials Module of Mercury CSD
inferredcites →https://doi.org/10.1021/cg801145copenalex-snapshot
Synthon Competition and Cooperation in Molecular Salts of Hydroxybenzoic Acids and Aminopyridines
inferredcites →https://doi.org/10.1021/cg801178mopenalex-snapshot
Cocrystals of Caffeine and Hydroxybenzoic Acids Composed of Multiple Supramolecular Heterosynthons: Screening via Solution-Mediated Phase Transformation and Structural Characterization
inferredcites →https://doi.org/10.1021/cg801253fopenalex-snapshot
Formation Kinetics and Stability of Carbamazepine−Nicotinamide Cocrystals Prepared by Mechanical Activation
inferredcites →https://doi.org/10.1021/cg801261hopenalex-snapshot
Crystal Engineering with Cocrystals of Benzo-[18]Crown-6 and Urea and Thiourea Derivatives
inferredcites →https://doi.org/10.1021/cg801397topenalex-snapshot
Vibrational Spectroscopic Studies of Cocrystals and Salts. 1. The Benzamide−Benzoic Acid System
inferredcites →https://doi.org/10.1021/cg900129fopenalex-snapshot
Pharmaceutical Cocrystals and Their Physicochemical Properties
inferredcites →https://doi.org/10.1021/cg9001972openalex-snapshot
Vibrational Spectroscopic Studies of Cocrystals and Salts. 2. The Benzylamine−Benzoic Acid System
inferredcites →https://doi.org/10.1021/cg9001994openalex-snapshot
Salt or Cocrystal? A New Series of Crystal Structures Formed from Simple Pyridines and Carboxylic Acids
inferredcites →https://doi.org/10.1021/cg900554hopenalex-snapshot
Indo−U.S. Workshop on Pharmaceutical Cocrystals and Polymorphs
inferredcites →https://doi.org/10.1021/cr9900432openalex-snapshot
From Molecules to Crystal Engineering: Supramolecular Isomerism and Polymorphism in Network Solids
inferredcites →https://doi.org/10.1021/ja00368a031openalex-snapshot
A new role for hydrogen-bond acceptors in influencing packing patterns of carboxylic acids and amides
inferredcites →https://doi.org/10.1021/mp0601345openalex-snapshot
The Salt−Cocrystal Continuum: The Influence of Crystal Structure on Ionization State
inferredcites →https://doi.org/10.1021/mp070001zopenalex-snapshot
An Overview of Pharmaceutical Cocrystals as Intellectual Property
inferredcites →https://doi.org/10.1039/b402150aopenalex-snapshot
Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?
inferredcites →https://doi.org/10.1039/b803866jopenalex-snapshot
Current directions in co-crystal growth
inferredcites →https://doi.org/10.1107/s0108768102003890openalex-snapshot
The Cambridge Structural Database: a quarter of a million crystal structures and rising
inferredcites →https://doi.org/10.1351/pac197127040647openalex-snapshot
Photodimerization in the solid state
inferredcites →https://doi.org/10.1517/17425240902828304openalex-snapshot
Pharmaceutical co-crystals–an opportunity for drug product enhancement
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Crystallization of Pharmaceutical Crystals
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A methodical investigation on the growth and characterization of a third-order nonlinear optical novel co-crystal of 8-hydroxyquinolinium phthalate: X-ray, Hirshfeld surface, optical, mechanical, thermal and DFT analysis
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Three pharmaceuticals cocrystals of adefovir: Syntheses, structures and dissolution study
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Design of Cocrystals for Molecules with Limited Hydrogen Bonding Functionalities: Propyphenazone as a Model System
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inferred← citeshttps://doi.org/10.1021/cg100670kopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/b927422gopenalex-snapshot
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inferred← citeshttps://doi.org/10.1039/c0cc01195aopenalex-snapshot
The growing world of crystal forms
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Novel form V of tolbutamide and a high Z′ crystal structure of form III
inferred← citeshttps://doi.org/10.1039/c0ce00461hopenalex-snapshot
Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance
inferred← citeshttps://doi.org/10.1039/c0ce00576bopenalex-snapshot
Supramolecular metathesis: co-former exchange in co-crystals of pyrazine with (R,R)-, (S,S)-, (R,S)- and (S,S/R,R)-tartaric acid
inferred← citeshttps://doi.org/10.1039/c0ce00657bopenalex-snapshot
Heterosynthon mediated tailored synthesis of pharmaceutical complexes: a solid-state NMR approach
inferred← citeshttps://doi.org/10.1039/c1cc10305aopenalex-snapshot
Polymorphs from supramolecular gels: four crystal forms of the same silver(i) supergelator crystallized directly from its gels
inferred← citeshttps://doi.org/10.1039/c1ce05152kopenalex-snapshot
Covalent assistance in supramolecular synthesis: in situ modification and masking of the hydrogen bonding functionality of the supramolecular reagent isoniazid in co-crystals
inferred← citeshttps://doi.org/10.1039/c1cs15171aopenalex-snapshot
Mechanochemistry: opportunities for new and cleaner synthesis
inferred← citeshttps://doi.org/10.1039/c2ce05796dopenalex-snapshot
Crystal engineering of energetic materials: Co-crystals of CL-20
inferred← citeshttps://doi.org/10.1039/c2ce06507jopenalex-snapshot
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
inferred← citeshttps://doi.org/10.1039/c2ce06588fopenalex-snapshot
Isostructurality in pharmaceutical salts: How often and how similar?
