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Reconstitution of Biosynthetic Machinery for Indole-Diterpene Paxilline in Aspergillus oryzae
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cbic.201000259openalex-snapshot
First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster
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Terretonin Biosynthesis Requires Methylation as Essential Step for Cyclization
inferredcites →https://doi.org/10.1007/s00438-003-0887-2openalex-snapshot
Molecular analysis of two cytochrome P450 monooxygenase genes required for paxilline biosynthesis in Penicillium paxilli, and effects of paxilline intermediates on mammalian maxi-K ion channels
inferredcites →https://doi.org/10.1007/s00438-005-1130-0openalex-snapshot
Molecular cloning and genetic analysis of a symbiosis-expressed gene cluster for lolitrem biosynthesis from a mutualistic endophyte of perennial ryegrass
inferredcites →https://doi.org/10.1016/j.febslet.2006.02.008openalex-snapshot
Four gene products are required for the fungal synthesis of the indole‐diterpene, paspaline
inferredcites →https://doi.org/10.1016/j.femsle.2004.08.025openalex-snapshot
Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae
inferredcites →https://doi.org/10.1016/j.phytochem.2009.03.019openalex-snapshot
Evolution of aromatic prenyltransferases in the biosynthesis of indole derivatives
inferredcites →https://doi.org/10.1016/s1389-1723(03)80153-6openalex-snapshot
dffA Gene from Aspergillus oryzae Encodes L-Ornithine N5-Oxygenase and Is Indispensable for Deferriferrichrysin Biosynthesis
inferredcites →https://doi.org/10.1021/bi00185a021openalex-snapshot
Tremorgenic Indole Alkaloids Potently Inhibit Smooth Muscle High-Conductance Calcium-Activated Potassium Channels
inferredcites →https://doi.org/10.1021/ja017183popenalex-snapshot
Biosynthesis of Nodulisporic Acid A: Precursor Studies
inferredcites →https://doi.org/10.1021/ja301386gopenalex-snapshot
Sequential Enzymatic Epoxidation Involved in Polyether Lasalocid Biosynthesis
inferredcites →https://doi.org/10.1021/ja303004gopenalex-snapshot
Identification and Characterization of Xiamycin A and Oxiamycin Gene Cluster Reveals an Oxidative Cyclization Strategy Tailoring Indolosesquiterpene Biosynthesis
inferredcites →https://doi.org/10.1021/jf00014a013openalex-snapshot
Synthesis and tremorgenicity of paxitriols and lolitriol: possible biosynthetic precursors of lolitrem B
inferredcites →https://doi.org/10.1021/np9004882openalex-snapshot
The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144
inferredcites →https://doi.org/10.1021/ol049115oopenalex-snapshot
Biosynthesis of Indole Diterpenes, Emindole, and Paxilline: Involvement of a Common Intermediate
inferredcites →https://doi.org/10.1038/ja.2007.83openalex-snapshot
A Novel Indole-diterpenoid, JBIR-03 with Anti-MRSA Activity from Dichotomomyces cejpii var. cejpii NBRC 103559
inferredcites →https://doi.org/10.1038/nchem.764openalex-snapshot
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
inferredcites →https://doi.org/10.1039/b909987popenalex-snapshot
Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
inferredcites →https://doi.org/10.1039/p19830001863openalex-snapshot
Tremorgenic mycotoxins from Penicillium crustosum. Biosynthesis of penitrem A
inferredcites →https://doi.org/10.1039/p19880002155openalex-snapshot
Studies on fungal products. Part 19. Isolation and structure of a novel indoloditerpene, emindole SA, from Emericella striata
inferredcites →https://doi.org/10.1046/j.1365-2958.2001.02265.xopenalex-snapshot
Molecular cloning and genetic analysis of an indole‐diterpene gene cluster from Penicillium paxilli
inferredcites →https://doi.org/10.1074/jbc.m701626200openalex-snapshot
Defining Paxilline Biosynthesis in Penicillium paxilli
inferredcites →https://doi.org/10.1128/aem.02146-08openalex-snapshot
Identification of Two Aflatrem Biosynthesis Gene Loci inAspergillus flavusand Metabolic Engineering ofPenicillium paxilliTo Elucidate Their Function
inferredcites →https://doi.org/10.1128/jb.180.10.2782-2787.1998openalex-snapshot
Menaquinone (Vitamin K 2 ) Biosynthesis: Localization and Characterization of the menA Gene from Escherichia coli
inferredcites →https://doi.org/10.1271/bbb.110366openalex-snapshot
Total Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α: Heterologous Expression of Four Biosynthetic Genes inAspergillus oryzae
inferredcites →https://doi.org/10.1271/bbb.59.1869openalex-snapshot
