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Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-4547(19991101)58:3<417::aid-jnr7>3.0.co;2-gopenalex-snapshot
Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity
inferredcites →https://doi.org/10.1002/ptr.1521openalex-snapshot
Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors
inferredcites →https://doi.org/10.1006/mcbr.2001.0304openalex-snapshot
Role of the Oncogenic Raf-1 in Orchestration of Discrete Nuclear Factor-κB-Activating Pathways
inferredcites →https://doi.org/10.1006/smim.2000.0210openalex-snapshot
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
inferredcites →https://doi.org/10.1007/bf02976432openalex-snapshot
Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation toin vitro cytotoxicity
inferredcites →https://doi.org/10.1007/bf02980124openalex-snapshot
Structure-related cytotoxicity and anti-hepatofibric effect of asiatic acid derivatives in rat hepatic stellate cell-line, HSC-T6
inferredcites →https://doi.org/10.1016/s0014-2999(03)02177-0openalex-snapshot
Inhibition of ultraviolet-A-modulated signaling pathways by asiatic acid and ursolic acid in HaCaT human keratinocytes
inferredcites →https://doi.org/10.1016/s0014-4835(03)00029-0openalex-snapshot
Human RPE-monocyte co-culture induces chemokine gene expression through activation of MAPK and NIK cascade
inferredcites →https://doi.org/10.1016/s0014-5793(02)02311-6openalex-snapshot
Induction of inducible nitric oxide synthase expression by 18β‐glycyrrhetinic acid in macrophages
inferredcites →https://doi.org/10.1016/s0021-9258(18)35698-9openalex-snapshot
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
inferredcites →https://doi.org/10.1016/s0026-895x(24)12172-4openalex-snapshot
p38 but Not p44/42 Mitogen-Activated Protein Kinase Is Required for Nitric Oxide Synthase Induction Mediated by Lipopolysaccharide in RAW 264.7 Macrophages
inferredcites →https://doi.org/10.1016/s0092-8674(00)80412-2openalex-snapshot
Innate Immunity: The Virtues of a Nonclonal System of Recognition
inferredcites →https://doi.org/10.1016/s0092-8674(02)00703-1openalex-snapshot
Missing Pieces in the NF-κB Puzzle
inferredcites →https://doi.org/10.1016/s0165-6147(02)00043-3openalex-snapshot
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
inferredcites →https://doi.org/10.1016/s0304-3835(02)00260-4openalex-snapshot
Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells
inferredcites →https://doi.org/10.1016/s0891-5849(00)00218-5openalex-snapshot
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
inferredcites →https://doi.org/10.1016/s0898-6568(00)00149-2openalex-snapshot
LPS induction of gene expression in human monocytes
inferredcites →https://doi.org/10.1016/s0952-7915(96)80131-2openalex-snapshot
Mitogen-activated protein kinase cascades and regulation of gene expression
inferredcites →https://doi.org/10.1016/s0960-894x(99)00658-7openalex-snapshot
Structure–activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicity
inferredcites →https://doi.org/10.1016/s0968-0004(98)01309-7openalex-snapshot
Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals
inferredcites →https://doi.org/10.1016/s1074-7613(02)00390-4openalex-snapshot
IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program
inferredcites →https://doi.org/10.1017/s1462399404007409openalex-snapshot
Sepsis: molecular mechanisms underlying lipopolysaccharide recognition
inferredcites →https://doi.org/10.1034/j.1600-065x.2003.00049.xopenalex-snapshot
Transducing signals from antigen receptors to nuclear factor κB
inferredcites →https://doi.org/10.1038/358417a0openalex-snapshot
Raf-1 activates MAP kinase-kinase
inferredcites →https://doi.org/10.1038/nature01180openalex-snapshot
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
inferredcites →https://doi.org/10.1038/nri910openalex-snapshot
NF-κB regulation in the immune system
inferredcites →https://doi.org/10.1038/sj.bjp.0702732openalex-snapshot
Pharmacological characterization of ATP‐ and LPS‐induced IL‐1β release in human monocytes
inferredcites →https://doi.org/10.1038/sj.bjp.0706718openalex-snapshot
Anti‐inflammatory effect of buddlejasaponin IV through the inhibition of iNOS and COX‐2 expression in RAW 264.7 macrophages via the NF‐κB inactivation
inferredcites →https://doi.org/10.1042/bst0280557openalex-snapshot
The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence
inferredcites →https://doi.org/10.1042/bst0310643openalex-snapshot
The role of MyD88-like adapters in Toll-like receptor signal transduction
inferredcites →https://doi.org/10.1055/s-2003-41127openalex-snapshot
