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Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities
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Outgoing claims: the papers this work cites, builds on, or argues with.
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New anti-actin drugs in the study of the organization and function of the actin cytoskeleton
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Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines
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Mechanism of antitumor action of PKC activator, gnidimacrin
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Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen
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Discrimination techniques applied to the NCI in vitro anti‐tumour drug screen: Predicting biochemical mechanism of action
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Selective Accumulation of the Endoplasmic Reticulum–Golgi Intermediate Compartment Induced by the Antitumor Drug KRN5500
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The Transient Increase of Tight Junction Permeability Induced by Bryostatin 1 Correlates with Rapid Downregulation of Protein Kinase C-α
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Evidence for a Direct Correlation between c-Jun NH2 Terminal Kinase 1 Activation, Cyclin D2 Expression, and G1/S Phase Transition in the Murine Hybridoma 7TD1 Cells
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The NCI In Vitro Anticancer Drug Discovery Screen
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Histamine Increases [Ca 2+ ] in and Activates Ca-K and Nonselective Cation Currents in Cultured Human Capillary Endothelial Cells
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Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin
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Metabolic Basis for the Actions of Analogs of Purines and Pyrimidines
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Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells
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Type 2A protein phosphatase, the complex regulator of numerous signaling pathways
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Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells
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Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation
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Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells
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Automated extraction of information in molecular biology
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Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics
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Gene expression data analysis
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Analysis of gene expression data using self‐organizing maps
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Actinomycin D as a novel SH2 domain ligand inhibits Shc/Grb2 interaction in B104‐1‐1 (neu*‐transformed NIH3T3) and SAA (hEGFR‐overexpressed NIH3T3) cells
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Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.
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Mode of action of the anticancer quassinoids — Inhibition of the plasma membrane NADH oxidase
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Dolastatin 11, a Marine Depsipeptide, Arrests Cells at Cytokinesis and Induces Hyperpolymerization of Purified Actin
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Neural network techniques for informatics of cancer drug discovery
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3 Combinatorial Chemistry as a Tool for Drug Discovery
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Application of High-throughput Screening Techniques to Drug Discovery
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Molecular modelling and drug design
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Biphasic effect of protein kinase C activators on spontaneous and glucocorticoid-induced apoptosis in primary mouse thymocytes
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Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A
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Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors
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On the constructive role of noise in spatial systems
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High-throughput screening of enzyme libraries
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High-throughput and ultra-high-throughput screening: solution- and cell-based approaches
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Forskolin and phorbol ester have opposite effects on the expression of mucin-associated sialyl-Lewisa in pancreatic cancer cells
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Total synthesis and stereochemistry of cytoblastin
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Comparison of survival between two groups using software SAS, S-PLUS and STATISTICA
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Molecular identification number for substructure searches
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Topological organic chemistry. 1. Graph theory and topological indices of alkanes
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On Characterization of Chemical Structure
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Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues
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The Actin Cytoskeleton is Required for the Trafficking of the B Cell Antigen Receptor to the Late Endosomes
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Systematic determination of genetic network architecture
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Molecular portraits of human breast tumours
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Potential for biomolecular imaging with femtosecond X-ray pulses
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Expression profiling using cDNA microarrays
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Gene expression informatics —it's all in your mine
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Systematic variation in gene expression patterns in human cancer cell lines
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Biopharmaceutical Research: Integrating information technology and drug discovery processes
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Expression of immediate early gene pip92 during anisomycin‐induced cell death is mediated by the JNK‐ and p38‐dependent activation of Elk1
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Cytoplasmic–nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
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Cluster analysis and display of genome-wide expression patterns
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Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
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Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation
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Knowledge-based analysis of microarray gene expression data by using support vector machines
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Polarized Expression of Ca2+ Pumps in Pancreatic and Salivary Gland Cells
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Trichothecene Mycotoxins Trigger a Ribotoxic Stress Response That Activates c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase and Induces Apoptosis
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Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release
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Phosphorylation of Serine 43 Is Not Required for Inhibition of c-Raf Kinase by the cAMP-dependent Protein Kinase
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The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment.
