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Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

inferredcites →https://doi.org/10.1002/eji.200636181openalex-snapshot

TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen‐induced T cell activation

inferredcites →https://doi.org/10.1006/cimm.1993.1071openalex-snapshot

In Vivo Activation of Natural Killer Cells and Priming of IL-2 Responsive Cytolytic Cells by Loxoribine (7-Allyl-8-oxoguanosine)

inferredcites →https://doi.org/10.1007/978-1-4615-1823-5_25openalex-snapshot

A New Approach to Vaccine Adjuvants

inferredcites →https://doi.org/10.1007/978-3-540-92165-3_17openalex-snapshot

Transcutaneous Immunization with Influenza Vaccines

inferredcites →https://doi.org/10.1007/s00281-007-0061-8openalex-snapshot

Toll-like receptors in the skin

inferredcites →https://doi.org/10.1007/s10156-008-0596-1openalex-snapshot

Pathogen recognition by innate receptors

inferredcites →https://doi.org/10.1016/j.addr.2005.12.003openalex-snapshot

Needle-free vaccine delivery☆

inferredcites →https://doi.org/10.1016/j.beha.2009.10.005openalex-snapshot

Interferon in chronic myeloid leukaemia: past and future

inferredcites →https://doi.org/10.1016/j.bmc.2003.12.008openalex-snapshot

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

inferredcites →https://doi.org/10.1016/j.bmc.2008.08.064openalex-snapshot

Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates

inferredcites →https://doi.org/10.1016/j.bmcl.2009.02.095openalex-snapshot

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation

inferredcites →https://doi.org/10.1016/j.bmcl.2009.02.100openalex-snapshot

Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline

inferredcites →https://doi.org/10.1016/j.cell.2006.02.015openalex-snapshot

Pathogen Recognition and Innate Immunity

inferredcites →https://doi.org/10.1016/j.chroma.2007.10.012openalex-snapshot

Determination of the chromatographic hydrophobicity index for ionisable solutes

inferredcites →https://doi.org/10.1016/j.coi.2008.06.002openalex-snapshot

Structures of TLR–ligand complexes

inferredcites →https://doi.org/10.1016/j.smim.2006.12.004openalex-snapshot

TLR signaling

inferredcites →https://doi.org/10.1016/j.vaccine.2009.03.018openalex-snapshot

Intradermal immunization improves protective efficacy of a novel TB vaccine candidate

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A universal anti-HIV-1 Tat epitope vaccine that is fully synthetic and self-adjuvanting

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Substituted guanine ribonucleosides as B cell activators

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Toll-like receptors as adjuvant receptors

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Review Article Imiquimod applied topically: a novel immune response modifier and new class of drug

inferredcites →https://doi.org/10.1016/s0968-0896(03)00369-9openalex-snapshot

Synthesis and structure–activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects

inferredcites →https://doi.org/10.1021/jm00047a014openalex-snapshot

Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

inferredcites →https://doi.org/10.1021/jm00177a004openalex-snapshot

5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents

inferredcites →https://doi.org/10.1021/jm0203581openalex-snapshot

Discovery of 8-Hydroxyadenines as a Novel Type of Interferon Inducer

inferredcites →https://doi.org/10.1021/jm049211vopenalex-snapshot

Synthesis and Structure−Activity-Relationships of 1H-Imidazo[4,5-c]quinolines That Induce Interferon Production

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Controlling Plasma Protein Binding: Structural Correlates of Interactions of Hydrophobic Polyamine Endotoxin Sequestrants with Human Serum Albumin

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Synthesis of a Highly Water-Soluble Derivative of Amphotericin B with Attenuated Proinflammatory Activity

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Toll-like receptors: critical proteins linking innate and acquired immunity

inferredcites →https://doi.org/10.1038/jid.2008.225openalex-snapshot

Resident and “Inflammatory” Dendritic Cells in Human Skin

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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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TLR7: A new sensor of viral infection

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Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

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Procedure for Selecting Monoclonal Antibodies for use in a Ligand Displacement Assay of Serum Antibody Levels

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Hairy Cell Leukemia: Current Concepts

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Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets

inferredcites →https://doi.org/10.1089/jir.1982.2.317openalex-snapshot

Comparison between Circulating Interferon and Drug Levels Following Administration of 2-amino-5-bromo-6-phenyl-4(3H)-Pyrimidinone (ABPP) to Different Animal Species

inferredcites →https://doi.org/10.1093/intimm/dxl046openalex-snapshot

Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists

inferredcites →https://doi.org/10.1111/j.0818-9641.2004.01285.xopenalex-snapshot

Shaping of adaptive immune responses to soluble proteins by TLR agonists: A role for IFN‐α/β

inferredcites →https://doi.org/10.1111/j.1600-065x.2008.00739.xopenalex-snapshot

Innate immunity to pathogens: diversity in receptors for microbial recognition

inferredcites →https://doi.org/10.1126/science.1093616openalex-snapshot

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

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Comparation Interferon-Inducing and Antiviral Properties of 2-Amino-5-Bromo-6-Methyl-4-Pyrimidinol (U-25,166), Tilorone Hydrochloride, and Polyinosinic-Polycytidylic Acid

