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Pathway Analysis for Drug Repositioning Based on Public Database Mining
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Effect of Onconase ± Tamoxifen on ASPC-1 Human Pancreatic Tumors in Nude Mice
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Coxibs: Pharmacology, Toxicity and Efficacy in Cancer Clinical Trials
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COX-2 Active Agents in the Chemoprevention of Colorectal Cancer
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Celecoxib Enhances Radiation Response of Secondary Bone Tumors of a Human Non-Small Cell Lung Cancer via Antiangiogenesis In Vivo
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Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer
inferredcites →https://doi.org/10.1007/s004320000225openalex-snapshot
Cyclooxygenase-2: a novel target for cancer chemotherapy?
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Systematic review and meta-analysis of COX-2 expression and polymorphisms in prostate cancer
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Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches
inferredcites →https://doi.org/10.1007/s11095-013-0984-9openalex-snapshot
Efficacy of Aerosolized Celecoxib Encapsulated Nanostructured Lipid Carrier in Non-small Cell Lung Cancer in Combination with Docetaxel
inferredcites →https://doi.org/10.1007/s12094-006-0005-0openalex-snapshot
Protein kinases and phosphatases as therapeutic targets in cancer
inferredcites →https://doi.org/10.1016/j.bcp.2005.01.001openalex-snapshot
Anticancer metal compounds in NCI's tumor-screening database: putative mode of action
inferredcites →https://doi.org/10.1016/j.bcp.2013.01.023openalex-snapshot
Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells
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Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors
inferredcites →https://doi.org/10.1016/j.canlet.2011.01.012openalex-snapshot
Targeting apoptosis pathways by Celecoxib in cancer
inferredcites →https://doi.org/10.1016/j.ccr.2013.02.014openalex-snapshot
The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia
inferredcites →https://doi.org/10.1016/j.cllc.2011.03.007openalex-snapshot
Phase I/II Trial of a COX-2 Inhibitor With Limited Field Radiation for Intermediate Prognosis Patients Who Have Locally Advanced Non–Small-Cell Lung Cancer: Radiation Therapy Oncology Group 0213
inferredcites →https://doi.org/10.1016/j.contraception.2006.03.018openalex-snapshot
Review of medical abortion using mifepristone in combination with a prostaglandin analogue
inferredcites →https://doi.org/10.1016/j.drudis.2007.01.011openalex-snapshot
Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches
inferredcites →https://doi.org/10.1016/j.drudis.2010.10.003openalex-snapshot
PubChem as a public resource for drug discovery
inferredcites →https://doi.org/10.1016/j.drudis.2011.02.016openalex-snapshot
In silico repositioning of approved drugs for rare and neglected diseases
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Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: A double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group
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Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA)
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Screening Agents for Preventive Efficacy in a Bladder Cancer Model: Study Design, End Points, and Gefitinib and Naproxen Efficacy
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Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
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Celecoxib synergizes human pancreatic ductal adenocarcinoma cells to sorafenib-induced growth inhibition
inferredcites →https://doi.org/10.1016/j.ygeno.2005.11.011openalex-snapshot
Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen
inferredcites →https://doi.org/10.1016/s0010-7824(03)00077-5openalex-snapshot
The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action
inferredcites →https://doi.org/10.1016/s0026-895x(25)10149-1openalex-snapshot
Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.
inferredcites →https://doi.org/10.1021/ci200192vopenalex-snapshot
Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining
inferredcites →https://doi.org/10.1021/ci9001876openalex-snapshot
PubChem as a Source of Polypharmacology
inferredcites →https://doi.org/10.1021/mp300547hopenalex-snapshot
Identification of Novel Breast Cancer Resistance Protein (BCRP) Inhibitors by Virtual Screening
inferredcites →https://doi.org/10.1038/35106036openalex-snapshot
The promise of retinoids to fight against cancer
inferredcites →https://doi.org/10.1038/75556openalex-snapshot
Gene Ontology: tool for the unification of biology
inferredcites →https://doi.org/10.1038/npre.2008.2243.1openalex-snapshot
PID: The Pathway Interaction Database
inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
inferredcites →https://doi.org/10.1038/nrc1074openalex-snapshot
5-Fluorouracil: mechanisms of action and clinical strategies
inferredcites →https://doi.org/10.1038/sj.bjp.0706399openalex-snapshot
Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer
inferredcites →https://doi.org/10.1038/sj.leu.2404528openalex-snapshot
Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma
inferredcites →https://doi.org/10.1038/sj.tpj.6500331openalex-snapshot
Linking pathway gene expressions to the growth inhibition response from the National Cancer Institute's anticancer screen and drug mechanism of action
inferredcites →https://doi.org/10.1056/nejmoa050405openalex-snapshot
Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
inferredcites →https://doi.org/10.1073/pnas.0405220101openalex-snapshot
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
inferredcites →https://doi.org/10.1073/pnas.82.16.5328openalex-snapshot
Actinomycin and DNA transcription.
