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Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells

https://doi.org/10.1021/jf072826r
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An updated and comprehensive review of the health benefits and pharmacological activities of hesperidin
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Hesperidin and tiger nut reduced carcinogenicity of DMBA in female rats
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Selection of bionic Co-former improves the dissolution of Neohesperidin via Co-amorphous solid dispersion with Naringin
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Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test
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JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro
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Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-κB-mediated inflammation
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Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells
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Preparation of crystalline nanocellulose/hydroxypropyl β cyclodextrin/carboxymethyl cellulose polyelectrolyte complexes and their controlled release of neohesperidin-copper (II) in vitro
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Passive asymmetric transport of hesperetin across isolated rabbit cornea
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Hesperidin guided injured spinal cord neural regeneration with a combination of MWCNT-collagen-hyaluronic acid composite: In-vitro analysis
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Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats
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Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide
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Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats
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Hesperidin pretreatment protects hypoxia–ischemic brain injury in neonatal rat
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Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cells
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Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
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Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity
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Sacculatane diterpenoids from the Chinese liverwort Pellia epiphylla with protection against H2O2-induced apoptosis of PC12 cells
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Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice
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Effects of hesperetin on dimethylsulphoxide induced cognitive dysfunction mediated through oxidative stress marker and neuroinflammation in hippocampus
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Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells
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Hesperetin ameliorates hyperglycemia induced retinal vasculopathy via anti-angiogenic effects in experimental diabetic rats
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RhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by H2O2 via the AKT-mediated ROS signaling pathway
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Flavonoids: an overview
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Hesperidin and Hesperetin from Orange Peel Water Extract Protect against NaIO 3 -Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Modulating PI3K/Akt/HIF-1α/BNIP3 Signaling
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Protective Effects of 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone to PC12 Cells against Cytotoxicity Induced by Hydrogen Peroxide
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Effect of Hesperetin against Oxidative Stress via ER- and TrkA-Mediated Actions in PC12 Cells
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Neuroprotective Effects of Citrus Flavonoids
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Modulation of Akt, JNK, and p38 Activation Is Involved in Citrus Flavonoid-Mediated Cytoprotection of PC12 Cells Challenged by Hydrogen Peroxide
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The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation
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Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells
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Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
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Hesperetin nanoparticles attenuate anxiogenic-like behavior and cerebral oxidative stress through the upregulation of antioxidant enzyme expression in experimental dementia of Alzheimer’s type
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Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect
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Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease
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Basic approach on the protective effects of hesperidin and naringin in Alzheimer’s disease
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Neohesperidin attenuates cerebral ischemia–reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway
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Citrus flavonoids and their antioxidant evaluation
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Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin
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Effects of hesperidin are not associated with changes in basal synaptic transmission, theta‐burst LTP, and membrane excitability in CA1 neuron
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Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice
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Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy
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Characterization of Chemical Constituents and Metabolites in Rat Plasma after Oral Administration of Zhi-Zi-Hou-Po Decoction by High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry
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Naringin, neohesperidin and their corresponding dihydrochalcones as bioactive substances: a symphony of bitter–sweet
inferred← citeshttps://doi.org/10.1093/mutage/gep001openalex-snapshot
Radioprotective effects of hesperidin against genotoxicity induced by -irradiation in human lymphocytes
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Effect of hesperidin extraction on cell proliferation and apoptosis of Alzheimer's disease induced by Aβ25–35
inferred← citeshttps://doi.org/10.1111/and.12091openalex-snapshot
Impact of micronised purified flavonoid fraction on increased malondialdehyde and decreased metalloproteinase-2 and metalloproteinase-9 levels in varicocele: outcome of an experimentally induced varicocele
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Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing
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Diosmetin derivatives as multifunctional anti‐AD ligands: Design, synthesis, and biological evaluation
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Physicochemical properties and mechanism of solubilised neohesperidin system based on inclusion complex of hydroxypropyl‐β‐cyclodextrin
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PHYSICOCHEMICAL CHARACTERIZATION OF THE ORANGE JUICE WASTE WATER OF A CITRUS BY-PRODUCT
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Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3–Overexpressing Human Embryonic Kidney 293 Cells
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Oxidative stress and cardiovascular health: therapeutic potential of polyphenols
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Protective effects of farrerol against hydrogen-peroxide-induced apoptosis in human endothelium-derived EA.hy926 cells
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Anti-depressant effect of hesperidin in diabetic rats
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Neohesperidin Induces Cell Cycle Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells
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Mitigation of H 2 O 2 -Induced Mitochondrial-Mediated Apoptosis in NG108-15 Cells by Novel Mesuagenin C from Mesua kunstleri (King) Kosterm
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Polyphenols as Modulators of Aquaporin Family in Health and Disease
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Antidepressant Flavonoids and Their Relationship with Oxidative Stress
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Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice
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Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells
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Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats
inferred← citeshttps://doi.org/10.1177/0960327110371696openalex-snapshot
Differential protection of pre-, co- and post-treatment of curcumin against hydrogen peroxide in PC12 cells
inferred← citeshttps://doi.org/10.1177/15593258221100986openalex-snapshot
Effective Parts of Gentiana straminea Maxim Attenuates Hypoxia-Induced Oxidative Stress and Apoptosis
inferred← citeshttps://doi.org/10.1179/1476830512y.0000000021openalex-snapshot
Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress
inferred← citeshttps://doi.org/10.1186/1472-6882-13-116openalex-snapshot
Attenuation of oxidative stress in U937 cells by polyphenolic-rich bark fractions of Burkea africana and Syzygium cordatum
inferred← citeshttps://doi.org/10.1186/s12934-019-1176-zopenalex-snapshot
Genetic variants of the oppA gene are involved in metabolic regulation of surfactin in Bacillus subtilis
inferred← citeshttps://doi.org/10.1186/s13065-015-0145-9openalex-snapshot
Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health
inferred← citeshttps://doi.org/10.1201/9781315369068-9openalex-snapshot
Neuroprotection by Dietary and Citrus Flavonoids
inferred← citeshttps://doi.org/10.12659/msm.912132openalex-snapshot
Upregulation of Nuclear Factor IA Suppresses Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Umbilical Vein Endothelial Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0087371openalex-snapshot
Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells
inferred← citeshttps://doi.org/10.15171/jlms.2019.26openalex-snapshot
Protective effect of Photobiomodulation Therapy and Bone Marrow Stromal Stem Cells Conditioned Media on Pheochromocytoma Cell Line 12 Against Oxidative Stress Induced by Hydrogen Peroxide
inferred← citeshttps://doi.org/10.18632/oncotarget.12091openalex-snapshot
Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells
inferred← citeshttps://doi.org/10.2147/dddt.s304624openalex-snapshot
Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury
inferred← citeshttps://doi.org/10.2174/1381612826666201127122313openalex-snapshot
An Up-to-Date Review on Citrus Flavonoids: Chemistry and Benefits in Health and Diseases
inferred← citeshttps://doi.org/10.2174/1871527320666210420135437openalex-snapshot
Role of Natural Plant Products Against Alzheimer’s Disease
inferred← citeshttps://doi.org/10.22270/jddt.v14i11.6823openalex-snapshot
Hesperetin attenuates neuroprotective effect against 3-Nitropropionic acid induced Huntington’s disease-like behavioral symptoms in rats
inferred← citeshttps://doi.org/10.2298/hemind140129025kopenalex-snapshot
Effect of plant extracts Kitaibelia vitifolia on antioxidant activity, chemical characteristics, microbiological status and sensory properties of Pirotski kachkaval cheese
inferred← citeshttps://doi.org/10.3109/10799893.2012.672994openalex-snapshot
Molecular role of catalase on oxidative stress-induced Ca 2+ signaling and TRP cation channel activation in nervous system
inferred← citeshttps://doi.org/10.3109/13880209.2015.1035795openalex-snapshot