inferred← citeshttps://doi.org/10.1039/c2ce25080bopenalex-snapshot
Co-crystals of caffeine and piracetam with 4-hydroxybenzoic acid: Unravelling the hidden hydrates of 1 : 1 co-crystals
inferred← citeshttps://doi.org/10.1039/c2ce25883hopenalex-snapshot
The supramolecular assemblies of 7-amino-2,4-dimethylquinolinium salts and the effect of a variety of anions on their luminescent properties
inferred← citeshttps://doi.org/10.1039/c2ce26008eopenalex-snapshot
Crystalline adducts of some substituted salicylic acids with 4-aminopyridine, including hydrates and solvates: contact and separated ionic complexes with diverse supramolecular synthons
inferred← citeshttps://doi.org/10.1039/c2nj40379jopenalex-snapshot
From 3D channelled frameworks to 2D layered structures in molecular salts of l -serine and dl -serine with oxalic acid
inferred← citeshttps://doi.org/10.1039/c3ce40107copenalex-snapshot
Towards ab initio screening of co-crystal formation through lattice energy calculations and crystal structure prediction of nicotinamide, isonicotinamide, picolinamide and paracetamol multi-component crystals
inferred← citeshttps://doi.org/10.1039/c3ce42347fopenalex-snapshot
High solubility crystalline hydrates of Na and K furosemide salts
inferred← citeshttps://doi.org/10.1039/c3cs60014aopenalex-snapshot
Mechanochemical preparation of co-crystals
inferred← citeshttps://doi.org/10.1039/c4ce00784kopenalex-snapshot
Dissolution and pharmacokinetic properties of two paliperidone cocrystals with 4-hydroxybenzoic and 4-aminobenzoic acid
inferred← citeshttps://doi.org/10.1039/c4ce00866aopenalex-snapshot
Polymorphism in cocrystals of urea:4,4′-bipyridine and salicylic acid:4,4′-bipyridine
inferred← citeshttps://doi.org/10.1039/c4ce01127aopenalex-snapshot
New cocrystals of ezetimibe with l -proline and imidazole
inferred← citeshttps://doi.org/10.1039/c5ce00992hopenalex-snapshot
Thermodynamic characteristics of cocrystal formation and melting points for rational design of pharmaceutical two-component systems
inferred← citeshttps://doi.org/10.1039/c5nj02013aopenalex-snapshot
Heat of formation distributions of components involved in bi-component cocrystals and simple binary eutectic mixtures
inferred← citeshttps://doi.org/10.1039/c6cc01289bopenalex-snapshot
Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies
inferred← citeshttps://doi.org/10.1039/c7ce00554gopenalex-snapshot
Two-component molecular crystals: evaluation of the formation thermodynamics based on melting points and sublimation data
inferred← citeshttps://doi.org/10.1039/c7ce01875dopenalex-snapshot
11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons
inferred← citeshttps://doi.org/10.1039/d2fd00077fopenalex-snapshot
Progress in understanding crystallisation: a personal perspective
inferred← citeshttps://doi.org/10.1039/d4cc02289kopenalex-snapshot
Structure of the caffeine–pyrogallol complex: revisiting a pioneering structural analysis of a model pharmaceutical cocrystal
inferred← citeshttps://doi.org/10.1039/d4mr00096jopenalex-snapshot
Mechanochemical kilogram-scale synthesis of rac -ibuprofen:nicotinamide co-crystals using a drum mill
inferred← citeshttps://doi.org/10.1063/1.5000468openalex-snapshot
Solubility of carbamazepine co-crystals in ethanolic solution
inferred← citeshttps://doi.org/10.1080/03639045.2018.1435687openalex-snapshot
Development of paracetamol-caffeine co-crystals to improve compressional, formulation and in vivo performance
inferred← citeshttps://doi.org/10.1080/03639045.2026.2624588openalex-snapshot
Solubility enhancement of rosuvastatin using co-crystal approach
