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Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogs

https://doi.org/10.1021/jm00127a009
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Crystal structure of phosphodiesterase 4D and inhibitor complex1
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The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I
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Structure-activity relationships involving the catechol subunit of rolipram
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Comparative molecular field analysis (CoMFA) of phthalazine derivatives as phosphodiesterase IV inhibitors
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The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I
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Orally active indole N-oxide PDE4 inhibitors
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Characterization of R-[11C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats
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Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure−Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones
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Novel Selective Phosphodiesterase (PDE4) Inhibitors. 4. Resolution, Absolute Configuration, and PDE4 Inhibitory Activity of cis-Tetra- and cis-Hexahydrophthalazinones
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The Next Generation of Phosphodiesterase Inhibitors: Structural Clues to Ligand and Substrate Selectivity of Phosphodiesterases
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Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors
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Recent Advances on Phosphodiesterase 4 Inhibitors for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease
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1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma
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Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
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Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition
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Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model.
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Synthesis and Structure-Activity Relationship of N-Arylrolipram Derivatives as Inhibitors of PDE4 Isozymes.
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Role of Phosphodiesterase 4 Isoenzyme in Alkaline Phosphatase Activation by Calcitonin in Porcine Kidney LLC-PK1 Cells
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Patent Evaluation: Pyrrolidinone PDE inhibitors
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TNF-α inhibitors and rheumatoid arthritis
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Benzofuran and quinoline carboxamides and quinoline sulfonamides as TNF inhibitors and as PDE4 inhibitors
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Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease
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(2RS,3aRS,9aRS)-3a-Methyl-2-phenyl-3,3a,9,9a-tetrahydro-1H-benzo[f]indol-4(2H)-one Hydrobromide
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