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New Synthesis of Β-Aryl-Gaba Drugs

https://doi.org/10.2139/ssrn.4530852
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Outgoing claims: the papers this work cites, builds on, or argues with.

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From Basic Science to Blockbuster Drug: The Discovery of Lyrica
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Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor
inferredcites →https://doi.org/10.1016/j.lfs.2011.11.003openalex-extracted
Positive impact of levetiracetam on emotional learning and memory in naive mice
inferredcites →https://doi.org/10.1021/acs.chemrev.8b00009openalex-extracted
Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions
inferredcites →https://doi.org/10.1021/ja057778aopenalex-extracted
Catalytic Four-Component Assembly Based on Allenylboronate Platform: New Access to Privileged Allylic Amine Structures
inferredcites →https://doi.org/10.1021/jacs.7b04722openalex-extracted
Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization
inferredcites →https://doi.org/10.1021/jm00037a021openalex-extracted
Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs
inferredcites →https://doi.org/10.1021/jm00074a007openalex-extracted
Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
inferredcites →https://doi.org/10.1021/jm00108a011openalex-extracted
Synthesis and biochemical evaluation of baclofen analogs locked in the baclofen solid-state conformation
inferredcites →https://doi.org/10.1021/jm00111a053openalex-extracted
3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase
inferredcites →https://doi.org/10.1021/jm00127a009openalex-extracted
Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogs
inferredcites →https://doi.org/10.1021/jo0108865openalex-extracted
Asymmetric Syntheses of Fused Bicyclic Lactams
inferredcites →https://doi.org/10.1021/ol102709sopenalex-extracted
Total Synthesis of (+)-Condylocarpine, (+)-Isocondylocarpine, and (+)-Tubotaiwine
inferredcites →https://doi.org/10.1111/j.1365-2125.2008.03158.xopenalex-extracted
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men
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