Cloning and Nucleotide Sequence of the Ribonuclease T1Gene (rntA) fromAspergillus oryzaeand Its Expression inSaccharomyces cerevisiaeandAspergillus oryzae
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem
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inferred← citeshttps://doi.org/10.1021/acs.orglett.2c00473openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/jacs.2c11170openalex-snapshot
Generation of Alternate Indole Diterpene Architectures in Two Species of Aspergilli
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Non-Canonical Type II Terpene Cyclases Deliver Rare Terpenoid Architectures
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Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids
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Total Synthesis of Paspaline A and Emindole PB Enabled by Computational Augmentation of a Transform-Guided Retrosynthetic Strategy
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Carbocyclization versus Oxycyclization on the Metal-Catalyzed Reactions of Oxyallenyl C3-Linked Indoles
inferred← citeshttps://doi.org/10.1021/ol503399bopenalex-snapshot
Elucidating the Cyclization Cascades in Xiamycin Biosynthesis by Substrate Synthesis and Enzyme Characterizations
inferred← citeshttps://doi.org/10.1038/nchem.2308openalex-snapshot
Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides
inferred← citeshttps://doi.org/10.1038/nchembio.2283openalex-snapshot
Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis
inferred← citeshttps://doi.org/10.1038/s41467-017-01659-1openalex-snapshot
Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives
inferred← citeshttps://doi.org/10.1038/s41467-020-15664-4openalex-snapshot
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
inferred← citeshttps://doi.org/10.1038/s41467-024-48771-7openalex-snapshot
Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining
inferred← citeshttps://doi.org/10.1038/s41570-023-00564-0openalex-snapshot
Engineered and total biosynthesis of fungal specialized metabolites
inferred← citeshttps://doi.org/10.1039/c4cc09512jopenalex-snapshot
Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis
inferred← citeshttps://doi.org/10.1039/c4np00073kopenalex-snapshot
Biosynthesis of fungal indole alkaloids
inferred← citeshttps://doi.org/10.1039/c4np00081aopenalex-snapshot
Unusual cyclic terpenoids with terminal pendant prenyl moieties: from occurrence to synthesis
inferred← citeshttps://doi.org/10.1039/c4np00084fopenalex-snapshot
Reconstructing fungal natural product biosynthetic pathways
inferred← citeshttps://doi.org/10.1039/c4np00099dopenalex-snapshot
Mechanistic studies on the indole prenyltransferases
inferred← citeshttps://doi.org/10.1039/c5np00090dopenalex-snapshot
Biosynthesis of fungal meroterpenoids
inferred← citeshttps://doi.org/10.1039/c5qo00416kopenalex-snapshot
A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces
inferred← citeshttps://doi.org/10.1039/c7sc01182bopenalex-snapshot
Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification
inferred← citeshttps://doi.org/10.1039/c8qo00756jopenalex-snapshot
Secopaxilline A, an indole-diterpenoid derivative from an aciduric Penicillium fungus, its identification and semisynthesis
inferred← citeshttps://doi.org/10.1039/c8qo01124aopenalex-snapshot
Genome mining for fungal polyketide-diterpenoid hybrids: discovery of key terpene cyclases and multifunctional P450s for structural diversification
inferred← citeshttps://doi.org/10.1039/c9np00051hopenalex-snapshot
Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
inferred← citeshttps://doi.org/10.1039/c9np00073aopenalex-snapshot
Total synthesis of alkaloids using both chemical and biochemical methods
inferred← citeshttps://doi.org/10.1039/c9ob00807aopenalex-snapshot
Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi
inferred← citeshttps://doi.org/10.1039/d0np00056fopenalex-snapshot
Chemistry of fungal meroterpenoid cyclases
inferred← citeshttps://doi.org/10.1039/d1np00062dopenalex-snapshot
Synthesis of rearranged indole diterpenes of the paxilline type
inferred← citeshttps://doi.org/10.1039/d2np00031hopenalex-snapshot
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host
inferred← citeshttps://doi.org/10.1039/d2np00041eopenalex-snapshot
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails
inferred← citeshttps://doi.org/10.1039/d2np00050dopenalex-snapshot
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining
inferred← citeshttps://doi.org/10.1039/d3np00033hopenalex-snapshot
Class II terpene cyclases: structures, mechanisms, and engineering
