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Evidence that Biosynthesis of the Neurotoxic Alkaloids Anatoxin-a and Homoanatoxin-a in the Cyanobacterium Oscillatoria PCC 6506 Occurs on a Modular Polyketide Synthase Initiated by l -Proline

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mnfr.200600185openalex-snapshot
Toxins of cyanobacteria
inferredcites →https://doi.org/10.1016/0041-0101(92)90432-5openalex-snapshot
Identification of anatoxin-A in benthic cyanobacteria (blue-green algae) and in associated dog poisonings at Loch Insh, Scotland
inferredcites →https://doi.org/10.1016/j.chembiol.2008.06.005openalex-snapshot
DKxanthene Biosynthesis—Understanding the Basis for Diversity-Oriented Synthesis in Myxobacterial Secondary Metabolism
inferredcites →https://doi.org/10.1016/j.toxicon.2007.03.025openalex-snapshot
First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand
inferredcites →https://doi.org/10.1016/s1074-5521(01)00054-0openalex-snapshot
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
inferredcites →https://doi.org/10.1021/es061983oopenalex-snapshot
Production of Anatoxin-a and a Novel Biosynthetic Precursor by the Cyanobacterium Aphanizomenon issatschenkoi
inferredcites →https://doi.org/10.1021/ja063611lopenalex-snapshot
Protein Assembly Line Components in Prodigiosin Biosynthesis: Characterization of PigA,G,H,I,J
inferredcites →https://doi.org/10.1021/tx0498152openalex-snapshot
Biosynthesis and Transformation of Homoanatoxin-a in the Cyanobacterium Raphidiopsis mediterranea Skuja and Structures of Three New Homologues
inferredcites →https://doi.org/10.1039/c39950001361openalex-snapshot
Biosynthesis of anatoxin-a in Anabaena flos-aquae and homoanatoxin-a in Oscillatoria formosa
inferredcites →https://doi.org/10.1073/pnas.212382199openalex-snapshot
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
inferredcites →https://doi.org/10.1074/jbc.m111738200openalex-snapshot
The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase
inferredcites →https://doi.org/10.1093/nar/gkh359openalex-snapshot
NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases
inferredcites →https://doi.org/10.1128/aac.01214-06openalex-snapshot
Cloning and Characterization of the Pyrrolomycin Biosynthetic Gene Clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. Strain UC 11065
inferredcites →https://doi.org/10.1128/aem.01225-07openalex-snapshot
Different Genotypes of Anatoxin-Producing Cyanobacteria Coexist in the Tarn River, France
inferredcites →https://doi.org/10.1128/jb.181.7.2166-2174.1999openalex-snapshot
Characterization of the Pyoluteorin Biosynthetic Gene Cluster of Pseudomonas fluorescens Pf-5
inferredcites →https://doi.org/10.1186/1471-2105-8-327openalex-snapshot
ASMPKS: an analysis system for modular polyketide synthases
inferredcites →https://doi.org/10.3390/md403228openalex-snapshot
The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors
inferredcites →https://doi.org/10.4324/9780203478073openalex-snapshot
Toxic Cyanobacteria in Water

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Marine Cyanobacteria Diversity and Biotechnological Potential in Caribbean Waters
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Alkaloids
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Five‐Membered Heterocyclic Rings and Their Fused Derivatives
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Appendix 2: Cyanobacteria Associated With the Production of Cyanotoxins
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Anatoxin‐a, Homoanatoxin‐a, and Natural Analogues
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Supplementary Tables
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Introduction
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Application of Molecular Tools in Monitoring Cyanobacteria and Their Potential Toxin Production
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Marine Cyanotoxins Potentially Harmful to Human Health
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Genomics of the Biosynthesis of Natural Products: From Genes to Metabolites
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Microalgal Biomass of Industrial Interest: Methods of Characterization
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Metabolomics Applied to Cyanobacterial Toxins and Natural Products
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Algal Polyketide Biosynthesis: Mechanism, Types, and Biotechnological Potential
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Secondary Metabolites of Cyanobacteria and Drug Development
