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Virtual Screening and Prediction of Site of Metabolism for Cytochrome P450 1A2 Ligands
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers
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Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation
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Role of cytochrome P450 IA2 in acetanilide 4-hydroxylation as determined with cDNA expression and monoclonal antibodies
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Cytochromes P450 and drug discovery
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Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2
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Application of the Relative Activity Factor Approach in Scaling from Heterologously Expressed Cytochromes P450 to Human Liver Microsomes: Studies on Amitriptyline as a Model Substrate
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Reappraisal of Human CYP Isoforms Involved in Imipramine N-Demethylation and 2-Hydroxylation: A Study Using Microsomes Obtained from Putative Extensive and Poor Metabolizers of S-Mephenytoin and Eleven Recombinant Human CYPs
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Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.
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Metabolism and bioactivation of clozapine by human liver in vitro.
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Multiple Cytochrome P-450s Involved in the Metabolism of Terbinafine Suggest a Limited Potential for Drug-Drug Interactions
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ETHOXYRESORUFIN: DIRECT FLUORIMETRIC ASSAY OF A MICROSOMAL O-DEALKYLATION WHICH IS PREFERENTIALLY INDUCIBLE BY 3-METHYLCHOLANTHRENE
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Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe.
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Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193.
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Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2.
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Human P450 metabolism of warfarin
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Properties of cytochrome P450 isoenzymes and their substrates part 2: properties of cytochrome P450 substrates
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Rate-Determining Steps in Phenacetin Oxidations by Human Cytochrome P450 1A2 and Selected Mutants
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Catalytic Site Prediction and Virtual Screening of Cytochrome P450 2D6 Substrates by Consideration of Water and Rescoring in Automated Docking
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Use of Simple Docking Methods To Screen a Virtual Library for Heteroactivators of Cytochrome P450 2C9
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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
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Cytochrome P450 and Chemical Toxicology
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Roles of Cytochromes P450 1A2 and 3A4 in the Oxidation of Estradiol and Estrone in Human Liver Microsomes
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Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4
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ADMET in silico modelling: towards prediction paradise?
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Involvement of CYP1A2 in mexiletine metabolism
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Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2
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Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine
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Summary of information on human CYP enzymes: human P450 metabolism data
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Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
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Oxidative Metabolism of Flunarizine and Cinnarizine by Microsomes from B-Lymphoblastoid Cell Lines Expressing Human Cytochrome P450 Enzymes.
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What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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