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Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jnr.21503openalex-snapshotResveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation
inferredcites →https://doi.org/10.1002/jnr.23199openalex-snapshotSIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
inferredcites →https://doi.org/10.1002/mnfr.200700290openalex-snapshotQuantification of free and protein‐bound trans‐resveratrol metabolites and identification of trans‐resveratrol‐C/O‐conjugated diglucuronides – Two novel resveratrol metabolites in human plasma
inferredcites →https://doi.org/10.1007/s00726-013-1518-9openalex-snapshotInvolvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells
inferredcites →https://doi.org/10.1007/s10571-009-9411-5openalex-snapshotProtective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons
inferredcites →https://doi.org/10.1007/s11064-011-0561-8openalex-snapshotResveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats
inferredcites →https://doi.org/10.1016/j.biochi.2011.11.001openalex-snapshotAntioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and NO bioavailability: Potential benefits to cardiovascular diseases
inferredcites →https://doi.org/10.1016/j.jnutbio.2008.05.003openalex-snapshotRETRACTED: Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose
inferredcites →https://doi.org/10.1016/j.jvs.2008.04.007openalex-snapshotResveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors
inferredcites →https://doi.org/10.1016/j.nbd.2006.06.002openalex-snapshotProtective effect of resveratrol against oxygen–glucose deprivation in organotypic hippocampal slice cultures: Involvement of PI3-K pathway
inferredcites →https://doi.org/10.1016/j.nbd.2012.08.018openalex-snapshotTargeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window
inferredcites →https://doi.org/10.1016/j.niox.2003.09.005openalex-snapshotOxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: effect on nitrosative and oxidative stress derived from microglial cells
inferredcites →https://doi.org/10.1021/cn300143mopenalex-snapshottrans -Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes
inferredcites →https://doi.org/10.1021/jf011429sopenalex-snapshotPhytoalexins from the Vitaceae: Biosynthesis, Phytoalexin Gene Expression in Transgenic Plants, Antifungal Activity, and Metabolism
inferredcites →https://doi.org/10.1021/jf3001108openalex-snapshotDistribution of Resveratrol Metabolites in Liver, Adipose Tissue, and Skeletal Muscle in Rats Fed Different Doses of This Polyphenol
inferredcites →https://doi.org/10.1021/jf9900884openalex-snapshotDetermination of Stilbenes (trans-Astringin,cis- andtrans-Piceid, andcis- andtrans-Resveratrol) in Portuguese Wines
inferredcites →https://doi.org/10.1038/sj.bjp.0703626openalex-snapshotNeuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons
inferredcites →https://doi.org/10.1039/a807226dopenalex-snapshotSimultaneous determination of cis- and trans-resveratrol in wines by capillary zone electrophoresis
inferredcites →https://doi.org/10.1046/j.1471-4159.2001.00107.xopenalex-snapshotEffect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1073/pnas.91.21.9926openalex-snapshotIsolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.
