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In silico Prediction of Total Human Plasma Clearance
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hlca.19970800210openalex-snapshot
Lipophilicity Behavior of Model and Medicinal Compounds containing a suilfide, sulfoxide, or sulfone moiety
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Prediction of Human Clearance from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis
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A comprehensive analysis of the role of correction factors in the allometric predictivity of clearance from rat, dog, and monkey to humans
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Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure
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A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.
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Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?
inferredcites →https://doi.org/10.1007/978-94-017-1026-8_2openalex-snapshot
Multivariate Data Analysis in Chemistry
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Allometric scaling of pharmacokinetic parameters in drug discovery: Can human CL, Vss and t1/2 be predicted fromin-vivo rat data?
inferredcites →https://doi.org/10.1007/s10822-011-9496-zopenalex-snapshot
DemQSAR: predicting human volume of distribution and clearance of drugs
inferredcites →https://doi.org/10.1016/0006-2952(94)90520-7openalex-snapshot
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
inferredcites →https://doi.org/10.1016/j.bmc.2007.12.042openalex-snapshot
Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity
inferredcites →https://doi.org/10.1016/j.ejmech.2008.07.027openalex-snapshot
First-principle, structure-based prediction of hepatic metabolic clearance values in human
inferredcites →https://doi.org/10.1016/j.ejps.2009.12.007openalex-snapshot
Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks
inferredcites →https://doi.org/10.1016/j.jmgm.2005.10.004openalex-snapshot
Quantitative structure–pharmacokinetic relationships for drug clearance by using statistical learning methods
inferredcites →https://doi.org/10.1016/j.jmgm.2009.08.002openalex-snapshot
Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs
inferredcites →https://doi.org/10.1016/s0022-3565(24)36999-xopenalex-snapshot
The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
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SIMCA: A Method for Analyzing Chemical Data in Terms of Similarity and Analogy
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Random Forest: A Classification and Regression Tool for Compound Classification and QSAR Modeling
inferredcites →https://doi.org/10.1021/ci1000295openalex-snapshot
Predicting Total Clearance in Humans from Chemical Structure
inferredcites →https://doi.org/10.1021/ci700018yopenalex-snapshot
New and Original pKa Prediction Method Using Grid Molecular Interaction Fields
inferredcites →https://doi.org/10.1021/jm030408hopenalex-snapshot
Prediction of Human Volume of Distribution Values for Neutral and Basic Drugs. 2. Extended Data Set and Leave-Class-Out Statistics
inferredcites →https://doi.org/10.1021/jm050200ropenalex-snapshot
A Hybrid Mixture Discriminant Analysis−Random Forest Computational Model for the Prediction of Volume of Distribution of Drugs in Human
inferredcites →https://doi.org/10.1021/jm900403jopenalex-snapshot
Physicochemical Determinants of Human Renal Clearance
inferredcites →https://doi.org/10.1021/jm9004658openalex-snapshot
In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set
inferredcites →https://doi.org/10.1080/00498250600683197openalex-snapshot
Prediction ofin vivodrug clearance fromin vitrodata. I: Impact of inter-individual variability
inferredcites →https://doi.org/10.1080/00498250600761662openalex-snapshot
Prediction of metabolic drug clearance in humans:In vitro–in vivoextrapolationvsallometric scaling
inferredcites →https://doi.org/10.1111/j.1365-2885.2006.00786.xopenalex-snapshot
Interspecies allometric scaling. Part I: prediction of clearance in large animals
inferredcites →https://doi.org/10.1111/j.1365-2885.2006.00787.xopenalex-snapshot
Interspecies allometric scaling: prediction of clearance in large animal species: Part II: mathematical considerations
inferredcites →https://doi.org/10.1124/dmd.105.004143openalex-snapshot
A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING
inferredcites →https://doi.org/10.1124/dmd.105.006619openalex-snapshot
EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF “DISCOVERY-LIKE” MOLECULES TO PREDICT HUMAN PHARMACOKINETICS
inferredcites →https://doi.org/10.1124/dmd.108.020479openalex-snapshot
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds
inferredcites →https://doi.org/10.1124/dmd.32.6.603openalex-snapshot
A COMPREHENSIVE QUANTITATIVE AND QUALITATIVE EVALUATION OF EXTRAPOLATION OF INTRAVENOUS PHARMACOKINETIC PARAMETERS FROM RAT, DOG, AND MONKEY TO HUMANS. I. CLEARANCE
inferredcites →https://doi.org/10.1177/0091270005285457openalex-snapshot
On the Observed Large Interspecies Overprediction of Human Clearance (“Vertical Allometry”) of UCN‐01: Further Support for a Proposed Model Based on Plasma Protein Binding
inferredcites →https://doi.org/10.1177/0091270012440282openalex-snapshot
Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance
inferredcites →https://doi.org/10.1208/s12248-009-9124-1openalex-snapshot
Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships
inferredcites →https://doi.org/10.1214/aos/1193342379openalex-snapshot
A Statistical Theory of Calibration
inferredcites →https://doi.org/10.1517/17425250903099649openalex-snapshot
Human clearance prediction: shifting the paradigm
inferredcites →https://doi.org/10.2174/156802611794480873openalex-snapshot
Predicting Clearance in Humans from In Vitro Data
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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