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New 2-Hydrazinothiazole Derivatives as Potential Mao-A, Mao-B, Ache, and Bche Inhibitorsri

https://doi.org/10.2139/ssrn.4782909
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Synthesis and Selective Human Monoamine Oxidase B Inhibition of Heterocyclic Hybrids Based on Hydrazine and Thiazole Scaffolds
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Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
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Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives
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Current Place of Monoamine Oxidase Inhibitors in the Treatment of Depression
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A new and rapid colorimetric determination of acetylcholinesterase activity
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Discovery and Development
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In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
inferredcites →https://doi.org/10.1016/j.bioorg.2020.103882openalex-extracted
Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity
inferredcites →https://doi.org/10.1016/j.bioorg.2020.104110openalex-extracted
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
inferredcites →https://doi.org/10.1016/j.bioorg.2022.106224openalex-extracted
Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation
inferredcites →https://doi.org/10.1016/j.bmc.2010.05.070openalex-extracted
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2010.06.007openalex-extracted
Investigations on the 2-thiazolylhydrazyne scaffold: Synthesis and molecular modeling of selective human monoamine oxidase inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2015.08.002openalex-extracted
Design and discovery of 2-(4-(1H-tetrazol-5-yl)-1H-pyrazol-1-yl)-4-(4-phenyl)thiazole derivatives as cardiotonic agents via inhibition of PDE3
inferredcites →https://doi.org/10.1016/j.bmcl.2013.02.017openalex-extracted
Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.bmcl.2016.07.010openalex-extracted
Design, synthesis and antimalarial evaluation of novel thiazole derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2017.05.032openalex-extracted
Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents
inferredcites →https://doi.org/10.1016/j.ejmech.2011.12.027openalex-extracted
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B
inferredcites →https://doi.org/10.1016/j.ejmech.2013.05.032openalex-extracted
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
inferredcites →https://doi.org/10.1016/j.ejmech.2017.10.050openalex-extracted
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
inferredcites →https://doi.org/10.1016/j.ejmech.2017.12.040openalex-extracted
Synthesis, anticancer activity and mechanism of action of new thiazole derivatives
inferredcites →https://doi.org/10.1016/j.ejmech.2019.02.016openalex-extracted
A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus
inferredcites →https://doi.org/10.1016/j.ejmech.2019.04.026openalex-extracted
Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents
inferredcites →https://doi.org/10.1016/j.ejmech.2019.05.039openalex-extracted
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase
inferredcites →https://doi.org/10.1016/j.ejmech.2019.05.082openalex-extracted
Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis
inferredcites →https://doi.org/10.1016/j.ejmech.2021.114097openalex-extracted
Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors
inferredcites →https://doi.org/10.1016/j.imu.2022.100880openalex-extracted
Molecular modeling in drug discovery
inferredcites →https://doi.org/10.1016/s0047-6374(01)00309-8openalex-extracted
Acetylcholinesterase in Alzheimer's disease
inferredcites →https://doi.org/10.1016/s0079-6123(08)62429-2openalex-extracted
Chapter 53: Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease
inferredcites →https://doi.org/10.1016/s0161-813x(03)00097-4openalex-extracted
Clinical Pharmacology of MAO Inhibitors: Safety and Future
inferredcites →https://doi.org/10.1016/s0361-9230(01)00613-xopenalex-extracted
Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B
inferredcites →https://doi.org/10.1017/s1461145705005833openalex-extracted
Targeting acetylcholinesterase and butyrylcholinesterase in dementia
inferredcites →https://doi.org/10.1021/acs.jmedchem.0c01863openalex-extracted
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate
inferredcites →https://doi.org/10.1021/acschemneuro.2c00132openalex-extracted
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/bi00739a027openalex-extracted
Amino acid sequence in the region of the reactive serine residue of eel acetylcholinesterase
inferredcites →https://doi.org/10.1021/jm060869dopenalex-extracted
Selective Inhibitory Activity against MAO and Molecular Modeling Studies of 2-Thiazolylhydrazone Derivatives
inferredcites →https://doi.org/10.1021/jm100120sopenalex-extracted
Synthesis, Stereochemical Separation, and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines
inferredcites →https://doi.org/10.1023/a:1015810312465openalex-extracted
Predicting Skin Permeability
inferredcites →https://doi.org/10.1038/nrn1035openalex-extracted
Neurobiology of butyrylcholinesterase
inferredcites →https://doi.org/10.1038/srep14836openalex-extracted
Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
inferredcites →https://doi.org/10.1038/srep42717openalex-extracted
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
inferredcites →https://doi.org/10.1039/d0ra06379gopenalex-extracted
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
inferredcites →https://doi.org/10.1080/07391102.2023.2274967openalex-extracted
Synthesis, characterization, molecular docking and molecular dynamics simulations of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives as potential cholinesterase/monoamine oxidase dual inhibitors for Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awy132openalex-extracted
The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
inferredcites →https://doi.org/10.1515/znc-2021-0058openalex-extracted
New indane derivatives containing 2-hydrazinothiazole as potential acetylcholinesterase and monoamine oxidase-B inhibitors
inferredcites →https://doi.org/10.2165/00002512-199813050-00002openalex-extracted
Monoamine Oxidase Inhibitors
inferredcites →https://doi.org/10.2174/1570159x11311030006openalex-extracted
Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
inferredcites →https://doi.org/10.3109/14756366.2014.987138openalex-extracted
(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies
inferredcites →https://doi.org/10.3109/14756366.2016.1158172openalex-extracted
Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures
inferredcites →https://doi.org/10.3389/fncel.2015.00124openalex-extracted
Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases
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