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DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s002800050600openalex-snapshot
Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro
inferredcites →https://doi.org/10.1016/0921-8777(95)00019-gopenalex-snapshot
DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors
inferredcites →https://doi.org/10.1016/j.bcp.2003.10.034openalex-snapshot
Subcellular localization of the camptothecin analogues, topotecan and gimatecan
inferredcites →https://doi.org/10.1016/j.bcp.2007.10.016openalex-snapshot
Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
inferredcites →https://doi.org/10.1016/j.bmc.2004.07.027openalex-snapshot
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2006.05.073openalex-snapshot
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
inferredcites →https://doi.org/10.1016/j.bmcl.2004.05.022openalex-snapshot
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2005.03.101openalex-snapshot
Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines
inferredcites →https://doi.org/10.1016/j.bmcl.2006.01.008openalex-snapshot
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2006.05.048openalex-snapshot
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
inferredcites →https://doi.org/10.1016/j.dnarep.2006.07.004openalex-snapshot
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes
inferredcites →https://doi.org/10.1016/j.jmb.2008.06.028openalex-snapshot
Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I
inferredcites →https://doi.org/10.1016/j.mrfmmm.2007.06.009openalex-snapshot
DNA topoisomerase II, genotoxicity, and cancer
inferredcites →https://doi.org/10.1016/j.tips.2005.01.008openalex-snapshot
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery
inferredcites →https://doi.org/10.1016/s0021-9258(17)38654-4openalex-snapshot
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
inferredcites →https://doi.org/10.1016/s0021-9258(18)42488-xopenalex-snapshot
DNA strand transfer reactions catalyzed by vaccinia topoisomerase I.
inferredcites →https://doi.org/10.1016/s0021-9258(18)54939-5openalex-snapshot
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
inferredcites →https://doi.org/10.1016/s0026-895x(25)10121-1openalex-snapshot
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.
inferredcites →https://doi.org/10.1016/s0065-230x(01)80016-6openalex-snapshot
Topoisomerase I-mediated DNA damage
inferredcites →https://doi.org/10.1016/s0079-6603(06)81005-6openalex-snapshot
Repair of Topoisomerase I‐Mediated DNA Damage
inferredcites →https://doi.org/10.1016/s0960-7404(97)00005-4openalex-snapshot
Cancer chemotherapy and biotherapy: Principles and practice
inferredcites →https://doi.org/10.1016/s0960-894x(03)00534-1openalex-snapshot
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
inferredcites →https://doi.org/10.1021/bi00200a013openalex-snapshot
Differential Interactions of Camptothecin Lactone and Carboxylate Forms with Human Blood Components
inferredcites →https://doi.org/10.1021/bi051987qopenalex-snapshot
The Geometry of DNA Supercoils Modulates Topoisomerase-Mediated DNA Cleavage and Enzyme Response to Anticancer Drugs
inferredcites →https://doi.org/10.1021/bi800774bopenalex-snapshot
Mitochondrial Topoisomerase I Sites in the Regulatory D-Loop Region of Mitochondrial DNA
inferredcites →https://doi.org/10.1021/bi962880topenalex-snapshot
Vaccinia DNA Topoisomerase I: Evidence Supporting a Free Rotation Mechanism for DNA Supercoil Relaxation
inferredcites →https://doi.org/10.1021/bi990947hopenalex-snapshot
Homocamptothecin, an E-Ring-Modified Camptothecin Analogue, Generates New Topoisomerase I-Mediated DNA Breaks
inferredcites →https://doi.org/10.1021/ja00968a057openalex-snapshot
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata 1,2
inferredcites →https://doi.org/10.1021/jm000029dopenalex-snapshot
Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
inferredcites →https://doi.org/10.1021/jm00027a005openalex-snapshot
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability
inferredcites →https://doi.org/10.1021/jm000498fopenalex-snapshot
Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model
inferredcites →https://doi.org/10.1021/jm0300476openalex-snapshot
Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids
inferredcites →https://doi.org/10.1021/jm030313fopenalex-snapshot
Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
inferredcites →https://doi.org/10.1021/jm040025zopenalex-snapshot
Synthesis and Anticancer Activity of Simplified Indenoisoquinoline Topoisomerase I Inhibitors Lacking Substituents on the Aromatic Rings
inferredcites →https://doi.org/10.1021/jm049146popenalex-snapshot
Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
inferredcites →https://doi.org/10.1021/jm050017yopenalex-snapshot
On the Binding of Indeno[1,2-c]isoquinolines in the DNA−Topoisomerase I Cleavage Complex
inferredcites →https://doi.org/10.1021/jm050076bopenalex-snapshot
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
inferredcites →https://doi.org/10.1021/jm051116eopenalex-snapshot
Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine
inferredcites →https://doi.org/10.1021/jm060046oopenalex-snapshot
Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
inferredcites →https://doi.org/10.1021/jm060564zopenalex-snapshot
Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
inferredcites →https://doi.org/10.1021/jm060974nopenalex-snapshot
A Systematic Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I Inhibitor
inferredcites →https://doi.org/10.1021/jm0613119openalex-snapshot
Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell Cultures
inferredcites →https://doi.org/10.1021/jm070307+openalex-snapshot
Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors
inferredcites →https://doi.org/10.1021/jm070361qopenalex-snapshot
Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
inferredcites →https://doi.org/10.1021/jm800259eopenalex-snapshot
Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
inferredcites →https://doi.org/10.1021/jm9803323openalex-snapshot
Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons
inferredcites →https://doi.org/10.1021/jm980400lopenalex-snapshot
Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues
inferredcites →https://doi.org/10.1021/jo048808fopenalex-snapshot
Novel Autoxidative Cleavage Reaction of 9-Fluoredenes Discovered during Synthesis of a Potential DNA-Threading Indenoisoquinoline
inferredcites →https://doi.org/10.1021/np800455bopenalex-snapshot
An Endophytic Fungus from Camptotheca acuminata That Produces Camptothecin and Analogues
inferredcites →https://doi.org/10.1038/nature02253openalex-snapshot
The Bloom's syndrome helicase suppresses crossing over during homologous recombination
inferredcites →https://doi.org/10.1038/nature03314openalex-snapshot
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
inferredcites →https://doi.org/10.1038/nature03395openalex-snapshot
Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB
inferredcites →https://doi.org/10.1038/nature05938openalex-snapshot
Antitumour drugs impede DNA uncoiling by topoisomerase I
inferredcites →https://doi.org/10.1038/ng987openalex-snapshot
Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy
inferredcites →https://doi.org/10.1038/nprot.2008.174openalex-snapshot
DNA cleavage assay for the identification of topoisomerase I inhibitors
inferredcites →https://doi.org/10.1038/nrc1951openalex-snapshot
The NCI60 human tumour cell line anticancer drug screen
inferredcites →https://doi.org/10.1038/nrc1977openalex-snapshot
Topoisomerase I inhibitors: camptothecins and beyond
inferredcites →https://doi.org/10.1038/nrc2607openalex-snapshot
Targeting DNA topoisomerase II in cancer chemotherapy
inferredcites →https://doi.org/10.1038/nrc2608openalex-snapshot
DNA topoisomerase II and its growing repertoire of biological functions
inferredcites →https://doi.org/10.1038/nrm831openalex-snapshot
Cellular roles of DNA topoisomerases: a molecular perspective
inferredcites →https://doi.org/10.1038/nsmb1264openalex-snapshot
Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI
inferredcites →https://doi.org/10.1038/sj.emboj.7601869openalex-snapshot
TDP1 facilitates chromosomal single‐strand break repair in neurons and is neuroprotective in vivo
inferredcites →https://doi.org/10.1038/sj.emboj.7601885openalex-snapshot
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?
inferredcites →https://doi.org/10.1038/sj.onc.1207409openalex-snapshot
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability
inferredcites →https://doi.org/10.1042/bst0331465openalex-snapshot
Recent advances in understanding structure–function relationships in the type II topoisomerase mechanism
inferredcites →https://doi.org/10.1046/j.1365-2443.2001.00452.xopenalex-snapshot
Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1054/drup.1999.0102openalex-snapshot
Topoisomerase I inhibitors: selectivity and cellular resistance
inferredcites →https://doi.org/10.1073/pnas.0801038105openalex-snapshot
Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
inferredcites →https://doi.org/10.1073/pnas.0803513105openalex-snapshot
Topoisomerase levels determine chemotherapy response in vitro and in vivo
inferredcites →https://doi.org/10.1073/pnas.182557199openalex-snapshot
Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1
inferredcites →https://doi.org/10.1073/pnas.191321998openalex-snapshot
Human mitochondrial topoisomerase I
inferredcites →https://doi.org/10.1073/pnas.202242599openalex-snapshot
Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage
inferredcites →https://doi.org/10.1073/pnas.202483499openalex-snapshot
Type IA DNA topoisomerases: Strictly one step at a time
inferredcites →https://doi.org/10.1073/pnas.211429198openalex-snapshot
The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily
inferredcites →https://doi.org/10.1073/pnas.242259599openalex-snapshot
The mechanism of topoisomerase I poisoning by a camptothecin analog
inferredcites →https://doi.org/10.1073/pnas.85.20.7501openalex-snapshot
DNA topoisomerase-targeting antitumor drugs can be studied in yeast.
inferredcites →https://doi.org/10.1073/pnas.93.21.11534openalex-snapshot
A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.