In vivoAnti-Inflammatory and Antinociceptive Effects of Liriodendrin Isolated from the Stem Bark ofAcanthopanax senticosus
inferredcites →https://doi.org/10.1055/s-2003-42791openalex-snapshot
Gene Expression Changes in the Human Fibroblast Induced byCentella asiaticaTriterpenoids
inferredcites →https://doi.org/10.1056/nejm199704103361506openalex-snapshot
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
inferredcites →https://doi.org/10.1073/pnas.90.6.2532openalex-snapshot
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
inferredcites →https://doi.org/10.1073/pnas.93.7.2774openalex-snapshot
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
inferredcites →https://doi.org/10.1074/jbc.272.41.25941openalex-snapshot
Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304
inferredcites →https://doi.org/10.1074/jbc.274.13.9108openalex-snapshot
Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation
inferredcites →https://doi.org/10.1074/jbc.m006814200openalex-snapshot
ATP-stimulated Release of Interleukin (IL)-1β and IL-18 Requires Priming by Lipopolysaccharide and Is Independent of Caspase-1 Cleavage
inferredcites →https://doi.org/10.1074/jbc.m110000200openalex-snapshot
Interaction between Active Pak1 and Raf-1 Is Necessary for Phosphorylation and Activation of Raf-1
inferredcites →https://doi.org/10.1080/10715760500467935openalex-snapshot
Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages
inferredcites →https://doi.org/10.1086/314659openalex-snapshot
Specific Inhibitors of p38 and Extracellular Signal‐Regulated Kinase Mitogen‐Activated Protein Kinase Pathways Block Inducible Nitric Oxide Synthase and Tumor Necrosis Factor Accumulation in Murine Macrophages Stimulated with Lipopolysaccharide and Interferon‐γ
inferredcites →https://doi.org/10.1096/fasebj.5.9.1907252openalex-snapshot
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
inferredcites →https://doi.org/10.1146/annurev.immunol.8.1.253openalex-snapshot
Interleukin-6: An Overview
inferredcites →https://doi.org/10.1161/hc3801.095693openalex-snapshot
Nitric Oxide Synthase (nNOS) Gene Transfer Modifies Venous Bypass Graft Remodeling
inferredcites →https://doi.org/10.1385/1-59259-374-7:291openalex-snapshot
Roles of Nitric Oxide and Superoxide in Inflammation
inferredcites →https://doi.org/10.1515/dmdi.2000.17.1-4.211openalex-snapshot
The Bioactivity of Saponins: Triterpenoid and Steroidal Glycosides
inferredcites →https://doi.org/10.1523/jneurosci.18-05-01633.1998openalex-snapshot
Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures
inferredcites →https://doi.org/10.4049/jimmunol.166.3.2011openalex-snapshot
The Inhibitory Action of Sodium Arsenite on Lipopolysaccharide-Induced Nitric Oxide Production in RAW 267.4 Macrophage Cells: A Role of Raf-1 in Lipopolysaccharide Signaling

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR‐1290
inferred← citeshttps://doi.org/10.1002/ptr.4838openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00044-016-1623-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10068-021-00929-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10616-025-00799-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10753-014-0087-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10753-015-0299-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10753-016-0398-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10753-016-0400-9openalex-snapshot
Astragaloside IV Inhibits the Inflammatory Injury of Chicken Type II Pneumocytes Induced by Avian Pathogenic Escherichia coli
inferred← citeshttps://doi.org/10.1007/s11010-009-0267-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11356-015-5022-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11626-021-00620-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12011-018-1333-yopenalex-snapshot
Selenium Pretreatment Alleviated LPS-Induced Immunological Stress Via Upregulation of Several Selenoprotein Encoding Genes in Murine RAW264.7 Cells
inferred← citeshttps://doi.org/10.1007/s12012-010-9072-0openalex-snapshot
Protective Effect of Sulforaphane on Human Vascular Endothelial Cells Against Lipopolysaccharide-Induced Inflammatory Damage
inferred← citeshttps://doi.org/10.1007/s12012-017-9424-0openalex-snapshot
Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats
inferred← citeshttps://doi.org/10.1007/s12013-013-9725-2openalex-snapshot
Asiatic Acid Inhibits Adipogenic Differentiation of Bone Marrow Stromal Cells
inferred← citeshttps://doi.org/10.1007/s13273-024-00477-zopenalex-snapshot
