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A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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ChemInform Abstract: Marine Natural Products
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Antithrombin Effect of Polyphenol‐Rich Extracts from Black Chokeberry and Grape Seeds
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An in vitro Study on the DNA Damaging Effects of Phytochemicals Partially Isolated from an Extract of Glinus lotoides
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Structure of a Retro-binding Peptide Inhibitor Complexed with Human α-Thrombin
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QSAR and Molecular Modeling Studiesof Factor Xa and Thrombin Inhibitors
inferredcites →https://doi.org/10.1007/s11095-013-1283-1openalex-snapshot
Bioactive Equivalence of Combinatorial Components Identified in Screening of an Herbal Medicine
inferredcites →https://doi.org/10.1016/0065-2571(84)90007-4openalex-snapshot
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
inferredcites →https://doi.org/10.1016/j.aca.2011.10.010openalex-snapshot
Enhanced chromatographic fingerprinting of herb materials by multi-wavelength selection and chemometrics
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Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis
inferredcites →https://doi.org/10.1016/j.cbpa.2007.08.012openalex-snapshot
Natural products as a screening resource
inferredcites →https://doi.org/10.1016/j.cbpa.2010.02.018openalex-snapshot
Privileged scaffolds for library design and drug discovery
inferredcites →https://doi.org/10.1016/j.chroma.2011.06.058openalex-snapshot
Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard
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Analysis and improved characterization of minor antioxidants from leaves of Malus doumeri using a combination of major constituents’ knockout with high-performance liquid chromatography–diode array detector–quadrupole time-of-flight tandem mass spectrometry
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Natural products in drug discovery
inferredcites →https://doi.org/10.1016/j.drudis.2009.05.009openalex-snapshot
Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?
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Isolation and identification of degradation products of salvianolic acid A by NMR and LC-MS
inferredcites →https://doi.org/10.1016/j.jchromb.2014.05.001openalex-snapshot
Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC–MS combined with enzyme channel blocking
inferredcites →https://doi.org/10.1016/j.jchromb.2014.10.010openalex-snapshot
Magnetic ligand fishing combination with high-performance liquid chromatography–diode array detector–mass spectrometry to screen and characterize cyclooxygenase-2 inhibitors from green tea
inferredcites →https://doi.org/10.1016/j.jep.2012.07.033openalex-snapshot
Compatibility art of traditional Chinese medicine: From the perspective of herb pairs
inferredcites →https://doi.org/10.1016/j.jep.2012.12.007openalex-snapshot
The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: Discovery of an active cardiac glycoside from Urginea maritima
inferredcites →https://doi.org/10.1016/j.jpba.2014.03.023openalex-snapshot
Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement
inferredcites →https://doi.org/10.1016/j.phymed.2013.03.004openalex-snapshot
The anti-diabetic effects and pharmacokinetic profiles of berberine in mice treated with Jiao-Tai-Wan and its compatibility
inferredcites →https://doi.org/10.1016/j.trac.2007.11.005openalex-snapshot
Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models
inferredcites →https://doi.org/10.1016/j.watres.2009.07.026openalex-snapshot
Application of the combination index (CI)-isobologram equation to study the toxicological interactions of lipid regulators in two aquatic bioluminescent organisms
inferredcites →https://doi.org/10.1016/s1074-5521(02)00238-7openalex-snapshot
Small Molecule Affinity Fingerprinting
inferredcites →https://doi.org/10.1021/ac051131ropenalex-snapshot
High-Throughput Screening for Enzyme Inhibitors Using Frontal Affinity Chromatography with Liquid Chromatography and Mass Spectrometry
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Statistical Molecular Design, Parallel Synthesis, and Biological Evaluation of a Library of Thrombin Inhibitors
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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
