On the public citation graph

Statistical Molecular Design, Parallel Synthesis, and Biological Evaluation of a Library of Thrombin Inhibitors

https://doi.org/10.1021/jm010833f
0 signed · 77 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471725331openalex-snapshot
A Use's Guide to Principal Components
inferredcites →https://doi.org/10.1002/9783906390406.ch12openalex-snapshot
Intelligent Combinatorial Libraries
inferredcites →https://doi.org/10.1002/cem.1180020306openalex-snapshot
PLS regression methods
inferredcites →https://doi.org/10.1002/j.1460-2075.1989.tb08511.xopenalex-snapshot
The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.
inferredcites →https://doi.org/10.1002/pro.5560010402openalex-snapshot
The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α ‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships
inferredcites →https://doi.org/10.1016/0021-9673(93)83247-popenalex-snapshot
Automated pKa determination at low solute concentrations by capillary electrophoresis
inferredcites →https://doi.org/10.1016/0049-3848(79)90014-8openalex-snapshot
D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin
inferredcites →https://doi.org/10.1016/0049-3848(83)90218-9openalex-snapshot
Cyclic amides of Nα-arylsulfonylaminoacylated 4-amidinophenylalanine - tight binding inhibitors of thrombin
inferredcites →https://doi.org/10.1016/0049-3848(84)90302-5openalex-snapshot
Inhibition of bovine and human thrombins by derivatives of benzamidine
inferredcites →https://doi.org/10.1016/s0169-7439(99)00010-6openalex-snapshot
Approaches to the design of combinatorial libraries
inferredcites →https://doi.org/10.1016/s0960-894x(99)00130-4openalex-snapshot
Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors
inferredcites →https://doi.org/10.1016/s0960-894x(99)00459-xopenalex-snapshot
The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element
inferredcites →https://doi.org/10.1016/s1074-5521(97)90072-7openalex-snapshot
Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes
inferredcites →https://doi.org/10.1021/ac990852lopenalex-snapshot
Congeneric Behavior in Estimations of Octanol−Water Partition Coefficients by Micellar Electrokinetic Chromatography
inferredcites →https://doi.org/10.1021/cc0000388openalex-snapshot
Chemography: The Art of Navigating in Chemical Space
inferredcites →https://doi.org/10.1021/ci970420gopenalex-snapshot
The Effectiveness of Reactant Pools for Generating Structurally-Diverse Combinatorial Libraries
inferredcites →https://doi.org/10.1021/ci990015kopenalex-snapshot
Evaluation of Reagent-Based and Product-Based Strategies in the Design of Combinatorial Library Subsets
inferredcites →https://doi.org/10.1021/jm991118xopenalex-snapshot
Statistical Molecular Design of Building Blocks for Combinatorial Chemistry
inferredcites →https://doi.org/10.1021/jo971367yopenalex-snapshot
Selective Monoacetylation of Unsymmetrical Diols Catalyzed by Silica Gel-Supported Sodium Hydrogen Sulfate
inferredcites →https://doi.org/10.1080/00401706.1978.10489693openalex-snapshot
Cross-Validatory Estimation of the Number of Components in Factor and Principal Components Models
inferredcites →https://doi.org/10.1097/00001721-199102000-00011openalex-snapshot
Thrombin structure and function
inferredcites →https://doi.org/10.1111/j.2517-6161.1974.tb00994.xopenalex-snapshot
Cross-Validatory Choice and Assessment of Statistical Predictions
inferredcites →https://doi.org/10.1172/jci115592openalex-snapshot
Characterization of a functional thrombin receptor. Issues and opportunities.