inferredcites →https://doi.org/10.1074/jbc.m204688200openalex-snapshot
Conversion of Phosphoglycolate to Phosphate Termini on 3′ Overhangs of DNA Double Strand Breaks by the Human Tyrosyl-DNA Phosphodiesterase hTdp1
inferredcites →https://doi.org/10.1074/jbc.m503320200openalex-snapshot
Human Topoisomerase IIα Rapidly Relaxes Positively Supercoiled DNA
inferredcites →https://doi.org/10.1074/jbc.m603747200openalex-snapshot
Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
inferredcites →https://doi.org/10.1074/jbc.m803493200openalex-snapshot
A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes
inferredcites →https://doi.org/10.1093/jnci/81.14.1088openalex-snapshot
Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm
inferredcites →https://doi.org/10.1093/nar/18.22.6611openalex-snapshot
Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin
inferredcites →https://doi.org/10.1093/nar/19.21.5973openalex-snapshot
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide
inferredcites →https://doi.org/10.1093/nar/25.21.4181openalex-snapshot
Processing of topoisomerase I cleavable complexes into DNA damage by transcription
inferredcites →https://doi.org/10.1093/nar/27.12.2443openalex-snapshot
Purification and characterization of human DNA topoisomerase IIIalpha
inferredcites →https://doi.org/10.1093/nar/30.5.1198openalex-snapshot
Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase
inferredcites →https://doi.org/10.1093/nar/gkh525openalex-snapshot
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases
inferredcites →https://doi.org/10.1093/nar/gki170openalex-snapshot
Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
inferredcites →https://doi.org/10.1093/nar/gkm463openalex-snapshot
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
inferredcites →https://doi.org/10.1093/nar/gkn1087openalex-snapshot
A novel approach for organelle-specific DNA damage targeting reveals different susceptibility of mitochondrial DNA to the anticancer drugs camptothecin and topotecan
inferredcites →https://doi.org/10.1093/nar/gkn466openalex-snapshot
Human topoisomerase II uses a two-metal-ion mechanism for DNA cleavage
inferredcites →https://doi.org/10.1124/jpet.103.063149openalex-snapshot
ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
inferredcites →https://doi.org/10.1124/mol.104.003889openalex-snapshot
Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
inferredcites →https://doi.org/10.1124/mol.105.021865openalex-snapshot
Inhibition of Human Tyrosyl-DNA Phosphodiesterase by Aminoglycoside Antibiotics and Ribosome Inhibitors
inferredcites →https://doi.org/10.1124/mol.106.024372openalex-snapshot
Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
inferredcites →https://doi.org/10.1124/mol.107.034637openalex-snapshot
Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
inferredcites →https://doi.org/10.1124/mol.107.041178openalex-snapshot
Reduced Expression of DNA Topoisomerase I in SF295 Human Glioblastoma Cells Selected for Resistance to Homocamptothecin and Diflomotecan
inferredcites →https://doi.org/10.1124/mol.54.1.50openalex-snapshot
Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison
inferredcites →https://doi.org/10.1126/science.2555920openalex-snapshot
DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts
inferredcites →https://doi.org/10.1126/science.279.5356.1534openalex-snapshot
A Model for the Mechanism of Human Topoisomerase I
inferredcites →https://doi.org/10.1126/science.286.5439.552openalex-snapshot
Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes
inferredcites →https://doi.org/10.1128/mcb.20.11.3977-3987.2000openalex-snapshot
Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff
inferredcites →https://doi.org/10.1128/mcb.21.21.7191-7198.2001openalex-snapshot
Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3′ Phosphatases
inferredcites →https://doi.org/10.1134/s0003683808020130openalex-snapshot
An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin
inferredcites →https://doi.org/10.1139/w05-122openalex-snapshot
Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin
inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.369openalex-snapshot
DNA Topoisomerases: Structure, Function, and Mechanism
inferredcites →https://doi.org/10.1146/annurev.pharmtox.41.1.53openalex-snapshot
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4554openalex-snapshot
Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic Analyses
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0938openalex-snapshot
Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
inferredcites →https://doi.org/10.1158/1535-7163.317.4.2openalex-snapshot
Silatecan DB-67 is a novel DNA topoisomerase I–targeted radiation sensitizer
inferredcites →https://doi.org/10.1158/1535-7163.mct-05-0456openalex-snapshot
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
inferredcites →https://doi.org/10.1158/1535-7163.mct-07-0441openalex-snapshot
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0568openalex-snapshot
Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0706openalex-snapshot
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0878openalex-snapshot
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
inferredcites →https://doi.org/10.1158/1535-7163.mct-09-0016openalex-snapshot
Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
inferredcites →https://doi.org/10.1200/jco.2007.15.5580openalex-snapshot
Predictive Biomarkers of Chemotherapy Efficacy in Colorectal Cancer: Results From the UK MRC FOCUS Trial
inferredcites →https://doi.org/10.1534/genetics.104.028795openalex-snapshot
Multiple Endonucleases Function to Repair Covalent Topoisomerase I Complexes in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.2174/1568011043352777openalex-snapshot
Camptothecins and Topoisomerase I; A Foot in the Door. Targeting the Genome Beyond Topoisomerase I with Camptothecins and Novel Anticancer Drugs; Importance of DNA Replication, Repair and Cell Cycle Checkpoints
inferredcites →https://doi.org/10.2174/1568011054222337openalex-snapshot
Interfacial Inhibitors of Protein-Nucleic Acid Interactions
inferredcites →https://doi.org/10.2174/1568026033452546openalex-snapshot