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Quantitative Purity–Activity Relationships of Natural Products: The Case of Anti-Tuberculosis Active Triterpenes from Oplopanax horridus
inferredcites →https://doi.org/10.1038/377754a0openalex-snapshot
Initial hydrophobic collapse in the folding of barstar
inferredcites →https://doi.org/10.1038/448126aopenalex-snapshot
A culture in the balance
inferredcites →https://doi.org/10.1038/nature11774openalex-snapshot
ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
inferredcites →https://doi.org/10.1038/nchembio.2007.17openalex-snapshot
High-throughput screening assays for the identification of chemical probes
inferredcites →https://doi.org/10.1038/nrd1657openalex-snapshot
The evolving role of natural products in drug discovery
inferredcites →https://doi.org/10.1039/a809395dopenalex-snapshot
Marine natural products
inferredcites →https://doi.org/10.1039/b926359dopenalex-snapshot
Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening
inferredcites →https://doi.org/10.1039/c0sc00620copenalex-snapshot
Chemoselective enrichment for natural products discovery
inferredcites →https://doi.org/10.1039/c2cc32833jopenalex-snapshot
Peroxidase-mimic bismuth–gold nanoparticles for determining the activity of thrombin and drug screening
inferredcites →https://doi.org/10.1039/c3cc48818gopenalex-snapshot
Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A
inferredcites →https://doi.org/10.1039/c4cc04498copenalex-snapshot
Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library
inferredcites →https://doi.org/10.1039/c4cc08728copenalex-snapshot
A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking
inferredcites →https://doi.org/10.1039/c5sc00534eopenalex-snapshot
Virtual screening for high affinity guests for synthetic supramolecular receptors
inferredcites →https://doi.org/10.1039/np9900700269openalex-snapshot
Marine natural products
inferredcites →https://doi.org/10.1055/s-2006-939550openalex-snapshot
An Overview of the Structure and Function of Thrombin
inferredcites →https://doi.org/10.1073/pnas.2033863100openalex-snapshot
How fast is protein hydrophobic collapse?
inferredcites →https://doi.org/10.1124/pr.58.3.10openalex-snapshot
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
inferredcites →https://doi.org/10.1126/science.1101176openalex-snapshot
Hydrophobic Collapse in Multidomain Protein Folding
inferredcites →https://doi.org/10.1126/science.1168243openalex-snapshot
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
inferredcites →https://doi.org/10.1158/0008-5472.can-09-1947openalex-snapshot
Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-1087openalex-snapshot
Evaluation of Combination Chemotherapy
inferredcites →https://doi.org/10.1161/01.cir.79.3.657openalex-snapshot
Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor.
inferredcites →https://doi.org/10.1371/journal.pone.0043918openalex-snapshot
A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment
inferredcites →https://doi.org/10.3390/ijms131013621openalex-snapshot
Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities
inferredcites →https://doi.org/10.3748/wjg.15.3073openalex-snapshot
A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/cmdc.201600489openalex-snapshot
Integration of Multiple Analytical and Computational Tools for the Discovery of High‐Potency Enzyme Inhibitors from Herbal Medicines
inferred← citeshttps://doi.org/10.1002/jssc.201600606openalex-snapshot
Comparative analysis of the main bioactive components of Xin‐Sheng‐Hua granule and its single herbs by ultrahigh performance liquid chromatography with tandem mass spectrometry
inferred← citeshttps://doi.org/10.1002/jssc.201700473openalex-snapshot
Comparative analysis of 15 chemical constituents in Scutellaria baicalensis stem‐leaf from different regions in China by ultra‐high performance liquid chromatography with triple quadrupole tandem mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00216-018-1081-zopenalex-snapshot
A fast and accurate method for the identification of peroxidase inhibitors from Radix Salvia Miltiorrhizae by on-flow biochemical assay coupled with LC/Q-TOF-MS: comparison with ultrafiltration-based affinity selection
inferred← citeshttps://doi.org/10.1007/s13659-024-00485-5openalex-snapshot
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species
inferred← citeshttps://doi.org/10.1016/b978-0-12-811147-5.00001-7openalex-snapshot
Traditional Chinese Medicine
inferred← citeshttps://doi.org/10.1016/b978-0-12-811710-1.00028-8openalex-snapshot
