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An Overview of Pharmaceutical Cocrystals as Intellectual Property
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Beiträge zur Alkoholbestimmung im Blut nach Widmark
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Screening for Inclusion Compounds and Systematic Construction of Three‐Component Solids by Liquid‐Assisted Grinding
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Structure of a Discrete Dichloride Hexahydrate Cube as a Tris(diisopropylamino)cyclopropenium Salt
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Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API
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Cocrystal Formation during Cogrinding and Storage is Mediated by Amorphous Phase
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General principles of pharmaceutical solid polymorphism A supramolecular perspective
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High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids
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Physical stability enhancement of theophylline via cocrystallization
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Pharmaceutical Cocrystal and Salts of Norfloxacin
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Use of aza-Cope rearrangement-Mannich cyclization reactions to achieve a general entry to Melodinus and Aspidosperma alkaloids. Stereocontrolled total syntheses of (.+-.)-deoxoapodine, (.+-.)-meloscine, and (.+-.)-epimeloscine and a formal synthesis of (.+-.)-1-acetylaspidoalbidine
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Crystal Engineering of Novel Cocrystals of a Triazole Drug with 1,4-Dicarboxylic Acids
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Crystal Engineering Approach To Forming Cocrystals of Amine Hydrochlorides with Organic Acids. Molecular Complexes of Fluoxetine Hydrochloride with Benzoic, Succinic, and Fumaric Acids
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The Predictably Elusive Form II of Aspirin
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Prediction and Observation of Isostructurality Induced by Solvent Incorporation in Multicomponent Crystals
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Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development
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Systematic analysis of the probabilities of formation of bimolecular hydrogen-bonded ring motifs in organic crystal structures
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Food and Drug Administration, Center for Drug Evaluation and Research
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Polymorphism in Molecular Crystals
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Crystal Engineering: Strategies and Architectures
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Theory, Practice, and Poetry in Vico
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Handbook of Pharmaceutical Salts: Properties, Selection, and Use
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Pharmaceutical Cocrystals: An Emerging Approach to Physical Property Enhancement
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Encyclopedia of pharmaceutical technology
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Patents and Regulatory Considerations of Pharmaceutical Cocrystals
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Alternative Solid Forms: Co‐crystals
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From a Binary to a Quaternary Cocrystal: An Unusual Supramolecular Synthon
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From a Binary to a Quaternary Cocrystal: An Unusual Supramolecular Synthon
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Rational Coformer or Solvent Selection for Pharmaceutical Cocrystallization or Desolvation
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Different Hydrogen-Bonded Interactions in the Cocrystals of Nicotinamide with Two Aromatic Acids
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X-Ray Crystallography and its Role in Understanding the Physicochemical Properties of Pharmaceutical Cocrystals
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Polymorphs and Cocrystals: A Comparative Analysis
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Predictive tools for cocrystal formation
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Prediction of small molecule crystal structures
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Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design
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Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review