Anti-inflammatory activity of Akebia quinata D. extracts by inhibiting MAPK and NF-κB signaling pathways in LPS-induced RAW 264.7 cells according to extraction solvents
inferred← citeshttps://doi.org/10.1007/s40883-025-00512-yopenalex-snapshot
Biopolymers and Medicinal Plants in Wound Healing: a Comprehensive Literature Review of Advances in Tissue Regeneration and Translational Applications
inferred← citeshttps://doi.org/10.1016/b978-0-12-398373-2.00002-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-805417-8.00028-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-812491-8.00038-2openalex-snapshot
Gotu Kola (Centella asiatica)
inferred← citeshttps://doi.org/10.1016/b978-0-12-819212-2.00021-9openalex-snapshot
Centella asiatica
inferred← citeshttps://doi.org/10.1016/b978-0-443-06992-5.00010-4openalex-snapshot
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Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.01.066openalex-snapshot
A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.03.057openalex-snapshot
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.carbpol.2014.11.035openalex-snapshot
Polysaccharides from Smilax glabra inhibit the pro-inflammatory mediators via ERK1/2 and JNK pathways in LPS-induced RAW264.7 cells
inferred← citeshttps://doi.org/10.1016/j.carbpol.2015.04.070openalex-snapshot
Activation of RAW 264.7 cells by a polysaccharide isolated from Antarctic bacterium Pseudoaltermonas sp. S-5
inferred← citeshttps://doi.org/10.1016/j.cbi.2015.06.038openalex-snapshot
2β, 3β, 23-trihydroxy-urs-12-ene-28-olic acid (TUA) isolated from Actinidia chinensis Radix inhibits NCI-H460 cell proliferation by decreasing NF-κB expression
inferred← citeshttps://doi.org/10.1016/j.cbi.2016.11.014openalex-snapshot
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Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis
inferred← citeshttps://doi.org/10.1016/j.cellimm.2010.05.011openalex-snapshot
Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells
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2′-Benzoyloxycinnamaldehyde inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells via regulation of AP-1 pathway
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Inhibitory effects of sulfated 20(S)-ginsenoside Rh2 on the release of pro-inflammatory mediators in LPS-induced RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.ejphar.2013.06.017openalex-snapshot
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Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages
inferred← citeshttps://doi.org/10.1016/j.etp.2010.04.002openalex-snapshot
Protective effects of asiaticoside on septic lung injury in mice
inferred← citeshttps://doi.org/10.1016/j.fct.2012.12.021openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.fct.2014.01.031openalex-snapshot
PGE2 production is suppressed by chemically-synthesized Δ7-eicosatrienoic acid in macrophages through the competitive inhibition of COX-2
inferred← citeshttps://doi.org/10.1016/j.febslet.2008.04.016openalex-snapshot
Dipyrithione inhibits lipopolysaccharide‐induced iNOS and COX‐2 up‐regulation in macrophages and protects against endotoxic shock in mice
inferred← citeshttps://doi.org/10.1016/j.fitote.2024.105918openalex-snapshot
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Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages
inferred← citeshttps://doi.org/10.1016/j.fsi.2016.07.038openalex-snapshot
Pinocembrin attenuates lipopolysaccharide-induced inflammatory responses in Labeo rohita macrophages via the suppression of the NF-κB signalling pathway
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e17807openalex-snapshot
Preparation, development, and scale-up of standardized pentacyclic triterpenoid-rich extract from Centella asiatica (L.) Urb. and study of its wound healing activity
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2016.01.048openalex-snapshot
Comparative studies on the immunoregulatory effects of three polysaccharides using high content imaging system
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.12.061openalex-snapshot
Designing selenium polysaccharides-based nanoparticles to improve immune activity of Hericium erinaceus
inferred← citeshttps://doi.org/10.1016/j.imbio.2010.12.008openalex-snapshot
Transduced PEP-1-FK506BP inhibits the inflammatory response in the Raw 264.7 cell and mouse models
inferred← citeshttps://doi.org/10.1016/j.indcrop.2020.112171openalex-snapshot
Stimulation of health-promoting triterpenoids accumulation in Centella asiatica (L.) Urban leaves triggered by postharvest application of methyl jasmonate and salicylic acid elicitors