Herbal medicine and biotechnology for the benefit of human health
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462307openalex-snapshot
Classification-based strategies to simplify complex traditional Chinese medicine (TCM) researches through liquid chromatography-mass spectrometry in the last decade (2011–2020): Theory, technical route and difficulty
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.11.028openalex-snapshot
Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.hermed.2021.100461openalex-snapshot
The effects of Boswellia (Frankincense) gel and hydrocolloid dressing on healing of second- and third-degree pressure ulcers among hospitalized patients
inferred← citeshttps://doi.org/10.1016/j.jep.2018.01.010openalex-snapshot
Bioactive fraction of Rhodiola algida against chronic hypoxia-induced pulmonary arterial hypertension and its anti-proliferation mechanism in rats
inferred← citeshttps://doi.org/10.1016/j.jep.2018.09.029openalex-snapshot
In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: Refocusing into multi-component potentials
inferred← citeshttps://doi.org/10.1016/j.jep.2023.116832openalex-snapshot
Discovery of effective combination from Renshen-Fuzi herbal pair against heart failure by spectrum-effect relationship analysis and zebrafish models
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2017.03.025openalex-snapshot
Label-free pharmacological profiling based on dynamic mass redistribution for characterization and authentication of hazardous natural products
inferred← citeshttps://doi.org/10.1016/j.jpba.2018.05.001openalex-snapshot
Uncovering potential anti-neuroinflammatory components of Modified Wuziyanzong Prescription through a target-directed molecular docking fingerprint strategy
inferred← citeshttps://doi.org/10.1016/j.phymed.2018.12.013openalex-snapshot
Quantitative fingerprint and quality control analysis of Compound Liquorice Tablet combined with antioxidant activities and chemometrics methods
inferred← citeshttps://doi.org/10.1016/j.ygyno.2017.12.018openalex-snapshot
Novel expression of CD11b in epithelial ovarian cancer: Potential therapeutic target
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b01251openalex-snapshot
Mass Spectrometry-Sensitive Probes Coupled with Direct Analysis in Real Time for Simultaneous Sensing of Chemical and Biological Properties of Botanical Drugs
inferred← citeshttps://doi.org/10.1021/acscatal.4c03560openalex-snapshot
Alcohols as Alkyl Synthons Enabled by Photoredox-Catalyzed Deoxygenative Activation
inferred← citeshttps://doi.org/10.1038/s41598-017-07087-xopenalex-snapshot
Simultaneous determination of hydrophilic and lipophilic constituents in herbal medicines using directly-coupled reversed-phase and hydrophilic interaction liquid chromatography-tandem mass spectrometry
inferred← citeshttps://doi.org/10.1101/2022.12.01.518649openalex-snapshot
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four Angelica species
inferred← citeshttps://doi.org/10.1186/s13020-020-00320-2openalex-snapshot
LC–MS-based multivariate statistical analysis for the screening of potential thrombin/factor Xa inhibitors from Radix Salvia Miltiorrhiza
inferred← citeshttps://doi.org/10.1186/s13020-020-00376-0openalex-snapshot
Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis
inferred← citeshttps://doi.org/10.14712/fb2021067030108openalex-snapshot
Asiatic Acid Induces Mitochondrial Apoptosis via Inhibition of JAK2/STAT3 Signalling Pathway in Human Osteosarcoma
inferred← citeshttps://doi.org/10.22038/ajp.2018.11593openalex-snapshot
Antimutagenic, antitumor and estrogen receptor binding activity of the rare plant Shortia galacifolia: An ethnobotanical and chemosystematic approach.
inferred← citeshttps://doi.org/10.3389/fphar.2017.00211openalex-snapshot
Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics
inferred← citeshttps://doi.org/10.3389/fphar.2025.1582677openalex-snapshot
Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway
inferred← citeshttps://doi.org/10.3390/nano13030555openalex-snapshot
Nanotechnology Involved in Treating Urinary Tract Infections: An Overview
inferred← citeshttps://doi.org/10.47307/gmc.2021.129.4.2openalex-snapshot
Potential therapy of Sambiloto plant (Andrographis paniculata) using multi-compounds analysis
inferred← citeshttps://doi.org/10.48130/targetome-0026-0002openalex-snapshot
Artificial intelligence algorithms drive the deciphering of traditional Chinese medicine by analyzing the chemicalome, targetome, and bioactivome
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