inferredcites →https://doi.org/10.1074/jbc.m112.410381openalex-snapshot
Retinoic Acid Induces Neurogenesis by Activating Both Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ)
inferredcites →https://doi.org/10.1080/07357900802232756openalex-snapshot
Phase II Study of Celecoxib with Cisplatin Plus Etoposide in Extensive-Stage Small Cell Lung Cancer
inferredcites →https://doi.org/10.1093/bib/bbr013openalex-snapshot
Exploiting drug-disease relationships for computational drug repositioning
inferredcites →https://doi.org/10.1093/bioinformatics/btp042openalex-snapshot
DSSTox chemical-index files for exposure-related experiments in ArrayExpress and Gene Expression Omnibus: enabling toxico-chemogenomics data linkages
inferredcites →https://doi.org/10.1093/bioinformatics/btq550openalex-snapshot
Investigating the correlations among the chemical structures, bioactivity profiles and molecular targets of small molecules
inferredcites →https://doi.org/10.1093/nar/30.1.207openalex-snapshot
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
inferredcites →https://doi.org/10.1093/nar/gkh073openalex-snapshot
Database resources of the National Center for Biotechnology Information: update
inferredcites →https://doi.org/10.1093/nar/gkj067openalex-snapshot
DrugBank: a comprehensive resource for in silico drug discovery and exploration
inferredcites →https://doi.org/10.1093/nar/gkl971openalex-snapshot
The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data
inferredcites →https://doi.org/10.1093/nar/gkm882openalex-snapshot
KEGG for linking genomes to life and the environment
inferredcites →https://doi.org/10.1093/nar/gkm958openalex-snapshot
DrugBank: a knowledgebase for drugs, drug actions and drug targets
inferredcites →https://doi.org/10.1093/nar/gkn751openalex-snapshot
EcoCyc: A comprehensive view of Escherichia coli biology
inferredcites →https://doi.org/10.1093/nar/gkn863openalex-snapshot
Reactome knowledgebase of human biological pathways and processes
inferredcites →https://doi.org/10.1093/nar/gkq1237openalex-snapshot
Entrez Gene: gene-centered information at NCBI
inferredcites →https://doi.org/10.1093/nar/gkr1162openalex-snapshot
MMDB: 3D structures and macromolecular interactions
inferredcites →https://doi.org/10.1093/nar/gks1193openalex-snapshot
NCBI GEO: archive for functional genomics data sets—update
inferredcites →https://doi.org/10.1093/neuonc/not053openalex-snapshot
Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma
inferredcites →https://doi.org/10.1093/oxfordjournals.bmb.a011632openalex-snapshot
Apoptosis and the immune system
inferredcites →https://doi.org/10.1093/rheumatology/kel195openalex-snapshot
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials
inferredcites →https://doi.org/10.1093/toxsci/kfp061openalex-snapshot
Toward a Public Toxicogenomics Capability for Supporting Predictive Toxicology: Survey of Current Resources and Chemical Indexing of Experiments in GEO and ArrayExpress
inferredcites →https://doi.org/10.1097/cad.0b013e3283330590openalex-snapshot
Epidermal growth factor receptor inhibitors in cancer treatment: advances, challenges and opportunities
inferredcites →https://doi.org/10.1111/j.1473-2165.2005.40215.xopenalex-snapshot
Topical retinoids in the treatment of photoaging
inferredcites →https://doi.org/10.1111/j.1527-3458.2008.00043.xopenalex-snapshot
The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties
inferredcites →https://doi.org/10.1111/j.1600-079x.2010.00791.xopenalex-snapshot
Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer
inferredcites →https://doi.org/10.1124/dmd.110.035808openalex-snapshot
Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening
inferredcites →https://doi.org/10.1126/science.1101637openalex-snapshot
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways
inferredcites →https://doi.org/10.1126/science.1132939openalex-snapshot