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Theophylline–citric acid co-crystals easily induced by DSC–FTIR microspectroscopy or different storage conditions
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Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time
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Cocrystallization of Dasatinib with different acids improves the solubility and physicochemical properties: A combined experimental and theoretical studies
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Following the surface response of caffeine cocrystals to controlled humidity storage by atomic force microscopy
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Solvent-free preparation of co-crystals of phenazine and acridine with vanillin
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Cocrystals of U-shaped ureadicarboxylic acid with 2-aminopyrimidine and melamine: rhombus-shaped cyclic heterotetramer motifs
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Near-Infrared Spectroscopy for Cocrystal Screening. A Comparative Study with Raman Spectroscopy
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Enhanced Aqueous Solubility of the Solid Forms of a BCS Class-II Anti-Tuberculosis Drug, Prothionamide
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Formation Thermodynamics of Two-Component Molecular Crystals: Polymorphism, Stoichiometry, and Impact of Enantiomers
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Strategy for Efficient Discovery of Cocrystals via a Network-Based Recommendation Model
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An Elusive Drug–Drug Cocrystal Prepared Using a Heteroseeding Strategy
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Hydrate vs Anhydrate under a Pressure-(De)stabilizing Effect of the Presence of Water in Solid Forms of Sulfamethoxazole
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On the Mechanism of Cocrystal Mechanochemical Reaction via Low Melting Eutectic: A Time-Resolved In Situ Monitoring Investigation
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Investigation into the Nucleation of the p -Hydroxybenzoic Acid:Glutaric Acid 1:1 Cocrystal from Stoichiometric and Non-Stoichiometric Solutions
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Unusual In Situ Transformation of Metastable Co-Crystal Forms into a Stable Form, in Solution and Solid State, and the [2 + 2] Photochemical Reactivity in the Crystalline Forms
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Cocrystals of Pentoxifylline: In Silico and Experimental Screening
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Building upon Supramolecular Synthons: Some Aspects of Crystal Engineering
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Selective Crystal Growth of Theophylline-Saccharin Cocrystal on Self-Assembled Monolayer from Incongruent System
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Ionic, Neutral, and Hybrid Acid–Base Crystalline Adducts of Lamotrigine with Improved Pharmaceutical Performance
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Crystal Engineering of Pharmaceutical Co-crystals: “NMR Crystallography” of Niclosamide Co-crystals
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00755openalex-snapshot
Cocrystal Engineering-Based Strategies for Enhancing the Permeability of Poorly Permeable APIs
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c00965openalex-snapshot
Structure Characterization and Property Evaluation of a Drug–Drug Cocrystal Involving Temozolomide and Luteolin
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c01081openalex-snapshot
Thymol–Menthol Deep Eutectic Solvents and Eutectogels as Pharmaceutical Crystallization Media
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00032openalex-snapshot
Chloral Hydrate Polymorphs and Cocrystal Revisited: Solving Two Pharmaceutical Cold Cases
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00243openalex-snapshot
Solid-State Chemistry and Polymorphism of the Nucleobase Adenine
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b00606openalex-snapshot
Cocrystals of Ethenzamide: Study of Structural and Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01160openalex-snapshot
Stability of Pharmaceutical Cocrystal During Milling: A Case Study of 1:1 Caffeine–Glutaric Acid
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01462openalex-snapshot
Iso-Structurality Induced Solid Phase Transformations: A Case Study with Lenalidomide
inferred← citeshttps://doi.org/10.1021/acs.cgd.6b01866openalex-snapshot