Non-Camptothecin DNA Topoisomerase I Inhibitors in Cancer Therapy
inferredcites →https://doi.org/10.2174/187152008784220357openalex-snapshot
Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Human Topoisomerase I Inhibitors
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Visible‐Light‐Induced Controlled Oxidation of N ‐Substituted 1,2,3,4‐Tetrahydroisoquinolines for the Synthesis of 3,4‐Dihydroisoquinolin‐1(2 H )‐ones and Isoquinolin‐1(2 H )‐ones
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Development of Mitochondria‐Targeting Photosensitizers via Topoisomerase I Inhibition
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Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double‐Stranded DNA and RNA: Differential Emissions and Anticancer Activities
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Copper‐Catalyzed Formal [4+2] Cycloaddition of Enoldiazoimides with Sulfur Ylides
inferred← citeshttps://doi.org/10.1002/ange.202307324openalex-snapshot
Adamantoid Scaffolds for Multiple Cargo Loading and Cellular Delivery as β‐Cyclodextrin Inclusion Complexes
inferred← citeshttps://doi.org/10.1002/anie.201405384openalex-snapshot
Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double‐Stranded DNA and RNA: Differential Emissions and Anticancer Activities
inferred← citeshttps://doi.org/10.1002/anie.201805323openalex-snapshot
Copper‐Catalyzed Formal [4+2] Cycloaddition of Enoldiazoimides with Sulfur Ylides
inferred← citeshttps://doi.org/10.1002/anie.202307324openalex-snapshot
Adamantoid Scaffolds for Multiple Cargo Loading and Cellular Delivery as β‐Cyclodextrin Inclusion Complexes
inferred← citeshttps://doi.org/10.1002/aoc.4231openalex-snapshot
New designed DNA light switch Ruthenium complexes as DNA photocleavers and Topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1002/aoc.4423openalex-snapshot
Topoisomerase I inhibitory and photocleavage activity of non‐dppz DNA ‘light switches’ based on ruthenium complexes containing nitro group
inferred← citeshttps://doi.org/10.1002/aoc.5312openalex-snapshot
Topo I inhibition, DNA photocleavage, Molecular docking and cytotoxicities of two new phenanthroline‐based ruthenium complexes
inferred← citeshttps://doi.org/10.1002/ardp.201500045openalex-snapshot
Generated 3D‐Common Feature Hypotheses Using the HipHop Method For Developing New Topoisomerase I Inhibitors
inferred← citeshttps://doi.org/10.1002/ardp.201700297openalex-snapshot
Silicon‐containing analogs of camptothecin as anticancer agents
inferred← citeshttps://doi.org/10.1002/ardp.70094openalex-snapshot
Design and Synthesis of New Multi‐Target Coumarin Analogues Acting as Carbonic Anhydrases IX/XII and Topoisomerase II Inhibitors With Apoptotic Potential
inferred← citeshttps://doi.org/10.1002/cbdv.71525openalex-snapshot
Seaweeds From the Veracruz Rocky Shore (Mexico) as Novel Sources of Bioactive Compounds Against Fusarium Species Pathogenic to Corn ( Zea mays )
inferred← citeshttps://doi.org/10.1002/cbf.70196openalex-snapshot
Comprehensive Overview of Therapeutic Strategies in Colon Cancer: Chemotherapy, Targeted Therapy, and Immunotherapy
inferred← citeshttps://doi.org/10.1002/chem.202401400openalex-snapshot
Two‐Phase Electrosynthesis of Dihydroxycoumestans: Discovery of a New Scaffold for Topoisomerase I Poison
inferred← citeshttps://doi.org/10.1002/chin.200946270openalex-snapshot
ChemInform Abstract: DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
inferred← citeshttps://doi.org/10.1002/cjoc.202300449openalex-snapshot
Recent Advances in Domino Synthesis of Fused Polycyclic N‐Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis
inferred← citeshttps://doi.org/10.1002/cmdc.201200322openalex-snapshot
Camptothecin‐7‐yl‐methanthiole: Semisynthesis and Biological Evaluation
inferred← citeshttps://doi.org/10.1002/cmdc.201700026openalex-snapshot
A Dual Topoisomerase Inhibitor of Intense Pro‐Apoptotic and Antileukemic Nature for Cancer Treatment
inferred← citeshttps://doi.org/10.1002/cmdc.201900633openalex-snapshot
Comparative in vitro Studies of the Topoisomerase I Inhibition and Anticancer Activities of Metallated N‐Confused Porphyrins and Metallated Porphyrins
inferred← citeshttps://doi.org/10.1002/cmdc.202200593openalex-snapshot
Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors
inferred← citeshttps://doi.org/10.1002/cphc.201601281openalex-snapshot
DNA with Different Local Torsional States Affects RecA‐Mediated Recombination Progression
inferred← citeshttps://doi.org/10.1002/cptc.202300318openalex-snapshot
Photoinduced [2+2] and [4+4] Cycloaddition and Cycloreversion Reactions for the Development of Photocontrollable DNA Binders
inferred← citeshttps://doi.org/10.1002/ejoc.201600746openalex-snapshot
Flexible Approach to (5Z,9Z)‐Dienoic Fatty Acids Relevant to the Synthesis of Demospongic Acids and Related Natural Products
inferred← citeshttps://doi.org/10.1002/em.21839openalex-snapshot
Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1002/em.21892openalex-snapshot
Recognition and repair of chemically heterogeneous structures at DNA ends
inferred← citeshttps://doi.org/10.1002/jbmr.1504openalex-snapshot
Regulation of RUNX2 transcription factor–DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity
inferred← citeshttps://doi.org/10.1002/jcb.24542openalex-snapshot
Cell‐cycle specific association of transcription factors and RNA polymerase ii with the human β‐globin gene locus
inferred← citeshttps://doi.org/10.1002/jms.3500openalex-snapshot
Changes in lipid distribution in E. coli strains in response to norfloxacin
inferred← citeshttps://doi.org/10.1002/mc.23685openalex-snapshot
SN‐38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2‐related factor 2 and enhances drug sensitivity of colorectal cancer cells
inferred← citeshttps://doi.org/10.1002/med.20239openalex-snapshot
Overcoming tumor multidrug resistance using drugs able to evade P‐glycoprotein or to exploit its expression
inferred← citeshttps://doi.org/10.1002/med.21290openalex-snapshot
Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry
inferred← citeshttps://doi.org/10.1002/med.21417openalex-snapshot
Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?
