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Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

https://doi.org/10.3390/antiox9070609
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: anin vitroandin vivostudy
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Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models
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Genistein Is Neuroprotective in Murine Models of Familial Amyotrophic Lateral Sclerosis and Stroke
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inferredcites →https://doi.org/10.1007/s10384-015-0415-zopenalex-snapshot
Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury
inferredcites →https://doi.org/10.1007/s11033-020-05346-1openalex-snapshot
Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways
inferredcites →https://doi.org/10.1007/s11064-015-1796-6openalex-snapshot
Protective Effect of Oral Hesperetin Against Unilateral Striatal 6-Hydroxydopamine Damage in the Rat
inferredcites →https://doi.org/10.1007/s11481-018-9824-3openalex-snapshot
Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model
inferredcites →https://doi.org/10.1007/s12035-017-0847-1openalex-snapshot
The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer’s Disease
inferredcites →https://doi.org/10.1007/s12035-018-1020-1openalex-snapshot
RETRACTED ARTICLE: Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway
inferredcites →https://doi.org/10.1007/s12035-019-1512-7openalex-snapshot
Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model
inferredcites →https://doi.org/10.1007/s12272-001-2130-1openalex-snapshot
Neuroprotective effects of chronic hesperetin administration in mice
inferredcites →https://doi.org/10.1007/s12272-019-01174-5openalex-snapshot
Hesperetin inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways
inferredcites →https://doi.org/10.1016/b978-0-12-394309-5.00006-7openalex-snapshot
Cell Biology of Ischemia/Reperfusion Injury
inferredcites →https://doi.org/10.1016/j.ajps.2017.08.004openalex-snapshot
Bioactive flavonoids in medicinal plants: Structure, activity and biological fate
inferredcites →https://doi.org/10.1016/j.bbadis.2012.11.018openalex-snapshot
Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease
inferredcites →https://doi.org/10.1016/j.bbr.2009.08.028openalex-snapshot
Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: Possible role of nitric oxide
inferredcites →https://doi.org/10.1016/j.biopha.2016.11.089openalex-snapshot
Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells
inferredcites →https://doi.org/10.1016/j.biopha.2017.11.047openalex-snapshot
Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.ejphar.2013.10.057openalex-snapshot
Minocycline modulates neuroprotective effect of hesperidin against quinolinic acid induced Huntington's disease like symptoms in rats: Behavioral, biochemical, cellular and histological evidences
inferredcites →https://doi.org/10.1016/j.gene.2019.144046openalex-snapshot
Functional analysis of flavonoid 3′-hydroxylase and flavonoid 3′,5′-hydroxylases from tea plant (Camellia sinensis), involved in the B-ring hydroxylation of flavonoids
inferredcites →https://doi.org/10.1016/j.jep.2016.10.040openalex-snapshot
Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo
inferredcites →https://doi.org/10.1016/j.lfs.2008.03.002openalex-snapshot
Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice
inferredcites →https://doi.org/10.1016/j.neulet.2008.04.056openalex-snapshot
Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
inferredcites →https://doi.org/10.1016/j.redox.2017.10.015openalex-snapshot
Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway
inferredcites →https://doi.org/10.1016/j.redox.2018.01.008openalex-snapshot
13 reasons why the brain is susceptible to oxidative stress
inferredcites →https://doi.org/10.1021/cn400213ropenalex-snapshot
Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/jf062816aopenalex-snapshot
Pharmacokinetics of (−)-Epigallocatechin-3-gallate in Conscious and Freely Moving Rats and Its Brain Regional Distribution
inferredcites →https://doi.org/10.1021/jf072826ropenalex-snapshot
Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells
inferredcites →https://doi.org/10.1021/jf104632aopenalex-snapshot
Effect of Hesperetin against Oxidative Stress via ER- and TrkA-Mediated Actions in PC12 Cells
inferredcites →https://doi.org/10.1021/jf8006568openalex-snapshot
Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity
inferredcites →https://doi.org/10.1038/s41598-017-11512-6openalex-snapshot
Polyphenols journey through blood-brain barrier towards neuronal protection
inferredcites →https://doi.org/10.1046/j.1471-4159.2003.01652.xopenalex-snapshot
Interaction between flavonoids and the blood–brain barrier: in vitro studies
inferredcites →https://doi.org/10.1055/s-0030-1249962openalex-snapshot
Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of StandardizedGinkgo bilobaExtract EGb 761®