Continuous Cocrystallization of Benzoic Acid and Isonicotinamide by Mixing-Induced Supersaturation: Exploring Opportunities between Reactive and Antisolvent Crystallization Concepts
inferred← citeshttps://doi.org/10.1021/acs.cgd.6c00914openalex-snapshot
A Review of Stoichiometrically Diverse Pharmaceutical Cocrystals: Preparation, Characterization, and Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00542openalex-snapshot
Adducts of N-Heterocyclic Drugs, Niacin, Allopurinol, and Amiloride, with 2,4-Pyridinedicarboxylic Acid Coformer
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00745openalex-snapshot
A Comprehensive Cocrystal Screening Study of Chlorothiazide
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00352openalex-snapshot
Crystallizing Ionic Cocrystals: Structural Characteristics, Thermal Behavior, and Crystallization Development of a Piracetam-CaCl2 Cocrystallization Process
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00684openalex-snapshot
Stable Cocrystals and Salts of the Antineoplastic Drug Apatinib with Improved Solubility in Aqueous Solution
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00849openalex-snapshot
Cocrystallization of Curcumin with Benzenediols and Benzenetriols via Rapid Solvent Removal
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00933openalex-snapshot
Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b01070openalex-snapshot
Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00249openalex-snapshot
Cocrystal of Apigenin with Higher Solubility, Enhanced Oral Bioavailability, and Anti-inflammatory Effect
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00591openalex-snapshot
Structural and Computational Insights into Cocrystal Interactions: A Case on Cocrystals of Antipyrine and Aminophenazone
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01365openalex-snapshot
Improving the Dissolution Rate of the Anticancer Drug Dabrafenib
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01688openalex-snapshot
Drug–Drug Cocrystals Provide Significant Improvements of Drug Properties in Treatment with Progesterone
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00987openalex-snapshot
Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01234openalex-snapshot
Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine…
inferred← citeshttps://doi.org/10.1021/acs.jpcb.5b05082openalex-snapshot
Influence of Secondary Interactions on the Structure, Sublimation Thermodynamics, and Solubility of Salicylate:4-Hydroxybenzamide Cocrystals. Combined Experimental and Theoretical Study
inferred← citeshttps://doi.org/10.1021/acs.oprd.4c00509openalex-snapshot
Development of the Crystallization Process for Rivaroxaban–Oxalic Acid Cocrystal Preparation Using a Combination of Phase Diagrams and In Situ Measurements
inferred← citeshttps://doi.org/10.1021/cg100099wopenalex-snapshot
Vibrational Spectroscopic Studies of Cocrystals and Salts. 3. Cocrystal Products Formed by Benzenecarboxylic Acids and Their Sodium Salts
inferred← citeshttps://doi.org/10.1021/cg1002176openalex-snapshot
Effect of Micellar Solubilization on Cocrystal Solubility and Stability
inferred← citeshttps://doi.org/10.1021/cg100484aopenalex-snapshot
Hierarchy of Supramolecular Synthons: Persistent Hydrogen Bonds Between Carboxylates and Weakly Acidic Hydroxyl Moieties in Cocrystals of Zwitterions
inferred← citeshttps://doi.org/10.1021/cg1005693openalex-snapshot
Co-Crystals of Active Pharmaceutical Ingredients - Acetazolamide
inferred← citeshttps://doi.org/10.1021/cg100670kopenalex-snapshot
Pharmaceutical Co-crystals with Isonicotinamide—Vitamin B3, Clofibric Acid, and Diclofenac—and Two Isonicotinamide Hydrates
inferred← citeshttps://doi.org/10.1021/cg101002xopenalex-snapshot
Structural Study of Salicylic Acid Salts of a Series of Azacycles and Azacrown Ethers
inferred← citeshttps://doi.org/10.1021/cg1010117openalex-snapshot
Fluconazole Cocrystals with Dicarboxylic Acids
inferred← citeshttps://doi.org/10.1021/cg1010192openalex-snapshot
Sulfoxides: Potent Co-Crystal Formers
inferred← citeshttps://doi.org/10.1021/cg1016388openalex-snapshot
Effect of Fluorination on Molecular Conformation in the Solid State: Tuning the Conformation of Cocrystal Formers
inferred← citeshttps://doi.org/10.1021/cg200492wopenalex-snapshot
Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals
inferred← citeshttps://doi.org/10.1021/cg201423qopenalex-snapshot
Improving the Solubility of Agomelatine via Cocrystals
inferred← citeshttps://doi.org/10.1021/cg300189vopenalex-snapshot
Utilizing Sulfoxide···Iodine Halogen Bonding for Cocrystallization
inferred← citeshttps://doi.org/10.1021/cg3002948openalex-snapshot
Polymorphs, Salts, and Cocrystals: What’s in a Name?
