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General Unified Threshold Model of Survival - a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Population models in pesticide risk assessment: Lessons for assessing population-level effects, recovery, and alternative exposure scenarios from modeling a small mammal
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Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrateGammarus pulexmodeled with prediction intervals
inferredcites →https://doi.org/10.1002/etc.5620070911openalex-snapshot
Relationships among models for acute toxic effects: Applications to fluctuating concentrations
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AN EQUATION DESCRIBING THE TIME COURSE AND VARIABILITY IN UPTAKE AND TOXICITY OF NARCOTIC CHEMICALS TO FISH
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TOXICOKINETICS IN AQUATIC SYSTEMS: MODEL COMPARISONS AND USE IN HAZARD ASSESSMENT
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A RESIDUE-BASED TOXICOKINETIC MODEL FOR PULSE-EXPOSURE TOXICITY IN AQUATIC SYSTEMS
inferredcites →https://doi.org/10.1002/etc.5620150326openalex-snapshot
TOXICOKINETICS-BASED SURVIVAL ANALYSIS IN BIOASSAYS USING NONPERSISTENT CHEMICALS
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THE INDIVIDUAL TOLERANCE CONCEPT IS NOT THE SOLE EXPLANATION FOR THE PROBIT DOSE–EFFECT MODEL
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THE POWER OF SIZE. 1. RATE CONSTANTS AND EQUILIBRIUM RATIOS FOR ACCUMULATION OF ORGANIC SUBSTANCES RELATED TO OCTANOL–WATER PARTITION RATIO AND SPECIES WEIGHT
inferredcites →https://doi.org/10.1002/ieam.105openalex-snapshot
Framework for traits-based assessment in ecotoxicology
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Potential application of population models in the European ecological risk assessment of chemicals II: Review of models and their potential to address environmental protection aims
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The Acute Toxicity of Selected Alkylphenols to Young and AdultDaphnia magna
inferredcites →https://doi.org/10.1007/bf00116339openalex-snapshot
Time-to-event analyses of ecotoxicity data
inferredcites →https://doi.org/10.1007/bf00469427openalex-snapshot
Statistical analysis of bioassays, based on hazard modelling
inferredcites →https://doi.org/10.1007/s00244-002-2127-xopenalex-snapshot
Toxicokinetics of Organic Contaminants in Hyalella azteca
inferredcites →https://doi.org/10.1007/s10646-006-0060-xopenalex-snapshot
Making Sense of Ecotoxicological Test Results: Towards Application of Process-based Models
inferredcites →https://doi.org/10.1007/s10646-006-0100-6openalex-snapshot
Modeling responses of Daphnia magna to pesticide pulse exposure under varying food conditions: intrinsic versus apparent sensitivity
inferredcites →https://doi.org/10.1007/s10646-008-0271-4openalex-snapshot
A biology-based approach for quantitative structure-activity relationships (QSARs) in ecotoxicity
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A biology-based approach for mixture toxicity of multiple endpoints over the life cycle
inferredcites →https://doi.org/10.1007/s11356-009-0124-6openalex-snapshot
Mechanistic effect models for ecological risk assessment of chemicals (MEMoRisk)—a new SETAC-Europe Advisory Group
inferredcites →https://doi.org/10.1007/s11356-009-0228-zopenalex-snapshot
CREAM: a European project on mechanistic effect models for ecological risk assessment of chemicals
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A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish
inferredcites →https://doi.org/10.1016/0043-1354(81)90190-1openalex-snapshot
Parametric analyses of mortality rates in bioassays
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A method for calculating effects, on aquatic organisms, of time varying concentrations
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An equation of lethality curves in tests with aquatic fauna
inferredcites →https://doi.org/10.1016/j.ecolmodel.2008.10.008openalex-snapshot
Estimation of no effect concentrations from exposure experiments when values scatter among individuals
inferredcites →https://doi.org/10.1016/j.ecolmodel.2010.01.015openalex-snapshot
Toxicokinetic–toxicodynamic modelling in an individual based context—Consequences of parameter variability
inferredcites →https://doi.org/10.1016/j.scitotenv.2009.10.066openalex-snapshot
Understanding toxicity as processes in time
inferredcites →https://doi.org/10.1016/s0043-1354(01)00106-3openalex-snapshot
ANALYSIS OF BIOASSAYS WITH TIME-VARYING CONCENTRATIONS
inferredcites →https://doi.org/10.1016/s0269-7491(00)00162-7openalex-snapshot
Bioaccumulation of persistent organic chemicals: mechanisms and models
inferredcites →https://doi.org/10.1021/es00011a019openalex-snapshot
Effects of light intensity on the phototoxicity of fluoranthene to a benthic macroinvertebrate