inferred← citeshttps://doi.org/10.1039/d4sc05963hopenalex-snapshot
Total biosynthesis of cotylenin diterpene glycosides as 14-3-3 protein–protein interaction stabilizers
inferred← citeshttps://doi.org/10.1039/d5ob01195gopenalex-snapshot
Genome mining reveals a highly oxidized bacterial perhydrophenanthrene meroterpenoid smelanic acid
inferred← citeshttps://doi.org/10.1039/d5sc02009copenalex-snapshot
An overlooked cyclase plays a central role in the biosynthesis of indole diterpenes
inferred← citeshttps://doi.org/10.1039/d6ra05338fopenalex-snapshot
ent -Kaurene, ent -kauran-16-ol, and shunted diterpenoids from an engineered strain of Aspergillus oryzae
inferred← citeshttps://doi.org/10.1073/pnas.1819254116openalex-snapshot
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum
inferred← citeshttps://doi.org/10.1080/09168451.2014.882759openalex-snapshot
A fungal prenyltransferase catalyzes the regular di-prenylation at positions 20 and 21 of paxilline
inferred← citeshttps://doi.org/10.1080/09168451.2015.1104234openalex-snapshot
Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host
inferred← citeshttps://doi.org/10.1080/09168451.2017.1399789openalex-snapshot
Subcellular localization of aphidicolin biosynthetic enzymes heterologously expressed in Aspergillus oryzae
inferred← citeshttps://doi.org/10.1080/09168451.2019.1606699openalex-snapshot
Production of the plant polyketide curcumin in Aspergillus oryzae: strengthening malonyl-CoA supply for yield improvement
inferred← citeshttps://doi.org/10.1080/09168451.2019.1618700openalex-snapshot
Elucidation of biosynthetic pathway of a plant hormone abscisic acid in phytopathogenic fungi
inferred← citeshttps://doi.org/10.1080/09168451.2019.1690976openalex-snapshot
Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts
inferred← citeshttps://doi.org/10.1080/14786419.2025.2553819openalex-snapshot
Research progress on isopentenyl compounds and their derivatives from marine sources
inferred← citeshttps://doi.org/10.1093/bbb/zbaa061openalex-snapshot
Recent advances in the total syntheses of indole diterpenoids
inferred← citeshttps://doi.org/10.1093/pcp/pcy138openalex-snapshot
Molecular Characterization of a Geranyl Diphosphate-Specific Prenyltransferase Catalyzing Stilbenoid Prenylation from Morus alba
inferred← citeshttps://doi.org/10.1111/1541-4337.12638openalex-snapshot
Chemical repertoire and biosynthetic machinery of the Aspergillus flavus secondary metabolome: A review
inferred← citeshttps://doi.org/10.1126/science.adt2096openalex-snapshot
Artificial farnesol epoxidase enables a concise synthesis of meroterpenoids
inferred← citeshttps://doi.org/10.1128/9781555819583.ch54openalex-snapshot
Biologically Active Secondary Metabolites from the Fungi
inferred← citeshttps://doi.org/10.1128/aem.00409-19openalex-snapshot
Ascomycete Aspergillus oryzae Is an Efficient Expression Host for Production of Basidiomycete Terpenes by Using Genomic DNA Sequences
inferred← citeshttps://doi.org/10.1128/aem.02496-13openalex-snapshot
Regiospecificities and Prenylation Mode Specificities of the Fungal Indole Diterpene Prenyltransferases AtmD and PaxD
inferred← citeshttps://doi.org/10.1128/microbiolspec.funk-0009-2016openalex-snapshot
Biologically Active Secondary Metabolites from the Fungi
inferred← citeshttps://doi.org/10.1186/s12864-015-1812-xopenalex-snapshot
Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation
inferred← citeshttps://doi.org/10.1186/s12896-019-0567-xopenalex-snapshot
Use of the kojA promoter, involved in kojic acid biosynthesis, for polyketide production in Aspergillus oryzae: implications for long-term production
inferred← citeshttps://doi.org/10.1186/s12934-022-01872-8openalex-snapshot
Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae
inferred← citeshttps://doi.org/10.1186/s12934-023-02071-9openalex-snapshot
High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae
inferred← citeshttps://doi.org/10.1186/s40694-020-00093-1openalex-snapshot
Promoter tools for further development of Aspergillus oryzae as a platform for fungal secondary metabolite production
inferred← citeshttps://doi.org/10.1186/s40694-022-00135-wopenalex-snapshot
Branching and converging pathways in fungal natural product biosynthesis
inferred← citeshttps://doi.org/10.1186/s40694-022-00140-zopenalex-snapshot
Subcellular localization of fungal specialized metabolites
inferred← citeshttps://doi.org/10.13345/j.cjb.170219openalex-snapshot
[Progress in fungal polyketide biosynthesis].
