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Trim4 Promotes Small-Molecule-Induced CORO1A Neddylated-Degradation for Triple Negative Breast Cancer Therapy

https://doi.org/10.2139/ssrn.4654255
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TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death
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Dynamic Imaging of Small Molecule Induced Protein–Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach
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E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance
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Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer
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Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B
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Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling
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Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFκB-dependent transcription
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Neddylation of PTEN regulates its nuclear import and promotes tumor development
inferredcites →https://doi.org/10.1038/s41467-022-30559-2openalex-extracted
Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells
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Advancing targeted protein degradation for cancer therapy
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Ubiquitin ligases: guardians of mammalian development
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
inferredcites →https://doi.org/10.1089/ars.2013.5795openalex-extracted
Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
inferredcites →https://doi.org/10.1101/2020.06.10.144303openalex-extracted
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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
inferredcites →https://doi.org/10.1126/science.1244917openalex-extracted
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
inferredcites →https://doi.org/10.1136/bmj-2022-071674openalex-extracted
Advances in systemic therapies for triple negative breast cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-21-2807openalex-extracted
Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
inferredcites →https://doi.org/10.1172/jci.insight.160606openalex-extracted
Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
inferredcites →https://doi.org/10.1186/s13046-018-1002-1openalex-extracted
Classification of triple-negative breast cancers based on Immunogenomic profiling
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ZCH-2B8a, an antibody targeting actin-binding protein coronin-1a, is a potential therapeutic agent for B-lineage malignancies
inferredcites →https://doi.org/10.3322/caac.21660openalex-extracted
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
inferredcites →https://doi.org/10.7150/jca.37164openalex-extracted
Role of the E3 Ubiquitin Ligase TRIM4 in Predicting the Prognosis of Hepatocellular Carcinoma
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Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins
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Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
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