inferred← citeshttps://doi.org/10.1021/cg300327xopenalex-snapshot
Phenazopyridine Cocrystal and Salts That Exhibit Enhanced Solubility and Stability
inferred← citeshttps://doi.org/10.1021/cg300702topenalex-snapshot
Selecting the Desired Solid Form by Membrane Crystallizers: Crystals or Cocrystals
inferred← citeshttps://doi.org/10.1021/cg3007102openalex-snapshot
Preparation and Solid-State Characterization of Three Novel Multicomponent Solid Forms of Oxcarbazepine: Improvement in Solubility through Saccharin Cocrystal
inferred← citeshttps://doi.org/10.1021/cg300887popenalex-snapshot
Co-Crystals and Co-Crystal Hydrates of the Antibiotic Nitrofurantoin: Structural Studies and Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/cg300895copenalex-snapshot
Polymorphs and Cocrystals of Nalidixic Acid
inferred← citeshttps://doi.org/10.1021/cg301356hopenalex-snapshot
Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids
inferred← citeshttps://doi.org/10.1021/cg301854fopenalex-snapshot
Tubular Arrangement of 1,3-Alternate Calix[4]arene with Bipyridines: A Platform for [2 + 2] Photocyclization
inferred← citeshttps://doi.org/10.1021/cg4000439openalex-snapshot
Understanding the Effects of Ionicity in Salts, Solvates, Co-Crystals, Ionic Co-Crystals, and Ionic Liquids, Rather than Nomenclature, Is Critical to Understanding Their Behavior
inferred← citeshttps://doi.org/10.1021/cg400583zopenalex-snapshot
Soluble Cocrystals of the Xanthine Oxidase Inhibitor Febuxostat
inferred← citeshttps://doi.org/10.1021/cg4006357openalex-snapshot
Polymorphic Co-crystals from Polymorphic Co-crystal Formers: Competition between Carboxylic Acid···Pyridine and Phenol···Pyridine Hydrogen Bonds
inferred← citeshttps://doi.org/10.1021/cg4009784openalex-snapshot
Charge-Assisted Soft Supramolecular Porous Frameworks: Effect of External Stimuli on Structural Transformation and Adsorption Properties
inferred← citeshttps://doi.org/10.1021/cg401131xopenalex-snapshot
Single-Step Co-Crystallization and Lipid Dispersion by Supercritical Enhanced Atomization
inferred← citeshttps://doi.org/10.1021/cg401889hopenalex-snapshot
Virtual Screening Identifies New Cocrystals of Nalidixic Acid
inferred← citeshttps://doi.org/10.1021/cg500155popenalex-snapshot
Formulation of Liquid Propofol as a Cocrystalline Solid
inferred← citeshttps://doi.org/10.1021/cg500388sopenalex-snapshot
Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin
inferred← citeshttps://doi.org/10.1021/cg500502jopenalex-snapshot
Controlled Synthesis of New 5-Fluorocytosine Cocrystals Based on the pKa Rule
inferred← citeshttps://doi.org/10.1021/cg501182topenalex-snapshot
Cocrystals of the Tuberculosis Drug Isoniazid: Polymorphism, Isostructurality, and Stability
inferred← citeshttps://doi.org/10.1021/cg501204kopenalex-snapshot
Synthon Hierarchies in Crystal Forms Composed of Theophylline and Hydroxybenzoic Acids: Cocrystal Screening via Solution-Mediated Phase Transformation
inferred← citeshttps://doi.org/10.1021/cg501310dopenalex-snapshot
Physical Stability Enhancement and Pharmacokinetics of a Lithium Ionic Cocrystal with Glucose
inferred← citeshttps://doi.org/10.1021/cg501772topenalex-snapshot
Tetramorphs of the Antibiotic Drug Trimethoprim: Characterization and Stability
inferred← citeshttps://doi.org/10.1021/cg501865hopenalex-snapshot
Molecular Recognition of Steroid Hormones in the Solid State: Stark Differences in Cocrystallization of β-Estradiol and Estrone
inferred← citeshttps://doi.org/10.1021/cg7008732openalex-snapshot
An Alternate Crystal Form of Gabapentin: A Cocrystal with Oxalic Acid
