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Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

https://doi.org/10.1021/jm049934e
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Crystal structure and refinement of cytochrome P450terp at 2·3 Å resolution
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National Cancer Institute
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Lead discovery using molecular docking
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CRYSTAL STRUCTURE OF SUBSTRATE-FREE PSEUDOMONAS PUTIDA CYTOCHROME P450
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Chemically modified heparins as inhibitors of heparan sulfate specific endo-.beta.-glucuronidase (heparanase) of metastatic melanoma cells
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Diversity in the Oxidation of Substrates by Cytochrome P450 2D6: Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding
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Use of Robust Classification Techniques for the Prediction of Human Cytochrome P450 2D6 Inhibition
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Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies
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Molecular Docking and High-Throughput Screening for Novel Inhibitors of Protein Tyrosine Phosphatase-1B
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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes
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Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite
inferredcites →https://doi.org/10.1073/pnas.050406897openalex-snapshot
Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity
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Metabolism of36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity
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Inhibition of Risperidone Metabolism by Fluoxetine in Patients With Schizophrenia: A Clinically Relevant Pharmacokinetic Drug Interaction
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GENERATION AND VALIDATION OF RAPID COMPUTATIONAL FILTERS FOR CYP2D6 AND CYP3A4
inferredcites →https://doi.org/10.1126/science.8342039openalex-snapshot
Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's
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Recent Advances: the Cytochrome P450 Enzymes

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