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Acid-Promoted DNA-Cleaving Activities and Total Synthesis of Varacin C

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Sodium nitroprusside-induced seizure and taurine release from rat hippocampus
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Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus
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First example of intramolecular photochemical oxygen migration from benzotrithiole 2-oxides to benzotrithiole 1-oxides
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First systematic synthesis and electrochemical oxidation of 4,7-diisopropyl-1,2,3-benzotrichalcogenoles containing both sulfur and selenium atoms
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Prodrug strategies in cancer therapy
inferredcites →https://doi.org/10.1016/s0960-894x(98)00066-3openalex-snapshot
DNA cleavage by 7-methylbenzopentathiepin: A simple analog of the antitumor antibiotic varacin
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Causes and consequences of tumour acidity and implications for treatment
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Superoxide radical and superoxide dismutase
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1,2-Dithiolan-3-one 1-Oxides: A Class of Thiol-Activated DNA-Cleaving Agents That Are Structurally Related to the Natural Product Leinamycin
inferredcites →https://doi.org/10.1021/ja00012a065openalex-snapshot
Varacin: a novel benzopentathiepin from Lissoclinum vareau that is cytotoxic toward a human colon tumor
inferredcites →https://doi.org/10.1021/ja00012a066openalex-snapshot
Isolation of a new series of seven-coordinate hydride compounds of tantalum(V) and their involvement in the catalytic hydrogenation of arene rings
inferredcites →https://doi.org/10.1021/ja00068a087openalex-snapshot
Total synthesis of the novel benzopentathiepin varacinium trifluoroacetate: the viability of "varacin-free base"
inferredcites →https://doi.org/10.1021/ja00132a033openalex-snapshot
A New Route to the Synthesis of the Naturally Occurring Benzopentathiepin Varacin
inferredcites →https://doi.org/10.1021/ja003309ropenalex-snapshot
Thiol-Independent DNA Alkylation by Leinamycin
inferredcites →https://doi.org/10.1021/ja971359zopenalex-snapshot
Oxidative DNA Cleavage by the Antitumor Antibiotic Leinamycin and Simple 1,2-Dithiolan-3-one 1-Oxides: Evidence for Thiol-Dependent Conversion of Molecular Oxygen to DNA-Cleaving Oxygen Radicals Mediated by Polysulfides
inferredcites →https://doi.org/10.1021/np50116a015openalex-snapshot
Varacin and Three New Marine Antimicrobial Polysulfides from the Far-Eastern Ascidian Polycitorsp.
inferredcites →https://doi.org/10.1021/tx000089mopenalex-snapshot
Mechanisms of DNA Damage by Leinamycin
inferredcites →https://doi.org/10.1172/jci107963openalex-snapshot
Catalase, superoxide dismutase, and virulence of Staphylococcus aureus. In vitro and in vivo studies with emphasis on staphylococcal--leukocyte interaction.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Liposomal formulation of model pentathiepin improves solubility and stability toward glutathione while preserving anticancer activity
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Structure‐activity‐relationships of the Stability of Six Pentathiepins Towards Glutathione: Possible Correlations with Biological Activities
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Oxidation of cyclic polysulfides fused to aromatics
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inferred← citeshttps://doi.org/10.1007/s00044-016-1759-8openalex-snapshot
Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins
inferred← citeshttps://doi.org/10.1007/s00213-011-2594-8openalex-snapshot
A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice
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Disulfide and multisulfide antitumor agents and their modes of action
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PEG-mediated one-pot multicomponent reactions for the efficient synthesis of functionalized dihydropyridines and their functional group dependent DNA cleavage activity
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107791openalex-snapshot
Synthesis and bioactivity evaluation of glycosylated resveratrol derivatives as antioxidative neuroprotection agents against cerebral Ischemia-Reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.02.059openalex-snapshot
Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.12.011openalex-snapshot
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA
inferred← citeshttps://doi.org/10.1016/j.bmcl.2005.02.003openalex-snapshot
DNA photocleavage and biological activity of a pyrene dihydrodioxin
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.02.072openalex-snapshot
DNA cleavage promoted by 2,9-dimethyl-4,7-diazadecane-2,9-dithiol (DDD) derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.05.015openalex-snapshot
Linear disulfide-containing low polymer as efficient DNA cleavage reagent
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.05.005openalex-snapshot
Conformational organizations of G-quadruplexes composed of d(G4T )3G4
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.04.003openalex-snapshot
The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product
inferred← citeshttps://doi.org/10.1016/j.cclet.2009.03.049openalex-snapshot
DNA cleavage promoted by diethylenetriaminepentaacetic acid (DTPA) derivatives
inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2015.07.023openalex-snapshot
Synthesis and antiproliferative properties of a new ceramide analog of varacin
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Naphthalimide–thiazoles as novel photonucleases: molecular design, synthesis, and evaluation
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Amine-catalyzed preparation of oxygenated derivatives of symmetric trisulfides
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Natural Products with Heteroatom-Rich Ring Systems
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Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms
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C-Lysine Conjugates: pH-Controlled Light-Activated Reagents for Efficient Double-Stranded DNA Cleavage with Implications for Cancer Therapy
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A Very Active Cu-Catalytic System for the Synthesis of Aryl, Heteroaryl, and Vinyl Sulfides
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Efficient Copper-Catalyzed S-Vinylation of Thiols with Vinyl Halides
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Control of Oxidative Posttranslational Cysteine Modifications: From Intricate Chemistry to Widespread Biological and Medical Applications
inferred← citeshttps://doi.org/10.1038/s41401-018-0005-yopenalex-snapshot
Varacin-1, a novel analog of varacin C, induces p53-independent apoptosis in cancer cells through ROS-mediated reduction of XIAP
inferred← citeshttps://doi.org/10.1039/b609523mopenalex-snapshot
A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms
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Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent
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Microwave-promoted regio- and stereoselective vinylation of heterocyclic thiols
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13.32 Product Class 32: 1,2,3-Trithioles, Their Benzo Derivatives, and Selenium and Tellurium Analogues
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Effect of a new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in the mouse brain
inferred← citeshttps://doi.org/10.1134/s1070428009090140openalex-snapshot
Asymmetric oxidation of 4-nitro-6-trifluoromethyl-1,2,3-benzotrithiole
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Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)
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Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action
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Bioactive Nitrogenous Metabolites from Ascidians
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