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Understanding False Positives in Reporter Gene Assays: in Silico Chemogenomics Approaches To Prioritize Cell-Based HTS Data
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Chemiluminescent and Bioluminescent Reporter Gene Assays
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Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
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Sesquiterpene lactones inhibit luciferase but not β-galactosidase activity in vitro and ex vivo
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Streamlining lead discovery by aligning in silico and high-throughput screening
inferredcites →https://doi.org/10.1016/j.drudis.2006.02.001openalex-snapshot
Critical review of the role of HTS in drug discovery
inferredcites →https://doi.org/10.1016/j.taap.2005.01.056openalex-snapshot
Research perspectives for pre-screening alternatives to animal experimentationOn the relevance of cytotoxicity measurements, barrier passage determinations and high throughput screening in vitro to select potentially hazardous compounds in large sets of chemicals
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Novel protein serine/threonine phosphatases: Variety is the spice of life
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Molecular mechanisms of blood vessel formation
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Nonleadlikeness and leadlikeness in biochemical screening
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Enrichment of High-Throughput Screening Data with Increasing Levels of Noise Using Support Vector Machines, Recursive Partitioning, and Laplacian-Modified Naive Bayesian Classifiers
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An Empirical Process for the Design of High-Throughput Screening Deck Filters
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Prediction of Biological Targets for Compounds Using Multiple-Category Bayesian Models Trained on Chemogenomics Databases
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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
inferredcites →https://doi.org/10.1021/jm010533yopenalex-snapshot
A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening
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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries
inferredcites →https://doi.org/10.1021/jm030191ropenalex-snapshot
Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs
inferredcites →https://doi.org/10.1021/jm049902ropenalex-snapshot
Deriving Knowledge through Data Mining High-Throughput Screening Data
inferredcites →https://doi.org/10.1021/jm060902wopenalex-snapshot
Bridging Chemical and Biological Space: “Target Fishing” Using 2D and 3D Molecular Descriptors
inferredcites →https://doi.org/10.1021/jm9602928openalex-snapshot
The Properties of Known Drugs. 1. Molecular Frameworks
inferredcites →https://doi.org/10.1038/nrd773openalex-snapshot
Protein kinases — the major drug targets of the twenty-first century?
inferredcites →https://doi.org/10.1039/b409865jopenalex-snapshot
Comparison of topological descriptors for similarity-based virtual screening using multiple bioactive reference structures
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Proteasome Inhibitors Reduce Luciferase and β-Galactosidase Activity in Tissue Culture Cells
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Transcriptional Modulation of Viral Reporter Gene Constructs Following Induction of the Cellular Stress Response
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p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
inferredcites →https://doi.org/10.1101/gad.9.10.1149openalex-snapshot
Inhibitors of mammalian G1 cyclin-dependent kinases.
inferredcites →https://doi.org/10.1177/1087057103008003007openalex-snapshot
Studies on Repository Compound Stability in DMSO under Various Conditions
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Molecular Diversity Management Strategies for Building and Enhancement of Diverse and Focused Lead Discovery Compound Screening Collections
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Analysing the Output from Primary Screening
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Etoposide, Topoisomerase II and Cancer
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Understanding False Positives in Reporter Gene Assays: In silico Chemogenomics Approaches to Prioritize Cell‐Based HTS Data.
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How Similar Are Similarity Searching Methods? A Principal Component Analysis of Molecular Descriptor Space
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