inferredcites →https://doi.org/10.1021/es011202dopenalex-snapshot
Prediction of Time-Dependent PAH Toxicity in Hyalella azteca Using a Damage Assessment Model
inferredcites →https://doi.org/10.1021/es0264347openalex-snapshot
Temperature-Dependent Effects of Cadmium onDaphnia magna: Accumulation versus Sensitivity
inferredcites →https://doi.org/10.1021/es0352348openalex-snapshot
Simultaneous Modeling of Multiple End Points in Life-Cycle Toxicity Tests
inferredcites →https://doi.org/10.1021/es049844zopenalex-snapshot
Time-Dependent Toxicity of Fluoranthene to Freshwater Invertebrates and the Role of Biotransformation on Lethal Body Residues
inferredcites →https://doi.org/10.1021/es050817yopenalex-snapshot
Modeling Receptor Kinetics in the Analysis of Survival Data for Organophosphorus Pesticides
inferredcites →https://doi.org/10.1021/es051120fopenalex-snapshot
Development of a Multi-Component Damage Assessment Model (MDAM) for Time-Dependent Mixture Toxicity with Toxicokinetic Interactions
inferredcites →https://doi.org/10.1021/es061727bopenalex-snapshot
New Ecotoxicological Model To Simulate Survival of Aquatic Invertebrates after Exposure to Fluctuating and Sequential Pulses of Pesticides
inferredcites →https://doi.org/10.1021/es070283wopenalex-snapshot
Modeling Combined Effects of Pulsed Exposure to Carbaryl and Chlorpyrifos on Gammarus Pulex
inferredcites →https://doi.org/10.1021/es801418xopenalex-snapshot
A Bayesian Approach to Analyzing Ecotoxicological Data
inferredcites →https://doi.org/10.1021/es903478bopenalex-snapshot
Toxicokinetic and Toxicodynamic Modeling Explains Carry-over Toxicity from Exposure to Diazinon by Slow Organism Recovery
inferredcites →https://doi.org/10.1021/es9805066openalex-snapshot
Analysis of the Time-Dependent Acute Aquatic Toxicity of Organophosphorus Pesticides: The Critical Target Occupation Model
inferredcites →https://doi.org/10.1021/es980507yopenalex-snapshot
An LC50 vs Time Model for the Aquatic Toxicity of Reactive and Receptor-Mediated Compounds. Consequences for Bioconcentration Kinetics and Risk Assessment
inferredcites →https://doi.org/10.1039/c0em00096eopenalex-snapshot
The potential of individual based population models to extrapolate effects measured at standardized test conditions to relevant environmental conditions—an example for 3,4-dichloroaniline on Daphnia magna
inferredcites →https://doi.org/10.1039/c0em00234hopenalex-snapshot
Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment
inferredcites →https://doi.org/10.1080/00031305.1995.10476112openalex-snapshot
Teaching about Approximate Confidence Regions Based on Maximum Likelihood Estimation
inferredcites →https://doi.org/10.1080/713610016openalex-snapshot
Realism and Relevance of Ecological Models Used in Chemical Risk Assessment
inferredcites →https://doi.org/10.1201/9781439813492openalex-snapshot
Linking Aquatic Exposure and Effects: Risk Assessment of Pesticides
inferredcites →https://doi.org/10.1897/04-055r.1openalex-snapshot
Time-dependent toxicity of dichlorodiphenyldichloroethylene to Hyalella azteca
inferredcites →https://doi.org/10.1897/04-657r.1openalex-snapshot
Dissipation kinetics and mobility of chlortetracycline, tylosin, and monensin in an agricultural soil in Northumberland County, Ontario, Canada
inferredcites →https://doi.org/10.1897/05-393r.1openalex-snapshot
Predicting effects on aquatic organisms from fluctuating or pulsed exposure to pesticides
inferredcites →https://doi.org/10.1897/06-398r.1openalex-snapshot
The theory underlying dose-response models influences predictions for intermittent exposures
inferredcites →https://doi.org/10.1897/06-437r.1openalex-snapshot
Modeling the effects of binary mixtures on survival in time
inferredcites →https://doi.org/10.1897/07-022r.1openalex-snapshot
An individual-based approach to model spatial population dynamics of invertebrates in aquatic ecosystems after pesticide contamination
inferredcites →https://doi.org/10.1897/07-642.1openalex-snapshot
Toxicodynamic assumptions in ecotoxicological hazard models
inferredcites →https://doi.org/10.1897/09-106.1openalex-snapshot
Bayesian multilevel discrete interval hazard analysis to predict dichlorodiphenyldichloroethylene mortality inHyalella aztecabased on body residues
inferredcites →https://doi.org/10.1897/ieam_2008-029.1openalex-snapshot
Ecological models in support of regulatory risk assessments of pesticides: developing a strategy for the future
inferredcites →https://doi.org/10.2307/3546255openalex-snapshot
An Alternative for NOEC Exists, but the Standard Model Has to Be Abandoned First
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Guts-Immobility: Accounting for Resuscitating Individuals in Aquatic Survival Studies within the General Unified Threshold Model for Survival
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Soil Nano‐ecotoxicology: What Have We Learned from Standard Tests and What May We Be Missing?