inferredcites →https://doi.org/10.1080/10408398.2018.1544885openalex-snapshot
Biosynthesis of citrus flavonoids and their health effects
inferredcites →https://doi.org/10.1080/14728222.2020.1738390openalex-snapshot
Silence superoxide dismutase 1 (SOD1): a promising therapeutic target for amyotrophic lateral sclerosis (ALS)
inferredcites →https://doi.org/10.1080/14756366.2019.1581184openalex-snapshot
New flavonoid – N , N -dibenzyl( N -methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
inferredcites →https://doi.org/10.1089/jmf.2017.4078openalex-snapshot
Beneficial Effects of Flavonoids Against Parkinson's Disease
inferredcites →https://doi.org/10.1089/jmf.2018.4183openalex-snapshot
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy
inferredcites →https://doi.org/10.1093/jn/131.2.235openalex-snapshot
Plasma Kinetics and Urinary Excretion of the Flavanones Naringenin and Hesperetin in Humans after Ingestion of Orange Juice and Grapefruit Juice
inferredcites →https://doi.org/10.1093/jn/136.2.404openalex-snapshot
Bioavailability Is Improved by Enzymatic Modification of the Citrus Flavonoid Hesperidin in Humans: A Randomized, Double-Blind, Crossover Trial
inferredcites →https://doi.org/10.1101/cshperspect.a028035openalex-snapshot
Pathology of Neurodegenerative Diseases
inferredcites →https://doi.org/10.1111/1541-4337.12351openalex-snapshot
The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective
inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04841.xopenalex-snapshot
Activation of pro‐survival Akt and ERK1/2 signalling pathways underlie the anti‐apoptotic effects of flavanones in cortical neurons
inferredcites →https://doi.org/10.1111/jnc.13607openalex-snapshot
Neuroinflammation: the devil is in the details
inferredcites →https://doi.org/10.1155/2013/394652openalex-snapshot
Cadmium Toxicity and Treatment
inferredcites →https://doi.org/10.1155/2014/797824openalex-snapshot
Protective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats
inferredcites →https://doi.org/10.1155/2015/272630openalex-snapshot
Neurodegeneration: Etiologies and New Therapies
inferredcites →https://doi.org/10.1155/2015/314560openalex-snapshot
Protective Mechanisms of Flavonoids in Parkinson’s Disease
inferredcites →https://doi.org/10.1155/2017/3279061openalex-snapshot
Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease
inferredcites →https://doi.org/10.1155/2018/7043213openalex-snapshot
Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences
inferredcites →https://doi.org/10.1177/0748233716665301openalex-snapshot
Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats
inferredcites →https://doi.org/10.1186/1750-1326-8-28openalex-snapshot
Genetics of amyotrophic lateral sclerosis: an update
inferredcites →https://doi.org/10.1211/jpp.60.10.0015openalex-snapshot
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study
inferredcites →https://doi.org/10.1385/jmn:17:1:89openalex-snapshot
Therapeutic Efficacy of EGb761 (Gingko biloba Extract) in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1590/0004-282x20190152openalex-snapshot
Free carnitine and branched chain amino acids are not good biomarkers in Huntington’s disease
inferredcites →https://doi.org/10.2174/1381612826666200107142541openalex-snapshot
Emerging Potential of Naturally Occurring Autophagy Modulators Against Neurodegeneration
inferredcites →https://doi.org/10.2174/157015909787602823openalex-snapshot
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
inferredcites →https://doi.org/10.3109/03602532.2014.1003649openalex-snapshot
Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity
inferredcites →https://doi.org/10.3109/13880200490893492openalex-snapshot
Absorption, Bioavailability, and Metabolism of Flavonoids
inferredcites →https://doi.org/10.3164/jcbn.09-15openalex-snapshot
Orange Juice and Hesperetin Supplementation to Hyperuricemic Rats Alter Oxidative Stress Markers and Xanthine Oxidoreductase Activity
inferredcites →https://doi.org/10.3389/fphar.2018.01383openalex-snapshot
Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain
inferredcites →https://doi.org/10.3390/antiox8090333openalex-snapshot
Anthocyanins and Their Metabolites as Therapeutic Agents for Neurodegenerative Disease
inferredcites →https://doi.org/10.3390/biom9110719openalex-snapshot
Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains
inferredcites →https://doi.org/10.3390/cells8070760openalex-snapshot
Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling
inferredcites →https://doi.org/10.3390/cells9030667openalex-snapshot
Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice
inferredcites →https://doi.org/10.3390/cells9061464openalex-snapshot
Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders
inferredcites →https://doi.org/10.3390/ijms15011080openalex-snapshot
The Function and Catalysis of 2-Oxoglutarate-Dependent Oxygenases Involved in Plant Flavonoid Biosynthesis
inferredcites →https://doi.org/10.3390/ijms20092293openalex-snapshot
Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration
inferredcites →https://doi.org/10.3390/jcm8050680openalex-snapshot
Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro
inferredcites →https://doi.org/10.3390/nu11030648openalex-snapshot
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling
inferredcites →https://doi.org/10.3390/nu11051082openalex-snapshot
RETRACTED: Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling
inferredcites →https://doi.org/10.3390/nu11071479openalex-snapshot
Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies
inferredcites →https://doi.org/10.3390/nu9090966openalex-snapshot
Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress
inferredcites →https://doi.org/10.3892/mmr.2018.9045openalex-snapshot
Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats
inferredcites →https://doi.org/10.3945/an.116.012948openalex-snapshot
Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity
inferredcites →https://doi.org/10.4103/0253-7613.115015openalex-snapshot
Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats
inferredcites →https://doi.org/10.4103/0972-2327.144003openalex-snapshot
Neuropsychological deficits in temporal lobe epilepsy: A comprehensive review
inferredcites →https://doi.org/10.5607/en.2015.24.4.325openalex-snapshot
The Role of Oxidative Stress in Neurodegenerative Diseases

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inferred← citeshttps://doi.org/10.1016/j.foodhyd.2025.111516openalex-snapshot
Unveiling the hypoglycemic of hesperetin-Cu(II) complex: impact on the physicochemical properties and digestibility of gelatinized corn starch
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e39780openalex-snapshot
Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.03.097openalex-snapshot
Metabolic footprints of chitosan primed red kidney bean under restricted irrigation
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.11.296openalex-snapshot
Investigation of the interaction behavior between quercetin and pepsin by spectroscopy and MD simulation methods
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141429openalex-snapshot
Hesperetin acts as a potent xanthine oxidase inhibitor: New evidence from its reactive oxygen suppression and enzyme binding
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141814openalex-snapshot
Therapeutic potential and limitation of condensed and hydrolyzed tannins in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.imu.2023.101339openalex-snapshot
Discovery of putative natural compounds inhibitor of the germinant spore receptor CspC in Clostridioides difficile infection: Gaining insights via In silico and bioinformatics approach
inferred← citeshttps://doi.org/10.1016/j.insi.2026.100678openalex-snapshot
Identification of key genes and pathways in corneal neovascularisation: integrating text mining and bioinformatic analysis
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114211openalex-snapshot
Hesperetin mitigates adipose tissue inflammation to improve obesity-associated metabolic health
inferred← citeshttps://doi.org/10.1016/j.jafr.2025.102272openalex-snapshot
Targeting mental health through pharmacologically active natural compounds: State of the art and future perspectives
inferred← citeshttps://doi.org/10.1016/j.jafr.2026.103273openalex-snapshot
LC-QTOF-MS characterization of bioactive phenolic and flavonoid compounds in the traditional Thai Tri-Kalphit tea and their antioxidant activities
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102873openalex-snapshot
Hesperetin loaded proposomal gel for topical antioxidant activity
inferred← citeshttps://doi.org/10.1016/j.jddst.2023.104166openalex-snapshot
Hesperidin microemulsion: Formulation optimization, characterization, and in vitro evaluation
inferred← citeshttps://doi.org/10.1016/j.jsps.2023.01.006openalex-snapshot
The role of selected flavonoids from bajakah tampala (Spatholobus littoralis Hassk.) stem on cosmetic properties: A review
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.136713openalex-snapshot
Hesperidin attenuate fibrillation and cytotoxicity of human insulin: Role of secondary structure and its hydrophobicity in protein aggregation
inferred← citeshttps://doi.org/10.1016/j.neuint.2023.105486openalex-snapshot
Structural fingerprinting of pleiotropic flavonoids for multifaceted Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neuro.2025.103310openalex-snapshot
Hesperidin mitigates lead-induced neurotoxicity via TFEB-dependent restoration of mitochondrial function, oxidative balance, and neuroinflammation in rats
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.02.007openalex-snapshot
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107861openalex-snapshot
Liver X receptors: A therapeutic target in demyelinating disorders
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154580openalex-snapshot
Flavonoids and saponins: What have we got or missed?
