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Synthesis, Stereochemical Separation, and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease
inferredcites →https://doi.org/10.1002/jhet.110openalex-snapshot
Synthesis and biological evaluation of novel conjugated coumarin‐thiazole systems
inferredcites →https://doi.org/10.1007/978-3-7091-9050-0_27openalex-snapshot
From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors
inferredcites →https://doi.org/10.1007/s00702-007-0674-zopenalex-snapshot
New insights into the structures and functions of human monoamine oxidases A and B
inferredcites →https://doi.org/10.1016/j.addr.2008.06.002openalex-snapshot
Monoamine oxidase inactivation: From pathophysiology to therapeutics
inferredcites →https://doi.org/10.1016/j.amjopharm.2006.12.001openalex-snapshot
Rasagiline (TVP-1012): A new selective monoamine oxidase inhibitor for Parkinson's disease
inferredcites →https://doi.org/10.1016/j.bbrc.2006.03.190openalex-snapshot
Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity
inferredcites →https://doi.org/10.1016/j.bmcl.2007.05.078openalex-snapshot
Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.
inferredcites →https://doi.org/10.1016/j.chroma.2007.10.009openalex-snapshot
High-performance liquid chromatographic separation of enantiomers and diastereomers of 2-methylcyclohexanone thiosemicarbazone, and determination of absolute configuration and configurational stability
inferredcites →https://doi.org/10.1016/s0006-2952(99)00340-8openalex-snapshot
Drug treatment of Parkinson’s disease
inferredcites →https://doi.org/10.1021/bi051847gopenalex-snapshot
Functional Role of the “Aromatic Cage” in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins,
inferredcites →https://doi.org/10.1021/bi900413gopenalex-snapshot
Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases
inferredcites →https://doi.org/10.1021/jm031087copenalex-snapshot
Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N -Propargylaminoindan Class
inferredcites →https://doi.org/10.1021/jm060869dopenalex-snapshot
Selective Inhibitory Activity against MAO and Molecular Modeling Studies of 2-Thiazolylhydrazone Derivatives
inferredcites →https://doi.org/10.1021/jm800132gopenalex-snapshot
Synthesis, Stereochemical Identification, and Selective Inhibitory Activity against Human Monoamine Oxidase-B of 2-Methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones
inferredcites →https://doi.org/10.1021/jm800885dopenalex-snapshot
A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone
inferredcites →https://doi.org/10.1021/tx700210jopenalex-snapshot
Oxidative Stress and Neurotoxicity
inferredcites →https://doi.org/10.1038/nrn1883openalex-snapshot
The therapeutic potential of monoamine oxidase inhibitors
inferredcites →https://doi.org/10.1038/sj.bjp.0703826openalex-snapshot
Rasagiline [N‐propargyl‐1R(+)‐aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
inferredcites →https://doi.org/10.1039/c0md00014kopenalex-snapshot
Synthesis and selective inhibition of human monoamine oxidases of a large scaffold of (4,5-substituted-thiazol-2-yl)hydrazones
inferredcites →https://doi.org/10.1073/pnas.0710626105openalex-snapshot
Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors
inferredcites →https://doi.org/10.1074/jbc.m500949200openalex-snapshot
Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors
inferredcites →https://doi.org/10.1107/s1600536811042486openalex-snapshot
(E)-2-(2-Methylcyclohexylidene)hydrazinecarbothioamide
inferredcites →https://doi.org/10.1111/j.1527-3458.2005.tb00269.xopenalex-snapshot
Neuroprotection by Rasagiline: A New Therapeutic Approach to Parkinson's Disease?