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Combined Toxicity of Chemicals: Final Thoughts and Concluding Remarks
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Ecological Modeling in Pesticide Risk Assessment: Chances and Challenges
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Diagnostics to assess toxicokinetic–toxicodynamic models with interval‐censored data
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Genetic variance of tolerance and the toxicant threshold model
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Toxicokinetic and toxicodynamic model for diazinon toxicity—mechanistic explanation of differences in the sensitivity of Daphnia magna and Gammarus pulex
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Time-dependent species sensitivity distributions
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EFFECT PROPAGATION IN A TOXICOKINETIC/TOXICODYNAMIC MODEL EXPLAINS DELAYED EFFECTS ON THE GROWTH OF UNICELLULAR GREEN ALGAESCENEDESMUS VACUOLATUS
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A method to predict and understand fish survival under dynamic chemical stress using standard ecotoxicity data
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Dynamics of contaminant accumulation in benthos: Route to understanding exposure to organic contaminants
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Toxicity of magnesium pulses to tropical freshwater species and the development of a duration-based water quality guideline
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Toxicokinetics and toxicodynamics of nickel in Enchytraeus crypticus
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Linking survival and biomarker responses over time
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Toxicodynamics of copper and cadmium in Folsomia candida exposed to simulated soil solutions
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Considerations for test design to accommodate energy-budget models in ecotoxicology: A case study for acetone in the pond snail Lymnaea stagnalis
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Modeling the contribution of toxicokinetic and toxicodynamic processes to the recovery of Gammarus pulex populations after exposure to pesticides
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Testing the individual effective dose hypothesis
inferred← citeshttps://doi.org/10.1002/etc.2502openalex-snapshot
A simulation study on effects of exposure to a combination of pesticides used in an orchard and tuber crop on the recovery time of a vulnerable aquatic invertebrate
inferred← citeshttps://doi.org/10.1002/etc.2585openalex-snapshot
A combined toxicokinetics and toxicodynamics approach to assess the effect of porewater composition on cadmium bioavailability to Folsomia candida
inferred← citeshttps://doi.org/10.1002/etc.2605openalex-snapshot
Comparing population recovery after insecticide exposure for four aquatic invertebrate species using models of different complexity
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Relationships between exposure and dose in aquatic toxicity tests for organic chemicals
inferred← citeshttps://doi.org/10.1002/etc.2802openalex-snapshot
Interaction between nickel and cobalt toxicity inEnchytraeus crypticusis due to competitive uptake
inferred← citeshttps://doi.org/10.1002/etc.3036openalex-snapshot
Uptake routes and toxicokinetics of silver nanoparticles and silver ions in the earthworm Lumbricus rubellus
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Ecological risk assessment of herbicides in Japan: Integrating spatiotemporal variation in exposure and effects using a multimedia model and algal density dynamics models
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Stage-dependent and sex-dependent sensitivity to water-soluble fractions of fresh and weathered oil in the marine copepodCalanus finmarchicus
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Comparison and evaluation of pesticide monitoring programs using a process-based mixture model
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Time-varying effects of aromatic oil constituents on the survival of aquatic species: Deviations between model estimates and observations
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A framework for predicting impacts on ecosystem services from (sub)organismal responses to chemicals
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Coupling toxicokinetic–toxicodynamic and population models for assessing aquatic ecological risks to time-varying pesticide exposures
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A Pulsed-Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment
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Comparison of the General Threshold Model of Survival and Dose–Response Models in Simulating the Acute Toxicity of Metals to Danio rerio
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A 3-Species Aquatic Community Model for Ecological Risk Assessment Using Basic Ecotoxicity Data
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Effect Modeling Quantifies the Difference Between the Toxicity of Average Pesticide Concentrations and Time-Variable Exposures from Water Quality Monitoring
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Development and Validation of a Mixture Toxicity Implementation in the Dynamic Energy Budget–Individual-Based Model: Effects of Copper and Zinc on Daphnia magna Populations
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Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
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Making Sense of Life-History Effects of the Antidepressant Citalopram in the Copepod Nitocra spinipes Using a Bioenergetics Model
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Applying a Hybrid Modeling Approach to Evaluate Potential Pesticide Effects and Mitigation Effectiveness for an Endangered Fish in Simulated Oxbow Habitats