inferred← citeshttps://doi.org/10.18174/658069openalex-snapshot
Shy Fungi - new drugs : Functional elucidation of unassigned biosynthetic pathways for novel natural products
inferred← citeshttps://doi.org/10.2183/pjab.96.031openalex-snapshot
Heterologous production of fungal natural products: Reconstitution of biosynthetic gene clusters in model host Aspergillus oryzae
inferred← citeshttps://doi.org/10.2323/jgam.2019.07.001openalex-snapshot
Efficient heterologous production of atrochrysone carboxylic acid-related polyketides in an Aspergillus oryzae host with enhanced malonyl-coenzyme A supply
inferred← citeshttps://doi.org/10.33612/diss.240014510openalex-snapshot
Synthetic biology tools for transcriptional activation and regulation of biosynthetic gene clusters in filamentous fungi
inferred← citeshttps://doi.org/10.3389/fbioe.2022.901037openalex-snapshot
Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi
inferred← citeshttps://doi.org/10.3389/fchem.2021.792810openalex-snapshot
Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
inferred← citeshttps://doi.org/10.3389/ffunb.2021.632542openalex-snapshot
Cleaning the Cellular Factory–Deletion of McrA in Aspergillus oryzae NSAR1 and the Generation of a Novel Kojic Acid Deficient Strain for Cleaner Heterologous Production of Secondary Metabolites
inferred← citeshttps://doi.org/10.3389/fmicb.2015.00077openalex-snapshot
Heterologous production of fungal secondary metabolites in Aspergilli
inferred← citeshttps://doi.org/10.3389/fmicb.2018.00690openalex-snapshot
Heterologous Production of a Novel Cyclic Peptide Compound, KK-1, in Aspergillus oryzae
inferred← citeshttps://doi.org/10.3390/jof8070686openalex-snapshot
Genomic and Chemical Profiling of B9, a Unique Penicillium Fungus Derived from Sponge
inferred← citeshttps://doi.org/10.3390/md15090285openalex-snapshot
Biogenetic Relationships of Bioactive Sponge Merotriterpenoids
inferred← citeshttps://doi.org/10.3390/toxins5081422openalex-snapshot
Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli
inferred← citeshttps://doi.org/10.3390/toxins7082701openalex-snapshot
Molecular Cloning and Functional Analysis of Gene Clusters for the Biosynthesis of Indole-Diterpenes in Penicillium crustosum and P. janthinellum
inferred← citeshttps://doi.org/10.3762/bjoc.22.21openalex-snapshot
Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis
inferred← citeshttps://doi.org/10.3987/rev-15-830openalex-snapshot
Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.72.548openalex-snapshot
Synthesis of Natural Products with Biosynthetic Machinery
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.74.854openalex-snapshot
Development of an Artificial Assembly Line Generating Skeletally Diverse Indole Alkaloids Inspired by Biogenetic Strategy
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.79.322openalex-snapshot
Synthetic Biology Based Construction of Fungal Diterpenoid Pyrone Library
inferred← citeshttps://doi.org/10.6013/jbrewsocjapan.112.592openalex-snapshot
Exploring Novel Natural Products by Harnessing the Biosynthetic Mechinery in Aspergillus oryzae
inferred← citeshttps://doi.org/10.6084/m9.figshare.12023424openalex-snapshot
Additional file 2 of Promoter tools for further development of Aspergillus oryzae as a platform for fungal secondary metabolite production
inferred← citeshttps://doi.org/10.6084/m9.figshare.20330194openalex-snapshot
Additional file 1 of Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae
inferred← citeshttps://doi.org/10.6084/m9.figshare.22619966openalex-snapshot
Additional file 1 of High-efficient production of mushroom polyketide compounds in a platform host Aspergillus oryzae
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