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A Simple Approach for Indexing the Oral Druglikeness of a Compound: Discriminating Druglike Compounds from Nondruglike Ones

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Success rates for new drugs entering clinical testing in the United States
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
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Is There a Difference between Leads and Drugs? A Historical Perspective
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Identification of Biological Activity Profiles Using Substructural Analysis and Genetic Algorithms
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Automated Pharmacophore Identification for Large Chemical Data Sets
inferredcites →https://doi.org/10.1021/jm015507eopenalex-snapshot
Simple Selection Criteria for Drug-like Chemical Matter
inferredcites →https://doi.org/10.1021/jm021053popenalex-snapshot
A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
inferredcites →https://doi.org/10.1021/jm030267jopenalex-snapshot
Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs
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Time-Related Differences in the Physical Property Profiles of Oral Drugs
inferredcites →https://doi.org/10.1021/jm9602928openalex-snapshot
The Properties of Known Drugs. 1. Molecular Frameworks
inferredcites →https://doi.org/10.1021/jm970666copenalex-snapshot
Can We Learn To Distinguish between “Drug-like” and “Nondrug-like” Molecules?
inferredcites →https://doi.org/10.1021/jm9706776openalex-snapshot
A Scoring Scheme for Discriminating between Drugs and Nondrugs
inferredcites →https://doi.org/10.1021/jm9903996openalex-snapshot
Properties of Known Drugs. 2. Side Chains
inferredcites →https://doi.org/10.1023/a:1008130001697openalex-snapshot
Property distribution of drug-related chemical databases*
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Current trends in lead discovery: Are we looking for the appropriate properties?
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Fundamentals of Neural Networks
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Gastrointestinal absorption of drugs: methods and studies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Properties that Make a Molecule a Good Drug
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A Simple Approach for Indexing the Oral Druglikeness of a Compound: Discriminating Druglike Compounds from Nondruglike Ones.
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The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening
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Recent Advances in the Assessment of Druglikeness Using 2D-Structural Descriptors
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Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni
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Lipid-based formulations for oral delivery of lipophilic drugs
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‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries
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Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety
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An interesting relationship between drug absorption and melting point
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Drug-Likeness, Druggability, and Molecular Developability via Chemometric Evaluation: A Review
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Integrating Everything: The Molecule Selection Toolkit, a System for Compound Prioritization in Drug Discovery
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Predicting Oral Druglikeness by Iterative Stochastic Elimination
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Atom Type Preferences, Structural Diversity, and Property Profiles of Known Drugs, Leads, and Nondrugs: A Comparative Assessment
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Influence of molecular properties on oral bioavailability of lipophilic drugs – Mapping of bulkiness and different measures of polarity
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Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines
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Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
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Drug Likeness Screening and Evaluation of Physicochemical Properties of Selected Medicinal Agents by Computer Aided Drug Design Tools
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Computational exploration of novel ROCK2 inhibitors for cardiovascular disease management; insights from high-throughput virtual screening, molecular docking, DFT and MD simulation
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Maximizing the outcome of early ADMET models: strategies to win the drug-hunting battles?
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Pharmacokinetic study with computational tools in the medicinal chemistry course
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Physicochemical and Pharmacokinetic Properties’ Screening of Selected Cardiovascular Agents: an in-silico Approach
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Protein-Ligand In- Silico Molecular Docking Model for Discovering Potential Drugs of COVID-19
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Development of Drug-likeness Model and Its Visualization
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Evaluation of blockbuster drugs under the Rule-of-five
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Benzimidazole-Triazole Hybrids as Antimicrobial and Antiviral Agents: A Systematic Review
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