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Action Mechanisms of Donepezil in Cardiac and Vascular Aspects: A Review

https://doi.org/10.2139/ssrn.4645306
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Donepezil improves vascular function in a mouse model of Alzheimer’s disease
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Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats
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Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury
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Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes
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Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism
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Regulation of Body Temperature by the Nervous System
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Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction
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Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model
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Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina
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TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons
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Nicotine promotes arteriogenesis
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Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
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Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial
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Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
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Bronchospasm caused by neostigmine
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N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina
inferredcites →https://doi.org/10.1021/acs.chemrestox.9b00509openalex-extracted
Donepezil Prevents ox-LDL-Induced Attachment of THP-1 Monocytes to Human Aortic Endothelial Cells (HAECs)
inferredcites →https://doi.org/10.1021/cn400094wopenalex-extracted
Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
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Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
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New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease
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Spontaneously hypertensive rats cholinergic hyper‐responsiveness: central and peripheral pharmacological mechanisms
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Effect of oral administration of zanapezil (TAK‐147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats
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Cerebral blood flow alteration following acute myocardial infarction in mice
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Acetylcholinesterase inhibitors attenuate angiogenesis
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The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
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Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1
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Lysine Succinylation and Lysine Malonylation in Histones
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Lysine Propionylation and Butyrylation Are Novel Post-translational Modifications in Histones
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Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats
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Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats
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NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES
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Alzheimer’s disease in the 100 years since Alzheimer’s death
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Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury
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2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
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Donepezil down‐regulates propionylation, 2‐hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion‐induced vascular dementia rats
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Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha‐7 nicotinic acetylcholine receptor and downregulation of cardiac and vascular arginase
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Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease
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Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis
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Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice
inferredcites →https://doi.org/10.1159/000363042openalex-extracted
A Non-Neuronal Cholinergic System Regulates Cellular ATP Levels to Maintain Cell Viability
inferredcites →https://doi.org/10.1161/01.cir.0000014987.32865.8eopenalex-extracted
Direct Evidence for Tumor Necrosis Factor-α Signaling in Arteriogenesis
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Carvedilol Produces Dose-Related Improvements in Left Ventricular Function and Survival in Subjects With Chronic Heart Failure
inferredcites →https://doi.org/10.1161/01.cir.99.22.2958openalex-extracted
Ganglionic Mechanisms Contribute to Diminished Vagal Control in Heart Failure
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Tissue Factor
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Prolonged Tpeak-to-Tend Interval on the Resting ECG Is Associated With Increased Risk of Sudden Cardiac Death
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Getting to the Heart of Alzheimer Disease
inferredcites →https://doi.org/10.1161/circulationaha.104.525493openalex-extracted
Efferent Vagal Nerve Stimulation Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein
inferredcites →https://doi.org/10.1161/hypertensionaha.109.149187openalex-extracted
Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition
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A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors
inferredcites →https://doi.org/10.1177/1074248419838509openalex-extracted
Cardiac 11 C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation
inferredcites →https://doi.org/10.1186/s12974-017-1033-0openalex-extracted
Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
inferredcites →https://doi.org/10.1253/circj.cj-13-0476openalex-extracted
Donepezil Markedly Improves Long-Term Survival in Rats With Chronic Heart Failure After Extensive Myocardial Infarction
inferredcites →https://doi.org/10.1253/circj.cj-14-0095openalex-extracted
Donepezil Can Improve Ischemic Muscle Atrophy by Activating Angiomyogenic Properties of Satellite Cells
inferredcites →https://doi.org/10.1253/circj.cj-17-0644openalex-extracted
Effect of Smoking Status on Monocyte Tissue Factor Activity, Carotid Atherosclerosis and Long-Term Prognosis in Metabolic Syndrome
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Effect of QT Prolongation in Patients Taking Cholinesterase Inhibitors (Donepezil) for Alzheimer’s Disease
inferredcites →https://doi.org/10.1253/circrep.cr-21-0086openalex-extracted
Measurement of Early and Late Repolarization Periods in Addition to QT Interval to Help Predict the Torsadogenic Risk of Donepezil Based on Reverse Translational Animal Research on Its Proarrhythmic Potential ― Reply ―
inferredcites →https://doi.org/10.1254/jphs.09302fpopenalex-extracted
Histological Protection by Donepezil Against Neurodegeneration Induced by Ischemia–Reperfusion in the Rat Retina
inferredcites →https://doi.org/10.1254/jphs.fp0051023openalex-extracted
Acetylcholine Inhibits the Hypoxia-Induced Reduction of Connexin43 Protein in Rat Cardiomyocytes
inferredcites →https://doi.org/10.1371/journal.pone.0020629openalex-extracted
Donepezil, Anti-Alzheimer's Disease Drug, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice
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The Second-Generation Active A Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects
inferredcites →https://doi.org/10.2169/internalmedicine.51.6671openalex-extracted
Cardiac Safety of Donepezil in Elderly Patients with Alzheimer Disease
inferredcites →https://doi.org/10.2170/physiolsci.rp002305openalex-extracted
Nitric Oxide Stimulates Vascular Endothelial Growth Factor Production in Cardiomyocytes Involved in Angiogenesis
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Tumor Necrosis Factor-α in Liver Ischemia/Reperfusion Injury
inferredcites →https://doi.org/10.3390/brainsci3010123openalex-extracted
The Role of Substance P in Ischaemic Brain Injury
inferredcites →https://doi.org/10.3390/ijms18091988openalex-extracted
The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side
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MicroRNA-98 rescues proliferation and alleviates ox-LDL-induced apoptosis in HUVECs by targeting LOX-1
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Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion
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