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100836openalex-snapshot
Composition and medicinal applications of Citrus essential oils: Current insights and future perspectives
inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100254openalex-snapshot
Effects of hesperetin on dimethylsulphoxide induced cognitive dysfunction mediated through oxidative stress marker and neuroinflammation in hippocampus
inferred← citeshttps://doi.org/10.1016/j.prmcm.2024.100485openalex-snapshot
Neuroprotective effects of Hibiscus sabdariffa var. altissima on cerebral ischemia‒Reperfusion injury in rats
inferred← citeshttps://doi.org/10.1016/j.prmcm.2025.100718openalex-snapshot
Traditional wisdom to modern science: Hesperetin and naringenin as emerging traditional Chinese medicine-based treatments for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.sciaf.2023.e01672openalex-snapshot
MS/MS-based molecular networking for mapping the chemical diversity of the pulp and peel extracts from Citrus japonica Thunb.; in vivo evaluation of their anti-inflammatory and anti-ulcer potential
inferred← citeshttps://doi.org/10.1016/j.scienta.2024.113738openalex-snapshot
Exploring the medicinal potential of Dendrobium: Uncovering the spatial distribution of flavonoids and alkaloids in 15 species of Dendrobium using MALDI-MSI
inferred← citeshttps://doi.org/10.1016/j.tice.2025.102951openalex-snapshot
Could hesperetin ameliorate doxorubicin-induced nephrotoxicity in rats via its antioxidant, antiapoptotic, and anti-inflammatory properties?
inferred← citeshttps://doi.org/10.1016/j.tifs.2024.104410openalex-snapshot
Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective
inferred← citeshttps://doi.org/10.1016/j.tjnut.2026.101697openalex-snapshot
Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101596openalex-snapshot
Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c03257openalex-snapshot
Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c06816openalex-snapshot
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c05570openalex-snapshot
Hesperetin Protects from Palmitic-Acid-Induced Lipotoxicity through the Inhibition of Glutaminolysis, mTORC1 Signaling, and Limited Apoptosis
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c16995openalex-snapshot
Dietary Citrus Flavonoid Hesperetin Attenuates Metabolic Dysfunction–Associated Steatotic Liver Disease via Modulation of MAPK–RARα Axis
inferred← citeshttps://doi.org/10.1021/acsfoodscitech.2c00165openalex-snapshot
Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review
inferred← citeshttps://doi.org/10.1038/s41598-022-25204-3openalex-snapshot
Evaluation of the mineral composition, phytochemical and proximate constituents of three culinary spices in Nigeria: a comparative study
inferred← citeshttps://doi.org/10.1038/s41598-025-25777-9openalex-snapshot
Hesperetin reduces neuronal death in an SHSY5Y Alzheimer’s model by inhibiting inflammation and apoptosis and pyroptosis cell death pathways
inferred← citeshttps://doi.org/10.1039/d0fo02736gopenalex-snapshot
Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD
inferred← citeshttps://doi.org/10.1039/d1ob01352aopenalex-snapshot
Current developments in the synthesis of 4-chromanone-derived compounds
inferred← citeshttps://doi.org/10.1080/00032719.2025.2555906openalex-snapshot
Sensitive Electrochemical Determination of Hesperetin at Gold Nanoparticles/Poly Luminol/Graphene Oxide/Glassy Carbon Electrode
inferred← citeshttps://doi.org/10.1080/00397911.2024.2358375openalex-snapshot
Catalytic synthesis of flavanone without stirring or heating
inferred← citeshttps://doi.org/10.1080/07391102.2023.2225621openalex-snapshot
Spectroscopic and in silico evaluation of hesperetin, aglycone flavanone, as a prospective regulatory ligand for human salivary α-amylase
inferred← citeshttps://doi.org/10.1080/10408398.2021.1969891openalex-snapshot
Nutrients and bioactives in citrus fruits: Different citrus varieties, fruit parts, and growth stages
inferred← citeshttps://doi.org/10.1080/10408398.2024.2435593openalex-snapshot
Flavonoids and the gut microbiome: a powerful duo for brain health
inferred← citeshttps://doi.org/10.1080/1061186x.2025.2576112openalex-snapshot
Thermosensitive transniosomal in situ gel of hesperetin for intranasal administration: novel approach for Parkinson’s therapy
inferred← citeshttps://doi.org/10.1080/10717544.2021.1949073openalex-snapshot
Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents
inferred← citeshttps://doi.org/10.1080/10942912.2023.2236327openalex-snapshot
Hesperidin plays beneficial roles in disorders associated with the central nervous system: a review
inferred← citeshttps://doi.org/10.1080/10942912.2023.2249263openalex-snapshot
A review on extraction technique and immune-boosting properties of Moringa oleifera Lam
inferred← citeshttps://doi.org/10.1080/14786419.2024.2345760openalex-snapshot
Protective effect of flavonoids on oxidative stress injury in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/14786419.2024.2444568openalex-snapshot
Investigation of the antibacterial activity of Rhamnus cathartica L. and its anti-QS potential on Pseudomonas aeruginosa PAO1
inferred← citeshttps://doi.org/10.1080/15376516.2024.2390646openalex-snapshot
Hesperetin protects against rotenone-induced motor disability and neurotoxicity via the regulation of SIRT1/NLRP3 signaling
inferred← citeshttps://doi.org/10.1080/17435889.2025.2552103openalex-snapshot
Emerging anti-inflammatory nanosystems targeted to the brain
inferred← citeshttps://doi.org/10.1080/19338244.2024.2394418openalex-snapshot
Apigenin ameliorates petrol vapors-induced oxidative stress as occupational and environmental pollutants in rats: An in vivo study
inferred← citeshttps://doi.org/10.1088/1755-1315/910/1/012045openalex-snapshot
Controlling Strategies of Citrus to Increase The Yield in The Country: A step Towards The Fight Against COVID-19
inferred← citeshttps://doi.org/10.1089/rej.2021.0071openalex-snapshot
Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the Antioxidant Profile in a Natural Rodent Model of Aging
inferred← citeshttps://doi.org/10.1093/bbb/zbag092openalex-snapshot
Neurite outgrowth–promoting furanocoumarins isolated from sudachi juice in PC12 cells
inferred← citeshttps://doi.org/10.1093/femsle/fnag087openalex-snapshot
Involvement of the recA -dependent response in antibacterial activity of hesperetin in Escherichia coli
inferred← citeshttps://doi.org/10.1097/md.0000000000045036openalex-snapshot
Based on network pharmacology, molecular docking, and validation experiments to investigate the active components and mechanisms of action of Tibetan Medog County Citrus medica L.: In antioxidant activity
inferred← citeshttps://doi.org/10.1099/jgv.0.001686openalex-snapshot
Hesperetin inhibits KSHV reactivation and is reversed by HIF1α overexpression
inferred← citeshttps://doi.org/10.1109/inhence52833.2021.9537212openalex-snapshot
A Promising Anti-inflammatory Drugs from Citrus Amblycarpa (Hassk.) Ochse Seeds
inferred← citeshttps://doi.org/10.1111/and.14562openalex-snapshot
Investigation of the effect of hesperidin on some reproductive parameters in testicular toxicity induced by B isphenol A
inferred← citeshttps://doi.org/10.1111/cbdd.14177openalex-snapshot
Analysis of bioactive compounds using LC–ESI–MS / MS , cytotoxic, antimicrobial effects, and enzyme activities from Cyclotrichium origanifolium
inferred← citeshttps://doi.org/10.1111/jocd.15230openalex-snapshot
Hesperetin attenuates UVA‐induced photodamage in human dermal fibroblast cells
inferred← citeshttps://doi.org/10.1134/s106816202306002xopenalex-snapshot
Recent Advances in Synthetic Aspects of Naringenin Flavonoid and its Bioprotective Effect (A Review)
inferred← citeshttps://doi.org/10.1142/s0192415x24500630openalex-snapshot
Flavonoids Derived from Chinese Medicine: Potential Neuroprotective Agents
inferred← citeshttps://doi.org/10.1155/2022/5419890openalex-snapshot
A Brief Review of Natural Products with Urate Transporter 1 Inhibition for the Treatment of Hyperuricemia
inferred← citeshttps://doi.org/10.1155/2023/4139117openalex-snapshot
A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents
inferred← citeshttps://doi.org/10.1177/1934578x211042540openalex-snapshot
Pharmacological Significance of Hesperidin and Hesperetin, Two Citrus Flavonoids, as Promising Antiviral Compounds for Prophylaxis Against and Combating COVID-19
inferred← citeshttps://doi.org/10.1177/1934578x241282497openalex-snapshot
Dendrobium Officinale Kimura & Migo Attenuates High Cholesterol Diet-Induced Atherosclerosis
inferred← citeshttps://doi.org/10.1186/s11671-025-04356-xopenalex-snapshot
Phytochemical based on nanoparticles for neurodegenerative alzheimer disease management: Update review
inferred← citeshttps://doi.org/10.1186/s12868-022-00720-0openalex-snapshot