inferredcites →https://doi.org/10.2174/0929867305666220319111501openalex-snapshot
Progress Towards the Discovery of Orally Active Thrombin Inhibitors
inferredcites →https://doi.org/10.2307/2530361openalex-snapshot
Statistics for Experimenters: An Introduction to Design, Data Analysis and Model Building.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/9783527619368.ch19openalex-snapshot
Efficient Strategies for Lead Optimization by Simultaneously Addressing Affinity, Selectivity and Pharmacokinetic Parameters
inferred← citeshttps://doi.org/10.1002/9783527623860.ch14openalex-snapshot
Calculated Molecular Properties and Multivariate Statistical Analysis
inferred← citeshttps://doi.org/10.1002/asia.202401648openalex-snapshot
A Mild and Catalyst‐Free Synthesis of Cannabidiols and Regioisomers Mediated by Fluorinated Alcohols
inferred← citeshttps://doi.org/10.1002/bmc.3567openalex-snapshot
Recognition and identification of active components from Radix Bupleuri using human neuroblastoma SH‐SY5Y cells
inferred← citeshttps://doi.org/10.1002/cem.861openalex-snapshot
The utility of multivariate design in PLS modeling
inferred← citeshttps://doi.org/10.1002/cem.901openalex-snapshot
Controlling coverage of D‐optimal onion designs and selections
inferred← citeshttps://doi.org/10.1002/chem.200800277openalex-snapshot
Selectivity of Neutral/Weakly Basic P1 Group Inhibitors of Thrombin and Trypsin by a Molecular Dynamics Study
inferred← citeshttps://doi.org/10.1007/7081_017openalex-snapshot
QSAR and Molecular Modeling Studiesof Factor Xa and Thrombin Inhibitors
inferred← citeshttps://doi.org/10.1007/978-1-60761-839-3_16openalex-snapshot
Methods for Combinatorial and Parallel Library Design
inferred← citeshttps://doi.org/10.1007/s10910-005-9035-zopenalex-snapshot
An overlooked property of plot methods
inferred← citeshttps://doi.org/10.1016/b0-08-044655-8/00001-5openalex-snapshot
One or More CH Bond(s) Formed by Substitution: Reduction of CHalogen and CChalcogen Bonds
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00256-xopenalex-snapshot
Library Design: Ligand and Structure-Based Principles for Parallel and Combinatorial Libraries
inferred← citeshttps://doi.org/10.1016/b978-0-443-31482-7.00102-8openalex-snapshot
One or More CH Bond(s) Formed by Substitution: Reduction of C—Halogen and C—Chalcogen Bonds
inferred← citeshttps://doi.org/10.1016/j.bmc.2007.07.047openalex-snapshot
Inhibitors of type III secretion in Yersinia: Design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.02.022openalex-snapshot
Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.07.065openalex-snapshot
Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure–activity relationships of novel dicamphanoyl-2′,2′-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents
inferred← citeshttps://doi.org/10.1016/j.chemolab.2004.04.001openalex-snapshot
D-optimal onion designs in statistical molecular design
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.01.010openalex-snapshot
Medicinal chemistry matters – a call for discipline in our discipline
inferred← citeshttps://doi.org/10.1016/j.jff.2017.03.015openalex-snapshot
Sequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion
inferred← citeshttps://doi.org/10.1016/j.jmgm.2004.03.003openalex-snapshot
Generation of QSAR sets with a self-organizing map
inferred← citeshttps://doi.org/10.1016/s0731-7085(03)00238-3openalex-snapshot
Determination of dissociation constants of labile drug compounds by capillary electrophoresis
inferred← citeshttps://doi.org/10.1016/s0960-894x(02)00585-1openalex-snapshot
Non-covalent thrombin inhibitors featuring P3-Heterocycles with P1-Bicyclic arginine surrogates
inferred← citeshttps://doi.org/10.1016/s0960-894x(03)00168-9openalex-snapshot
Design, synthesis, and structure–activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors
inferred← citeshttps://doi.org/10.1016/s1359-6446(02)02203-1openalex-snapshot
If channel blockers; Thrombin inhibitors
inferred← citeshttps://doi.org/10.1016/s1464-3383(04)80125-8openalex-snapshot
Papers on combinatorial chemistry or solid-phase synthesis from other journals - January 2002
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01642openalex-snapshot
Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability
inferred← citeshttps://doi.org/10.1021/cc020039vopenalex-snapshot
Comprehensive Survey of Combinatorial Library Synthesis: 2001
inferred← citeshttps://doi.org/10.1021/cc0340325openalex-snapshot
On the Representation of Combinatorial Libraries
inferred← citeshttps://doi.org/10.1021/cc034068xopenalex-snapshot
OptiDock: Virtual HTS of Combinatorial Libraries by Efficient Sampling of Binding Modes in Product Space
inferred← citeshttps://doi.org/10.1021/cc060095mopenalex-snapshot
Comprehensive Survey of Combinatorial Library Synthesis: 2005
inferred← citeshttps://doi.org/10.1021/ci049626popenalex-snapshot
Virtual Screening and Scaffold Hopping Based on GRID Molecular Interaction Fields
inferred← citeshttps://doi.org/10.1021/ci200107bopenalex-snapshot
A Multivariate Chemical Similarity Approach to Search for Drugs of Potential Environmental Concern
inferred← citeshttps://doi.org/10.1021/ci3000776openalex-snapshot
Pharmacophore Fingerprint-Based Approach to Binding Site Subpocket Similarity and Its Application to Bioisostere Replacement
inferred← citeshttps://doi.org/10.1021/ci6005596openalex-snapshot
A Multivariate Approach to Investigate Docking Parameters' Effects on Docking Performance
inferred← citeshttps://doi.org/10.1021/ci9000508openalex-snapshot
CAUTION: Popular “Benchmark” Data Sets Do Not Distinguish the Merits of 3D QSAR Methods
inferred← citeshttps://doi.org/10.1021/ci9003305openalex-snapshot
GARLig: A Fully Automated Tool for Subset Selection of Large Fragment Spaces via a Self-Adaptive Genetic Algorithm
inferred← citeshttps://doi.org/10.1021/jm061259gopenalex-snapshot
SHOP: Scaffold HOPping by GRID-Based Similarity Searches
inferred← citeshttps://doi.org/10.1021/jm070741bopenalex-snapshot
Design, Synthesis, and Multivariate Quantitative Structure−Activity Relationship of SalicylanilidesPotent Inhibitors of Type III Secretion inYersinia
inferred← citeshttps://doi.org/10.1021/jm401169aopenalex-snapshot
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity
inferred← citeshttps://doi.org/10.1038/srep23840openalex-snapshot
A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines
inferred← citeshttps://doi.org/10.1039/b705344dopenalex-snapshot
Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold
inferred← citeshttps://doi.org/10.1039/c1cc12694fopenalex-snapshot
Chemoselectivity in the Cu-catalyzed O-arylation of phenols and aliphatic alcohols
inferred← citeshttps://doi.org/10.1080/00498254.2024.2352598openalex-snapshot
Perspectives on the use of machine learning for ADME prediction at AstraZeneca
inferred← citeshttps://doi.org/10.1107/s1600536807043887openalex-snapshot
Benzene-1,2,3-triyl tris(benzenesulfonate)
inferred← citeshttps://doi.org/10.11606/t.9.2017.tde-31082017-152110openalex-snapshot
Quimioterápicos potencialmente ativos em endemias tropicais e tuberculose: estudos de QSAR na série de 5-nitroderivados benzidrazídicos e o planejamento de pró-fármacos de ação prolongada
inferred← citeshttps://doi.org/10.1177/1087057108314651openalex-snapshot
Label-Free Primary Screening and Affinity Ranking of Fragment Libraries Using Parallel Analysis of Protein Panels
inferred← citeshttps://doi.org/10.1211/0022357055867openalex-snapshot
Experimental modelling of drug membrane permeability by capillary electrophoresis using liposomes, micelles and microemulsions
inferred← citeshttps://doi.org/10.1517/13543776.12.8.1181openalex-snapshot
Therapeutic applications of serine protease inhibitors
inferred← citeshttps://doi.org/10.1517/13543776.2014.959493openalex-snapshot
Prolinamide derivatives as thrombin inhibitors for the treatment of thrombin-mediated diseases: a patent evaluation of US2013296245
inferred← citeshttps://doi.org/10.1529/biophysj.106.099150openalex-snapshot
Quantum and Molecular Dynamics Study for Binding of Macrocyclic Inhibitors to Human α-Thrombin
inferred← citeshttps://doi.org/10.2174/092986710791233661openalex-snapshot
Statistical Molecular Design of Balanced Compound Libraries for QSAR Modeling
inferred← citeshttps://doi.org/10.48730/p5qa-vc44openalex-snapshot
Design, synthesis and biological evaluation of sphingosine kinase inhibitors for the treatment of prostate cancer
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.