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Neurotoxic Alkaloids from Cyanobacteria
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An Insight to Cyanotoxins: Diversity, Chemistry, and Mode of Action
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Cyanobacteria as a source of secondary metabolites
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New insights into the biodiversity and applications of cyanobacteria (blue-green algae)—Prospects and challenges
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Transdisciplinary approaches for the study of cyanobacteria and cyanotoxins
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Geosmin Attracts Aedes aegypti Mosquitoes to Oviposition Sites
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Anatoxin-a: Overview on a harmful cyanobacterial neurotoxin from the environmental scale to the molecular target
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Anatoxin-a-producing Raphidiopsis mediterranea Skuja var. grandis Hill is one ecotype of non-heterocytous Cuspidothrix issatschenkoi (Usačev) Rajaniemi et al. in Japanese lakes
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Identification of genes for anatoxin-a biosynthesis in Cuspidothrix issatschenkoi
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Distribution and population dynamics of potential anatoxin-a-producing cyanobacteria in Lake Dianchi, China
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The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria
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Molecular tools to detect anatoxin-a genes in aquatic ecosystems: Toward a new nested PCR-based method
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Guanitoxin, re-naming a cyanobacterial organophosphate toxin
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Molecular and morphological characterization of a novel dihydroanatoxin-a producing Microcoleus species (cyanobacteria) from the Russian River, California, USA
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Genomic characterization of coexisting anatoxin-producing and non-toxigenic Microcoleus subspecies in benthic mats from the Wolastoq, New Brunswick, Canada
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A new quantitative PCR assay for detection of potentially anatoxin-producing cyanobacteria
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Growth and anatoxin-a production of Microcoleus (Cyanobacteria) strains from streams in California, USA
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WITHDRAWN: Cyanobacterial bioactive molecules – Biosynthesis and genetic regulation
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Inhibiting soil and water loss in a saline soil through cyanobacterization
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Neurotoxic cyanobacterial toxins
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First report of (homo)anatoxin-a and dog neurotoxicosis after ingestion of benthic cyanobacteria in The Netherlands
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Synthesis, configuration assignment, and simultaneous quantification by liquid chromatography coupled to tandem mass spectrometry, of dihydroanatoxin-a and dihydrohomoanatoxin-a together with the parent toxins, in axenic cyanobacterial strains and in environmental samples
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Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria
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Effects of nitrogen and phosphorus on anatoxin-a, homoanatoxin-a, dihydroanatoxin-a and dihydrohomoanatoxin-a production by Phormidium autumnale
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The co-existence of Microcoleus strains with gene variations in the anatoxin-a biosynthesis cluster can explain the different toxin profiles observed in freshwater benthic mats
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Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies
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Genomic and Untargeted Metabolomic Analysis of Secondary Metabolites in the Streptomyces griseoaurantiacus Strain MH191 Shows Media-Based Dependency for the Production of Bioactive Compounds with Potential Antifungal Activity
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Biosynthesis of Anatoxins in Cyanobacteria: Identification of the Carboxy-anatoxins as the Penultimate Biosynthetic Intermediates
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Total synthesis of largamide H
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Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein–protein interactions