The functional mechanisms of synchronizing royal jelly consumption and physical activity on rat with multiple sclerosis-like behaviors hallmarks based on bioinformatics analysis, and experimental survey
inferred← citeshttps://doi.org/10.1186/s12935-025-03828-5openalex-snapshot
Role of hesperidin/hesperetin against chemotherapy-induced cardiotoxicity: a systematic review of non-clinical studies
inferred← citeshttps://doi.org/10.1186/s12985-023-02160-6openalex-snapshot
A study on the effect of natural products against the transmission of B.1.1.529 Omicron
inferred← citeshttps://doi.org/10.1186/s13027-025-00676-wopenalex-snapshot
Targeting Fusobacterium nucleatum in colorectal cancer: therapeutic strategies and future directions
inferred← citeshttps://doi.org/10.1186/s40360-024-00792-0openalex-snapshot
Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity
inferred← citeshttps://doi.org/10.1186/s41936-025-00524-8openalex-snapshot
Eucalyptus alba Reinw Ex. Blume (Myrtaceae) extracts mitigate behavioral changes, neurohistopathological alterations, and hypothalamus-pituitary-adrenal axis dysregulation following prenatal stress in a rat model
inferred← citeshttps://doi.org/10.1208/s12249-022-02323-8openalex-snapshot
Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage
inferred← citeshttps://doi.org/10.1208/s12249-026-03484-6openalex-snapshot
Development and Characterization of Amorphous PVP K30–Phosphatidylcholine Dispersions for the Fixed-Dose Co-Delivery of Hesperetin and Cannabidiol Prepared by Hot-Melt Extrusion
inferred← citeshttps://doi.org/10.12873/454arzaopenalex-snapshot
Proximate Composition, Antioxidant Activity, Total Phenol and Vitamin C Content of Pineapple Combined with Orange Juice
inferred← citeshttps://doi.org/10.13057/biodiv/d230946openalex-snapshot
Antibacterial and antioxidant activity of endophytic fungi isolated from Peronema canescens leaves
inferred← citeshttps://doi.org/10.14499/indonesianjcanchemoprev14iss3pp181-188openalex-snapshot
Cytotoxic Activity and Senescence Modulatory Effect of Hesperetin on Triple-Negative Breast Cancer Cells and Kidney Cells Co-Treatment with Cisplatin
inferred← citeshttps://doi.org/10.1515/med-2025-1215openalex-snapshot
Mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
inferred← citeshttps://doi.org/10.15586/ijfs.v33i2.2009openalex-snapshot
Citrus species: Modern functional food and nutraceutical-based product ingredient
inferred← citeshttps://doi.org/10.17660/actahortic.2024.1399.36openalex-snapshot
Citrus health benefits: evidence from pre-clinical and clinical studies
inferred← citeshttps://doi.org/10.19080/artoaj.2020.25.556292openalex-snapshot
Hesperidin Flavonoids from Orange Peel Show Benefits for Human Health
inferred← citeshttps://doi.org/10.20935/acadbiol7873openalex-snapshot
Boswellia dalzielii bark extract mitigates ischemic brain injury via antioxidant and anti-inflammatory effects
inferred← citeshttps://doi.org/10.20944/preprints202010.0189.v1openalex-snapshot
An Advanced Mode of Antioxidants Delivery System Effective in the Treatment of ROS and Skin Permeation of The Cosmetic Formulations - The Possible Application of Clove Oil, Eugenol and New Eugenol Derivative
inferred← citeshttps://doi.org/10.20944/preprints202312.1822.v1openalex-snapshot
An Evaluation of the Anti-QS Activity and Virulence Factors Production Potential of Rhamnus cathartica L. against Some Gram-Positive and Gram-Negative Bacteria
inferred← citeshttps://doi.org/10.21037/atm-22-3136openalex-snapshot
Research progress on the mechanism of action of hesperetin in cerebral ischemia: a narrative review
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5036368/v1openalex-snapshot
Explore of potential targets and mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments
inferred← citeshttps://doi.org/10.2139/ssrn.4884468openalex-snapshot
Protective Mechanism of Alpinia Officinarum Hance Against Cisplatin-Induced Acute Kidney Injury Based on Ultra-High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry Combined with Network Pharmacology
inferred← citeshttps://doi.org/10.21608/bvmj.2023.255548.1765openalex-snapshot
Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice
inferred← citeshttps://doi.org/10.2174/0118715273400444251015050402openalex-snapshot
Hesperetin Early Intervention Reduces Β-Amyloid Production in APP/PS1 Mice by Decreasing Beta and Gamma-Secretase Enzyme