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Effect of topoisomerase poisoning by antitumor drugs VM 26, fostriecin and camptothecin on DNA repair replication by mammalian cell extracts
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Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm
inferredcites →https://doi.org/10.1093/jnci/83.11.757openalex-snapshot
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
inferredcites →https://doi.org/10.1093/jnci/83.11.766openalex-snapshot
Effects of a Low-Fat Diet on Levels of Oxidative Damage to DNA in Human Peripheral Nucleated Blood Cells
inferredcites →https://doi.org/10.1093/jnci/86.24.1853openalex-snapshot
Use of the Kohonen Self-organizing Map to Study the Mechanisms of Action of Chemotherapeutic Agents
inferredcites →https://doi.org/10.1093/nar/18.4.1007openalex-snapshot
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells
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Adenosine Triphosphate Induces Inhibition of Na+ Absorption in Mouse Endometrial Epithelium: A Ca2+-Dependent Mechanism1
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Thapsigargin Induces Apoptosis in Cultured Human Aortic Smooth Muscle Cells
inferredcites →https://doi.org/10.1111/j.0006-341x.2000.00503.xopenalex-snapshot
Bootstrap Confidence Intervals for Adaptive Cluster Sampling
inferredcites →https://doi.org/10.1111/j.0006-341x.2000.00616.xopenalex-snapshot
Sample Size Estimation for Survival Outcomes in Cluster‐Randomized Studies with Small Cluster Sizes
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Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole
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Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity
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Neural Computing in Cancer Drug Development: Predicting Mechanism of Action
inferredcites →https://doi.org/10.1126/science.258.5081.451openalex-snapshot
Age and Duration of Weathering by 40 K- 40 Ar and 40 Ar/ 39 Ar Analysis of Potassium-Manganese Oxides
inferredcites →https://doi.org/10.1126/science.275.5298.343openalex-snapshot
An Information-Intensive Approach to the Molecular Pharmacology of Cancer
inferredcites →https://doi.org/10.1126/science.285.5425.251openalex-snapshot
Ploidy Regulation of Gene Expression
inferredcites →https://doi.org/10.1126/science.285.5425.254openalex-snapshot
A Functional Assay for Centromere-Associated Sister Chromatid Cohesion
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Using Linear Algebra for Intelligent Information Retrieval
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Genomic Views of the Immune System
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Down-Regulation of Protein Kinase C by Parathyroid Hormone and Mezerein Differentially Modulates cAMP Production and Phosphate Transport in Opossum Kidney Cells
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Current Status and Recent Developments in Anthracenone Antipsoriatics
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MEASURING CLUSTER SIMILARITY ACROSS METHODS
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure
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Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis
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Ontology Recapitulates Physiology
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Transcriptomic analysis of the NCI-60 cancer cell lines
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inferred← citeshttps://doi.org/10.1021/ci700132uopenalex-snapshot
Chemoinformatic Analysis of NCI Preclinical Tumor Data: Evaluating Compound Efficacy from Mouse Xenograft Data, NCI-60 Screening Data, and Compound Descriptors
inferred← citeshttps://doi.org/10.1021/ci700141xopenalex-snapshot
Chemical Data Mining of the NCI Human Tumor Cell Line Database
inferred← citeshttps://doi.org/10.1021/ci7001445openalex-snapshot
Improving the Performance of Self-Organizing Maps via Growing Representations
inferred← citeshttps://doi.org/10.1021/ci700188uopenalex-snapshot
Flexible Web Service Infrastructure for the Development and Deployment of Predictive Models
inferred← citeshttps://doi.org/10.1021/ja034162hopenalex-snapshot
Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces a rgillaceus through Combinatorial Biosynthesis
inferred← citeshttps://doi.org/10.1021/ja0705487openalex-snapshot
Syntheses of the Eastern Halves of Ritterazines B, F, G, and H, Leading to Reassignment of the 5,5-Spiroketal Stereochemistry of Ritterazines B and F
inferred← citeshttps://doi.org/10.1021/jacs.6c10980openalex-snapshot
Enantioselective Hydroarylation via Chiral Transient Directing Groups: Access to Chiral Benzo-Fused Heterocycles with Collaborative Enantiomeric Control
inferred← citeshttps://doi.org/10.1021/jm0201060openalex-snapshot
Array-Based Structure and Gene Expression Relationship Study of Antitumor Sulfonamides IncludingN-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide andN-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide
inferred← citeshttps://doi.org/10.1021/jm051029mopenalex-snapshot
Assessment of in Vitro and in Vivo Activities in the National Cancer Institute's Anticancer Screen with Respect to Chemical Structure, Target Specificity, and Mechanism of Action
inferred← citeshttps://doi.org/10.1021/jm700964uopenalex-snapshot
Design and Synthesis of 4-Substituted Indolo[3,2-e][1,2,3]triazolo[1,5-a]pyrimidine Derivatives with Antitumor Activity
inferred← citeshttps://doi.org/10.1021/jm701301mopenalex-snapshot
Fluorescence Spectroscopic Profiling of Compound Libraries
inferred← citeshttps://doi.org/10.1021/mp049953kopenalex-snapshot
Exploratory Chemoinformatic Analysis of Cell Type-Selective Anticancer Drug Targeting
inferred← citeshttps://doi.org/10.1021/tx700365eopenalex-snapshot
Characterization of Diversity in Toxicity Mechanism Using in Vitro Cytotoxicity Assays in Quantitative High Throughput Screening
inferred← citeshttps://doi.org/10.1023/a:1023893700386openalex-snapshot
A Rational Approach to Personalized Anticancer Therapy: Chemoinformatic Analysis Reveals Mechanistic Gene-Drug Associations
inferred← citeshttps://doi.org/10.1038/nchembio.1365openalex-snapshot
Rethinking cellular drug response
inferred← citeshttps://doi.org/10.1038/nchembio.625openalex-snapshot
Natural products reveal cancer cell dependence on oxysterol-binding proteins
inferred← citeshttps://doi.org/10.1038/nrc1951openalex-snapshot
The NCI60 human tumour cell line anticancer drug screen
inferred← citeshttps://doi.org/10.1038/s41467-025-66163-3openalex-snapshot
MetaboLM: a metabolomic language model for multi-disease early prediction and risk stratification
inferred← citeshttps://doi.org/10.1038/s42003-020-0765-zopenalex-snapshot
A normalized drug response metric improves accuracy and consistency of anticancer drug sensitivity quantification in cell-based screening
inferred← citeshttps://doi.org/10.1038/sj.tpj.6500331openalex-snapshot
Linking pathway gene expressions to the growth inhibition response from the National Cancer Institute's anticancer screen and drug mechanism of action
inferred← citeshttps://doi.org/10.1039/9781849732093-00346openalex-snapshot
Adverse Outcome Pathways: A Way of Linking Chemical Structure to In Vivo Toxicological Hazards
inferred← citeshttps://doi.org/10.1039/d5ob00059aopenalex-snapshot
Fast and effective preparation of highly cytotoxic hybrid molecules of schweinfurthin E and OSW-1
inferred← citeshttps://doi.org/10.1073/pnas.0511292103openalex-snapshot
An efficient rapid system for profiling the cellular activities of molecular libraries
inferred← citeshttps://doi.org/10.1080/1463677042000189624openalex-snapshot
Signs, markers, profiles, and signatures: clinical haematology meets the new genetics (1980–2000)
inferred← citeshttps://doi.org/10.1089/ars.2013.5322openalex-snapshot
Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
inferred← citeshttps://doi.org/10.1093/bioinformatics/btg302openalex-snapshot
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data
inferred← citeshttps://doi.org/10.1093/bioinformatics/btq550openalex-snapshot
Investigating the correlations among the chemical structures, bioactivity profiles and molecular targets of small molecules
inferred← citeshttps://doi.org/10.1093/nar/gkm795openalex-snapshot
STITCH: interaction networks of chemicals and proteins
inferred← citeshttps://doi.org/10.1097/00001756-200402090-00031openalex-snapshot
Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map
inferred← citeshttps://doi.org/10.1097/01.cad.0000224442.78211.27openalex-snapshot
Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects
inferred← citeshttps://doi.org/10.1124/mol.105.017061openalex-snapshot
Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines
inferred← citeshttps://doi.org/10.1124/mol.111.077107openalex-snapshot
Functional Evaluation of a Fluorescent Schweinfurthin: Mechanism of Cytotoxicity and Intracellular Quantification
inferred← citeshttps://doi.org/10.1126/scitranslmed.aaf7444openalex-snapshot
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6494319openalex-snapshot
Data from Ligand-Directed Surface Profiling of Human Cancer Cells with Combinatorial Peptide Libraries
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6494319.v1openalex-snapshot
Data from Ligand-Directed Surface Profiling of Human Cancer Cells with Combinatorial Peptide Libraries
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6500421openalex-snapshot
Data from Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
inferred← citeshttps://doi.org/10.1158/0008-5472.can-05-2748openalex-snapshot
Ligand-Directed Surface Profiling of Human Cancer Cells with Combinatorial Peptide Libraries
inferred← citeshttps://doi.org/10.1158/0008-5472.can-05-4061openalex-snapshot
Breast Cancer Growth Prevention by Statins
inferred← citeshttps://doi.org/10.1158/0008-5472.can-09-2422openalex-snapshot
Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
inferred← citeshttps://doi.org/10.1158/1535-7163.1565.3.12openalex-snapshot
In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6531843openalex-snapshot
