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Dual-Site Chemosensor for Monitoring ·OH-Cysteine Redox in Cells and In Vivo

https://doi.org/10.1021/jacs.2c10855
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mechanism of Cysteine Oxidation by a Hydroxyl Radical: A Theoretical Study
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Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes
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Reactive oxygen species and DNA damage response in cancer
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Near infrared dye-conjugated oxidative stress amplifying polymer micelles for dual imaging and synergistic anticancer phototherapy
inferredcites →https://doi.org/10.1016/j.bmcl.2011.07.081openalex-snapshot
Inhibition of xc- transporter-mediated cystine uptake by sulfasalazine analogs
inferredcites →https://doi.org/10.1016/j.cbpa.2008.07.028openalex-snapshot
Expanding the functional diversity of proteins through cysteine oxidation
inferredcites →https://doi.org/10.1016/j.cclet.2019.08.013openalex-snapshot
Fluorescent probes for detection of biothiols based on “aromatic nucleophilic substitution-rearrangement” mechanism
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.chom.2018.05.009openalex-snapshot
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.12.022openalex-snapshot
Reactive oxygen species, cellular redox systems, and apoptosis
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.11.013openalex-snapshot
The basics of thiols and cysteines in redox biology and chemistry
inferredcites →https://doi.org/10.1016/j.redox.2018.07.018openalex-snapshot
The interplay between mitochondrial reactive oxygen species formation and the coenzyme Q reduction level
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inferredcites →https://doi.org/10.1016/j.snb.2022.131742openalex-snapshot
Monitoring the different changing behaviors of •OH and cysteine in two ferroptosis pathways by a dual-functional fluorescence probe
inferredcites →https://doi.org/10.1016/s0304-3835(03)00238-6openalex-snapshot
Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells
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Fluorescence Probe for Imaging N-Methyl- d -aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy
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An Edaravone-Guided Design of a Rhodamine-Based Turn-on Fluorescent Probe for Detecting Hydroxyl Radicals in Living Systems
inferredcites →https://doi.org/10.1021/acs.analchem.1c04895openalex-snapshot
Red and Near-Infrared Fluorescent Probe for Distinguishing Cysteine and Homocysteine through Single-Wavelength Excitation with Distinctly Dual Emissions
inferredcites →https://doi.org/10.1021/cr300508popenalex-snapshot
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Molecular Rotor Measures Viscosity of Live Cells via Fluorescence Lifetime Imaging
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inferredcites →https://doi.org/10.1021/jacs.0c10840openalex-snapshot
Rapid Reaction, Slow Dissociation Aggregation, and Synergetic Multicolor Emission for Imaging the Restriction and Regulation of Biosynthesis of Cys and GSH
inferredcites →https://doi.org/10.1021/jacs.6b12845openalex-snapshot
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Ferroptosis: mechanisms, biology and role in disease
inferredcites →https://doi.org/10.1038/s41586-022-05022-3openalex-snapshot
A non-canonical vitamin K cycle is a potent ferroptosis suppressor
inferredcites →https://doi.org/10.7150/thno.66663openalex-snapshot
Ferroptotic stress promotes macrophages against intracellular bacteria

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synthesis of Oxygen Vacancy‐Enriched POM Heterostructure with Enhanced Metal–Support Interactions via Supercritical Anti‐Solvent Method for Ultratrace Cysteine Analysis
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inferred← citeshttps://doi.org/10.1016/j.aca.2025.344364openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.aca.2025.344726openalex-snapshot
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Recent advances in fluorescence probes for hydroxyl radicals
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Development of a near-infrared ratiometric fluorescent probe for real-time detection of HClO in real samples, oxidative stress model, and ferroptosis model
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A responsive aggregation-induced emission fluorescent probe for the detection of cysteine in food, serum samples and oxidative stress environments
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Single fluorescent probe reveals glutathione-viscosity crosstalk in the endoplasmic reticulum during ferroptosis and extracellular vesicles in synergistic ferroptosis-apoptosis
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Morphology-engineered CuxOy/3ATP electrochemical sensor for ultrasensitive detection of hydroxyl radicals in micro-nanobubble systems
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A ratiometric fluorescent probe for cysteine and glutathione differentiation and its application for cysteine detection in foods
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Enhanced aggregation induced emission by H-bond between the barbiturate molecules containing hydroxyl group
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Simultaneous dual-channel fluorescent probe for Cys and ONOO− enables rapid monitoring of dynamic redox balance changes during ferroptosis
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Recent developments of small-molecule fluorescent probes for the detection of hydroxyl radical in biological systems
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Pattern Recognition and Visual Detection of Aldehydes Using a Single ESIPT Dye
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Dual-Channel/Localization Single-Molecule Fluorescence Probe for Monitoring ATP and HOCl in Early Diagnosis and Therapy of Rheumatoid Arthritis
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Near-Infrared Fluorescence Probe with a New Recognition Moiety for the Specific Detection of Cysteine to Study the Corresponding Physiological Processes in Cells, Zebrafish, and Arabidopsis thaliana
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Dual-Site Chemosensor for Visualizing •OH–GSH Redox and Tracking Ferroptosis-Inducing Pathways In Vivo
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Illumination of Hydroxyl Radical Generated in Cells during Ferroptosis, Arabidopsis thaliana, and Mice Using a New Turn-On Near-Infrared Fluorescence Probe
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Regulating Sensing Patterns in Fluorescent Probes for Discriminative Detection of Biothiols
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A Dual-Channel Fluorescence Probe for Early Diagnosis and Treatment Monitoring of Acute Kidney Injury by Detecting HOCl and Cys with Different Fluorescence Signals
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inferred← citeshttps://doi.org/10.1021/acs.analchem.5c03834openalex-snapshot
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Orthogonal NIR/Ratiometric Probe for Simultaneous Imaging of NO and ATP in Acute Lung Injury: Elucidating Metabolic Dysregulation and Therapeutic Screening
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Cellular Redox Regulation and Fluorescence Imaging
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Biosensing of Cysteine through the Induction of Oxygen Vacancies in a Cu/Zr Heterostructure Prepared by Supercritical Antisolvent Technique
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Multi-Stimuli-Responsive Polyamides Containing Benzophenothiazine Being Sensitive to TNP, Acid, Voltage, and Light
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A dual-responsive ratiometric indicator designed for in vivo monitoring of oxidative stress and antioxidant capacity
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An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants
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