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Using Transcriptomics and Metabolomics to Understand Species Differences in Sensitivity to Chlorpyrifos in Japanese Quail and Double-Crested Cormorant Embryos
inferred← citeshttps://doi.org/10.1002/etc.5176openalex-snapshot
Interactive Metal Mixture Toxicity to Daphnia magna Populations as an Emergent Property in a Dynamic Energy Budget Individual-Based Model
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Comparison of Species Sensitivity Distributions for Sediment-Associated Nonionic Organic Chemicals Through Equilibrium Partitioning Theory and Spiked-Sediment Toxicity Tests with Invertebrates
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TWAc-Check: A New Approach to Determine the Appropriate Use of Time-Weighted Average Concentration in Aquatic Risk Assessment
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Fish Species Sensitivity Ranking Depends on Pesticide Exposure Profiles
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Predicting Combined Effects of Chemical Stressors: Population-Level Effects of Organic Chemical Mixtures with a Dynamic Energy Budget Individual-Based Model
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BeeGUTS—A Toxicokinetic–Toxicodynamic Model for the Interpretation and Integration of Acute and Chronic Honey Bee Tests
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The Capacity of Freshwater Ecosystems to Recover from Exceedences of Aquatic Life Criteria
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Modeling Time-Dependent Aquatic Toxicity of Hydrocarbons: Role of Organism Weight, Temperature, and Substance Hydrophobicity
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Variation of Tolerance to Isothiazolinones Among Daphnia pulex Clones
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Investigating Population-Level Toxicity of the Antidepressant Citalopram in Harpacticoid Copepods Using In Vivo Methods and Bioenergetics-Based Population Modeling
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A Framework for Algae Modeling in Regulatory Risk Assessment
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Connecting Suborganismal Data to Bioenergetic Processes: Killifish Embryos Exposed to a Dioxin-Like Compound
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A Toxicokinetic–Toxicodynamic Modeling Workflow Assessing the Quality of Input Mortality Data
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Extrapolating Metal (Cu, Ni, Zn) Toxicity from Individuals to Populations Across Daphnia Species Using Mechanistic Models: The Roles of Uncertainty Propagation and Combined Physiological Modes of Action
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A Review of Mechanistic Models for Predicting Adverse Effects in Sediment Toxicity Testing
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In Silico Acute Aquatic Hazard Assessment and Prioritization Using a Grouped Target Site Model: A Case Study of Organic Substances Reported in Permian Basin Hydraulic Fracturing Operations
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Identifying and Predicting Delayed Mortality with Toxicokinetic–Toxicodynamic Models
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Biotic Ligand Modeling for the Effect of Major Cations on the Uptake of Cadmium in Folsomia candida Exposed in a Sand-Solution Medium
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Comparing Sensitivity of Different Bee Species to Pesticides: A TKTD modeling approach
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The Importance of Including Variable Exposure Concentrations When Assessing Toxicity of Sediment-Associated Pharmaceuticals to an Amphipod
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Population Modeling in Metal Risk Assessment: Extrapolation of Toxicity Tests to the Population Level
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Advancing Soil Risk Assessment: A Novel Earthworm Cocoon Test with a Complementary Toxicokinetic–Toxicodynamic Modeling Approach
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SolBeePopecotox: A Population Model for Pesticide Risk Assessments of Solitary Bees
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Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: A brief discussion of concepts
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Bad habits die hard: The NOEC's persistence reflects poorly on ecotoxicology
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Influence of exposure and toxicokinetics on measures of aquatic toxicity for organic contaminants: A case study review
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Highly time-variable exposure to chemicals—toward an assessment strategy
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Draft DG SANCO document: Addressing the new challenges for risk assessment—an industry perspective
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Priorities to improve the ecological risk assessment and management for pesticides in surface water
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The use of traits-based approaches and eco(toxico)logical models to advance the ecological risk assessment framework for chemicals
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Assessing pesticide risks to threatened and endangered species using population models: Findings and recommendations from a CropLife America Science Forum
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Using toxicokinetic-toxicodynamic modeling as an acute risk assessment refinement approach in vertebrate ecological risk assessment
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Population-level effects and recovery of aquatic invertebrates after multiple applications of an insecticide
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How to use mechanistic effect models in environmental risk assessment of pesticides: Case studies and recommendations from the SETAC workshop MODELINK