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PlankticTychonema(Cyanobacteria) in the large lakes south of the Alps: phylogenetic assessment and toxigenic potential
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Genomic insights into the taxonomy, safety and biotechnological potential of Aphanizomenon flos-aquae and related Nostocales
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Geosmin attracts Aedes aegypti mosquitoes to oviposition sites
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Structure of the prolyl-acyl carrier protein oxidase involved in the biosynthesis of the cyanotoxin anatoxin-a
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Genetic Diversity and Anatoxin Profiles of Freshwater Benthic Cyanobacteria From Nova Scotia (Canada)
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Advances in genomics, transcriptomics and proteomics of toxin‐producing cyanobacteria
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Fine-scale spatial variability in anatoxin-a and homoanatoxin-a concentrations in benthic cyanobacterial mats: implication for monitoring and management
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Environmental conditions that influence toxin biosynthesis in cyanobacteria
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Biosynthesis of Cylindrospermopsin and 7-Epicylindrospermopsin in Oscillatoria sp. Strain PCC 6506: Identification of the cyr Gene Cluster and Toxin Analysis
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Application of Real-Time PCR To Estimate Toxin Production by the Cyanobacterium Planktothrix sp
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Anatoxin-a Synthetase Gene Cluster of the Cyanobacterium Anabaena sp. Strain 37 and Molecular Methods To Detect Potential Producers
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The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites
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Análises moleculares, químicas e ecotoxicológicas de cianobactérias presentes em florações de lagoas do estado de São Paulo
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Análise genômica de isolados brasileiros de Cylindrospermopsis raciborskii com enfoque em cilindrospermopsina e fixação biológica de N2
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Biossíntese do organofosforado anatoxina-a(s) pela cianobactéria Sphaerospermopsis torques-reginae ITEP-024
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Revealing the biosynthesis of guanitoxin, a naturally occurring neurotoxic organophosphate
inferred← citeshttps://doi.org/10.11606/t.9.2023.tde-18082023-123742openalex-snapshot
Ecotoxicological studies of metabolites produced by two Brazilian cyanobacterial strains
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Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria
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Cyanobacterial toxins
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CHAPTER CIRCADIAN RHYTHMS
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CHAPTER TAXONOMY, PHYLOGENY AND EVOLUTION
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Adaptation of an L-Proline Adenylation Domain to Use 4-Propyl-L-Proline in the Evolution of Lincosamide Biosynthesis
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Modeling Cyanotoxin Production, Fate and Transport in Surface Waterbodies
inferred← citeshttps://doi.org/10.18174/401209openalex-snapshot
Trimming proline dehydrogenase : protein and cofactor minimization
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Aphanizomenon flos-aquae and 161 closely related Nostocales genomes: insights for biotechnology
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Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins
inferred← citeshttps://doi.org/10.32657/10356/50703openalex-snapshot
Dynamics of cyanobacteria and cyanotoxins in Kranji Reservoir
inferred← citeshttps://doi.org/10.3354/ame01516openalex-snapshot
Spatial and temporal variability in Phormidium mats and associated anatoxin-a and homoanatoxin-a in two New Zealand rivers
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Bloom Dynamics of Cyanobacteria and Their Toxins: Environmental Health Impacts and Mitigation Strategies
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Toxic/Bioactive Peptide Synthesis Genes Rearranged by Insertion Sequence Elements Among the Bloom-Forming Cyanobacteria Planktothrix
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1769963openalex-snapshot
Spatiotemporal dynamics of benthic Microcoleus in a Swiss lotic system
