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E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

https://doi.org/10.1021/jacs.2c10784
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jssc.200500116openalex-snapshot
Two‐dimensional separation of peptides using RP‐RP‐HPLC system with different pH in first and second separation dimensions
inferredcites →https://doi.org/10.1002/pmic.201000722openalex-snapshot
Reversed‐phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells
inferredcites →https://doi.org/10.1007/978-1-4939-9145-7_7openalex-snapshot
Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies
inferredcites →https://doi.org/10.1016/j.cell.2013.02.024openalex-snapshot
Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins
inferredcites →https://doi.org/10.1016/j.cell.2017.10.016openalex-snapshot
Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases
inferredcites →https://doi.org/10.1016/j.cell.2019.11.031openalex-snapshot
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
inferredcites →https://doi.org/10.1016/j.celrep.2019.09.079openalex-snapshot
Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
inferredcites →https://doi.org/10.1016/j.chembiol.2021.01.005openalex-snapshot
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
inferredcites →https://doi.org/10.1016/j.chembiol.2021.04.002openalex-snapshot
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation
inferredcites →https://doi.org/10.1016/j.molcel.2019.07.013openalex-snapshot
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation
inferredcites →https://doi.org/10.1016/j.molcel.2019.12.013openalex-snapshot
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
inferredcites →https://doi.org/10.1016/j.str.2019.10.005openalex-snapshot
Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820
inferredcites →https://doi.org/10.1016/s0092-8674(03)00722-0openalex-snapshot
COP9 Signalosome
inferredcites →https://doi.org/10.1016/s1097-2765(00)80156-2openalex-snapshot
Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases
inferredcites →https://doi.org/10.1021/acschembio.5b00216openalex-snapshot
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
inferredcites →https://doi.org/10.1021/acschembio.8b00692openalex-snapshot
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
inferredcites →https://doi.org/10.1021/jacs.1c00990openalex-snapshot
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras
inferredcites →https://doi.org/10.1021/jacs.1c03980openalex-snapshot
Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
inferredcites →https://doi.org/10.1038/nature17416openalex-snapshot
Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome
inferredcites →https://doi.org/10.1038/nature18611openalex-snapshot
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
inferredcites →https://doi.org/10.1038/nchembio.1858openalex-snapshot
Catalytic in vivo protein knockdown by small-molecule PROTACs
inferredcites →https://doi.org/10.1038/nchembio.2329openalex-snapshot
Structural basis of PROTAC cooperative recognition for selective protein degradation
inferredcites →https://doi.org/10.1038/nchembio.2363openalex-snapshot
Selective degradation of splicing factor CAPERα by anticancer sulfonamides
inferredcites →https://doi.org/10.1038/ncomms13166openalex-snapshot
Targeted inhibition of the COP9 signalosome for treatment of cancer
inferredcites →https://doi.org/10.1038/nmeth.1322openalex-snapshot
Universal sample preparation method for proteome analysis
inferredcites →https://doi.org/10.1038/nmeth.1638openalex-snapshot
A public genome-scale lentiviral expression library of human ORFs
inferredcites →https://doi.org/10.1038/nrm1547openalex-snapshot
Function and regulation of cullin–RING ubiquitin ligases
inferredcites →https://doi.org/10.1038/s41467-019-09358-9openalex-snapshot
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
inferredcites →https://doi.org/10.1038/s41573-021-00371-6openalex-snapshot
PROTAC targeted protein degraders: the past is prologue
inferredcites →https://doi.org/10.1038/s41586-020-2000-yopenalex-snapshot
NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly
inferredcites →https://doi.org/10.1038/s41586-020-2168-1openalex-snapshot
Multispecific drugs herald a new era of biopharmaceutical innovation
inferredcites →https://doi.org/10.1038/s41586-020-2374-xopenalex-snapshot
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
inferredcites →https://doi.org/10.1038/s41588-020-0635-0openalex-snapshot
Selective Mediator dependence of cell-type-specifying transcription
inferredcites →https://doi.org/10.1038/s41589-019-0279-5openalex-snapshot
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
inferredcites →https://doi.org/10.1038/s41589-019-0294-6openalex-snapshot
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
inferredcites →https://doi.org/10.1038/s41589-019-0304-8openalex-snapshot
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
inferredcites →https://doi.org/10.1038/s41589-019-0362-yopenalex-snapshot
Development of targeted protein degradation therapeutics
inferredcites →https://doi.org/10.1038/s41589-019-0378-3openalex-snapshot
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
inferredcites →https://doi.org/10.1038/s41589-019-0411-6openalex-snapshot
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
inferredcites →https://doi.org/10.1038/s41589-020-0469-1openalex-snapshot
Unifying principles of bifunctional, proximity-inducing small molecules
inferredcites →https://doi.org/10.1038/s41589-020-0594-xopenalex-snapshot
Rational discovery of molecular glue degraders via scalable chemical profiling
inferredcites →https://doi.org/10.1038/s41589-022-01177-2openalex-snapshot
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders
inferredcites →https://doi.org/10.1073/pnas.1521738113openalex-snapshot
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
inferredcites →https://doi.org/10.1073/pnas.96.16.9124openalex-snapshot
Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
inferredcites →https://doi.org/10.1101/2022.08.15.503206openalex-snapshot
Proteome-scale induced proximity screens reveal highly potent protein degraders and stabilizers
inferredcites →https://doi.org/10.1126/sciadv.abd6263openalex-snapshot
Targeting oncoproteins with a positive selection assay for protein degraders
inferredcites →https://doi.org/10.1126/science.1075901openalex-snapshot
Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1
