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De Novo Design of Multitarget Ligands with an Iterative Fragment-Growing Strategy

https://doi.org/10.1021/ci500021v
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Recent progress in fragment-based lead discovery
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Multi-target therapeutics: when the whole is greater than the sum of the parts
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Fragments, network biology and designing multiple ligands
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From fragment to clinical candidate—a historical perspective
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From magic bullets to designed multiple ligands
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A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
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Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery
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LigBuilder 2: A Practical de Novo Drug Design Approach
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Simple Size-Independent Measure of Ligand Efficiency
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Designed Multiple Ligands. An Emerging Drug Discovery Paradigm
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Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase
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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
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Recent Developments in Fragment-Based Drug Discovery
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Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase
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Finding multiple target optimal intervention in disease‐related molecular network
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Why is cancer drug discovery so difficult?
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A decade of fragment-based drug design: strategic advances and lessons learned
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Designing Multi-Target Drugs
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Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms
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Evaluation of classical NSAIDs and COX-2 selective inhibitors on purified ovine enzymes and human whole blood
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Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis
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The Protein Data Bank
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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
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Rule of Three
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Fragment screening by biochemical assay
inferredcites →https://doi.org/10.1517/17460441.2.6.799openalex-snapshot
How to design multi-target drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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