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Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis

https://doi.org/10.1021/ja303004g
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte
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inferredcites →https://doi.org/10.1021/ja061469iopenalex-snapshot
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inferredcites →https://doi.org/10.1038/nchem.764openalex-snapshot
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inferredcites →https://doi.org/10.1039/b909987popenalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.0337542100openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.0337625100openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.1106919108openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.201399298openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.211433198openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m109.064683openalex-snapshot
Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site
inferredcites →https://doi.org/10.1074/jbc.m205621200openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m506689200openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m710421200openalex-snapshot
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inferredcites →https://doi.org/10.1093/emboj/cdg275openalex-snapshot
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A subfamily of MalT-related ATP-dependent regulators in the LuxR family
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inferredcites →https://doi.org/10.1128/aem.05780-11openalex-snapshot
New Nystatin-Related Antifungal Polyene Macrolides with Altered Polyol Region Generated via Biosynthetic Engineering of Streptomyces noursei
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A Relationship between the Mevalonate Pathway and Isoprenoid Production in Actinomycetes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems
inferred← citeshttps://doi.org/10.1039/c3np70047jopenalex-snapshot
Natural sesquiterpenoids
inferred← citeshttps://doi.org/10.1039/c3np70067dopenalex-snapshot
Sesquiterpenyl indoles
inferred← citeshttps://doi.org/10.1039/c3np70117dopenalex-snapshot
Marine natural products
inferred← citeshttps://doi.org/10.1039/c4np00121dopenalex-snapshot
A twist of nature – the significance of atropisomers in biological systems
inferred← citeshttps://doi.org/10.1039/c5qo00416kopenalex-snapshot
A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces
inferred← citeshttps://doi.org/10.1039/c6sc03875aopenalex-snapshot
Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
inferred← citeshttps://doi.org/10.1039/c7cs00458copenalex-snapshot
Synthetic and biosynthetic routes to nitrogen–nitrogen bonds
inferred← citeshttps://doi.org/10.1039/c7sc01182bopenalex-snapshot
Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification
inferred← citeshttps://doi.org/10.1039/c9np00051hopenalex-snapshot
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
inferred← citeshttps://doi.org/10.1039/c9np00062copenalex-snapshot
Natural disesquiterpenoids: an update
inferred← citeshttps://doi.org/10.1039/d0np00056fopenalex-snapshot
Chemistry of fungal meroterpenoid cyclases
inferred← citeshttps://doi.org/10.1039/d0np00066copenalex-snapshot
Bacterial terpenome
inferred← citeshttps://doi.org/10.1039/d0ob02162hopenalex-snapshot
The chemistry and biology of fungal meroterpenoids (2009–2019)
inferred← citeshttps://doi.org/10.1039/d1cc04739fopenalex-snapshot
Enantioselective first total syntheses of the antiviral natural products xiamycins D and E
inferred← citeshttps://doi.org/10.1039/d1ob02115jopenalex-snapshot
Electrocatalysis as a key strategy for the total synthesis of natural products
inferred← citeshttps://doi.org/10.1039/d2sc03479dopenalex-snapshot
Total syntheses of naturally occurring antiviral indolosesquiterpene alkaloids, xiamycins C–F via Csp 3 –H functionalization
inferred← citeshttps://doi.org/10.1039/d2sc07119copenalex-snapshot
Total synthesis of atropisomeric indolosesquiterpenoids via N–N bond formation: dixiamycins A and B
inferred← citeshttps://doi.org/10.1039/d4cc03070bopenalex-snapshot
Total synthesis of (+)-oridamycins A and B
inferred← citeshttps://doi.org/10.1039/d4np00048jopenalex-snapshot
The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis
inferred← citeshttps://doi.org/10.1039/d4qo01773kopenalex-snapshot
Highly regioselective oxidative Csp 2 –H amination for indolosesquiterpene alkaloids: total synthesis of (+)-dioridamycin
inferred← citeshttps://doi.org/10.1039/d4ra01834fopenalex-snapshot
Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review
inferred← citeshttps://doi.org/10.1039/d4sc01396dopenalex-snapshot
Highly chemoselective oxidative dimerization of indolosesquiterpene alkaloids: a biomimetic approach to dixiamycin
inferred← citeshttps://doi.org/10.1039/d4sc08319aopenalex-snapshot
Biosynthesis of the tetrahydroxynaphthalene-derived meroterpenoid furaquinocin via reductive deamination and intramolecular hydroalkoxylation of an alkene
inferred← citeshttps://doi.org/10.1039/d5np00011dopenalex-snapshot
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity
inferred← citeshttps://doi.org/10.1093/jimb/kuab001openalex-snapshot
Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete
inferred← citeshttps://doi.org/10.1099/ijsem.0.007269openalex-snapshot
Actinopolyspora sabaoui sp. nov., a novel halophilic actinobacterium isolated from Ghardaïa soil, Algeria
inferred← citeshttps://doi.org/10.1111/1751-7915.14382openalex-snapshot
Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery
inferred← citeshttps://doi.org/10.1128/aem.00600-24openalex-snapshot
Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity
inferred← citeshttps://doi.org/10.1134/s1070428013020012openalex-snapshot
Advances in the synthesis of cycloalka[b]indoles
inferred← citeshttps://doi.org/10.3390/biom10081147openalex-snapshot
Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes
inferred← citeshttps://doi.org/10.3390/md11062113openalex-snapshot
Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428
inferred← citeshttps://doi.org/10.3390/md12052590openalex-snapshot
Natural Products from Mangrove Actinomycetes
inferred← citeshttps://doi.org/10.3390/md13084814openalex-snapshot
Marine Indole Alkaloids
inferred← citeshttps://doi.org/10.3390/md17040211openalex-snapshot
Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999
inferred← citeshttps://doi.org/10.3390/md20060404openalex-snapshot
Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents
inferred← citeshttps://doi.org/10.3390/ph16060872openalex-snapshot
Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents
inferred← citeshttps://doi.org/10.3390/toxins8070195openalex-snapshot
Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli
inferred← citeshttps://doi.org/10.3762/bjoc.22.21openalex-snapshot
Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis
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