inferred← citeshttps://doi.org/10.1021/cg701000qopenalex-snapshot
Polymorphism: The Same and Not Quite the Same
inferred← citeshttps://doi.org/10.1021/cg800183vopenalex-snapshot
Co-Crystal Polymorphs from a Solvent-Mediated Transformation
inferred← citeshttps://doi.org/10.1021/cg800198eopenalex-snapshot
Crystal Engineering - Inclusion Compounds, Molecular Networks, Cocrystals, and Polymorphs
inferred← citeshttps://doi.org/10.1021/cg800519dopenalex-snapshot
Crystal Structures of Norfloxacin Hydrates
inferred← citeshttps://doi.org/10.1021/cg800565aopenalex-snapshot
Hierarchy of Supramolecular Synthons: Persistent Carboxylic Acid···Pyridine Hydrogen Bonds in Cocrystals That also Contain a Hydroxyl Moiety
inferred← citeshttps://doi.org/10.1021/cg800585dopenalex-snapshot
The Role of π-Stacking in the Composition of Phloroglucinol and Phenazine Cocrystals
inferred← citeshttps://doi.org/10.1021/cg800632ropenalex-snapshot
Role of Cocrystal and Solution Chemistry on the Formation and Stability of Cocrystals with Different Stoichiometry
inferred← citeshttps://doi.org/10.1021/cg8007359openalex-snapshot
Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine
inferred← citeshttps://doi.org/10.1021/cg801132ropenalex-snapshot
Design of Cocrystals via New and Robust Supramolecular Synthon between Carboxylic Acid and Secondary Amide: Honeycomb Network with Jailed Aromatics
inferred← citeshttps://doi.org/10.1021/cg801347dopenalex-snapshot
Wöhler and Liebig Revisited: 176 Years of Polymorphism in Benzamide - and the Story Still Continues!
inferred← citeshttps://doi.org/10.1021/cg900129fopenalex-snapshot
Pharmaceutical Cocrystals and Their Physicochemical Properties
inferred← citeshttps://doi.org/10.1021/cg900647yopenalex-snapshot
Salts of Hydrates of Imiquimod, an Immune Response Modifier
inferred← citeshttps://doi.org/10.1021/cg901002yopenalex-snapshot
The Reemergence of Cocrystals: The Crystal Clear Writing Is on the WallIntroduction to Virtual Special Issue on Pharmaceutical Cocrystals
inferred← citeshttps://doi.org/10.1021/cg901010vopenalex-snapshot
Effects of Crystal Form on Solubility and Pharmacokinetics: A Crystal Engineering Case Study of Lamotrigine
inferred← citeshttps://doi.org/10.1021/cg9012685openalex-snapshot
Supramolecular Assembly of Protonated Xanthine Alkaloids in Their Perchlorate Salts
inferred← citeshttps://doi.org/10.1021/cg9015178openalex-snapshot
Polymorphs and Solvates of a Cocrystal Involving an Analgesic Drug, Ethenzamide, and 3,5-Dinitrobenzoic Acid
inferred← citeshttps://doi.org/10.1021/ja100146fopenalex-snapshot
Crystal Engineering of Pharmaceutical Co-crystals: Application of Methyl Paraben as Molecular Hook
inferred← citeshttps://doi.org/10.1021/ja403264copenalex-snapshot
Crystal Engineering: From Molecule to Crystal
inferred← citeshttps://doi.org/10.1021/jp101303jopenalex-snapshot
Lidocaine/ l -Menthol Binary System: Cocrystallization versus Solid-State Immiscibility
inferred← citeshttps://doi.org/10.1021/jp803019mopenalex-snapshot
Screening for Cocrystallization Tendency: The Role of Intermolecular Interactions
inferred← citeshttps://doi.org/10.1021/mp300574jopenalex-snapshot
Halogen Bonding and Pharmaceutical Cocrystals: The Case of a Widely Used Preservative
inferred← citeshttps://doi.org/10.1021/op900137jopenalex-snapshot
A Practical Solid Form Screen Approach To Identify a Pharmaceutical Glutaric Acid Cocrystal for Development
inferred← citeshttps://doi.org/10.1039/9781782622659-00262openalex-snapshot
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