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Miyabenol A Inhibits LPS-Induced NO Production via IKK/IκB Inactivation in RAW 264.7 Macrophages: Possible Involvement of the p38 and PI3K Pathways

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0140-6736(91)92376-dopenalex-snapshot
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
inferredcites →https://doi.org/10.1016/j.ejphar.2007.07.034openalex-snapshot
Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-κB, ERK1/2, and p38 kinase
inferredcites →https://doi.org/10.1016/j.intimp.2007.11.003openalex-snapshot
Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways
inferredcites →https://doi.org/10.1016/j.mam.2004.09.003openalex-snapshot
The role of nitric oxide in cardiovascular diseases
inferredcites →https://doi.org/10.1016/j.neuint.2006.04.010openalex-snapshot
Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms
inferredcites →https://doi.org/10.1016/j.phrs.2003.11.004openalex-snapshot
Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression
inferredcites →https://doi.org/10.1016/s0014-4835(03)00029-0openalex-snapshot
Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade
inferredcites →https://doi.org/10.1016/s0092-8674(00)80406-7openalex-snapshot
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
inferredcites →https://doi.org/10.1016/s0092-8674(02)00703-1openalex-snapshot
Missing Pieces in the NF-κB Puzzle
inferredcites →https://doi.org/10.1016/s0301-472x(02)00777-4openalex-snapshot
NFκB-dependent signaling pathways
inferredcites →https://doi.org/10.1016/s0891-5849(00)00218-5openalex-snapshot
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
inferredcites →https://doi.org/10.1016/s0898-6568(99)00018-2openalex-snapshot
Involvement of Mitogen-Activated Protein Kinase Homologues in the Regulation of Lipopolysaccharide-Mediated Induction of Cyclo-oxygenase-2 but not Nitric Oxide Synthase in RAW 264.7 Macrophages
inferredcites →https://doi.org/10.1021/np049686popenalex-snapshot
Resveratrol Derivatives from the Roots of Vitis thunbergii
inferredcites →https://doi.org/10.1038/sj.bjp.0707271openalex-snapshot
Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway
inferredcites →https://doi.org/10.1055/s-2005-864151openalex-snapshot
Laxifolone A Suppresses LPS/IFN-γ-Induced NO Synthesis by Attenuating NF-κB Translocation: Role of NF-κB p105 Level
inferredcites →https://doi.org/10.1055/s-2007-993786openalex-snapshot
(+)-Vitisin A Inhibits Influenza A Virus-Induced RANTES Production in A549 Alveolar Epithelial Cells through Interference with Akt and STAT1 Phosphorylation
inferredcites →https://doi.org/10.1074/jbc.273.6.3285openalex-snapshot
p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor
inferredcites →https://doi.org/10.1074/jbc.m101103200openalex-snapshot
Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38
inferredcites →https://doi.org/10.1084/jem.177.6.1779openalex-snapshot
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.
inferredcites →https://doi.org/10.1086/314659openalex-snapshot
Specific Inhibitors of p38 and Extracellular Signal‐Regulated Kinase Mitogen‐Activated Protein Kinase Pathways Block Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Accumulation in Murine Macrophages Stimulated with Lipopolysaccharide and Interferon‐γ
inferredcites →https://doi.org/10.1096/fj.04-2691fjeopenalex-snapshot
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF‐κB‐independent mechanism
inferredcites →https://doi.org/10.1101/gad.1228704openalex-snapshot
Signaling to NF-κB
inferredcites →https://doi.org/10.1128/mcb.19.7.4798openalex-snapshot
Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit
inferredcites →https://doi.org/10.1152/ajplung.2000.279.5.l895openalex-snapshot
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
inferredcites →https://doi.org/10.1177/154405910708600902openalex-snapshot
p38 Pathway Kinases as Anti-inflammatory Drug Targets
inferredcites →https://doi.org/10.1189/jlb.1103561openalex-snapshot
Effects ofcis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes
inferredcites →https://doi.org/10.2174/156802606775270297openalex-snapshot
Selective Inhibitors of Inducible Nitric Oxide Synthase: Potential Agents for the Treatment of Inflammatory Diseases?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review
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P38α contributes to TNF ‐α‐induced IL ‐8 production in human gingival cells
inferred← citeshttps://doi.org/10.1002/mnfr.200900318openalex-snapshot
Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3‐kinase/Akt‐induced IFN‐γ secretion in LPS‐activated peritoneal macrophages
inferred← citeshttps://doi.org/10.1007/s10600-026-04982-6openalex-snapshot
A New Lignan from the Stems of Vitis thunbergii
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Bioactive stilbenes from plants
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Glutamine induces nuclear degradation of the NF-κB p65 subunit in Caco-2/TC7 cells
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Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.10.008openalex-snapshot
Protective mechanisms of resveratrol derivatives against TNF-α-induced inflammatory responses in rat mesangial cells
inferred← citeshttps://doi.org/10.1016/j.fct.2017.12.037openalex-snapshot
Gypenosides protect retinal pigment epithelium cells from oxidative stress
inferred← citeshttps://doi.org/10.1016/j.foodres.2022.111831openalex-snapshot
Chemical composition and anti-inflammatory activity of water extract from black cocoa tea (Camellia ptilophylla)