inferredcites →https://doi.org/10.1136/bmj.310.6979.575openalex-snapshot
Fortnightly Review: Drug treatment of Parkinson's disease
inferredcites →https://doi.org/10.1146/annurev.neuro.22.1.197openalex-snapshot
MONOAMINE OXIDASE: From Genes to Behavior
inferredcites →https://doi.org/10.1517/13543776.15.12.1763openalex-snapshot
Recent development of monoamine oxidase inhibitors
inferredcites →https://doi.org/10.2174/0929867043364757openalex-snapshot
Regulation of MAO-A and MAO-B Gene Expression
inferredcites →https://doi.org/10.2174/0929867043364775openalex-snapshot
Clinical Applications of MAO-Inhibitors
inferredcites →https://doi.org/10.2174/0929867043364784openalex-snapshot
Structure and Mechanism of Monoamine Oxidase
inferredcites →https://doi.org/10.2174/1381612043383421openalex-snapshot
Recent Approaches to Novel Anti-Alzheimer Therapy
inferredcites →https://doi.org/10.2174/1570159x15666171128145423openalex-snapshot
Computer-aided Drug Design Applied to Parkinson Targets

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4782909openalex-extracted
New 2-Hydrazinothiazole Derivatives as Potential Mao-A, Mao-B, Ache, and Bche Inhibitorsri
inferred← citeshttps://doi.org/10.1002/ardp.201200318openalex-snapshot
Synthesis and Selective Human Monoamine Oxidase B Inhibition of Heterocyclic Hybrids Based on Hydrazine and Thiazole Scaffolds
inferred← citeshttps://doi.org/10.1002/jhet.1856openalex-snapshot
Microwave and Ultrasound‐Assisted Synthesis of Thiosemicarbazones and Their Corresponding (4,5‐Substituted‐thiazol‐2‐yl)hydrazines
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Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies
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Nitrogen heterocycles as potential monoamine oxidase inhibitors: Synthetic aspects
inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.12.019openalex-snapshot
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103299openalex-snapshot
Critical evaluation of current Alzheimer’s drug discovery (2018–19) & futuristic Alzheimer drug model approach
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Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.03.042openalex-snapshot
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.01.038openalex-snapshot
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128994openalex-snapshot
Design, synthesis, in-vitro, in-vivo and ex-vivo pharmacology of thiazolidine-2,4-dione derivatives as selective and reversible monoamine oxidase-B inhibitors
inferred← citeshttps://doi.org/10.1016/j.chroma.2012.08.007openalex-snapshot
3-Methylcyclohexanone thiosemicarbazone: Determination of E/Z isomerization barrier by dynamic high-performance liquid chromatography, configuration assignment and theoretical study of the mechanisms involved by the spontaneous, acid and base catalyzed processes
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.04.006openalex-snapshot
Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.10.032openalex-snapshot
Recent advances in the development of selective human MAO-B inhibitors: (Hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.10.035openalex-snapshot
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.05.032openalex-snapshot
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.10.050openalex-snapshot
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.12.013openalex-snapshot
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible h MAO-A inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.05.078openalex-snapshot
Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112787openalex-snapshot
A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer’s disease agents: A review
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.141154openalex-snapshot
Synthesis, biological evaluation, molecular docking, molecular dynamics, and ADME studies of novel thiouracil derivatives as dual inhibitors of butyrylcholinesterase and acetylcholinesterase enzymes
inferred← citeshttps://doi.org/10.1021/jm200716yopenalex-snapshot
Synthesis and Study of a Series of 3-Arylcoumarins as Potent and Selective Monoamine Oxidase B Inhibitors
inferred← citeshttps://doi.org/10.1021/jm400336xopenalex-snapshot
Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-ones
inferred← citeshttps://doi.org/10.1021/jm501690ropenalex-snapshot
New Frontiers in Selective Human MAO-B Inhibitors
inferred← citeshttps://doi.org/10.1039/c0cc05804aopenalex-snapshot
Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition
inferred← citeshttps://doi.org/10.1080/10426507.2020.1722667openalex-snapshot
Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives
inferred← citeshttps://doi.org/10.1080/10426507.2024.2427148openalex-snapshot
New 2-hydrazinothiazole derivatives as potential MAO-A, MAO-B, AChE, and BChE inhibitors
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4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
inferred← citeshttps://doi.org/10.1107/s1600536811042486openalex-snapshot
(E)-2-(2-Methylcyclohexylidene)hydrazinecarbothioamide
inferred← citeshttps://doi.org/10.1111/cbdd.12629openalex-snapshot
Coumarin: A Privileged Scaffold for the Design and Development of Antineurodegenerative Agents
inferred← citeshttps://doi.org/10.1248/cpb.c14-00616openalex-snapshot
Synthesis, Antibacterial, Antioxidant Activity and QSAR Studies of Novel 2-Arylidenehydrazinyl-4-arylthiazole Analogues
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New indane derivatives containing 2-hydrazinothiazole as potential acetylcholinesterase and monoamine oxidase-B inhibitors
inferred← citeshttps://doi.org/10.1515/znc-2021-0223openalex-snapshot
Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor
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Patent-related survey on new monoamine oxidase inhibitors and their therapeutic potential
inferred← citeshttps://doi.org/10.15272/ajbps.v4i36.577openalex-snapshot
Molecular Docking Studies on (Hetero)arlylidene(4-substituted-thiazol-2-yl)hydrazines as MAO-B Inhibitors
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Unlocking Triplet Carbene Reactivity: Photocatalyst-Free Synthesis of 1,1-Disubstituted Hydrazines via Visible-Light N–H Insertion
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New Aspects of Monoamine Oxidase B Inhibitors: The Key Role of Halogens to Open the Golden Door
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Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold
inferred← citeshttps://doi.org/10.2174/1570159x15666171128145423openalex-snapshot
Computer-aided Drug Design Applied to Parkinson Targets
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Identification of new anti- Candida compounds by ligand-based pharmacophore virtual screening
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Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
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Significance of Thiazole-based Heterocycles for Bioactive Systems
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