inferredcites →https://doi.org/10.1074/jbc.m305204200openalex-snapshotNF-E2-related Factor-2 Mediates Neuroprotection against Mitochondrial Complex I Inhibitors and Increased Concentrations of Intracellular Calcium in Primary Cortical Neurons
inferredcites →https://doi.org/10.1089/neu.2010.1291openalex-snapshotResveratrol Attenuates Behavioral Impairments and Reduces Cortical and Hippocampal Loss in a Rat Controlled Cortical Impact Model of Traumatic Brain Injury
inferredcites →https://doi.org/10.1111/j.1600-079x.2010.00820.xopenalex-snapshotMelatonin synergistically increases resveratrol‐induced heme oxygenase‐1 expression through the inhibition of ubiquitin‐dependent proteasome pathway: a possible role in neuroprotection
inferredcites →https://doi.org/10.1113/jphysiol.2013.257964openalex-snapshotTemporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique
inferredcites →https://doi.org/10.1124/jpet.112.194142openalex-snapshotResveratrol Inhibits Paraquat-Induced Oxidative Stress and Fibrogenic Response by Activating the Nuclear Factor Erythroid 2-Related Factor 2 Pathway
inferredcites →https://doi.org/10.1124/mol.110.064535openalex-snapshotResveratrol Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity through Its Anti-Inflammatory Actions
inferredcites →https://doi.org/10.1128/mcb.22.9.2883-2892.2002openalex-snapshotEnhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter
inferredcites →https://doi.org/10.1158/0008-5472.can-10-2364openalex-snapshotRepeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
inferredcites →https://doi.org/10.1186/1742-2094-4-25openalex-snapshotResveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia
inferredcites →https://doi.org/10.1186/1756-9966-28-96openalex-snapshotResveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use
inferredcites →https://doi.org/10.1210/jc.2010-1812openalex-snapshotA Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal
inferredcites →https://doi.org/10.1254/jphs.fp0071206openalex-snapshotNeuroprotective Effect of Smilacis chinae Rhizome on NMDA-Induced Neurotoxicity In Vitro and Focal Cerebral Ischemia In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0064160openalex-snapshotVector-Free and Transgene-Free Human iPS Cells Differentiate into Functional Neurons and Enhance Functional Recovery after Ischemic Stroke in Mice
inferredcites →https://doi.org/10.1523/jneurosci.2818-05.2005openalex-snapshotApoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia
inferredcites →https://doi.org/10.3945/ajcn.2009.28641openalex-snapshotEffects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
inferredcites →https://doi.org/10.4077/cjp.2012.baa012openalex-snapshotEffect of Resveratrol on Oxidative and Inflammatory Stress in Liver and Spleen of Streptozotocin-Induced Type 1 Diabetic Rats
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/1873-3468.14835openalex-snapshotResveratrol and its metabolites elicit neuroprotection via high‐affinity binding to the laminin receptor at low nanomolar concentrations
inferred← citeshttps://doi.org/10.1002/jhet.3230openalex-snapshotIsolation, Structural Characterization, and Validation of a New Compound Present in Non‐Carbonyl Curcuma longa (NCCL): A Potential Lead for Stroke
inferred← citeshttps://doi.org/10.1002/jssc.201700054openalex-snapshotExtraction and separation of lactate dehydrogenase inhibitors from Poria cocos (Schw.) Wolf based on a hyphenated technique and in vitro methods
inferred← citeshttps://doi.org/10.1002/mnfr.201600111openalex-snapshotResveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3
inferred← citeshttps://doi.org/10.1007/s00210-023-02616-0openalex-snapshotPiceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection
inferred← citeshttps://doi.org/10.1007/s10787-016-0271-6openalex-snapshotNeurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms
inferred← citeshttps://doi.org/10.1007/s11418-018-1173-2openalex-snapshotOxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis
inferred← citeshttps://doi.org/10.1007/s11684-021-0832-yopenalex-snapshotResveratrol promotes the survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral ischemia
inferred← citeshttps://doi.org/10.1007/s12035-017-0539-xopenalex-snapshotPKA-GSK3β and β-Catenin Signaling Play a Critical Role in Trans-Resveratrol Mediated Neuronal Differentiation in Human Cord Blood Stem Cells