inferred← citeshttps://doi.org/10.1002/med.21546openalex-snapshot
Topoisomerase 1B poisons: Over a half‐century of drug leads, clinical candidates, and serendipitous discoveries
inferred← citeshttps://doi.org/10.1002/mrc.4255openalex-snapshot
DOSY NMR and MALDI‐TOF evidence of covalent binding the DNA duplex by trimethylammonium salts of topotecan upon near UV irradiation
inferred← citeshttps://doi.org/10.1002/ps.2313openalex-snapshot
Effects of camptothecin and hydroxycamptothecin on insect cell lines Sf21 and IOZCAS‐Spex‐II
inferred← citeshttps://doi.org/10.1002/qua.27314openalex-snapshot
QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods
inferred← citeshttps://doi.org/10.1002/slct.201601152openalex-snapshot
Design, Synthesis and in vitro Anticancer Activity of a Cu(II) Complex of Carminic Acid: A Novel Small Molecule Inhibitor of Human DNA Topoisomerase I and Topoisomerase II
inferred← citeshttps://doi.org/10.1002/slct.202103314openalex-snapshot
Fluorophore Tagged Mixed Ligand Copper(II) Complexes: Synthesis, Structural Characterization, Protein Binding, DNA Cleavage and Anticancer Activity
inferred← citeshttps://doi.org/10.1002/slct.202301700openalex-snapshot
Design, Synthesis, and Anticancer Evaluation of Hemithioindigos via Inhibition of Human Topoisomerases
inferred← citeshttps://doi.org/10.1002/slct.202504389openalex-snapshot
Synthesis, Characterization, and Biological Evaluation of Novel Isatin‐Bearing Amino Acid Derivatives: Cytotoxic Activity and Prospective Applications in Medicinal Chemistry
inferred← citeshttps://doi.org/10.1002/smo2.70070openalex-snapshot
A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy
inferred← citeshttps://doi.org/10.1002/yea.1837openalex-snapshot
Sensitive detection of chemical‐induced genotoxicity by the Cypridina secretory luciferase reporter assay, using DNA repair‐deficient strains of Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_10openalex-snapshot
Topoisomerase I Inhibitors: Chemical Biology
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_15openalex-snapshot
Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_16openalex-snapshot
Tyrosyl-DNA-Phosphodiesterase
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_17openalex-snapshot
Ubiquitin and Ubiquitin-Like Proteins in Repair of Topoisomerase-Mediated DNA Damage
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_19openalex-snapshot
Topoisomerases and Apoptosis
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_3openalex-snapshot
Mitochondrial Topoisomerases
inferred← citeshttps://doi.org/10.1007/978-1-4614-0323-4_6openalex-snapshot
DNA Topoisomerase I and Illegitimate Recombination
inferred← citeshttps://doi.org/10.1007/978-1-4614-1531-2_122openalex-snapshot
Topoisomerases and Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4614-1531-2_127openalex-snapshot
DNA Topology and Topoisomerases
inferred← citeshttps://doi.org/10.1007/978-1-4614-6436-5_122-3openalex-snapshot
Topoisomerases and Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4614-6436-5_127-3openalex-snapshot
DNA Topology and Topoisomerases
inferred← citeshttps://doi.org/10.1007/978-3-030-16031-9_20openalex-snapshot
Regulation of DNA Topology by Topoisomerases: Mathematics at the Molecular Level
inferred← citeshttps://doi.org/10.1007/978-3-030-54027-2_9openalex-snapshot
Camptothecin: Occurrence, Chemistry and Mode of Action
inferred← citeshttps://doi.org/10.1007/978-3-031-33602-7_1openalex-snapshot
Antibody–Drug Conjugates: A New Therapeutic Approach for Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-3-031-41720-7_2openalex-snapshot
Diversity of Thermophilic Prokaryotes
inferred← citeshttps://doi.org/10.1007/978-3-319-30705-3_12openalex-snapshot
Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs
inferred← citeshttps://doi.org/10.1007/978-3-642-36202-6_200-1openalex-snapshot
Natural Products as Topoisomerase II Inhibitors
inferred← citeshttps://doi.org/10.1007/978-981-13-0053-0_4openalex-snapshot
Endophytes: A Gold Mine of Enzyme Inhibitors
inferred← citeshttps://doi.org/10.1007/s00018-010-0591-4openalex-snapshot
Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2
inferred← citeshttps://doi.org/10.1007/s00044-015-1446-1openalex-snapshot
nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα
inferred← citeshttps://doi.org/10.1007/s00044-022-02862-6openalex-snapshot
Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA
inferred← citeshttps://doi.org/10.1007/s00214-013-1379-zopenalex-snapshot
Microscopic modes and free energies for topoisomerase I-DNA covalent complex binding with non-camptothecin inhibitors by molecular docking and dynamics simulations
inferred← citeshttps://doi.org/10.1007/s00294-019-00984-wopenalex-snapshot
Abortive activity of Topoisomerase I: a challenge for genome integrity?
