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Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small‐molecule screening and structural databases
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Transthyretin mutations in hyperthyroxinemia and amyloid diseases
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The Cyclin-Dependent Kinase (CDK) Inhibitor Flavopiridol Inhibits Glycogen Phosphorylase
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Inhibition of the G2/M Transition of the Cell Cycle by Methyl- 2,5-dihydroxycinnamate in Human Lymphoid Cells
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Src Family Tyrosine Kinases and Growth Factor Signaling
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Proteinase-activated Receptors
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Leukemic Cell Insensitivity to Cyclophosphamide and other Oxazaphosphorines Mediated by Aldehyde Dehydrogenase(s)
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Structural basis for chemical inhibition of CDK2
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NMR-based screening methods for lead discovery
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Immunohistochemical study of the expression of drug-resistant proteins in large cell neuroendocrine carcinoma of the lung
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The specific inhibition of the DNA-directed RNA synthesis by rifamycin
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Effect of iron-chelating agents on inhibitors of ribonucleotide reductase
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Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase
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Eupatoriopicrin-induced lipid peroxidation in liver and tumour tissue of the mouse
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Investigations on organotin, organolead, lead(IV), and lead(II) dithiolates
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High constitutive expression of heat shock protein 90α in human acute leukemia cells
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Chemoprotection against cancer by Phase 2 enzyme induction
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Proteinase-Activated Receptors
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Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-Induced Adipogenesis
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Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors
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Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells
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Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases
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Multiple roles of cysteine in biocatalysis
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Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
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Characterization of quercetin binding site on DNA gyrase
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Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? 1 1Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; COX, cyclooxygenase; LT, leukotriene; 5-LOX, 5-lipoxygenase; PG, prostaglandin; DFU,…
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Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells
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Glutathionylation of proteins by glutathione disulfide S-oxide
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Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
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The Hsp90 complex—a super-chaperone machine as a novel drug target
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Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
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Minichromosome replication in vitro: inhibition of re-replication by replicatively assembled nucleosomes.
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Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids.
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Caracemide, a site-specific irreversible inhibitor of protein R1 of Escherichia coli ribonucleotide reductase.
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X-ray crystallographic study of boronic acid adducts with subtilisin BPN' (Novo). A model for the catalytic transition state.
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Relibase: Design and Development of a Database for Comprehensive Analysis of Protein–Ligand Interactions
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p53 ACCUMULATION ASSOCIATED WITH bcl-2, THE PROLIFERATION MARKER MIB-1 AND SURVIVAL IN PATIENTS WITH PROSTATE CANCER SUBJECTED TO WATCHFUL WAITING
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Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.
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The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
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11-Oxygenated cytotoxic 8,9-secokauranes from a New Zealand liverwort, Lepidolaena taylorii
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Hemostatic Alterations in Patients with Benign and Malignant Colorectal Disease During Major Abdominal Surgery
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Coagulative System Activation and Fibrinolytic System Inhibition Activities Arise From Tumoral Draining Vein in Colon Carcinoma
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Structure and function of the radical enzyme ribonucleotide reductase
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Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent
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The Hallmarks of Cancer
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Bcl-xL Deamidation Is a Critical Switch in the Regulation of the Response to DNA Damage
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Taking the Study of Cancer Cell Survival to a New Dimension
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Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells
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Apoptosis and toxicology—what relevance?