inferred← citeshttps://doi.org/10.1007/s12035-018-0986-zopenalex-snapshotResveratrol Prevents the Cellular Damages Induced by Monocrotophos via PI3K Signaling Pathway in Human Cord Blood Mesenchymal Stem Cells
inferred← citeshttps://doi.org/10.1007/s12035-026-05999-2openalex-snapshotThe Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Crosstalk Between Oxidative Stress and M1/M2 Microglial Polarization Following Ischemic Stroke
inferred← citeshttps://doi.org/10.1016/j.bbr.2016.02.030openalex-snapshotProtective effect of resveratrol against chronic intermittent hypoxia-induced spatial memory deficits, hippocampal oxidative DNA damage and increased p47Phox NADPH oxidase expression in young rats
inferred← citeshttps://doi.org/10.1016/j.brainres.2016.08.032openalex-snapshotResveratrol limits diabetes-associated cognitive decline in rats by preventing oxidative stress and inflammation and modulating hippocampal structural synaptic plasticity
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105779openalex-snapshotSIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury
inferred← citeshttps://doi.org/10.1016/j.jsps.2024.102097openalex-snapshotThe ethanol extract of cocoa pod husk minimizes hyperalgesia and blood glucose levels in diabetic neuropathy model through transient receptor protein vanilloid (TRPV)-1
inferred← citeshttps://doi.org/10.1016/j.pbb.2016.04.007openalex-snapshotResveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats
inferred← citeshttps://doi.org/10.1021/acs.jafc.6b04538openalex-snapshotNeuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
inferred← citeshttps://doi.org/10.1021/acs.jafc.9b07147openalex-snapshotNeuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells
inferred← citeshttps://doi.org/10.1021/acsptsci.3c00271openalex-snapshotModulation of Abundance and Location of High-Mobility Group Box 1 in Human Microglia and Macrophages under Oxygen–Glucose Deprivation
inferred← citeshttps://doi.org/10.1039/c3fo60397kopenalex-snapshotResveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons
inferred← citeshttps://doi.org/10.1039/c5fo01124hopenalex-snapshotEffects of piceatannol and pterostilbene against β-amyloid-induced apoptosis on the PI3K/Akt/Bad signaling pathway in PC12 cells
inferred← citeshttps://doi.org/10.1080/02726351.2014.981904openalex-snapshotPolyphenols and Bionanoparticle Combinations as Neuroprotective and Anticarcinogenic Agents: A Potential Neuropharmacological Solution to Combat Cerebral Stroke and Cancer
inferred← citeshttps://doi.org/10.1080/1028415x.2015.1125654openalex-snapshotModulation of oxidative stress, inflammation, autophagy and expression of Nrf2 in hippocampus and frontal cortex of rats fed with açaí-enriched diets
inferred← citeshttps://doi.org/10.1093/jimb/kuag017openalex-snapshotMetabolic engineering of Escherichia coli for resveratrol production using food-grade D-xylose as a carbon source
inferred← citeshttps://doi.org/10.1093/nutrit/nuy010openalex-snapshotEffect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.1111/cns.70384openalex-snapshotChronic Intermittent Hypoxia‐Induced Neural Injury: Pathophysiology, Neurodegenerative Implications, and Therapeutic Insights
inferred← citeshttps://doi.org/10.1111/jcmm.70008openalex-snapshot3,3′,4,5′‐Tetramethoxy‐trans‐stilbene and 3,4′,5‐trimethoxy‐trans‐stilbene prevent oxygen–glucose deprivation‐induced injury in brain endothelial cell
inferred← citeshttps://doi.org/10.1134/s1068162021010210openalex-snapshotHeterocyclic Resveratrol Analogs. Synthesis and Physiological Activity: Part 1–Analogs Obtained by the Replacement of Aryl Residues with Heterocyclic Fragments
inferred← citeshttps://doi.org/10.1155/2019/8798069openalex-snapshotCalycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α Pathway in HT22 Cells
inferred← citeshttps://doi.org/10.1155/2021/8402157openalex-snapshotDevelopment and Validation of a Stability-Indicating HPLC Method for the Simultaneous Determination of trans-Resveratrol and cis-Resveratrol in an Injectable Solution
inferred← citeshttps://doi.org/10.1159/000374009openalex-snapshotSonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro
inferred← citeshttps://doi.org/10.1159/000481611openalex-snapshotResveratrol Enhances Neurite Outgrowth and Synaptogenesis Via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury
inferred← citeshttps://doi.org/10.1159/000494593openalex-snapshotResveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1