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How TK-TD and population models for aquatic macrophytes could support the risk assessment for plant protection products
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Assessing the relevance of ecotoxicological studies for regulatory decision making
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How to Evaluate the Quality of Toxicokinetic—Toxicodynamic Models in the Context of Environmental Risk Assessment
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Predictive Models in Ecotoxicology: Bridging the Gap Between Scientific Progress and Regulatory Applicability
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Fit Reduced GUTS Models Online: From Theory to Practice
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Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment
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Short-term to long-term extrapolation of lethal effects of an herbicide on the marine mysid shrimp Americamysis Bahia by use of the General Unified Threshold Model of Survival (GUTS)
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Predictive models in ecotoxicology: Bridging the gap between scientific progress and regulatory applicability—Remarks and research needs
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Application of General Unified Threshold Models of Survival Models for Regulatory Aquatic Pesticide Risk Assessment Illustrated with an Example for the Insecticide Chlorpyrifos
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Robust Likelihood-Based Approach for Automated Optimization and Uncertainty Analysis of Toxicokinetic-Toxicodynamic Models
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Mechanistic Effect Modeling of Earthworms in the Context of Pesticide Risk Assessment: Synthesis of the FORESEE Workshop
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Comparison of two modeling frameworks for unifying the toxicant-affected percentage of aquatic species, individuals, and time into a single metric
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Uncertainty analysis and updated user guidance for interspecies correlation estimation models and low toxicity compounds
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Proposal for a tiered regulatory framework for the aquatic risk assessment of pesticides in Brazil
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Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus
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Pesticide exposure assessment for surface waters in the EU . Part 2: Determination of statistically based run‐off and drainage scenarios for Germany
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Assessment of acute toxicity tests and rhizotron experiments to characterize lethal and sublethal control of soil‐based pests
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Prospective Environmental Risk Assessment for Sediment-Bound Organic Chemicals: A Proposal for Tiered Effect Assessment
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Bioaccumulation and Toxicity of Organic Chemicals in Terrestrial Invertebrates
inferred← citeshttps://doi.org/10.1007/978-1-0716-1960-5_23openalex-snapshot
In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives
inferred← citeshttps://doi.org/10.1007/978-3-319-66084-4_14openalex-snapshot
Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model
inferred← citeshttps://doi.org/10.1007/978-3-319-66084-4_6openalex-snapshot
Non-model Species in Ecological Risk Assessment
inferred← citeshttps://doi.org/10.1007/978-981-13-9447-8_16openalex-snapshot
Transforming Environmental Chemistry and Toxicology to Meet the Anthropocene Sustainability Challenges Beyond Silent Spring
inferred← citeshttps://doi.org/10.1007/s00128-020-02807-yopenalex-snapshot
Comparison Among Test Substrates in Metal Uptake and Toxicity to Folsomia candida and Hordeum vulgare
inferred← citeshttps://doi.org/10.1007/s00244-015-0129-8openalex-snapshot
Ammonia Toxicity to the Freshwater Planarian Polycelis felina: Contrasting Effects of Continuous Versus Discontinuous Exposures
inferred← citeshttps://doi.org/10.1007/s00244-015-0186-zopenalex-snapshot
Erratum to: Ammonia Toxicity to the Freshwater Planarian Polycelis felina: Contrasting Effects of Continuous Versus Discontinuous Exposures
inferred← citeshttps://doi.org/10.1007/s00244-017-0407-8openalex-snapshot
Cadmium Compartmentalization in the Pulmonate Snail Lymnaea stagnalis: Improving Our Understanding of Exposure
inferred← citeshttps://doi.org/10.1007/s00244-021-00908-1openalex-snapshot
Assessing the Relative Toxicity of Different Road Salts and Effect of Temperature on Salinity Toxicity: LCx Values versus No-Effect Concentration (NEC) Values
inferred← citeshttps://doi.org/10.1007/s00244-022-00950-7openalex-snapshot
Extrapolating Contaminant Effects from Individuals to Populations: A Case Study on Nanoparticle Toxicity to Daphnia Fed Environmentally Relevant Food Levels
inferred← citeshttps://doi.org/10.1007/s00244-022-00963-2openalex-snapshot
Physiological Dependency Explains Temperature Differences in Sensitivity Towards Chemical Exposure
inferred← citeshttps://doi.org/10.1007/s10201-017-0522-2openalex-snapshot
Lower sensitivity of cyprinid fishes to three acetylcholinesterase inhibitor pesticides: an evaluation based on no-effect concentrations
inferred← citeshttps://doi.org/10.1007/s10646-011-0810-2openalex-snapshot
Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic
inferred← citeshttps://doi.org/10.1007/s10646-012-0917-0openalex-snapshot
Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
inferred← citeshttps://doi.org/10.1007/s10646-012-1027-8openalex-snapshot
Dynamic bioavailability of copper in soil estimated by uptake and elimination kinetics in the springtail Folsomia candida
inferred← citeshttps://doi.org/10.1007/s10646-013-1047-zopenalex-snapshot