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The proteasome: structure, function, and role in the cell
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Cancer preventive effects of flavonoids—a review
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Cancer chemotherapy and biotherapy: Principles and practice
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Cytotoxic michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone
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Synthesis and anti-cancer activity of 2-alkylaminomethyl- 5-(E)-alkylidene cyclopentanone hydrochlorides
inferredcites →https://doi.org/10.1016/s0968-0896(99)00195-9openalex-snapshot
Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
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Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana
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Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90
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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
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Potential for proteasome inhibition in the treatment of cancer
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Reactive compounds and in vitro false positives in HTS
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Scoring a bull's-eye against cancer genome targets
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Alcohol consumption and cancer of the gastrointestinal tract
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Inhibition of osteoblast apoptosis by thrombin
inferredcites →https://doi.org/10.1021/bi00183a028openalex-snapshot
Structures of Horse Liver Alcohol Dehydrogenase Complexed with NAD+ and Substituted Benzyl Alcohols
inferredcites →https://doi.org/10.1021/bi002786jopenalex-snapshot
Stimulation of Topoisomerase II-Mediated DNA Damage via a Mechanism Involving Protein Thiolation
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Redundancy of Mammalian Proteasome β Subunit Function during Endoplasmic Reticulum Associated Degradation
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Crystal Structure of Vat(D): An Acetyltransferase That Inactivates Streptogramin Group A Antibiotics,
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Functional Analysis of the Copper-Dependent Quercetin 2,3-Dioxygenase. 1. Ligand-Induced Coordination Changes Probed by X-ray Crystallography: Inhibition, Ordering Effect, and Mechanistic Insights
inferredcites →https://doi.org/10.1021/bi015974yopenalex-snapshot
Functional Analysis of the Copper-Dependent Quercetin 2,3-Dioxygenase. 2. X-ray Absorption Studies of Native Enzyme and Anaerobic Complexes with the Substrates Quercetin and Myricetin
inferredcites →https://doi.org/10.1021/bi0255266openalex-snapshot
Role of Hydrogen Bonds in the Reaction Mechanism of Chalcone Isomerase
inferredcites →https://doi.org/10.1021/ci000150topenalex-snapshot
Comparison of the NCI Open Database with Seven Large Chemical Structural Databases
inferredcites →https://doi.org/10.1021/ci970085wopenalex-snapshot
Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues
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Mining and Visualizing Large Anticancer Drug Discovery Databases
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Privileged Molecules for Protein Binding Identified from NMR-Based Screening
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Synthesis and Cytotoxicity of Water-Soluble Ambrosin Prodrug Candidates
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A Conformational and Structure−Activity Relationship Study of Cytotoxic 3,5-Bis(arylidene)-4-piperidones and Related N-Acryloyl Analogues
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Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities
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Do Structurally Similar Molecules Have Similar Biological Activity?
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Kinase Inhibitors: Not Just for Kinases Anymore
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Design, Synthesis, and Evaluation of Novel Boronic-Chalcone Derivatives as Antitumor Agents
inferredcites →https://doi.org/10.1021/jm970432topenalex-snapshot
Cytotoxic Activities of Mannich Bases of Chalcones and Related Compounds
inferredcites →https://doi.org/10.1021/jm980403yopenalex-snapshot
Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin
inferredcites →https://doi.org/10.1021/jm980471kopenalex-snapshot
Ajoene Is an Inhibitor and Subversive Substrate of Human Glutathione Reductase and Trypanosoma cruzi Trypanothione Reductase: Crystallographic, Kinetic, and Spectroscopic Studies
inferredcites →https://doi.org/10.1023/a:1005525110045openalex-snapshot
Effects of Bleaching on Secondary Metabolite Chemistry of Alcyonacean Soft Corals
inferredcites →https://doi.org/10.1023/a:1013900130415openalex-snapshot
Thrombin Regulation of Cell Function through Protease-Activated Receptors: Implications for Therapeutic Intervention
inferredcites →https://doi.org/10.1023/a:1016214030069openalex-snapshot
A Phase I Trial of Weekly Gemcitabine and Subcutaneous Interferon Alpha in Patients with Refractory Renal Cell Carcinoma
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Filtering databases and chemical libraries
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The role of integrin-linked kinase (ILK) in cancer progression
inferredcites →https://doi.org/10.1038/73439openalex-snapshot
A gene expression database for the molecular pharmacology of cancer
inferredcites →https://doi.org/10.1038/79025openalex-snapshot
Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase.