inferred← citeshttps://doi.org/10.1159/000514136openalex-snapshotImpact of Mediterranean Diet prior to Stroke on the Prognosis of Patients Undergoing Endovascular Treatment
inferred← citeshttps://doi.org/10.1177/0271678x221079902openalex-snapshotSIRT1 mediates hypoxic postconditioning- and resveratrol-induced protection against functional connectivity deficits after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.1515/hsz-2018-0269openalex-snapshotResveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK/SIRT1/autophagy signaling pathway
inferred← citeshttps://doi.org/10.3164/jcbn.21-23openalex-snapshotProtective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes
inferred← citeshttps://doi.org/10.3390/antiox15091112openalex-snapshotTrans-Vitisin B Targets Neuroinflammation, Oxidative Stress, and Tau Pathology to Improve Behavioral Outcomes in a Mouse Model of Parkinson’s Disease
inferred← citeshttps://doi.org/10.3390/biom14020154openalex-snapshotCurcumin and Resveratrol: Nutraceuticals with so Much Potential for Pseudoachondroplasia and Other ER-Stress Conditions
inferred← citeshttps://doi.org/10.3390/cells9112351openalex-snapshotPotential Drug Candidates to Treat TRPC6 Channel Deficiencies in the Pathophysiology of Alzheimer’s Disease and Brain Ischemia
inferred← citeshttps://doi.org/10.3390/ijms19020426openalex-snapshotPreventive Effects of Resveratrol on Endocannabinoid System and Synaptic Protein Modifications in Rat Cerebral Cortex Challenged by Bilateral Common Carotid Artery Occlusion and Reperfusion
inferred← citeshttps://doi.org/10.3390/ijms22020833openalex-snapshotA Review of Plant Extracts and Plant-Derived Natural Compounds in the Prevention/Treatment of Neonatal Hypoxic-Ischemic Brain Injury
inferred← citeshttps://doi.org/10.3390/ijms22084210openalex-snapshotPreventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins
inferred← citeshttps://doi.org/10.3390/ijms231911678openalex-snapshotResveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture
inferred← citeshttps://doi.org/10.3390/ijms26125779openalex-snapshotResveratrol Mitigates Inflammation by Modulating Tumor Necrosis Factor-Alpha Receptors (TNFRs) in a 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Rat Model of Colitis
inferred← citeshttps://doi.org/10.3390/ijms27010295openalex-snapshotBiologically Informed Machine Learning Prioritizes Dietary Supplements That Protect Neural Crest Cells from Ethanol-Induced Epigenetic Dysregulation and Developmental Impairment
inferred← citeshttps://doi.org/10.3390/jdad3020027openalex-snapshotLow Brain Levels of Dietary Polyphenols and Their Conjugates: Reassessing Mechanisms of Alzheimer’s Disease Prevention
inferred← citeshttps://doi.org/10.3390/jpm13020268openalex-snapshotResveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia
inferred← citeshttps://doi.org/10.3390/molecules19067850openalex-snapshotInhibition of Cancer Derived Cell Lines Proliferation by Synthesized Hydroxylated Stilbenes and New Ferrocenyl-Stilbene Analogs. Comparison with Resveratrol
inferred← citeshttps://doi.org/10.3390/nano14020199openalex-snapshotNeuroprotective Effect of Solid Lipid Nanoparticles Loaded with Lepidium sativum (L.) Seed Bioactive Components Enhance Bioavailability and Wnt/β-Catenin/Camk-II Signaling Cascade in SH-SY5Y Neuroblastoma Cells
inferred← citeshttps://doi.org/10.3390/nu11051000openalex-snapshotResveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion
inferred← citeshttps://doi.org/10.3390/nu8060367openalex-snapshotPiceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity
inferred← citeshttps://doi.org/10.34133/bmr.0108openalex-snapshotRes@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency
inferred← citeshttps://doi.org/10.34172/ps.2021.61openalex-snapshotResveratrol prevents lipopolysaccharide-induced cognitive impairment in rats through regulation of hippocampal GluA1-containing AMPA receptors
inferred← citeshttps://doi.org/10.4172/neuropsychiatry.1000549openalex-snapshotRole of N-Acylethanolamines in the Neuroinflammation: Ultramicronized Palmitoylethanolamide in the Relief of Chronic Pain and Neurodegenerative DiseasesRole of N-Acylethanolamines in the Neuroinflammation: Ultramicronized Palmitoylethanolamide in the Relief of Chronic Pain and Neurodegenerative…
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