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
inferredcites →https://doi.org/10.1126/scitranslmed.3001318openalex-snapshot
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
inferredcites →https://doi.org/10.1126/scitranslmed.3002648openalex-snapshot
Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2165openalex-snapshot
Molecular Determinants of Retinoic Acid Sensitivity in Pancreatic Cancer
inferredcites →https://doi.org/10.1158/1940-6207.capr-10-0038openalex-snapshot
The Epidermal Growth Factor Receptor Inhibitor Gefitinib Prevents the Progression of Pancreatic Lesions to Carcinoma in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model
inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0183openalex-snapshot
A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
inferredcites →https://doi.org/10.1159/000053235openalex-snapshot
Influence of Octreotide and Tamoxifen on Tumor Growth and Liver Metastasis in N-Nitrosobis(2-oxopropyl)amine-Induced Pancreatic Cancer in Syrian Hamsters
inferredcites →https://doi.org/10.1159/000288708openalex-snapshot
Effects of Capecitabine and Celecoxib in Experimental Pancreatic Cancer
inferredcites →https://doi.org/10.1179/acb.66.1.2062508openalex-snapshot
EPIDERMAL GROWTH FACTOR RECEPTOR TARGETED THERAPIES FOR SOLID TUMOURS
inferredcites →https://doi.org/10.1182/blood.v72.2.567.567openalex-snapshot
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
inferredcites →https://doi.org/10.1182/blood.v76.9.1704.1704openalex-snapshot
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]
inferredcites →https://doi.org/10.1186/1476-4598-8-7openalex-snapshot
Chmp 1A is a mediator of the anti-proliferative effects of All-trans Retinoic Acid in human pancreatic cancer cells
inferredcites →https://doi.org/10.1186/1477-7819-11-16openalex-snapshot
Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer
inferredcites →https://doi.org/10.1186/bcr3409openalex-snapshot
A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer
inferredcites →https://doi.org/10.1200/jco.2005.08.326openalex-snapshot
Phase II and Tumor Pharmacodynamic Study of Gefitinib in Patients with Advanced Breast Cancer
inferredcites →https://doi.org/10.1269/jrr.07014openalex-snapshot
Combination Treatment with Ionising Radiation and Gefitinib (`Iressa', ZD1839), an Epidermal Growth Factor Receptor (EGFR) Inhibitor, Significantly Inhibits Bladder Cancer Cell Growth in vitro and in vivo
inferredcites →https://doi.org/10.1371/journal.pbio.0060184openalex-snapshot
WikiPathways: Pathway Editing for the People
inferredcites →https://doi.org/10.1371/journal.pone.0004346openalex-snapshot
A Pathway-Based View of Human Diseases and Disease Relationships
inferredcites →https://doi.org/10.1371/journal.pone.0006447openalex-snapshot
Mining Biological Pathways Using WikiPathways Web Services
inferredcites →https://doi.org/10.1371/journal.pone.0012741openalex-snapshot
Active Site Conformational Dynamics in Human Uridine Phosphorylase 1
inferredcites →https://doi.org/10.1371/journal.pone.0033174openalex-snapshot
Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0043376openalex-snapshot
Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice
inferredcites →https://doi.org/10.1371/journal.pone.0044631openalex-snapshot
Integrating Constitutive Gene Expression and Chemoactivity: Mining the NCI60 Anticancer Screen
inferredcites →https://doi.org/10.1371/journal.pone.0053263openalex-snapshot
Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib
inferredcites →https://doi.org/10.1517/13543784.2013.766715openalex-snapshot
Concurrent celecoxib with 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel for stages II – III invasive breast cancer: the OOTR-N001 study
inferredcites →https://doi.org/10.1586/14737140.4.6.1113openalex-snapshot
Targeting protein kinases in cancer therapy: a success?
