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Modeling Phospholipidosis Induction: Reliability and Warnings

https://doi.org/10.1021/ci400113t
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Outgoing claims: the papers this work cites, builds on, or argues with.

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In Silico Studies of the Relationship Between Chemical Structure and Drug Induced Phospholipidosis
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Similarity Based Descriptors – Useful for Classification of Substrates of the Human Multidrug Transporter P‐Glycoprotein?
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Comparative pharmacology of mianserin, its main metabolites and 6-azamianserin
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Validation of an in vitro screen for phospholipidosis using a high-content biology platform
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Ketoconazole-induced hepatic phospholipidosis in the mouse and its association with de-N-acetyl ketoconazole
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Biomarkers to monitor drug-induced phospholipidosis
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Cationic amphiphilic drugs and phospholipid storage disorder.
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A widely applicable set of descriptors
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Characterisation of a potential biomarker of phospholipidosis from amiodarone-treated rats
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Predicting Phospholipidosis: A Fluorescence Noncell Based in Vitro Assay for the Determination of Drug–Phospholipid Complex Formation in Early Drug Discovery
inferredcites →https://doi.org/10.1021/ci300155yopenalex-snapshot
In silico Prediction of Total Human Plasma Clearance
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Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules
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Evaluation of a Published in Silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential
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New and Original pKa Prediction Method Using Grid Molecular Interaction Fields
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In Silico and In Vitro Filters for the Fast Estimation of Skin Permeation and Distribution of New Chemical Entities
inferredcites →https://doi.org/10.1021/jm201082aopenalex-snapshot
In Silico Assay for Assessing Phospholipidosis Potential of Small Druglike Molecules: Training, Validation, and Refinement Using Several Data Sets
inferredcites →https://doi.org/10.1021/jm7013953openalex-snapshot
Assessment of Drug−Lipid Complex Formation by a High-Throughput Langmuir-Balance and Correlation to Phospholipidosis
inferredcites →https://doi.org/10.1021/jm9004658openalex-snapshot
In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set
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Predicting Blood−Brain Barrier Permeation from Three-Dimensional Molecular Structure
inferredcites →https://doi.org/10.1021/mp100103eopenalex-snapshot
Predicting Phospholipidosis Using Machine Learning
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Phospholipidosis as a Function of Basicity, Lipophilicity, and Volume of Distribution of Compounds
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Early effects of gentamicin, tobramycin, and amikacin on the human kidney
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hERG binding feature analysis of structurally diverse compounds by QSAR and fragmental analysis
inferredcites →https://doi.org/10.1078/0940-2993-00338openalex-snapshot
Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential
inferredcites →https://doi.org/10.1080/15376510701857262openalex-snapshot
Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models
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The metabolism or atropine in man
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Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro
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Aminoglycosides: Nephrotoxicity
inferredcites →https://doi.org/10.1152/ajplung.00434.2003openalex-snapshot
Effects of metabolites and analogs of amiodarone on alveolar macrophages: structure-activity relationship
inferredcites →https://doi.org/10.1177/0192623309352496openalex-snapshot
A Strategy for Risk Management of Drug-Induced Phospholipidosis
inferredcites →https://doi.org/10.1177/019262339702500111openalex-snapshot
Cationic Amphiphilic Drug-Induced Phospholipidosis
inferredcites →https://doi.org/10.1177/153537020122600903openalex-snapshot
Drug-Induced Phospholipidosis: Are There Functional Consequences?
inferredcites →https://doi.org/10.1289/ehp.845553openalex-snapshot
Pulmonary and Generalized Lysosomal Storage Induced by Amphiphilic Drugs
inferredcites →https://doi.org/10.1293/tox.21.9openalex-snapshot
Drug-induced Phospholipidosis -Pathological Aspects and Its Prediction
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Drug-induced phospholipidosis: issues and future directions
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PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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