inferredcites →https://doi.org/10.1126/science.1244851openalex-snapshot
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
inferredcites →https://doi.org/10.1126/science.1244917openalex-snapshot
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
inferredcites →https://doi.org/10.1126/science.aal3755openalex-snapshot
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
inferredcites →https://doi.org/10.1126/science.aao5902openalex-snapshot
Chemically induced proximity in biology and medicine
inferredcites →https://doi.org/10.1126/science.aat0572openalex-snapshot
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
inferredcites →https://doi.org/10.1146/annurev-biochem-090120-013613openalex-snapshot
Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis
inferredcites →https://doi.org/10.3791/61787openalex-snapshot
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Trim4 Promotes Small-Molecule-Induced CORO1A Neddylated-Degradation for Triple Negative Breast Cancer Therapy
inferred← citeshttps://doi.org/10.1002/ange.3307512openalex-snapshot
Proteomics‐Driven Strategies for Proximity‐Inducing Drug Discovery
inferred← citeshttps://doi.org/10.1002/anie.3307512openalex-snapshot
Proteomics‐Driven Strategies for Proximity‐Inducing Drug Discovery
inferred← citeshttps://doi.org/10.1002/mog2.70058openalex-snapshot
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
inferred← citeshttps://doi.org/10.1002/wrna.1877openalex-snapshot
Challenges in Therapeutically Targeting the RNA ‐Recognition Motif
inferred← citeshttps://doi.org/10.1007/978-1-0716-5508-5_3openalex-snapshot
Utilization of Functional Degradation Pathways for the Characterization of Ubiquitin-Proteasome System Tool Compounds
inferred← citeshttps://doi.org/10.1016/b978-0-443-21816-3.00004-xopenalex-snapshot
Protease-mediated degradation
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Molecular glues and induced proximity: An evolution of tools and discovery
inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.10.007openalex-snapshot
Degradome analysis to identify direct protein substrates of small-molecule degraders
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104307openalex-snapshot
Modulating the phosphorylation status of target proteins through bifunctional molecules
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104480openalex-snapshot
Rational discovery of molecular glue degraders based on block chemistry
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118055openalex-snapshot
Global landscape of PROTAC: Perspectives from patents, drug pipelines, clinical trials, and licensing transactions
inferred← citeshttps://doi.org/10.1016/j.jddst.2026.109004openalex-snapshot
Next-generation PROTACs (proteolysis targeting chimeras) in oncology: Targeting the undruggable proteome
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.01.022openalex-snapshot
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.03.004openalex-snapshot
An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation
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Emerging strategies for prospective discovery of molecular glue degraders
inferred← citeshttps://doi.org/10.1016/j.slasd.2023.12.008openalex-snapshot
Screening for molecular glues – Challenges and opportunities
inferred← citeshttps://doi.org/10.1016/j.tips.2023.08.007openalex-snapshot
Proteomic approaches advancing targeted protein degradation
inferred← citeshttps://doi.org/10.1016/j.xgen.2024.100651openalex-snapshot
Pooled endogenous protein tagging and recruitment for systematic profiling of protein function
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5c00800openalex-snapshot
Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00723openalex-snapshot
Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00949openalex-snapshot
Phenotypic Screening for Targeted Protein Degradation: Strategies, Challenges, and Emerging Opportunities
inferred← citeshttps://doi.org/10.1021/acscentsci.3c00395openalex-snapshot
Proximity-Based Modalities for Biology and Medicine
inferred← citeshttps://doi.org/10.1021/acschembio.4c00191openalex-snapshot
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs
inferred← citeshttps://doi.org/10.1021/jacs.2c11098openalex-snapshot
Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence
inferred← citeshttps://doi.org/10.1021/jacs.5c12299openalex-snapshot
From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology
inferred← citeshttps://doi.org/10.1021/jacsau.4c00442openalex-snapshot
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
inferred← citeshttps://doi.org/10.1038/s41467-024-49739-3openalex-snapshot
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
inferred← citeshttps://doi.org/10.1038/s41467-024-52966-3openalex-snapshot
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2
inferred← citeshttps://doi.org/10.1038/s41467-026-72524-3openalex-snapshot
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1
inferred← citeshttps://doi.org/10.1038/s41580-024-00729-9openalex-snapshot
Targeted protein degradation: from mechanisms to clinic
inferred← citeshttps://doi.org/10.1038/s41589-024-01590-9openalex-snapshot
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
inferred← citeshttps://doi.org/10.1038/s41594-024-01257-yopenalex-snapshot
Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
inferred← citeshttps://doi.org/10.1080/17460441.2024.2306845openalex-snapshot
Molecular glue degraders: exciting opportunities for novel drug discovery
inferred← citeshttps://doi.org/10.1126/sciadv.ado6492openalex-snapshot
Mechanism of degrader-targeted protein ubiquitinability
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3161717/v1openalex-snapshot
Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics
inferred← citeshttps://doi.org/10.2147/ijgm.s502644openalex-snapshot
Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia
inferred← citeshttps://doi.org/10.3389/fnmol.2024.1370509openalex-snapshot
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
inferred← citeshttps://doi.org/10.3390/ijms232315440openalex-snapshot
Targeted Protein Degradation: Clinical Advances in the Field of Oncology
inferred← citeshttps://doi.org/10.3390/plants13212997openalex-snapshot
Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection
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TRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy
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