A toxicokinetic model for thiamethoxam in rats: implications for higher-tier risk assessment
inferred← citeshttps://doi.org/10.1007/s10646-013-1149-7openalex-snapshot
Reconsidering sufficient and optimal test design in acute toxicity testing
inferred← citeshttps://doi.org/10.1007/s10646-014-1413-5openalex-snapshot
Sensitivity of animals to chemical compounds links to metabolic rate
inferred← citeshttps://doi.org/10.1007/s10646-015-1479-8openalex-snapshot
Population level effects of multiwalled carbon nanotubes in Daphnia magna exposed to pulses of triclocarban
inferred← citeshttps://doi.org/10.1007/s10646-017-1763-xopenalex-snapshot
Toxicodynamic modeling of zebrafish larvae to metals using stochastic death and individual tolerance models: comparisons of model assumptions, parameter sensitivity and predictive performance
inferred← citeshttps://doi.org/10.1007/s10646-018-1940-6openalex-snapshot
Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates
inferred← citeshttps://doi.org/10.1007/s10646-024-02790-8openalex-snapshot
Effects of α-olefin sulfonate (AOS) on Tubifex tubifex: toxicodynamic-toxicokinetic inferences from the general unified threshold (GUTS) model, biomarker responses and molecular docking predictions
inferred← citeshttps://doi.org/10.1007/s10646-024-02796-2openalex-snapshot
Arctic copepod copper sensitivity and comparison with Antarctic and temperate copepods
inferred← citeshttps://doi.org/10.1007/s10695-026-01790-1openalex-snapshot
The price of protection: an integrated toxicological and modelling assessment of flubendiamide exposure in Anabas testudineus
inferred← citeshttps://doi.org/10.1007/s11356-014-2605-5openalex-snapshot
The ChimERA project: coupling mechanistic exposure and effect models into an integrated platform for ecological risk assessment
inferred← citeshttps://doi.org/10.1007/s11356-018-2065-4openalex-snapshot
Biochemical and life cycle effects of triclosan chronic toxicity to earthworm Eisenia fetida
inferred← citeshttps://doi.org/10.1007/s11356-019-04423-8openalex-snapshot
Exploring inter-species sensitivity to a model hydrocarbon, 2-Methylnaphtalene, using a process-based model
inferred← citeshttps://doi.org/10.1007/s11356-022-19111-3openalex-snapshot
A critical review of effect modeling for ecological risk assessment of plant protection products
inferred← citeshttps://doi.org/10.1007/s11356-024-34595-xopenalex-snapshot
Benzalkonium chloride induced acute toxicity and its multifaceted implications on growth, hematological metrics, biochemical profiles, and stress-responsive biomarkers in tilapia (Oreochromis mossambicus)
inferred← citeshttps://doi.org/10.1007/s11783-026-2286-6openalex-snapshot
Mechanistic understanding of emerging contaminant toxicity in plants through the adverse outcome pathway framework
inferred← citeshttps://doi.org/10.1007/s12595-026-00618-3openalex-snapshot
Integrated Toxicodynamic and Computational Modeling Approaches to Assess the Aquatic Toxicity of Cypermethrin and Spinosad in Cyprinus carpio: A GUTS, QSAR and Molecular Docking Study
inferred← citeshttps://doi.org/10.1007/s41742-022-00443-4openalex-snapshot
Nitrate-Induced Toxicity and Potential Attenuation of Behavioural and Stress Biomarkers in Tubifex tubifex
inferred← citeshttps://doi.org/10.1007/s41742-025-00836-1openalex-snapshot
Biopesticide (Azadirachtin) as a Sustainable Alternative to Conventional Pesticides (Chlorpyrifos and λ-Cyhalothrin) for Mosquito Control in the Dengue Vector, Aedes aegypti: Insights from Physiological, Histopathological and Molecular Docking Analyses
inferred← citeshttps://doi.org/10.1007/s43538-025-00389-zopenalex-snapshot
Acute oxybenzone exposure induces behavioural, histological and haematological responses in Labeo rohita (Hamilton, 1822) fingerlings
inferred← citeshttps://doi.org/10.1007/s44169-025-00085-5openalex-snapshot
Chemical Ecological Risk Assessment for Aquatic Life Under Climate Change: A Review from Occurrence, Bioaccumulation, and Toxicity Perspective
inferred← citeshttps://doi.org/10.1016/b978-0-12-800949-9.00012-7openalex-snapshot
Copepods as References Species in Estuarine and Marine Waters
inferred← citeshttps://doi.org/10.1016/b978-0-12-803371-5.00002-3openalex-snapshot
Contemporary Methods for Statistical Design and Analysis
inferred← citeshttps://doi.org/10.1016/b978-0-12-803371-5.00003-5openalex-snapshot
Dynamic Modeling for Uptake and Effects of Chemicals
inferred← citeshttps://doi.org/10.1016/b978-0-12-824467-8.00007-3openalex-snapshot
Toxicodynamics of phytonutrients
inferred← citeshttps://doi.org/10.1016/b978-0-323-98367-9.00023-8openalex-snapshot
Principles and concepts in toxicokinetic
inferred← citeshttps://doi.org/10.1016/b978-0-443-15976-3.00148-3openalex-snapshot
Advances in pesticide risk reduction
inferred← citeshttps://doi.org/10.1016/b978-0-444-52512-3.00242-4openalex-snapshot
Advances in Pesticide Risk Reduction
inferred← citeshttps://doi.org/10.1016/bs.acc.2025.06.005openalex-snapshot
Metabolomics of heavy metal exposure
inferred← citeshttps://doi.org/10.1016/bs.fp.2022.06.002openalex-snapshot
Using ecotoxicology for conservation: From biomarkers to modeling
inferred← citeshttps://doi.org/10.1016/j.agsy.2020.102865openalex-snapshot
A knowledge-based approach to designing control strategies for agricultural pests
inferred← citeshttps://doi.org/10.1016/j.apsoil.2023.104880openalex-snapshot
High sensitivity to dietary imidacloprid exposure in early life stages of Folsomia quadrioculata (Collembola) populations from contrasting climates
inferred← citeshttps://doi.org/10.1016/j.aquatox.2011.11.016openalex-snapshot
Macroinvertebrate community response to repeated short-term pulses of the insecticide imidacloprid
inferred← citeshttps://doi.org/10.1016/j.aquatox.2015.09.005openalex-snapshot
Prediction of acute toxicity of cadmium and lead to zebrafish larvae by using a refined toxicokinetic-toxicodynamic model
inferred← citeshttps://doi.org/10.1016/j.aquatox.2015.12.007openalex-snapshot
What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?