Data from In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-05-0224openalex-snapshot
Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-06-0239openalex-snapshot
Targeting changes in cancer: assessing pathway stability by comparing pathway gene expression coherence levels in tumor and normal tissues
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-06-0640openalex-snapshot
Spotlight on molecular profiling: “Integromic” analysis of the NCI-60 cancer cell lines
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-06-0787openalex-snapshot
Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-07-2308openalex-snapshot
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-10-0517openalex-snapshot
The Synthetic Caged Garcinia Xanthone Cluvenone Induces Cell Stress and Apoptosis and Has Immune Modulatory Activity
inferred← citeshttps://doi.org/10.1186/1472-6769-8-2openalex-snapshot
Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II
inferred← citeshttps://doi.org/10.1186/1757-2215-5-30openalex-snapshot
Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
inferred← citeshttps://doi.org/10.1186/gb-2003-4-12-r82openalex-snapshot
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
inferred← citeshttps://doi.org/10.1186/s13321-019-0390-3openalex-snapshot
Identifying new topoisomerase II poison scaffolds by combining publicly available toxicity data and 2D/3D-based virtual screening
inferred← citeshttps://doi.org/10.1186/s43094-019-0001-1openalex-snapshot
Matrix metalloproteinase9 as the protein target in anti-breast cancer drug discovery: an approach by targeting hemopexin domain
inferred← citeshttps://doi.org/10.1201/9780203913390.ch25openalex-snapshot
Data Mining Applications in Drug Discovery
inferred← citeshttps://doi.org/10.1371/journal.pone.0044631openalex-snapshot
Integrating Constitutive Gene Expression and Chemoactivity: Mining the NCI60 Anticancer Screen
inferred← citeshttps://doi.org/10.1371/journal.pone.0188817openalex-snapshot
Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
inferred← citeshttps://doi.org/10.1371/journal.pone.0243336openalex-snapshot
Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action
inferred← citeshttps://doi.org/10.17077/etd.vl5ggswbopenalex-snapshot
Schweinfurthins as novel anticancer agents
inferred← citeshttps://doi.org/10.17077/etd.z01dif98openalex-snapshot
Mechanisms of the anti-proliferative actions of the schweinfurthins in cancer cells
inferred← citeshttps://doi.org/10.2174/1389450111007011341openalex-snapshot
Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells
inferred← citeshttps://doi.org/10.2174/1568026054637665openalex-snapshot
Chemical and Biological Profiling of an Annotated Compound Library Directed to the Nuclear Receptor Family
inferred← citeshttps://doi.org/10.2174/156802607782194761openalex-snapshot
Complementarity Between Public and Commercial Databases: New Opportunities in Medicinal Chemistry Informatics
inferred← citeshttps://doi.org/10.2174/157016007780077158openalex-snapshot
Chemogenomics of Sensitivity and Resistance to Anticancer Drugs
inferred← citeshttps://doi.org/10.2174/157018011793663840openalex-snapshot
Discovery of BRM Targeted Therapies: Novel Reactivation of an Anticancer Gene
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-3b08xopenalex-snapshot
Bio-inspired synthesis and profiling of a potent antiviral flavonol targeting the lipid exchanger OSBP
inferred← citeshttps://doi.org/10.3233/bd-2004-19103openalex-snapshot
Integromic Analysis of the NCI-60 Cancer Cell Lines
inferred← citeshttps://doi.org/10.3390/pr8101230openalex-snapshot
A New Computational Approach to Evaluating Systemic Gene–Gene Interactions in a Pathway Affected by Drug LY294002
inferred← citeshttps://doi.org/10.3410/f.6754956.7110059openalex-snapshot
Faculty Opinions recommendation of STITCH: interaction networks of chemicals and proteins.
inferred← citeshttps://doi.org/10.3987/com-04-10244openalex-snapshot
Antitumor Agents 238. Anti-tubulin and in vitro Cytotoxic Effects of N-Substituted Allocolchicinoids
inferred← citeshttps://doi.org/10.3987/com-06-10686openalex-snapshot
A Ready One-pot Preparation for Pteridine and Isoxazolo[3,4-d]pyrimidine Derivatives
inferred← citeshttps://doi.org/10.4172/2153-0645.1000110openalex-snapshot
Pharmacogenomic Analysis Identifies Increased Efficacy of Oxaliplatin in ABCB1 Overexpressing Tumors
inferred← citeshttps://doi.org/10.53846/goediss-3480openalex-snapshot
Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
inferred← citeshttps://doi.org/10.70675/11cced54z0209z4fc6zaa4ezd7e08e2cd201openalex-snapshot
Synthèse et pharmacomodulation de composés antitumoraux naturels à motif hexahydroxanthène
inferred← citeshttps://doi.org/10.70675/4cf5ceadz24a5z4e83zaaccz10a4bf56eb61openalex-snapshot
Analogues et outils moléculaires de composés naturels ciblant la protéine OSBP : synthèse et validation biologique
inferred← citeshttps://doi.org/10.70675/7d208b19z2743z484azadccza1c9df153e97openalex-snapshot
Vers la découverte du mécanisme d’action de stilbènes prénylés isolés de Macaranga spp.
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