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3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase
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Inverting the Enantiopreference of Nitrilase‐Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror‐Image Strategy
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Enantiocomplementary Michael Additions of Acetaldehyde to Aliphatic Nitroalkenes Catalyzed by Proline‐Based Carboligases
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Morita‐Baylis‐Hillman Reaction Accessing GABA Intermediates: Synthesis of New Lipophilic Hydroxylated γ ‐Nitroesters
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Development of a new synthesis approach for S-pregabalin by optimizing the preparation stages
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Effect of valproate on lipogenesis in neonatal rat brain
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The effect of sodium valproate on extracellular GABA and other amino acids in the rat ventral hippocampus: an in vivo microdialysis study
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3-Alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents
inferred← citeshttps://doi.org/10.1016/0920-1211(93)90070-nopenalex-snapshot
Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin
inferred← citeshttps://doi.org/10.1016/0920-1211(95)00028-9openalex-snapshot
Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA
inferred← citeshttps://doi.org/10.1016/0922-4106(93)90155-3openalex-snapshot
Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies
inferred← citeshttps://doi.org/10.1016/0922-4106(93)90156-4openalex-snapshot
Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies
inferred← citeshttps://doi.org/10.1016/0922-4106(93)90204-mopenalex-snapshot
[3H]Gabapentin may label a system-L-like neutral amino acid carrier in brain
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00311-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.brainres.2007.10.017openalex-snapshot
The effect of electroacupuncture on spontaneous recurrent seizure and expression of GAD67 mRNA in dentate gyrus in a rat model of epilepsy
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Tailor-made amino acids in the design of small-molecule blockbuster drugs
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New horizons in the development of antiepileptic drugs: Innovative strategies
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Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery
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Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type Ca2+ channels
inferred← citeshttps://doi.org/10.1016/j.pbb.2018.01.003openalex-snapshot
Gabapentin reduces haloperidol-induced vacuous chewing movements in mice
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Novel anticonvulsant drugs
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Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice
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The 5-exo-trig radical cyclization reaction under reductive and oxidative conditions in the synthesis of optically pure GABA derivatives
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The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C–H insertion of α-diazoacetamides
inferred← citeshttps://doi.org/10.1016/j.tet.2023.133648openalex-snapshot
New synthesis of β-aryl-GABA drugs
inferred← citeshttps://doi.org/10.1016/j.tetasy.2006.12.001openalex-snapshot
Stereoselective synthesis of γ-amino acids
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A facile chemoenzymatic approach to chiral non-racemic β-alkyl-γ-amino acids and 2-alkylsuccinic acids. A concise synthesis of (S)-(+)-Pregabalin
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Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom
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A simple synthesis of γ-aminoacids
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Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α,β-unsaturated carboxylic acid esters: an approach to γ-amino acids
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Efficient synthesis of (−)-(R)- and (+)-(S)-rolipram
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Asymmetric synthesis of α,β-substituted γ-amino acids via conjugate addition
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Ca2+ channel α2δ ligands: novel modulators of neurotransmission
inferred← citeshttps://doi.org/10.1016/s0014-5793(98)00335-4openalex-snapshot
Activation of two types of brain glutamate dehydrogenase isoproteins by gabapentin
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Effect of valproate on the metabolism of the central nervous system
inferred← citeshttps://doi.org/10.1016/s0960-894x(01)80855-6openalex-snapshot
Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant.