inferred← citeshttps://doi.org/10.1080/10837450.2026.2624727openalex-snapshot
Zoomlab™-guided co-crystal engineering of nilotinib for improved dissolution
inferred← citeshttps://doi.org/10.1080/15421406.2014.954769openalex-snapshot
Synthesis, Thermal Studies, Spectroscopy Characterization, and Crystal Structure of Nicotinamidium Oxamate
inferred← citeshttps://doi.org/10.1080/15421406.2022.2141059openalex-snapshot
Packing structure and non-classical hydrogen bonding interactions of the toluene solvate crystal of 1,8-bis(4-methylbenzoyl)naphthalene-2,7-diyl dibenzoate: Role of toluene molecule in determination of the spatial arrangement of the major constituent molecules
inferred← citeshttps://doi.org/10.1101/2025.07.16.664812openalex-snapshot
Synchrotron XRD based Structural analysis of Novel Fleroxacin Cocrystals synthesized using coformers
inferred← citeshttps://doi.org/10.1107/s2052520615010872openalex-snapshot
Is there any point in making co-crystals?
inferred← citeshttps://doi.org/10.1107/s2052520617011477openalex-snapshot
First-line antituberculosis drug, pyrazinamide, its pharmaceutically relevant cocrystals and a salt
inferred← citeshttps://doi.org/10.1107/s2053229618017904openalex-snapshot
Succinic, fumaric, adipic and oxalic acid cocrystals of promethazine hydrochloride
inferred← citeshttps://doi.org/10.1107/s2056989015017569openalex-snapshot
Redetermined structure of 4,4′-bipyridine–1,4-phenylenediacetic acid (1/1) co-crystal
inferred← citeshttps://doi.org/10.1124/pr.112.005660openalex-snapshot
Strategies to Address Low Drug Solubility in Discovery and Development
inferred← citeshttps://doi.org/10.1134/s107036321402042xopenalex-snapshot
Design of pharmaceutical cocrystals for drug solubility improvement
inferred← citeshttps://doi.org/10.1208/s12249-021-01938-7openalex-snapshot
Physicomechanical, stability, and pharmacokinetic evaluation of aceclofenac dimethyl urea cocrystals
inferred← citeshttps://doi.org/10.1515/ncrs-2015-0005openalex-snapshot
Co-Crystal structure of 1,3-phenylenediacetic acid and 2,5-bis(4-pyridyl)- 1,3,4-oxadiazole (1:1), C22H18N4O5
inferred← citeshttps://doi.org/10.1515/ncrs-2016-0005openalex-snapshot
Crystal structure of bis(μ3-isophthalato-κ 3 O:O′:O′′)(μ2-1,4-\ bis((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)benzene-κ2 N:N′)dizinc(II), C22H19N2O4Zn
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2843561/v1openalex-snapshot
Synthesis and structure characterization of three pharmaceutical compounds based on tinidazole compounds
inferred← citeshttps://doi.org/10.3109/03639045.2012.689764openalex-snapshot
Evaluation of performance of co crystals of mefloquine hydrochloride in tablet dosage form
inferred← citeshttps://doi.org/10.3233/jcm-2012-0417openalex-snapshot
On the energetic and geometric description of the interaction between the isonipecotic and 1,1-cylobutanedicarboxilic acids
inferred← citeshttps://doi.org/10.3390/cryst12101457openalex-snapshot
2D Monte Carlo Simulation of Cocrystal Formation Using Patchy Particles
inferred← citeshttps://doi.org/10.3390/cryst13060947openalex-snapshot
Synthesis and Structure Characterization of Three Pharmaceutical Compounds Based on Tinidazole
inferred← citeshttps://doi.org/10.3390/pharmaceutics3030601openalex-snapshot
Co-Crystal Screening of Diclofenac
inferred← citeshttps://doi.org/10.4172/2153-2435.1000402openalex-snapshot
Effect of Povacoat or Soluplus on Solid-State Characterization of Indomethacin-Nicotinamide Co-Crystal Formation
inferred← citeshttps://doi.org/10.5772/50626openalex-snapshot
Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers
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