inferred← citeshttps://doi.org/10.1016/j.indcrop.2024.118579openalex-snapshot
Impact of UV-A and UV-C radiation to enhance triterpenoids and related gene expression in triterpenoid pathway of Centella asiatica postharvest
inferred← citeshttps://doi.org/10.1016/j.intimp.2008.10.008openalex-snapshot
Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation
inferred← citeshttps://doi.org/10.1016/j.intimp.2009.04.011openalex-snapshot
Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-κB and JNK/AP-1 activation
inferred← citeshttps://doi.org/10.1016/j.intimp.2009.11.014openalex-snapshot
Anti-resorptive saurolactam exhibits in vitro anti-inflammatory activity via ERK–NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2011.01.002openalex-snapshot
Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages
inferred← citeshttps://doi.org/10.1016/j.intimp.2011.11.018openalex-snapshot
Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge
inferred← citeshttps://doi.org/10.1016/j.intimp.2012.06.022openalex-snapshot
Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2014.04.019openalex-snapshot
δ-Amyrone, a specific inhibitor of cyclooxygenase-2, exhibits anti-inflammatory effects in vitro and in vivo of mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2015.03.022openalex-snapshot
Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2016.07.010openalex-snapshot
Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke
inferred← citeshttps://doi.org/10.1016/j.intimp.2017.07.005openalex-snapshot
Asiatic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts
inferred← citeshttps://doi.org/10.1016/j.intimp.2018.03.034openalex-snapshot
Anti-inflammatory effect of Apo-9′-fucoxanthinone via inhibition of MAPKs and NF-kB signaling pathway in LPS-stimulated RAW 264.7 macrophages and zebrafish model
inferred← citeshttps://doi.org/10.1016/j.jep.2012.01.016openalex-snapshot
Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: Suppression of NF-κB activation and MAPK signaling
inferred← citeshttps://doi.org/10.1016/j.jep.2013.07.008openalex-snapshot
Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia
inferred← citeshttps://doi.org/10.1016/j.jep.2015.08.028openalex-snapshot
Heme oxygenase 1-mediated novel anti-inflammatory activities of Salvia plebeia and its active components
inferred← citeshttps://doi.org/10.1016/j.jep.2017.08.006openalex-snapshot
Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line
inferred← citeshttps://doi.org/10.1016/j.jep.2022.115865openalex-snapshot
A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.
inferred← citeshttps://doi.org/10.1016/j.jfda.2016.02.009openalex-snapshot
Chemical composition and anti-inflammatory activities of essential oil from Trachydium roylei
inferred← citeshttps://doi.org/10.1016/j.jff.2013.04.004openalex-snapshot
Anti-inflammatory effect of the hexane fraction from Orostachys japonicus in RAW 264.7 cells by suppression of NF-κB and PI3K-Akt signaling
inferred← citeshttps://doi.org/10.1016/j.jff.2014.12.031openalex-snapshot
Anti-inflammatory effect of litsenolide B2 isolated from Litsea japonica fruit via suppressing NF-κB and MAPK pathways in LPS-induced RAW264.7 cells
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105353openalex-snapshot
Immunomodulatory effects of L. helveticus WHH2580 fermented milk on an immunosuppressed murine model
inferred← citeshttps://doi.org/10.1016/j.lfs.2011.09.021openalex-snapshot
Anti-inflammatory effect of transduced PEP-1-Cyclophilin A in Raw 264.7 cells and 12-O-tetradecanoylphorbol-13-acetate-induced mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2013.10.014openalex-snapshot
Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2015.07.016openalex-snapshot
The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.117064openalex-snapshot
Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt/NF-κB pathway
inferred← citeshttps://doi.org/10.1016/j.micpath.2018.01.022openalex-snapshot
Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells
inferred← citeshttps://doi.org/10.1016/j.nutos.2021.01.001openalex-snapshot
Honey reverses disease progression, has anti-nociceptive and anti-inflammatory effects in a rat model of knee osteoarthritis induced by monosodium iodoacetate
inferred← citeshttps://doi.org/10.1016/j.pbb.2011.09.014openalex-snapshot
Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax
inferred← citeshttps://doi.org/10.1016/j.pbb.2014.03.004openalex-snapshot
Asiaticoside attenuates memory impairment induced by transient cerebral ischemia–reperfusion in mice through anti-inflammatory mechanism