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Pharmacological potential of ampelopsin in Rattan tea
inferred← citeshttps://doi.org/10.1016/j.intimp.2011.12.001openalex-snapshot
Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways
inferred← citeshttps://doi.org/10.1016/j.phytol.2011.07.009openalex-snapshot
Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.taap.2011.08.013openalex-snapshot
Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1016/j.yexcr.2011.01.025openalex-snapshot
Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways
inferred← citeshttps://doi.org/10.1021/jf903629jopenalex-snapshot
Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-κB Transactivation Inhibition
inferred← citeshttps://doi.org/10.1021/np400800hopenalex-snapshot
Inhibitory Effect of a Callophycin A Derivative on iNOS Expression via Inhibition of Akt in Lipopolysaccharide-Stimulated RAW 264.7 Cells
inferred← citeshttps://doi.org/10.1155/2012/436786openalex-snapshot
Ethanolic Extract ofVitis thunbergiiExhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits
inferred← citeshttps://doi.org/10.1155/2013/409321openalex-snapshot
Anti-Inflammatory Effect of Procyanidins from Wild Grape (Vitis amurensis) Seeds in LPS-Induced RAW 264.7 Cells
inferred← citeshttps://doi.org/10.1155/2013/409421openalex-snapshot
A Special Ingredient (VtR) Containing Oligostilbenes Isolated from Vitis thunbergii Prevents Bone Loss in Ovariectomized Mice: In Vitro and In Vivo Study
inferred← citeshttps://doi.org/10.1155/2013/846740openalex-snapshot
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide
inferred← citeshttps://doi.org/10.1155/2016/7216912openalex-snapshot
Anti-Inflammatory Effect of Rhapontici Radix Ethanol Extract via Inhibition of NF-κB and MAPK and Induction of HO-1 in Macrophages
inferred← citeshttps://doi.org/10.1371/journal.pone.0035922openalex-snapshot
Anti-Inflammatory Activities of Inotilone from Phellinus linteus through the Inhibition of MMP-9, NF-κB, and MAPK Activation In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1371/journal.pone.0050668openalex-snapshot
High-Mobility Group Box-1 Induces Proinflammatory Cytokines Production of Kupffer Cells through TLRs-Dependent Signaling Pathway after Burn Injury
inferred← citeshttps://doi.org/10.1371/journal.pone.0079084openalex-snapshot
Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0143077openalex-snapshot
Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification
inferred← citeshttps://doi.org/10.2741/3702openalex-snapshot
Functional role of Akt in macrophage-mediated innate immunity
inferred← citeshttps://doi.org/10.3389/fchem.2021.679592openalex-snapshot
Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors
inferred← citeshttps://doi.org/10.3389/fphar.2016.00148openalex-snapshot
Gypenoside Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of Mitogen-Activated Protein Kinase Mediated Nuclear Factor Kappa B Pathway In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3390/antiox15020169openalex-snapshot
Bioactive Components of Parthenocissus quinquefolia with Antioxidant and Anti-Inflammatory Properties: A Systematic Review
inferred← citeshttps://doi.org/10.3390/antiox9111067openalex-snapshot
Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model
inferred← citeshttps://doi.org/10.3390/ijms18081638openalex-snapshot
Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke
inferred← citeshttps://doi.org/10.3390/ijms221910220openalex-snapshot
In Silico Identification and Evaluation of Natural Products as Potential Tumor Necrosis Factor Function Inhibitors Using Advanced Enalos Asclepios KNIME Nodes
inferred← citeshttps://doi.org/10.3390/molecules21060818openalex-snapshot
Anti-Inflammatory Effects of Melandrii Herba Ethanol Extract via Inhibition of NF-κB and MAPK Signaling Pathways and Induction of HO-1 in RAW 264.7 Cells and Mouse Primary Macrophages
inferred← citeshttps://doi.org/10.3390/molecules24030386openalex-snapshot
20-Hydroxy-3-Oxolupan-28-Oic Acid Attenuates Inflammatory Responses by Regulating PI3K–Akt and MAPKs Signaling Pathways in LPS-Stimulated RAW264.7 Macrophages
inferred← citeshttps://doi.org/10.3390/molecules24030563openalex-snapshot
New Anti-inflammatory Flavonol Glycosides from Lindera akoensis Hayata
inferred← citeshttps://doi.org/10.3390/molecules30092025openalex-snapshot
Investigating Natural Product Inhibitors of IKKα: Insights from Integrative In Silico and Experimental Validation
inferred← citeshttps://doi.org/10.3390/nu11081746openalex-snapshot
Remission Effects of Dietary Soybean Isoflavones on DSS-Induced Murine Colitis and an LPS-Activated Macrophage Cell Line
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Cedrela sinensis Leaves Suppress Oxidative Stress and Expressions of iNOS and COX-2 via MAPK Signaling Pathways in RAW 264.7 Cells
inferred← citeshttps://doi.org/10.3892/etm.2017.4197openalex-snapshot
Oral administration of ampelopsin protects against acute brain injury in rats following focal cerebral ischemia
inferred← citeshttps://doi.org/10.3923/ijp.2017.457.464openalex-snapshot
Vitis thunbergii var. taiwaniana Leaf Extract Reduces Blood Glucose Levels in Mice with Streptozotocin-induced Diabetes
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NF-κB and Therapeutic Approach
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Anti-inflammatory effect of methanol extract fromErigeron CanadensisL. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFκB and MAPKs activation in macrophages
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