inferred← citeshttps://doi.org/10.1007/s00706-011-0617-0openalex-snapshot
Effective asymmetric synthesis of the key chiral building blocks of 20(S)- and 20(R)-camptothecins
inferred← citeshttps://doi.org/10.1007/s00709-019-01440-9openalex-snapshot
Molecular characterization and overexpression analyses of secologanin synthase to understand the regulation of camptothecin biosynthesis in Nothapodytes nimmoniana (Graham.) Mabb.
inferred← citeshttps://doi.org/10.1007/s10495-016-1290-xopenalex-snapshot
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway
inferred← citeshttps://doi.org/10.1007/s10593-020-02717-1openalex-snapshot
Diazapyrenes: interaction with nucleic acids and biological activity
inferred← citeshttps://doi.org/10.1007/s10822-013-9695-xopenalex-snapshot
Development of purely structure-based pharmacophores for the topoisomerase I-DNA-ligand binding pocket
inferred← citeshttps://doi.org/10.1007/s10886-018-0960-2openalex-snapshot
Mechanism of Resistance to Camptothecin, a Cytotoxic Plant Secondary Metabolite, by Lymantria sp. Larvae
inferred← citeshttps://doi.org/10.1007/s10895-015-1644-8openalex-snapshot
DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit
inferred← citeshttps://doi.org/10.1007/s11030-025-11185-8openalex-snapshot
Identification of low-toxicity DNA topoisomerase I inhibitors with potential blood–brain barrier penetrability for glioblastoma therapy: structure-based virtual screening reveals promising novel Scaffolds
inferred← citeshttps://doi.org/10.1007/s11033-012-1647-3openalex-snapshot
ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage
inferred← citeshttps://doi.org/10.1007/s11101-013-9291-7openalex-snapshot
Phytochemicals as anticancer and chemopreventive topoisomerase II poisons
inferred← citeshttps://doi.org/10.1007/s11101-019-09635-xopenalex-snapshot
Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC–MS
inferred← citeshttps://doi.org/10.1007/s11101-020-09685-6openalex-snapshot
Natural compounds with bis-methylene-interrupted Z-double bonds: plant sources, strategies of total synthesis, biological activity, and perspectives
inferred← citeshttps://doi.org/10.1007/s11103-017-0690-9openalex-snapshot
De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb.
inferred← citeshttps://doi.org/10.1007/s11172-015-1005-4openalex-snapshot
Drug design based on the carbon/silicon switch strategy
inferred← citeshttps://doi.org/10.1007/s11172-015-1128-7openalex-snapshot
Synthesis and transformations of metallacycles. 45. Cross-cyclomagnesiation of 1,2-dienes in the synthesis of 5Z,9Z-dienoic acids, efficient inhibitors of human topoisomerase I
inferred← citeshttps://doi.org/10.1007/s11172-023-4049-xopenalex-snapshot
Synthesis of polyether macrodiolides based on acetylenic derivatives of (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid
inferred← citeshttps://doi.org/10.1007/s11888-017-0374-5openalex-snapshot
Resistance Mechanisms to Colorectal Cancer Therapeutics and the Clinical Implications
inferred← citeshttps://doi.org/10.1007/s12272-018-1004-8openalex-snapshot
Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure–activity relationship studies
inferred← citeshttps://doi.org/10.1007/s40242-015-5256-2openalex-snapshot
Cytotoxicities, telomerase and topoisomerases I inhibitory activities and interactions of terpyridine derivatives with DNAs
inferred← citeshttps://doi.org/10.1007/s42764-024-00132-wopenalex-snapshot
MUS81 UFMylation at K400 promotes cell survival in response to camptothecin-induced replication stress
inferred← citeshttps://doi.org/10.1016/b978-0-12-382030-3.00006-4openalex-snapshot
DNA-Interactive Agents
inferred← citeshttps://doi.org/10.1016/b978-0-12-384999-1.10008-3openalex-snapshot
DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance
inferred← citeshttps://doi.org/10.1016/b978-0-12-397833-2.00012-1openalex-snapshot
Advances in Cancer Chemotherapeutic Drug Research in China
inferred← citeshttps://doi.org/10.1016/b978-0-12-411492-0.00028-6openalex-snapshot
Antineoplastic Agents
inferred← citeshttps://doi.org/10.1016/b978-0-12-818549-0.00010-8openalex-snapshot
DNA intercalation and topoisomerase inhibition
inferred← citeshttps://doi.org/10.1016/b978-0-12-822312-3.00018-7openalex-snapshot
Computational Approaches Toward Development of Topoisomerase I Inhibitor: A Clinically Validated Target
inferred← citeshttps://doi.org/10.1016/b978-0-443-15862-9.00009-6openalex-snapshot
Drugs Interacting with Nucleic Acids
inferred← citeshttps://doi.org/10.1016/b978-0-443-16032-5.00005-1openalex-snapshot
Resistance of prostate cancer to topoisomerase inhibitors
inferred← citeshttps://doi.org/10.1016/b978-0-443-44041-0.00004-0openalex-snapshot
Targeting topoisomerases in oncology
inferred← citeshttps://doi.org/10.1016/b978-0-444-62649-3.00007-7openalex-snapshot
Other Anticancer Drugs Targeting DNA and DNA-Associated Enzymes
inferred← citeshttps://doi.org/10.1016/b978-0-444-63406-1.00004-0openalex-snapshot
Food-Borne Topoisomerase Inhibitors
inferred← citeshttps://doi.org/10.1016/b978-0-444-63603-4.00001-2openalex-snapshot
Topoisomerase I Inhibitors Derived from Natural Products: Structure–Activity Relationships and Antitumor Potency
inferred← citeshttps://doi.org/10.1016/b978-0-444-63929-5.00002-4openalex-snapshot
Advances in the Chemistry of Natural and Semisynthetic Topoisomerase I/II Inhibitors
inferred← citeshttps://doi.org/10.1016/bs.armc.2020.05.002openalex-snapshot
Transcriptional regulation of MYC through G-quadruplex structures
inferred← citeshttps://doi.org/10.1016/bs.mie.2019.07.003openalex-snapshot
Enzymatic activity in single cells
inferred← citeshttps://doi.org/10.1016/j.ab.2014.02.003openalex-snapshot
Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads
inferred← citeshttps://doi.org/10.1016/j.abb.2011.10.008openalex-snapshot
Inhibition of human DNA topoisomerase IB by a Cyclometalated Gold III compound: Analysis on the different steps of the enzyme catalytic cycle