inferred← citeshttps://doi.org/10.1016/j.phymed.2011.08.003openalex-snapshot
Modified Wu-Zi-Yan-Zong prescription, a traditional Chinese polyherbal formula, suppresses lipopolysaccharide-induced neuroinflammatory processes in rat astrocytes via NF-κB and JNK/p38 MAPK signaling pathways
inferred← citeshttps://doi.org/10.1016/j.phymed.2015.11.003openalex-snapshot
Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2015.11.019openalex-snapshot
Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells
inferred← citeshttps://doi.org/10.1016/j.phyplu.2024.100533openalex-snapshot
In-vitro and in-vivo anti-inflammatory properties of extracts and isolates of Pangdahai
inferred← citeshttps://doi.org/10.1016/j.phytol.2011.07.009openalex-snapshot
Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/IκB/NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells
inferred← citeshttps://doi.org/10.1016/j.phytol.2016.12.014openalex-snapshot
Selective oxidation-reduction and esterification of asiatic acid by Pestalotiopsis microspora and anti-HCV activity
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2025.102822openalex-snapshot
PDGFR mediates lumbar spinal stenosis-induced neuropathic pain by regulating JAK2/STAT3 signaling in activated macrophages
inferred← citeshttps://doi.org/10.1016/j.tifs.2018.07.024openalex-snapshot
Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing
inferred← citeshttps://doi.org/10.1016/j.vph.2018.08.005openalex-snapshot
Asiatic acid stabilizes cytoskeletal proteins and prevents TNF-α-induced disorganization of cell-cell junctions in human aortic endothelial cells
inferred← citeshttps://doi.org/10.1016/s1734-1140(12)70912-xopenalex-snapshot
Anti-inflammatory and antinociceptive effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine in mice
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c02476openalex-snapshot
Peptides from Extruded Lupin (Lupinus albus L.) Regulate Inflammatory Activity via the p38 MAPK Signal Transduction Pathway in RAW 264.7 Cells
inferred← citeshttps://doi.org/10.1021/jf8019369openalex-snapshot
Miyabenol A Inhibits LPS-Induced NO Production via IKK/IκB Inactivation in RAW 264.7 Macrophages: Possible Involvement of the p38 and PI3K Pathways
inferred← citeshttps://doi.org/10.1038/aps.2009.93openalex-snapshot
Macrophage receptors of polysaccharide isolated from a marine filamentous fungus Phoma herbarum YS4108
inferred← citeshttps://doi.org/10.1038/aps.2014.16openalex-snapshot
Cyclovirobuxinum D suppresses lipopolysaccharide-induced inflammatory responses in murine macrophages in vitro by blocking JAK-STAT signaling pathway
inferred← citeshttps://doi.org/10.1038/jid.2011.49openalex-snapshot
Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice
inferred← citeshttps://doi.org/10.1038/s41401-019-0319-4openalex-snapshot
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ
inferred← citeshttps://doi.org/10.1038/s41598-022-17686-yopenalex-snapshot
The compound losartan cream inhibits scar formation via TGF-β/Smad pathway
inferred← citeshttps://doi.org/10.1039/c4ra02784aopenalex-snapshot
Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review
inferred← citeshttps://doi.org/10.1039/c5fo01557jopenalex-snapshot
The anti-inflammatory effect of a glycosylation product derived from the high hydrostatic pressure enzymatic hydrolysate of a flatfish byproduct
inferred← citeshttps://doi.org/10.1039/c6fo90026gopenalex-snapshot
Correction: The anti-inflammatory effect of a glycosylation product derived from the high hydrostatic pressure enzymatic hydrolysate of a flatfish byproduct
inferred← citeshttps://doi.org/10.1039/c6ra04597aopenalex-snapshot
Design, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents
inferred← citeshttps://doi.org/10.1039/c7fo01442bopenalex-snapshot
Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1039/c8fo00563jopenalex-snapshot
SAXS characterization of the interactions among digested food compounds and the anti-oxidant and anti-inflammatory activities of the formed nanocomplexes
inferred← citeshttps://doi.org/10.1039/c9tb01327jopenalex-snapshot
An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing
inferred← citeshttps://doi.org/10.1055/a-1008-6138openalex-snapshot
Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review
inferred← citeshttps://doi.org/10.1055/a-1438-2816openalex-snapshot
Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines
inferred← citeshttps://doi.org/10.1080/03639045.2019.1701002openalex-snapshot
Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects
inferred← citeshttps://doi.org/10.1080/10286020.2012.702761openalex-snapshot
Two new oxidation products obtained from the biotransformation of asiatic acid by the fungusFusarium avenaceumAS 3.4594
inferred← citeshttps://doi.org/10.1080/10286020.2015.1054377openalex-snapshot
Unusual microbial lactonization and hydroxylation of asiatic acid by Umbelopsis isabellina
inferred← citeshttps://doi.org/10.1080/13880209.2017.1278778openalex-snapshot
Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells
inferred← citeshttps://doi.org/10.1080/13880209.2026.2638602openalex-snapshot
Therapeutic potential of Asiaticoside in wound healing after endoscopic submucosal dissection (ESD)
inferred← citeshttps://doi.org/10.1080/14786419.2014.903480openalex-snapshot
Chemical constituents fromMelastoma dodecandrumand their inhibitory activity on interleukin-8 production in HT-29 cells
inferred← citeshttps://doi.org/10.1080/15376516.2016.1273422openalex-snapshot
RETRACTED ARTICLE: Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis
inferred← citeshttps://doi.org/10.1097/fjc.0000000000000304openalex-snapshot
Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice
inferred← citeshttps://doi.org/10.11002/fsp.2024.31.3.462openalex-snapshot
Anti-inflammatory effect of beluga lentil extract in RAW 264.7 macrophages
inferred← citeshttps://doi.org/10.11002/kjfp.2015.22.5.735openalex-snapshot
Anti-inflammatory effect of barley leaf ethanol extract in LPS-stimulated RAW264.7 macrophage
inferred← citeshttps://doi.org/10.1111/1440-1681.12472openalex-snapshot
Asiatic acid alleviates cardiovascular remodelling in rats with L‐ NAME ‐induced hypertension
inferred← citeshttps://doi.org/10.1152/ajplung.00444.2015openalex-snapshot
Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury
inferred← citeshttps://doi.org/10.1155/2011/895857openalex-snapshot
Antinociceptive Activities and the Mechanisms of Anti‐Inflammation of Asiatic Acid in Mice
inferred← citeshttps://doi.org/10.1155/2012/109636openalex-snapshot
Gelam Honey Inhibits the Production of Proinflammatory, Mediators NO, PGE2 , TNF-α, and IL-6 in Carrageenan-Induced Acute Paw Edema in Rats
inferred← citeshttps://doi.org/10.1155/2012/848093openalex-snapshot
Identification of Major Active Ingredients Responsible for Burn Wound Healing ofCentella asiaticaHerbs
inferred← citeshttps://doi.org/10.1155/2017/7383104openalex-snapshot
Kyungheechunggan‐Tang‐01, a New Herbal Medication, Suppresses LPS‐Induced Inflammatory Responses through JAK/STAT Signaling Pathway in RAW 264.7 Macrophages
inferred← citeshttps://doi.org/10.1155/2021/7381620openalex-snapshot
Anti-Inflammatory and Anti-Vascular Leakage Effects by Combination of Centella asiatica and Vitis vinifera L. Leaf Extracts
inferred← citeshttps://doi.org/10.11606/t.5.2016.tde-04082016-152420openalex-snapshot
Efeito da redução da função colinérgica na mecânica pulmonar e na histopatologia pulmonar em modelo experimental de inflamação aguda induzida por instilação de LPS em camundongos geneticamente modificados
inferred← citeshttps://doi.org/10.1177/2472630317751840openalex-snapshot
Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound
inferred← citeshttps://doi.org/10.1186/1476-9255-6-2openalex-snapshot
Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines
inferred← citeshttps://doi.org/10.1186/s12906-017-1865-2openalex-snapshot
Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)
inferred← citeshttps://doi.org/10.1186/s12906-018-2192-yopenalex-snapshot
Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)
inferred← citeshttps://doi.org/10.1186/s12906-026-05420-4openalex-snapshot
Mechanistic evaluation of pachymic acid in breast cancer via network pharmacology and in vitro validation
inferred← citeshttps://doi.org/10.1186/s12951-024-02387-7openalex-snapshot
Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement
inferred← citeshttps://doi.org/10.1208/s12249-019-1488-7openalex-snapshot
Strategies for Improving Healing of the Gastric Epithelium Using Oral Solid Dispersions Loaded with Pentacyclic Triterpene–Rich Centella Extract
inferred← citeshttps://doi.org/10.1208/s12249-025-03276-4openalex-snapshot
Development of Diclofenac Acid Encapsulated Transferosomal gel with Enhanced Antioxidant and Anti-Inflammatory Activities for the Management of Musculoskeletal Pain
inferred← citeshttps://doi.org/10.1248/bpb.34.906openalex-snapshot
23-Hydroxytormentic Acid and Niga-Ichgoside F1 Isolated from Rubus coreanus Attenuate Cisplatin-Induced Cytotoxicity by Reducing Oxidative Stress in Renal Epithelial LLC-PK1 Cells