inferred← citeshttps://doi.org/10.3389/fsufs.2022.1036111openalex-snapshot
Microcystis sp. AE03 strain in Dal Lake harbors cylindrospermopsin and microcystin synthetase gene cluster
inferred← citeshttps://doi.org/10.3390/life11040356openalex-snapshot
Natural Product Gene Clusters in the Filamentous Nostocales Cyanobacterium HT-58-2
inferred← citeshttps://doi.org/10.3390/microorganisms8121849openalex-snapshot
Current Status and Future Strategies to Increase Secondary Metabolite Production from Cyanobacteria
inferred← citeshttps://doi.org/10.3390/molecules23061476openalex-snapshot
Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms
inferred← citeshttps://doi.org/10.3390/plants13192707openalex-snapshot
Azolla as a Safe Food: Suppression of Cyanotoxin-Related Genes and Cyanotoxin Production in Its Symbiont, Nostoc azollae
inferred← citeshttps://doi.org/10.3390/toxics11080643openalex-snapshot
Occurrence, Distribution and Toxins of Benthic Cyanobacteria in German Lakes
inferred← citeshttps://doi.org/10.3390/toxins12110724openalex-snapshot
Understanding the Differences in the Growth and Toxin Production of Anatoxin-Producing Cuspidothrix issatschenkoi Cultured with Inorganic and Organic N Sources from a New Perspective: Carbon/Nitrogen Metabolic Balance
inferred← citeshttps://doi.org/10.3390/toxins12110726openalex-snapshot
Mass Occurrence of Anatoxin-a- and Dihydroanatoxin-a-Producing Tychonema sp. in Mesotrophic Reservoir Mandichosee (River Lech, Germany) as a Cause of Neurotoxicosis in Dogs
inferred← citeshttps://doi.org/10.3390/toxins14050357openalex-snapshot
Spatio-Temporal Monitoring of Benthic Anatoxin-a-Producing Tychonema sp. in the River Lech, Germany
inferred← citeshttps://doi.org/10.3390/toxins15060388openalex-snapshot
Cyanotoxins and Other Bioactive Compounds from the Pasteur Cultures of Cyanobacteria (PCC)
inferred← citeshttps://doi.org/10.3390/toxins17110554openalex-snapshot
Exposure Type and Duration Determine Ecotoxicological Effects of Cyanobacteria Anatoxins on the Benthic Amphipod Hyalella azteca
inferred← citeshttps://doi.org/10.3390/toxins18090395openalex-snapshot
Multiclass Cyanotoxins in Aquatic Environments: Occurrence, Impacts and Detection Techniques
inferred← citeshttps://doi.org/10.3390/toxins2102359openalex-snapshot
Diversity and Impact of Prokaryotic Toxins on Aquatic Environments: A Review
inferred← citeshttps://doi.org/10.3390/toxins4100900openalex-snapshot
Within-Mat Variability in Anatoxin-a and Homoanatoxin-a Production among Benthic Phormidium (Cyanobacteria) Strains
inferred← citeshttps://doi.org/10.3390/toxins6061896openalex-snapshot
Impact of Nitrogen Sources on Gene Expression and Toxin Production in the Diazotroph Cylindrospermopsis raciborskii CS-505 and Non-Diazotroph Raphidiopsis brookii D9
inferred← citeshttps://doi.org/10.3390/toxins6071951openalex-snapshot
Impact of Environmental Factors on the Regulation of Cyanotoxin Production
inferred← citeshttps://doi.org/10.3390/w14244107openalex-snapshot
Effects of Extracts Containing Metabolites of Different Cyanobacteria from an Ambient Spring (Central Europe) on Zooplankters Daphnia magna and Duckweed Spirodela polyrhiza
inferred← citeshttps://doi.org/10.3762/bjoc.7.191openalex-snapshot
Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes
inferred← citeshttps://doi.org/10.4081/aiol.2017.6429openalex-snapshot
Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research
inferred← citeshttps://doi.org/10.4236/jwarp.2015.71004openalex-snapshot
Molecular and Chemical Analyses of Cyanobacterial Blooms in Tropical Lagoons from Southeast Brazil
inferred← citeshttps://doi.org/10.5772/intechopen.97701openalex-snapshot
Overview of PCR Methods Applied for the Identification of Freshwater Toxigenic Cyanobacteria
inferred← citeshttps://doi.org/10.5812/ajehe.10051openalex-snapshot
Cyanobacteria Characteristics and Methods for Isolation and Accurate Identification of Cyanotoxins: A Review Article
inferred← citeshttps://doi.org/10.64898/2026.06.26.734624openalex-snapshot
Plasmid-encoded anatoxin biosynthesis in benthic cyanobacteria
inferred← citeshttps://doi.org/10.70675/6de19aa9z9de2z408cz8696z6f761f2c19f0openalex-snapshot
Caractérisation des proliférations nostocaléennes anciennes et futures via les akinètes présents dans les sédiments
inferred← citeshttps://doi.org/10.70675/f30cf2d4ze3a1z438dz86bfz67afec0a1a18openalex-snapshot
Nouvelles perpectives sur les produits naturels de cyanobactéries d'eau douce et leurs clusters de gènes, apportées par l'intégration de données à haut débit
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