inferredcites →https://doi.org/10.1038/bjc.1989.13openalex-snapshot
Enhanced cytostatic activity of the sesquiterpene lactone eupatoriopicrin by glutathione depletion
inferredcites →https://doi.org/10.1038/nature01913openalex-snapshot
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
inferredcites →https://doi.org/10.1038/nrd1130openalex-snapshot
Clinical biomarkers in drug discovery and development
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Strategies in the design of antiviral drugs
inferredcites →https://doi.org/10.1038/nrd941openalex-snapshot
Integration of virtual and high-throughput screening
inferredcites →https://doi.org/10.1038/sj.bjc.6601095openalex-snapshot
Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis
inferredcites →https://doi.org/10.1038/sj.leu.2402464openalex-snapshot
Developmental Therapeutics Program at the NCI: molecular target and drug discovery process
inferredcites →https://doi.org/10.1038/sj.onc.1205749openalex-snapshot
Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation
inferredcites →https://doi.org/10.1038/sj.onc.1205872openalex-snapshot
Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block
inferredcites →https://doi.org/10.1038/sj.onc.1206940openalex-snapshot
The role of glutathione-S-transferase in anti-cancer drug resistance
inferredcites →https://doi.org/10.1038/sj.tpj.6500116openalex-snapshot
Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data
inferredcites →https://doi.org/10.1042/0264-6021:3600001openalex-snapshot
Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
inferredcites →https://doi.org/10.1042/bj20030346openalex-snapshot
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1
inferredcites →https://doi.org/10.1042/bj20030690openalex-snapshot
Response of yeast to the regulated expression of proteins in the Bcl-2 family
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01673.xopenalex-snapshot
Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25
inferredcites →https://doi.org/10.1046/j.1464-4096.2001.01170.xopenalex-snapshot
p53 and bcl-2 immunohistochemistry in preoperative biopsies as predictors of biochemical recurrence after radical prostatectomy
inferredcites →https://doi.org/10.1046/j.1538-7836.2003.00208.xopenalex-snapshot
Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: possible relevance to HIF-1α
inferredcites →https://doi.org/10.1054/bjoc.2001.1976openalex-snapshot
Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2
inferredcites →https://doi.org/10.1055/s-2003-37501openalex-snapshot
Statins Can Inhibit Proliferation of Human Breast Cancer Cells in Vitro
inferredcites →https://doi.org/10.1056/nejm198806233182502openalex-snapshot
Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal Translocation
inferredcites →https://doi.org/10.1056/nejm199702133360703openalex-snapshot
Variant-Sequence Transthyretin (Isoleucine 122) in Late-Onset Cardiac Amyloidosis in Black Americans
inferredcites →https://doi.org/10.1073/pnas.051632198openalex-snapshot
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
inferredcites →https://doi.org/10.1073/pnas.220392197openalex-snapshot
Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks
inferredcites →https://doi.org/10.1073/pnas.220430297openalex-snapshot
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
inferredcites →https://doi.org/10.1073/pnas.252626999openalex-snapshot
Biliverdin reductase: A major physiologic cytoprotectant
inferredcites →https://doi.org/10.1073/pnas.262506299openalex-snapshot
Anaerobic enzyme⋅substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase
inferredcites →https://doi.org/10.1073/pnas.87.7.2843openalex-snapshot
Fibril in senile systemic amyloidosis is derived from normal transthyretin.