inferred← citeshttps://doi.org/10.1248/bpb.b13-00634openalex-snapshot
Retraction: Asiatic Acid from Potentilla chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation
inferred← citeshttps://doi.org/10.1248/bpb.b18-00276openalex-snapshot
Asiatic Acid, Corosolic Acid, and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1
inferred← citeshttps://doi.org/10.12677/tcm.2022.112openalex-snapshot
Analysis of Professor Wang Xiaoqin’s Experience in Treating IGA Nephropathy with Qi-Yin Deficiency with Qingxin Lianzi Decoction
inferred← citeshttps://doi.org/10.12791/ksbec.2021.30.4.351openalex-snapshot
Comparison of Growth Characteristics and Physiological Activity of Two Centella asiatica Cultivars in Greenhouse Soil Culture
inferred← citeshttps://doi.org/10.1292/jvms.18-0250openalex-snapshot
Anti-inflammatory effects of olive-derived hydroxytyrosol on lipopolysaccharide-induced inflammation in RAW264.7 cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0031350openalex-snapshot
Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro
inferred← citeshttps://doi.org/10.1371/journal.pone.0135558openalex-snapshot
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice
inferred← citeshttps://doi.org/10.14416/j.ijast.2015.11.001openalex-snapshot
Review: The Bioavailability Activity of Centella asiatica
inferred← citeshttps://doi.org/10.14814/phy2.16136openalex-snapshot
Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision‐cut liver slices
inferred← citeshttps://doi.org/10.15188/kjopp.2014.04.28.2.146openalex-snapshot
Effect of Gami-sopungsan on Inflammation and DNCB-induced Dermatitis in NC/Nga in Mice
inferred← citeshttps://doi.org/10.18311/jnr/2023/34055openalex-snapshot
Plants Used in the Treatment of Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.18632/oncotarget.21151openalex-snapshot
Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARγ/NLRP3 inflammasome signaling pathway
inferred← citeshttps://doi.org/10.18632/oncotarget.24542openalex-snapshot
Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway
inferred← citeshttps://doi.org/10.18632/oncotarget.6100openalex-snapshot
Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin
inferred← citeshttps://doi.org/10.20307/nps.2016.22.1.20openalex-snapshot
Biological Activities and Stability of a Standardized Pentacyclic Triterpene Enriched Centella asiatica Extract
inferred← citeshttps://doi.org/10.20307/nps.2019.25.2.92openalex-snapshot
The Potential of Centella asiatica (Linn.) Urban as an Anti-Microbial and Immunomodulator Agent: A Review
inferred← citeshttps://doi.org/10.20402/ajbc.2017.0195openalex-snapshot
Anti-inflammatory Effect of Galium aparine Extract in RAW 264.7 Cells
inferred← citeshttps://doi.org/10.20402/ajbc.2019.0270openalex-snapshot
Anti-inflammatory Effect of Brazilin in RAW264.7 Cells
inferred← citeshttps://doi.org/10.20402/ajbc.2019.0311openalex-snapshot
Anti-inflammatory Effect of Zeaxanthin in RAW264.7 Cells
inferred← citeshttps://doi.org/10.20402/ajbc.2022.0064openalex-snapshot
The Antioxidant and Anti-inflammatory Activities of Echinacea angustifolia Hot Water Extract
inferred← citeshttps://doi.org/10.20402/ajbc.2024.0013openalex-snapshot
Skin-soothing Effects of Oenothera biennis Flower Extract
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4096694/v1openalex-snapshot
Reversal of stress- or chemotherapy-induced immunosuppression by socheongryong-tang aqueous extract
inferred← citeshttps://doi.org/10.21315/mjms2019.26.5.5openalex-snapshot
Ethanol Extract of Centella asiatica (Gotu Kola) Attenuates Tubular Injury Through Inhibition of Inflammatory Cytokines and Enhancement of Anti-Fibrotic Factor in Mice with 5/6 Subtotal Nephrectomy
inferred← citeshttps://doi.org/10.2147/dddt.s179876openalex-snapshot
Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways
inferred← citeshttps://doi.org/10.2147/ijn.s241923openalex-snapshot
Preparation and in vitro and in vivo Study of Asiaticoside-Loaded Nanoemulsions and Nanoemulsions-Based Gels for Transdermal Delivery
inferred← citeshttps://doi.org/10.2147/ott.s98849openalex-snapshot
AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
inferred← citeshttps://doi.org/10.2174/092986713805219082openalex-snapshot
The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications
inferred← citeshttps://doi.org/10.2174/1871520619666191211103006openalex-snapshot
Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review
inferred← citeshttps://doi.org/10.22038/ijbms.2019.29012.7002openalex-snapshot
Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats.