inferred← citeshttps://doi.org/10.1016/j.abb.2012.12.013openalex-snapshot
A derivative of the natural compound kakuol affects DNA relaxation of topoisomerase IB inhibiting the cleavage reaction
inferred← citeshttps://doi.org/10.1016/j.abb.2018.02.006openalex-snapshot
Real-time analysis of cleavage and religation activity of human topoisomerase 1 based on ternary fluorescence resonance energy transfer DNA substrate
inferred← citeshttps://doi.org/10.1016/j.abb.2024.110231openalex-snapshot
Computational discovery of novel GPX4 inhibitors from herbal sources as potential ferroptosis inducers in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.aca.2013.07.016openalex-snapshot
High-throughput detection of drugs binding to proteins using desorption electrospray ionization mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.actatropica.2022.106613openalex-snapshot
Type II DNA topoisomerases in trypanosomatid and apicomplexan parasites
inferred← citeshttps://doi.org/10.1016/j.apmt.2020.100783openalex-snapshot
New horizons in benzothiazole scaffold for cancer therapy: Advances in bioactivity, functionality, and chemistry
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.05.011openalex-snapshot
Synergistic albumin nanoplatform with pseudo-parabola-tuned chemotherapy and PROTAC-induced BRD4 degradation for amplified cancer therapy
inferred← citeshttps://doi.org/10.1016/j.arabjc.2018.03.009openalex-snapshot
Benzo[7,8]indolizinoquinoline scaffolds based on Mg(ClO4)2-promoted regiospecific imide reduction and π-cyclization of N-acyliminium species. Analogues of the topo-1 poison rosettacin and 22-hydroxyacuminatine alkaloids
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.105376openalex-snapshot
Computational assessment of the reactivity and pharmaceutical potential of novel triazole derivatives: An approach combining DFT calculations, molecular dynamics simulations, and molecular docking
inferred← citeshttps://doi.org/10.1016/j.bbagen.2026.130932openalex-snapshot
Flavonoids: Novel topoisomerase inhibitors in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2012.06.002openalex-snapshot
Mitochondrial DNA damage and its consequences for mitochondrial gene expression
inferred← citeshttps://doi.org/10.1016/j.bbamem.2015.12.007openalex-snapshot
Langmuir monolayers and Differential Scanning Calorimetry for the study of the interactions between camptothecin drugs and biomembrane models
inferred← citeshttps://doi.org/10.1016/j.bbapap.2013.09.017openalex-snapshot
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
inferred← citeshttps://doi.org/10.1016/j.bbcan.2012.09.002openalex-snapshot
Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.07.003openalex-snapshot
Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.05.140openalex-snapshot
In situ reactivity of electrochemically generated semiquinone on Emodin and its CuII/MnII complexes with pyrimidine based nucleic acid bases and calf thymus DNA: Insight into free radical induced cytotoxicity of anthracyclines
inferred← citeshttps://doi.org/10.1016/j.bcab.2019.101243openalex-snapshot
Acalypha wilkesiana flowers: Phenolic profiling, cytotoxic activity of their biosynthesized silver nanoparticles and molecular docking study for its constituents as Topoisomerase-I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.03.023openalex-snapshot
Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2010.09.026openalex-snapshot
A sandwiched microarray platform for benchtop cell-based high throughput screening
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121814openalex-snapshot
De novo engineering of both an omega-3 fatty acid-derived nanocarrier host and a prodrug guest to potentiate drug efficacy against colorectal malignancies
inferred← citeshttps://doi.org/10.1016/j.bioorg.2016.04.007openalex-snapshot
Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents
inferred← citeshttps://doi.org/10.1016/j.bioorg.2016.09.002openalex-snapshot
Synthesis and biological evaluation of imidazopyridinyl-1,3,4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.03.033openalex-snapshot
Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103409openalex-snapshot
E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103629openalex-snapshot
Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.104303openalex-snapshot
New synthetic analogues of natural 5Z,9Z-dienoic acids: Stereoselective synthesis and study of the anticancer activity
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.104396openalex-snapshot
Inhibition of histone deacetylases, topoisomerases and epidermal growth factor receptor by metal-based anticancer agents: Design & synthetic strategies and their medicinal attributes
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.104631openalex-snapshot
A NMR study of binding the metabolite of SN38 derivatives to a model nicked DNA decamer mimicking target of Topo I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105065openalex-snapshot
Design and synthesis of novel 20(S)-α-aminophosphonate derivatives of camptothecin as potent antitumor agents
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105174openalex-snapshot
Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105349openalex-snapshot
4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure–activity relationships
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105789openalex-snapshot
Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106560openalex-snapshot
Design and synthesis of uracil/thiouracil based quinoline scaffolds as topoisomerases I/II inhibitors for chemotherapy: A new hybrid navigator with DFT calculation
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107697openalex-snapshot
Novel antibody-drug conjugates based on DXd-ADC technology
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.108043openalex-snapshot