inferred← citeshttps://doi.org/10.1016/s0960-894x(98)00465-xopenalex-snapshot
General synthesis of 3-substituted alkenyl gaba as potential anticonvulsants
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Acute effects of gabapentin and pregabalin on rat forebrain cellular GABA, glutamate, and glutamine concentrations
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01922openalex-snapshot
Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis
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Palladium-Catalyzed E-Selective Oxidative Amination of Aromatic Amine with 3-Butenoic Acid
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Mechanism of Inactivation of Escherichia coli Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-furancarboxylic Acid,
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inferred← citeshttps://doi.org/10.1021/jm049762lopenalex-snapshot
Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein
inferred← citeshttps://doi.org/10.1021/jo0104227openalex-snapshot
Synthesis of γ-Amino Acids by Rearrangement of α-Cyanocyclopropanone Hydrates: Application to the Regioselective Labeling of Amino Acids
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Enantioselective Synthesis of β-Aryl-γ-amino Acid Derivatives via Cu-Catalyzed Asymmetric 1,4-Reductions of γ-Phthalimido-Substituted α,β-Unsaturated Carboxylic Acid Esters
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Highly Diastereoselective Michael Addition Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid. Preparation of α-Hydroxy-γ-amino Acid Derivatives
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Rh-Catalyzed Asymmetric Hydrogenation of γ-Phthalimido-Substituted α,β-Unsaturated Carboxylic Acid Esters: An Efficient Enantioselective Synthesis of β-Aryl-γ-amino Acids
inferred← citeshttps://doi.org/10.1021/op2001832openalex-snapshot
Chemical Development of an α2δ Ligand, (3S,5R)-3-(Aminomethyl)-5-methyloctanoic Acid
inferred← citeshttps://doi.org/10.1023/a:1016277507865openalex-snapshot
Pharmacokinetic Analysis and Antiepileptic Activity of N-Valproyl Derivatives of GABA and Glycine
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The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study
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A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives
inferred← citeshttps://doi.org/10.1039/b924964hopenalex-snapshot
Asymmetric organocatalysis in total synthesis – a trial by fire
inferred← citeshttps://doi.org/10.1073/pnas.1703019114openalex-snapshot
PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation
inferred← citeshttps://doi.org/10.1080/00397919308009764openalex-snapshot
Conjugate Addition of Organocuprates to Methyl Crotonate Linked to Chiral Oxazolidones
inferred← citeshttps://doi.org/10.1080/10739149.2013.876545openalex-snapshot
CRITICAL REVIEW ON THE ANALYTICAL METHODS FOR THE DETERMINATION OF ZWITTERIONIC ANTIEPILEPTIC DRUGS—VIGABATRIN, PREGABALIN, AND GABAPENTIN—IN BULK AND FORMULATIONS
inferred← citeshttps://doi.org/10.1101/cshperspect.a022780openalex-snapshot
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet
inferred← citeshttps://doi.org/10.1179/016911106779499055openalex-snapshot
Neuropathic pain with case examples and current therapeutic approaches
inferred← citeshttps://doi.org/10.1248/bpb.b14-00278openalex-snapshot
Transdermal Administration of Aqueous Pregabalin Solution as a Potential Treatment Option for Patients with Neuropathic Pain to Avoid Central Nervous System-Mediated Side Effects
inferred← citeshttps://doi.org/10.1517/17425255.2013.749239openalex-snapshot
Pharmacokinetic and pharmacodynamic profile of pregabalin and its role in the treatment of epilepsy
inferred← citeshttps://doi.org/10.1586/14737175.8.7.1013openalex-snapshot
Efficacy and tolerability of pregabalin in partial epilepsy
inferred← citeshttps://doi.org/10.21608/rpbs.2018.5918openalex-snapshot
Anxiolytic-like effect of Pregabalin in mice tested in the dark/light box and the elevated plus maze test: effect on cannabinoid CB1 receptors
inferred← citeshttps://doi.org/10.2174/092986710791698549openalex-snapshot
A Role of GABA Analogues in the Treatment of Neurological Diseases
inferred← citeshttps://doi.org/10.2174/1567205018666210713125333openalex-snapshot
Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
inferred← citeshttps://doi.org/10.2174/157488906775245291openalex-snapshot
An Update on GABA Analogs for CNS Drug Discovery
inferred← citeshttps://doi.org/10.3109/10409238.2016.1173010openalex-snapshot
Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit
inferred← citeshttps://doi.org/10.3389/fcell.2022.969575openalex-snapshot
Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles
inferred← citeshttps://doi.org/10.3390/biom10081196openalex-snapshot
A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids
inferred← citeshttps://doi.org/10.6515/acs.201911_35(6).20190429bopenalex-snapshot
Gabapentin Reduces Blood Pressure and Heart Rate through the Nucleus Tractus Solitarii.
inferred← citeshttps://doi.org/10.70675/b3a67e82z6291z4503zb577z15bae45f7523openalex-snapshot
Caractérisation du métabolisme cérébral chez le rat : étude par spectroscopie RMN du carbone 13
inferred← citeshttps://doi.org/10.7599/hmr.2011.31.2.55openalex-snapshot
Clinical Application of α2-δ Ligand
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