inferred← citeshttps://doi.org/10.1016/j.aquatox.2016.12.009openalex-snapshot
Photosynthetic efficiency predicts toxic effects of metal nanomaterials in phytoplankton
inferred← citeshttps://doi.org/10.1016/j.aquatox.2019.02.018openalex-snapshot
Predicting the toxic effects of Cu and Cd on Chlamydomonas reinhardtii with a DEBtox model
inferred← citeshttps://doi.org/10.1016/j.aquatox.2020.105481openalex-snapshot
Conventional and nano-copper pesticides are equally toxic to the estuarine amphipod Leptocheirus plumulosus
inferred← citeshttps://doi.org/10.1016/j.aquatox.2021.105837openalex-snapshot
The toxicity and toxicokinetics of imidacloprid and a bioactive metabolite to two aquatic arthropod species
inferred← citeshttps://doi.org/10.1016/j.aquatox.2021.106015openalex-snapshot
Development of a toxicokinetic-toxicodynamic model simulating chronic copper toxicity to the Zebra mussel based on subcellular fractionation
inferred← citeshttps://doi.org/10.1016/j.aquatox.2022.106389openalex-snapshot
Bridging the lab to field divide: Advancing oil spill biological effects models requires revisiting aquatic toxicity testing
inferred← citeshttps://doi.org/10.1016/j.aquatox.2025.107489openalex-snapshot
Application of TKTD models in predicting time-resolved bioaccumulation and toxicity of pesticides to aquatic organisms
inferred← citeshttps://doi.org/10.1016/j.aquatox.2025.107559openalex-snapshot
Model-based refinement of metal water quality criteria: Advances in biotic ligand model, multiple linear regression, and toxicokinetic-toxicodynamic approaches
inferred← citeshttps://doi.org/10.1016/j.aquatox.2026.107802openalex-snapshot
A DEB–TKTD model for assessing the combined effects of imidacloprid, temperature and food availability on aquatic insects
inferred← citeshttps://doi.org/10.1016/j.cbpc.2021.109164openalex-snapshot
λ cyhalothrin induced toxicity and potential attenuation of hematological, biochemical, enzymological and stress biomarkers in Cyprinus carpio L. at environmentally relevant concentrations: A multiple biomarker approach
inferred← citeshttps://doi.org/10.1016/j.cbpc.2022.109450openalex-snapshot
Behavioral and physiological toxicity thresholds of a freshwater vertebrate (Heteropneustes fossilis) and invertebrate (Branchiura sowerbyi), exposed to zinc oxide nanoparticles (nZnO): A General Unified Threshold model of Survival (GUTS)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2012.04.021openalex-snapshot
Individual sensitivity distribution evaluation from survival data using a mechanistic model: Implications for ecotoxicological risk assessment
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2012.05.074openalex-snapshot
Time-related survival effects of two gluconasturtiin hydrolysis products on the terrestrial isopod Porcellio scaber
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2013.01.076openalex-snapshot
Life-stage-dependent sensitivity of the cyclopoid copepod Mesocyclops leuckarti to triphenyltin
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2014.04.062openalex-snapshot
Ecological interactions affecting population-level responses to chemical stress in Mesocyclops leuckarti
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2014.09.068openalex-snapshot
Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2014.12.034openalex-snapshot
A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2016.11.122openalex-snapshot
Causes of highway road dust toxicity to an estuarine amphipod: Evaluating the effects of nicotine
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2018.08.102openalex-snapshot
Effects of environmentally relevant concentrations of tris (2-butoxyethyl) phosphate on growth and transcription of genes involved in the GH/IGF and HPT axes in zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2018.10.146openalex-snapshot
Effect of soil properties on Pb bioavailability and toxicity to the soil invertebrate Enchytraeus crypticus
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2018.12.197openalex-snapshot
Toxicokinetic and toxicodynamic (TK-TD) modeling to study oxidative stress-dependent toxicity of heavy metals in zebrafish
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2019.02.102openalex-snapshot
Predicting the survival of zebrafish larvae exposed to fluctuating pulses of lead and cadmium
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2020.129433openalex-snapshot
Toxicokinetics of copper and cadmium in the soil model Enchytraeus crypticus (Oligochaeta)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.131930openalex-snapshot
Delineation of the exposure-response causality chain of chronic copper toxicity to the zebra mussel, Dreissena polymorpha, with a TK-TD model based on concepts of biotic ligand model and subcellular metal partitioning model
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.134042openalex-snapshot
Exposures to deltamethrin on immature Chironomus columbiensis drive sublethal and transgenerational effects on their reproduction and wing morphology
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.135959openalex-snapshot
The amphipod Parhyale hawaiensis as a promising model in ecotoxicology
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.136482openalex-snapshot
Subcellular localization and compartment-specific toxicokinetics of cadmium, arsenic, and zinc in brandling worm Eisenia fetida
inferred← citeshttps://doi.org/10.1016/j.cotox.2017.07.003openalex-snapshot
Quantitative systems toxicology
inferred← citeshttps://doi.org/10.1016/j.cris.2024.100089openalex-snapshot
Acclimation temperature influences the thermal sensitivity of injury accumulation in Folsomia candida at extreme low and high temperatures
inferred← citeshttps://doi.org/10.1016/j.crmicr.2025.100442openalex-snapshot
Gut microbial communities in chronic rhinosinusitis patients in response to 1,8-Cineol treatment
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2011.08.006openalex-snapshot
Comparison of bioassays with different exposure time patterns: The added value of dynamic modelling in predictive ecotoxicology
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2014.01.036openalex-snapshot
Effects of cadmium and lead on the life-cycle parameters of juvenile earthworm Eisenia fetida
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2016.11.011openalex-snapshot
Combined effect of temperature and ammonia on molecular response and survival of the freshwater crustacean Gammarus pulex
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2017.12.040openalex-snapshot
Development of multi-metal interaction model for Daphnia magna : Significance of metallothionein in cellular redistribution
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2018.10.084openalex-snapshot
A combined toxicokinetics and toxicodynamics approach to investigate delayed lead toxicity in the soil invertebrate Enchytraeus crypticus
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.05.022openalex-snapshot
Exposure pattern-specific species sensitivity distributions for the ecological risk assessments of insecticides.