Protective effect of Lepidium sativum seed extract against hydrogen peroxide-induced cytotoxicity and oxidative stress in human liver cells (HepG2)
inferred← citeshttps://doi.org/10.3136/fstr.20.629openalex-snapshot
Cellular Antioxidant Activity and Pharmacokinetic Study of Polymethoxylated Flavonoids in Extract of Citrus reticulata ‘Chachi’ Peel
inferred← citeshttps://doi.org/10.3389/fbioe.2020.01025openalex-snapshot
Synthesis of Hydrophobic Propionyl Neohesperidin Ester Using an Immobilied Enzyme and Description of Its Anti-proliferative and Pro-apoptotic Effects on MCF-7 Human Breast Cancer Cells
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1197646openalex-snapshot
The neuromodulatory effects of flavonoids and gut Microbiota through the gut-brain axis
inferred← citeshttps://doi.org/10.3389/fmolb.2024.1353387openalex-snapshot
Identification of mulberry leaf flavonoids and evaluating their protective effects on H2O2-induced oxidative damage in equine skeletal muscle satellite cells
inferred← citeshttps://doi.org/10.3389/fnagi.2021.729949openalex-snapshot
Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer’s Disease: A Review Article
inferred← citeshttps://doi.org/10.3389/fnins.2022.1042865openalex-snapshot
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
inferred← citeshttps://doi.org/10.3389/fphar.2022.983470openalex-snapshot
Citrus aurantium ‘Changshan-huyou’—An ethnopharmacological and phytochemical review
inferred← citeshttps://doi.org/10.3390/agriculture12050588openalex-snapshot
Antioxidant, Anti-Inflammatory Activities, and Neuroprotective Behaviors of Phyllanthus emblica L. Fruit Extracts
inferred← citeshttps://doi.org/10.3390/antiox10071003openalex-snapshot
Hesperetin Nanocrystals Improve Mitochondrial Function in a Cell Model of Early Alzheimer Disease
inferred← citeshttps://doi.org/10.3390/antiox12010149openalex-snapshot
Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System
inferred← citeshttps://doi.org/10.3390/antiox12030669openalex-snapshot
A Scientometric Study to a Critical Review on Promising Anticancer and Neuroprotective Compounds: Citrus Flavonoids
inferred← citeshttps://doi.org/10.3390/antiox9070609openalex-snapshot
Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
inferred← citeshttps://doi.org/10.3390/antiox9090797openalex-snapshot
Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health
inferred← citeshttps://doi.org/10.3390/biom12050626openalex-snapshot
Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health
inferred← citeshttps://doi.org/10.3390/biomedicines12030552openalex-snapshot
Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy
inferred← citeshttps://doi.org/10.3390/foods11030273openalex-snapshot
Aged Pericarpium Citri Reticulatae ‘Chachi’ Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells
inferred← citeshttps://doi.org/10.3390/ijms18122754openalex-snapshot
Flavonoids of Kudzu Root Fermented by Eurtotium cristatum Protected Rat Pheochromocytoma Line 12 (PC12) Cells against H2O2-Induced Apoptosis
inferred← citeshttps://doi.org/10.3390/md18060306openalex-snapshot
Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators
inferred← citeshttps://doi.org/10.3390/microorganisms8020199openalex-snapshot
Polyphenols in Alzheimer’s Disease and in the Gut–Brain Axis
inferred← citeshttps://doi.org/10.3390/molecules21101312openalex-snapshot
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?
inferred← citeshttps://doi.org/10.3390/molecules24224093openalex-snapshot
The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742
inferred← citeshttps://doi.org/10.3390/molecules26092442openalex-snapshot
6,7,4′-Trihydroxyflavanone Mitigates Methamphetamine-Induced Neurotoxicity in SH-SY5y Cells via Nrf2/heme Oxyganase-1 and PI3K/Akt/mTOR Signaling Pathways
inferred← citeshttps://doi.org/10.3390/molecules27175395openalex-snapshot
Structural Investigation of Hesperetin-7-O-Glucoside Inclusion Complex with β-Cyclodextrin: A Spectroscopic Assessment
inferred← citeshttps://doi.org/10.3390/molecules31081356openalex-snapshot
Chemical Composition of Eriodictyon californicum (California Yerba Santa) Cultivated in Ontario, Oregon, USA
inferred← citeshttps://doi.org/10.3390/nu12102907openalex-snapshot
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.3390/nu14132647openalex-snapshot
Bioavailability of Hesperidin and Its Aglycone Hesperetin—Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)—Mini-Review
inferred← citeshttps://doi.org/10.3390/nu15183927openalex-snapshot
Biological Properties and Antimicrobial Potential of Cocoa and Its Effects on Systemic and Oral Health
inferred← citeshttps://doi.org/10.3390/ph16060859openalex-snapshot
Efficiency of Bone Marrow-Derived Mesenchymal Stem Cells and Hesperetin in the Treatment of Streptozotocin-Induced Type 1 Diabetes in Wistar Rats
inferred← citeshttps://doi.org/10.3390/w11061183openalex-snapshot
Catalytic Efficiency of Red Mud for the Degradation of Olive Mill Wastewater through Heterogeneous Fenton’s Process
inferred← citeshttps://doi.org/10.3390/w11122481openalex-snapshot
Wastewater Management in Citrus Processing Industries: An Overview of Advantages and Limits
inferred← citeshttps://doi.org/10.4162/nrp.2020.14.5.438openalex-snapshot
Curcumin and hesperetin attenuate D-galactose-induced brain senescence in vitro and in vivo
inferred← citeshttps://doi.org/10.5897/ajb10.2080openalex-snapshot
Assessment of MCF-7 cells as an in vitro model system for evaluation of chemical oxidative stressors
inferred← citeshttps://doi.org/10.5897/jmpr12.1217openalex-snapshot
Protective effect of extracts of calyx from Diospyros kaki on H 2 O 2 -induced cytotoxicity in PC12 cells
inferred← citeshttps://doi.org/10.7324/japs.2023.141134openalex-snapshot
Synthesis, spectroscopic characterization, thermal studies, and molecular docking of novel Cr(III), Fe(III), and Co(II) complexesbased on Schiff base: In vitro antibacterial and antitumor activities
inferred← citeshttps://doi.org/10.9724/kfcs.2011.27.4.067openalex-snapshot
Neuroprotective Effects of Extracts from Diospyros kaki L. Peel
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