inferred← citeshttps://doi.org/10.22889/kjp.2025.56.1.21openalex-snapshot
Anti-inflammatory Effects of Lesleigha yamadae in RAW 264.7 Cells
inferred← citeshttps://doi.org/10.22889/kjp.2026.57.1.31openalex-snapshot
Anti-inflammatory Effects of Carex kobomugi in RAW 264.7 Cells
inferred← citeshttps://doi.org/10.3109/08923970903575708openalex-snapshot
A synthetic hydroxypropenone inhibits nitric oxide, prostaglandin E2, and proinflammatory cytokine synthesis
inferred← citeshttps://doi.org/10.3109/08923973.2011.557383openalex-snapshot
Involvement of mitogen-activated protein kinase activation in cyclooxygenase-2 and transforming growth factor-β production in alveolar macrophage from chronic bronchitis rats
inferred← citeshttps://doi.org/10.3109/08923973.2016.1153109openalex-snapshot
Chikusetsusaponin V attenuates lipopolysaccharide-induced liver injury in mice
inferred← citeshttps://doi.org/10.3109/09637486.2014.886184openalex-snapshot
Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillusL.) on croton oil-induced ear edema andPropionibacterium acnesplus LPS-induced liver damage in mice
inferred← citeshttps://doi.org/10.3109/10715760903300709openalex-snapshot
3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease
inferred← citeshttps://doi.org/10.3109/10715762.2014.880113openalex-snapshot
Three pentacyclic triterpenes protect H9c2 cardiomyoblast cells against high-glucose-induced injury
inferred← citeshttps://doi.org/10.3109/13880209.2012.685946openalex-snapshot
Factors affecting the content of pentacyclic triterpenes inCentella asiaticaraw materials
inferred← citeshttps://doi.org/10.3181/0810-rm-298openalex-snapshot
In Vitro and In Vivo Modulation of Cartilage Degradation by a Standardized Centella asiatica Fraction
inferred← citeshttps://doi.org/10.3389/fbioe.2021.707479openalex-snapshot
Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3389/fbioe.2026.1934456openalex-snapshot
Bioceramic bone tissue-engineered substitutes with anti-inflammatory effects in periodontitis
inferred← citeshttps://doi.org/10.3389/fimmu.2016.00533openalex-snapshot
Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2–MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1896372openalex-snapshot
Asiatic acid remodels the gastric precancerous immune microenvironment by targeting STING
inferred← citeshttps://doi.org/10.3389/fphar.2018.00892openalex-snapshot
Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
inferred← citeshttps://doi.org/10.3389/fphar.2019.00620openalex-snapshot
The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/Reperfusion via Inhibiting the Jak2/Stat3 Signaling Pathway
inferred← citeshttps://doi.org/10.3389/fphar.2020.00690openalex-snapshot
Neuroprotective Effect of Catalpol via Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms
inferred← citeshttps://doi.org/10.3390/antiox13030311openalex-snapshot
Anti-Inflammatory Effects of Anthocyanin-Enriched Black Soybean Seed Coat (BSSC) Crude Extract on LPS-Induced Acute Liver Injury in Mice
inferred← citeshttps://doi.org/10.3390/antiox13040483openalex-snapshot
Comparison of the Antioxidant Potency of Four Triterpenes of Centella asiatica against Oxidative Stress
inferred← citeshttps://doi.org/10.3390/antiox15060688openalex-snapshot
Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-Inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies
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