inferred← citeshttps://doi.org/10.2174/0122150838378147250818072318openalex-snapshot
Effects of Herbal Extracts, Glycomacropeptides, and Probiotics on Urolithiasis Prevention: An Overview
inferred← citeshttps://doi.org/10.2174/1389557523666230907093441openalex-snapshot
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review
inferred← citeshttps://doi.org/10.2174/1570159x20666211217163540openalex-snapshot
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease
inferred← citeshttps://doi.org/10.2174/1570180820666230509115220openalex-snapshot
Medicinal Plants and Bioactive Compounds with Potential Anti-inflammatory and Antidiabetic Activities: A Review
inferred← citeshttps://doi.org/10.2174/9789815040197123010013openalex-snapshot
Pharmacology of Rosmarinic Acid against Psychological Disorders
inferred← citeshttps://doi.org/10.29254/2077-4214-2024-2-173-88-94openalex-snapshot
THE INFLUENCE OF TOCOPHEROL ON THE TOXIC PROPERTIES OF CADMIUM (REVIEW OF FOREIGN LITERATURE)
inferred← citeshttps://doi.org/10.31083/ijp44072openalex-snapshot
Comparative Phytochemical Analysis and Ethnopharmacological Potential of Nine Aloe Species Grown in the Western Highlands of Saudi Arabia
inferred← citeshttps://doi.org/10.31083/j.fbe1404027openalex-snapshot
Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline
inferred← citeshttps://doi.org/10.31083/j.jin2101042openalex-snapshot
Citrus limon L. (lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration
inferred← citeshttps://doi.org/10.3233/jad-215493openalex-snapshot
Interaction Between Diet and Microbiota in the Pathophysiology of Alzheimer’s Disease: Focus on Polyphenols and Dietary Fibers
inferred← citeshttps://doi.org/10.3389/fcell.2026.1890060openalex-snapshot
Citrus flavanones (naringenin, hesperidin, and hesperetin) in oral and gastric carcinogenesis: mechanistic insights into oxidative stress, cell death, epigenetic regulation, non-coding RNAs, and tumor microenvironment remodeling
inferred← citeshttps://doi.org/10.3389/fcimb.2024.1356003openalex-snapshot
An overview of anti-Hepatitis B virus flavonoids and their mechanisms of action
inferred← citeshttps://doi.org/10.3389/fnagi.2022.877078openalex-snapshot
Multi-Omics Integration in Mice With Parkinson’s Disease and the Intervention Effect of Cyanidin-3-O-Glucoside
inferred← citeshttps://doi.org/10.3389/fnut.2022.1043095openalex-snapshot
Impacts of hesperidin on whey protein functionality: Interacting mechanism, antioxidant capacity, and emulsion stabilizing effects
inferred← citeshttps://doi.org/10.3389/fnut.2025.1706146openalex-snapshot
Harnessing hesperidin for brain metabolism: epigenetic signatures, cellular homeostasis, synaptic function, and neuroprotection in age-related diseases and neurodegenerative diseases
inferred← citeshttps://doi.org/10.3389/fnut.2026.1856961openalex-snapshot
Cycloastragenol improves tolerance to acute hypoxic exhaustive exercise stress in mice: integrated network pharmacology and experimental evidence
inferred← citeshttps://doi.org/10.3389/fonc.2022.837408openalex-snapshot
Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha
inferred← citeshttps://doi.org/10.3389/fphar.2021.612078openalex-snapshot
Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
inferred← citeshttps://doi.org/10.3389/fphar.2021.639651openalex-snapshot
Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy
inferred← citeshttps://doi.org/10.3389/fphar.2021.735087openalex-snapshot
Hesperetin Exhibits Anti-Inflammatory Effects on Chondrocytes via the AMPK Pathway to Attenuate Anterior Cruciate Ligament Transection-Induced Osteoarthritis
inferred← citeshttps://doi.org/10.3389/fphar.2023.1120616openalex-snapshot
Potential of natural flavonols and flavanones in the treatment of ulcerative colitis
inferred← citeshttps://doi.org/10.3389/fphar.2026.1826774openalex-snapshot
Protective effect of hesperetin against myelosuppression and splenic inflammation via modulating TLR4/MYD88/NF-κB signaling: molecular docking and experimental validation
inferred← citeshttps://doi.org/10.3390/ani12050627openalex-snapshot
Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Dogs
inferred← citeshttps://doi.org/10.3390/ani12131654openalex-snapshot
Feeding Fiber-Bound Polyphenol Ingredients at Different Levels Modulates Colonic Postbiotics to Improve Gut Health in Cats
inferred← citeshttps://doi.org/10.3390/antiox10010021openalex-snapshot
Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics
inferred← citeshttps://doi.org/10.3390/antiox10020140openalex-snapshot
Antioxidant and Anti-Inflammatory Activity of Citrus Flavanones Mix and Its Stability after In Vitro Simulated Digestion
inferred← citeshttps://doi.org/10.3390/antiox11112197openalex-snapshot
Structural Requirements for the Neuroprotective and Anti-Inflammatory Activities of the Flavanone Sterubin
inferred← citeshttps://doi.org/10.3390/antiox11122470openalex-snapshot
Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents
inferred← citeshttps://doi.org/10.3390/antiox12010180openalex-snapshot
Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy
inferred← citeshttps://doi.org/10.3390/antiox12020280openalex-snapshot
Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action
inferred← citeshttps://doi.org/10.3390/antiox12030663openalex-snapshot
The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline
inferred← citeshttps://doi.org/10.3390/antiox12040972openalex-snapshot
Synergistic Combination of Citrus Flavanones as Strong Antioxidant and COX-Inhibitor Agent
inferred← citeshttps://doi.org/10.3390/antiox13010050openalex-snapshot
Ultra-High-Resolution Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry Analysis of Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) and Antioxidant and Hypocholesterolemic Properties
inferred← citeshttps://doi.org/10.3390/antiox14080998openalex-snapshot
Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities
inferred← citeshttps://doi.org/10.3390/antiox15081007openalex-snapshot
Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation
inferred← citeshttps://doi.org/10.3390/antiox9080742openalex-snapshot
Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits
inferred← citeshttps://doi.org/10.3390/app11094221openalex-snapshot
Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa
inferred← citeshttps://doi.org/10.3390/biomedicines9020099openalex-snapshot
Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3390/books978-3-0365-2640-9openalex-snapshot
New Insights in Oral Health and Diets
inferred← citeshttps://doi.org/10.3390/brainsci13081144openalex-snapshot
Involvement of Nrf2 Activation and NF-kB Pathway Inhibition in the Antioxidant and Anti-Inflammatory Effects of Hesperetin in Activated BV-2 Microglial Cells
inferred← citeshttps://doi.org/10.3390/cells10102719openalex-snapshot
RETRACTED: Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions
inferred← citeshttps://doi.org/10.3390/cells12020252openalex-snapshot
Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3390/cimb46080478openalex-snapshot
Hypomyelination Leukodystrophy 16 (HLD16)-Associated Mutation p.Asp252Asn of TMEM106B Blunts Cell Morphological Differentiation
inferred← citeshttps://doi.org/10.3390/cimb48060596openalex-snapshot
Time-Resolved Secondary Metabolite Profiling of Seeded and Seedless Ougan at Commercial Harvest Maturity
inferred← citeshttps://doi.org/10.3390/d15060724openalex-snapshot
Comparative Metabolome Profiles and Antioxidant Potential of Four Coffea arabica L. Varieties Differing in Fruit Color
inferred← citeshttps://doi.org/10.3390/environments13020120openalex-snapshot
Modification of the Polyphenolic Profile and Enhancement of Antioxidant Activity of Waste Orange Peel Extracts Using Alkali-Catalyzed Ethanol Organosolv Treatment
inferred← citeshttps://doi.org/10.3390/foods13121931openalex-snapshot
Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/horticulturae10030208openalex-snapshot
Optimized Production of a Hesperidin-Enriched Extract with Enhanced Antioxidant Activity from Waste Orange Peels Using a Glycerol/Sodium Butyrate Deep Eutectic Solvent
inferred← citeshttps://doi.org/10.3390/ijerph19148288openalex-snapshot
Application of High-Performance Liquid Chromatography with Diode Array Detection to Simultaneous Analysis of Reference Antioxidants and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) in Free Radical Scavenging Test
inferred← citeshttps://doi.org/10.3390/ijerph191912380openalex-snapshot
Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review
inferred← citeshttps://doi.org/10.3390/ijms221810035openalex-snapshot
Hesperetin Inhibits Expression of Virulence Factors and Growth of Helicobacter pylori
inferred← citeshttps://doi.org/10.3390/ijms232214014openalex-snapshot
Rejuvenation: Turning Back Time by Enhancing CISD2
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