Design, synthesis and anticancer evaluation of 4-Substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as dual topoisomerase I and II inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109186openalex-snapshot
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110173openalex-snapshot
Design, synthesis, and biological evaluation of novel selenium-matrine hybrid compounds as topo I -targeted anticancer agents
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110271openalex-snapshot
Synthesis and evaluation of pyrazole-fused quinoline hybrids as dual-function anticancer and fluorescent live-cell imaging agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.03.051openalex-snapshot
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.08.058openalex-snapshot
Novel synthetic 2-amino-10-(3,5-dimethoxy)benzyl-9(10H)-acridinone derivatives as potent DNA-binding antiproliferative agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.10.057openalex-snapshot
3-Arylisoquinolines as novel topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.12.026openalex-snapshot
Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.11.010openalex-snapshot
Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.11.020openalex-snapshot
Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.02.036openalex-snapshot
Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.04.002openalex-snapshot
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.04.031openalex-snapshot
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.04.079openalex-snapshot
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.10.030openalex-snapshot
Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.12.033openalex-snapshot
Synthesis and biological activity of ferrocenyl indeno[1,2-c]isoquinolines as topoisomerase II inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.02.015openalex-snapshot
Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.09.034openalex-snapshot
Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.09.045openalex-snapshot
Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.03.065openalex-snapshot
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.07.001openalex-snapshot
Design, synthesis and evaluation of novel sophoridinic imine derivatives containing conjugated planar structure as potent anticancer agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.11.037openalex-snapshot
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.06.014openalex-snapshot
Identification of topoisomerases as molecular targets of cytosporolide C and its analog
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115527openalex-snapshot
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2023.117530openalex-snapshot
Development of novel quinoline-NO donor hybrids inducing human breast cancer cells apoptosis via inhibition of topoisomerase I
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.06.108openalex-snapshot
Hsp90 inhibition: Elimination of shock and stress
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.06.016openalex-snapshot
Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.03.107openalex-snapshot
Synthesis, single crystal and antitumor activities of benzimidazole–quinazoline hybrids
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.03.108openalex-snapshot
Dual-acting histone deacetylase-topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.04.011openalex-snapshot
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIα inhibitory activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.06.042openalex-snapshot
Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.12.014openalex-snapshot
Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.03.039openalex-snapshot
Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.01.048openalex-snapshot
Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128146openalex-snapshot
New camptothecin derivatives for generalized oncological chemotherapy: Synthesis, stereochemistry and biology
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128606openalex-snapshot
Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships
inferred← citeshttps://doi.org/10.1016/j.canlet.2010.01.004openalex-snapshot
Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor
inferred← citeshttps://doi.org/10.1016/j.carbon.2021.11.028openalex-snapshot
DNA binding graphene quantum dots inhibit dual topoisomerases for cancer chemotherapy
inferred← citeshttps://doi.org/10.1016/j.cclet.2013.05.018openalex-snapshot
Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor
inferred← citeshttps://doi.org/10.1016/j.cclet.2014.05.048openalex-snapshot
Discovery of a series of pyridopyrimidine derivatives as potential topoisomerase I inhibitors
inferred← citeshttps://doi.org/10.1016/j.cclet.2025.112172openalex-snapshot
Pecanthines A–C, unprecedented dimeric β-carboline alkaloids from the seeds of Peganum harmala
inferred← citeshttps://doi.org/10.1016/j.cej.2023.144177openalex-snapshot
Design of red-emitting 1D zinc coordination polymer for targeted drug delivery to nucleus
inferred← citeshttps://doi.org/10.1016/j.cell.2016.02.036openalex-snapshot
RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.03.027openalex-snapshot
Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117604openalex-snapshot
Dynamicity of Topoisomerase 1 binding at super-enhancers regulates TLR-responsive gene expression program in macrophages
inferred← citeshttps://doi.org/10.1016/j.chembiol.2010.04.012openalex-snapshot
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
inferred← citeshttps://doi.org/10.1016/j.chembiol.2021.04.015openalex-snapshot
Getting stressed over topoisomerase I poisons
inferred← citeshttps://doi.org/10.1016/j.chroma.2009.10.035openalex-snapshot
Extending the use of “Inverted Chirality Columns Approach” for enantiomeric excess determination in absence of reference samples: Application to a water-soluble camptothecin derivative
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