inferredcites →https://doi.org/10.2174/0929867003375335openalex-snapshot
Propofol in Anesthesia. Mechanism of Action, Structure-Activity Relationships, and Drug Delivery
inferredcites →https://doi.org/10.2174/1381612811306010115openalex-snapshot
Chemoprevention of Cancers in Gastrointestinal Tract with Cyclooxygenase 2 Inhibitors
inferredcites →https://doi.org/10.2217/fon.12.196openalex-snapshot
Safety and Therapeutic Effect of Metronomic Chemotherapy with Cyclophosphamide and Celecoxib in Advanced Breast Cancer Patients
inferredcites →https://doi.org/10.2337/diabetes.51.3.797openalex-snapshot
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.2741/s128openalex-snapshot
Targeting EGFR in bilio-pancreatic and liver carcinoma
inferredcites →https://doi.org/10.3349/ymj.2004.45.3.435openalex-snapshot
Retinoic Acid Receptor-β Expression in Stage I Non-Small Cell Lung Cancer and Adjacent Normal Appearing Bronchial Epithelium
inferredcites →https://doi.org/10.3389/fonc.2011.00052openalex-snapshot
Phase I study of celecoxib with concurrent irinotecan, cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer
inferredcites →https://doi.org/10.3892/ijo.25.1.203openalex-snapshot
Gefitinib (‘Iressa’, ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation
inferredcites →https://doi.org/10.3892/or.2011.1200openalex-snapshot
Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers
inferredcites →https://doi.org/10.7314/apjcp.2013.14.4.2343openalex-snapshot
Effects of Celecoxib on Cycle Kinetics of Gastric Cancer Cells and Protein Expression of Cytochrome C and Caspase-9
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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In Silico Modeling of FDA-Approved Drugs for Discovery of Anti-Cancer Agents: A Drug-Repurposing Approach
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AI-driven gene-sets, networks, pathways, and interactions analyses of multi-omics data
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ExPDrug: Integration of an interpretable neural network and knowledge graph for pathway-based drug repurposing
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Turning genome-wide association study findings into opportunities for drug repositioning
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Design of efficient computational workflows for in silico drug repurposing
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Computational drug repurposing to predict approved and novel drug-disease associations
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Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases
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Pathway-Based Drug Repositioning for Cancers: Computational Prediction and Experimental Validation
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Improving computational drug repositioning through multi-source disease similarity networks
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How good are publicly available web services that predict bioactivity profiles for drug repurposing?
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Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases
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Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning
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DDR: efficient computational method to predict drug–target interactions using graph mining and machine learning approaches
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Enhanced drug-disease association prediction through representation learning on similarity networks
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DrPOCS: Drug Repositioning Based on Projection Onto Convex Sets
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In Vitro Screening for Drug Repositioning
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Systems Biology Approaches to a Rational Drug Discovery Paradigm
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Software Architectures and Efficient Data Sharing for Promoting Continuous Drug Re-purposing
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Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning
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An Innovative Drug Repurposing Approach to Restrain Endometrial Cancer Metastatization
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Rewired Pathways and Disrupted Pathway Crosstalk in Schizophrenia Transcriptomes by Multiple Differential Coexpression Methods
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Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target
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Extending In Silico Mechanism-of-Action Analysis by Annotating Targets with Pathways: Application to Cellular Cytotoxicity Readouts
inferred← citeshttps://doi.org/10.4314/jcas.v16i1.1openalex-snapshot
Drug repurposing: cost effectiveness and impact on emerging and neglected diseases
inferred← citeshttps://doi.org/10.5772/intechopen.100858openalex-snapshot
Trends in Molecular Aspects and Therapeutic Applications of Drug Repurposing for Infectious Diseases
inferred← citeshttps://doi.org/10.6084/m9.figshare.12986610openalex-snapshot
Additional file 1 of Expression correlation attenuates within and between key signaling pathways in chronic kidney disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.12986613openalex-snapshot
Additional file 2 of Expression correlation attenuates within and between key signaling pathways in chronic kidney disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.7998443openalex-snapshot
Modelling Drosophila melanogaster signalling pathways using Hipathia: a new insigth on fruit fly's cell expression
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