inferredcites →https://doi.org/10.1073/pnas.93.7.2735openalex-snapshot
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
inferredcites →https://doi.org/10.1074/jbc.m004485200openalex-snapshot
Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site
inferredcites →https://doi.org/10.1074/jbc.m106282200openalex-snapshot
Induction of Vascular Endothelial Growth Factor Expression and Hypoxia-inducible Factor 1α Protein by the Oxidative Stressor Arsenite
inferredcites →https://doi.org/10.1074/jbc.m209114200openalex-snapshot
Induction of Hypoxia-inducible Factor-1α by Transcriptional and Translational Mechanisms
inferredcites →https://doi.org/10.1074/jbc.m301032200openalex-snapshot
Inhibition of Proteasome Activity Induces Concerted Expression of Proteasome Genes and de Novo Formation of Mammalian Proteasomes
inferredcites →https://doi.org/10.1074/jbc.m301391200openalex-snapshot
Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes
inferredcites →https://doi.org/10.1074/jbc.m301877200openalex-snapshot
DNA Damage-mediated Apoptosis Induced by Selenium Compounds
inferredcites →https://doi.org/10.1074/jbc.m306201200openalex-snapshot
An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress
inferredcites →https://doi.org/10.1074/jbc.m308862200openalex-snapshot
The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
inferredcites →https://doi.org/10.1080/00397919908086130openalex-snapshot
Regioselective Alkylation and Arylation At The 6-Position Of Pyrimidine: Synthesis Of 5- Alkyl-6-Arylmethyl-2,4-Pyrimidinediones
inferredcites →https://doi.org/10.1080/078538902321012423openalex-snapshot
Programmed cell death: many ways for cells to die decently
inferredcites →https://doi.org/10.1080/15257779908041535openalex-snapshot
Synthesis of Alkenyl Acyclonucleosides Derivatives of 5-Halogenouracil as Antiviral and Antitumoral Agents
inferredcites →https://doi.org/10.1080/713609333openalex-snapshot
Acetaldehyde, Microbes, and Cancer of the Digestive Tract
inferredcites →https://doi.org/10.1081/dmr-120015695openalex-snapshot
GLUTATHIONE CONJUGATES AND THEIR SYNTHETIC DERIVATIVES AS INHIBITORS OF GLUTATHIONE-DEPENDENT ENZYMES INVOLVED IN CANCER AND DRUG RESISTANCE
inferredcites →https://doi.org/10.1089/1540658041850625openalex-snapshot
Reference Systems for Kinase Drug Discovery: Chemical Genetic Approaches to Cell-Based Assays
inferredcites →https://doi.org/10.1093/bioinformatics/btg302openalex-snapshot
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data
inferredcites →https://doi.org/10.1093/emboj/17.16.4829openalex-snapshot
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
inferredcites →https://doi.org/10.1093/emboj/19.16.4383openalex-snapshot
The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains
inferredcites →https://doi.org/10.1093/emboj/cdg240openalex-snapshot
The mitogen‐activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB
inferredcites →https://doi.org/10.1093/emboj/cdg349openalex-snapshot
The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome
inferredcites →https://doi.org/10.1093/jnci/81.14.1088openalex-snapshot
Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm
inferredcites →https://doi.org/10.1093/jnci/83.11.757openalex-snapshot
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
inferredcites →https://doi.org/10.1096/fj.03-0329fjeopenalex-snapshot
IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis
inferredcites →https://doi.org/10.1097/00001622-200211000-00007openalex-snapshot
Proteasome inhibitors as new anticancer drugs
inferredcites →https://doi.org/10.1097/00005650-197605000-00001openalex-snapshot
Continuity of Medical Care
inferredcites →https://doi.org/10.1097/01.lab.0000059936.28369.19openalex-snapshot
DNA Arrays in Clinical Oncology: Promises and Challenges
inferredcites →https://doi.org/10.1101/gad.13.1.64openalex-snapshot
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
inferredcites →https://doi.org/10.1111/j.1365-2141.1994.tb04917.xopenalex-snapshot
Characterization of platelet aggregation induced by human colon adenocarcinoma cells and its inhibition by snake venom peptides, trigramin and rhodostomin
inferredcites →https://doi.org/10.1111/j.1749-6632.2002.tb04690.xopenalex-snapshot
Glutathione in Defense and Signaling
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Ajoene, a Compound of Garlic, Induces Apoptosis in Human Promyeloleukemic Cells, Accompanied by Generation of Reactive Oxygen Species and Activation of Nuclear Factor κB
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International Union of Pharmacology. XXVIII. Proteinase-Activated Receptors
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Reactions of Alpha Methylene Lactone Tumor Inhibitors with Model Biological Nucleophiles
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Inhibition of Phosphofructokinase by Quinone Methide and α-Methylene Lactone Tumor Inhibitors
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