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.05.045openalex-snapshot
Gill damage and delayed mortality of Northern shrimp (Pandalus borealis) after short time exposure to anti-parasitic veterinary medicine containing hydrogen peroxide
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.111043openalex-snapshot
A biological characteristic extrapolation of compound toxicity for different developmental stage species with toxicokinetic-toxicodynamic model
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.111215openalex-snapshot
When the average hides the risk of Bt-corn pollen on non-target Lepidoptera: Application to Aglais io in Catalonia
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.111788openalex-snapshot
Understanding the effects of metal pre-exposure on the sensitivity of zebrafish larvae to metal toxicity: A toxicokinetics–toxicodynamics approach
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.112212openalex-snapshot
Issues, challenges, directives, and limitations concerning the improvement of environmental risk assessment of pharmaceutically active compounds
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113907openalex-snapshot
Drivers of copper sensitivity in copepods: A meta-analysis of LC50s
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113917openalex-snapshot
Size- and sex-related sensitivity differences of aquatic crustaceans to imidacloprid
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113977openalex-snapshot
Comparing the acute and chronic toxicity of flupyradifurone and imidacloprid to non-target aquatic arthropod species
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.114499openalex-snapshot
Modelling the effects of the pyrethroid insecticide cypermethrin on the life cycle of the soil dwelling annelid Enchytraeus crypticus, an original experimental design to calibrate a DEB-TKTD model
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.114504openalex-snapshot
A Novel Lepidoptera bioassay analysed using a reduced GUTS model
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.114599openalex-snapshot
Toxicokinetics and toxicodynamics of Ag nanomaterials (NM300K) in the soil environment–impact on Enchytraeus crypticus (Oligochaeta)
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115250openalex-snapshot
Physiological variables in machine learning QSARs allow for both cross-chemical and cross-species predictions
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.116355openalex-snapshot
Modeling temperature-dependent life-cycle toxicity of thiamethoxam in Chironomus riparius using a DEB-TKTD model
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117062openalex-snapshot
Bee sensitivity derived from acute contact tests biased by standardised protocols?
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120240openalex-snapshot
Daily temperature fluctuation exacerbates phenanthrene toxicity in Enchytraeus albidus: Links between membrane remodeling, lipid reserves, and reproduction
inferred← citeshttps://doi.org/10.1016/j.ecofro.2024.11.011openalex-snapshot
Effects of pesticides on fish: An overview of evolution of bioassays and cutting edge technologies
inferred← citeshttps://doi.org/10.1016/j.ecolind.2016.03.038openalex-snapshot
Hill coefficient-based stochastic switch-like signal directly governs damage-recovery dynamics in freshwater fish in response to pulse copper
inferred← citeshttps://doi.org/10.1016/j.ecolind.2023.109987openalex-snapshot
Hypoxia is common in temperate headwaters and driven by hydrological extremes
inferred← citeshttps://doi.org/10.1016/j.ecolind.2024.113049openalex-snapshot
Time dependence effect of metal toxicology and application in WQC derivation of main water basins in China
inferred← citeshttps://doi.org/10.1016/j.ecolmodel.2011.11.012openalex-snapshot
Simplified Dynamic Energy Budget model for analysing ecotoxicity data
inferred← citeshttps://doi.org/10.1016/j.ecolmodel.2013.06.018openalex-snapshot
Coupling different mechanistic effect models for capturing individual- and population-level effects of chemicals: Lessons from a case where standard risk assessment failed
inferred← citeshttps://doi.org/10.1016/j.ecolmodel.2013.09.007openalex-snapshot
Incorporating toxicokinetics into an individual-based model for more realistic pesticide exposure estimates: A case study of the wood mouse
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