inferredcites →https://doi.org/10.1128/aac.2.2.73openalex-snapshot

Tilorone Hydrochloride: an Oral Interferon-Inducing Agent

inferredcites →https://doi.org/10.1128/iai.01527-07openalex-snapshot

Immunization with a Toll-Like Receptor 7 and/or 8 Agonist Vaccine Adjuvant Increases Protective Immunity againstLeishmania majorin BALB/c Mice

inferredcites →https://doi.org/10.1182/blood-2009-08-238543openalex-snapshot

Plasmacytoid dendritic cell–derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

inferredcites →https://doi.org/10.1248/cpb.56.1417openalex-snapshot

Lipophilicity Measurement of Drugs by Reversed Phase HPLC over Wide pH Range Using an Alkaline-Resistant Silica-Based Stationary Phase, XBridgeTM Shield RP18

inferredcites →https://doi.org/10.1385/ir:36:1:127openalex-snapshot

Professional antigen-presenting cells of the skin

inferredcites →https://doi.org/10.1586/14760584.7.8.1201openalex-snapshot

Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice

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Pegylated IFN-α2a and ribavirin in the treatment of hepatitis C

inferredcites →https://doi.org/10.4049/jimmunol.174.3.1259openalex-snapshot

Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8

inferredcites →https://doi.org/10.4161/hv.5.6.8175openalex-snapshot

Potential adjuvantic properties of innate immune stimuli

inferredcites →https://doi.org/10.4161/hv.6.1.10702openalex-snapshot

Letter from the Editor

inferredcites →https://doi.org/10.4161/hv.6.4.10866openalex-snapshot

Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine**

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A pH‐sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier

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Toll‐Like Receptor 7 Inactive Ligands Enhanced Cytokine Induction by Conjugation to Weak Antigens

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An Enzyme‐Directed Imidazoquinoline for Cancer Immunotherapy

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Base‐Promoted Heterocyclization of Fluorinated Alkynylphosphonates with Select ortho‐Aminobenzonitriles

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Syntheses of Human TLR8-Specific Small-Molecule Agonists

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Formulation and Development of Protein Biopharmaceuticals

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New antagonists of toll-like receptor 7 discovered through 3D ligand-based virtual screening

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6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine

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Chemical adaptation: bridging synthetic chemistry with drug development

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Design, microwave-mediated synthesis and biological evaluation of novel 4-aryl(alkyl)amino-3-nitroquinoline and 2,4-diaryl(dialkyl)amino-3-nitroquinolines as anticancer agents

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Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists

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Novel 1H-imidazo[4,5-c]quinoline derivatives as TLR-7 modulators with pro-apoptotic properties in breast cancer cell line

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Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7

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Toward self-adjuvanting subunit vaccines: Model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines

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Human Toll-like Receptor (TLR) 8-Specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines

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Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines

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Medicinal Chemistry of Next Generation Vaccine Adjuvants

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Structure–Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

inferred← citeshttps://doi.org/10.1021/acs.orglett.0c04138openalex-snapshot

Copper-Catalyzed Formal [3 + 3] Annulations of Arylketoximes and o-Fluorobenzaldehydes: An Entry to Quinoline Compounds

inferred← citeshttps://doi.org/10.1021/acsami.0c20607openalex-snapshot

Lipid-Polyglutamate Nanoparticle Vaccine Platform

inferred← citeshttps://doi.org/10.1021/acsbiomaterials.0c00485openalex-snapshot

Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1021/acscentsci.8b00823openalex-snapshot

Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses

inferred← citeshttps://doi.org/10.1021/acschembio.0c00924openalex-snapshot

Receptor–Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands

inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00610openalex-snapshot

Synthetic Multicomponent Nanovaccines Based on the Molecular Co-assembly of β-Peptides Protect against Influenza A Virus

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.1c00267openalex-snapshot

Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.3c00301openalex-snapshot

Call for Papers: Medicinal Chemistry of Next Generation Vaccine Adjuvants

inferred← citeshttps://doi.org/10.1021/acsomega.3c06343openalex-snapshot

Structural Optimization and Biological Evaluation of Isoxazolo[5,4-d]pyrimidines as Selective Toll-Like Receptor 7 Agonists

inferred← citeshttps://doi.org/10.1021/acsomega.4c11297openalex-snapshot

Efflux-Enhanced Imidazoquinolines To Exploit Chemoresistance

inferred← citeshttps://doi.org/10.1021/acsptsci.4c00163openalex-snapshot

Design and Synthesis of Polyphenolic Imidazo[4,5-c]quinoline Derivatives to Modulate Toll Like Receptor-7 Agonistic Activity and Adjuvanticity

inferred← citeshttps://doi.org/10.1021/jacs.1c03772openalex-snapshot

Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators

inferred← citeshttps://doi.org/10.1021/jm101535eopenalex-snapshot

Structure−Activity Relationships in Nucleotide Oligomerization Domain 1 (Nod1) Agonistic γ-Glutamyldiaminopimelic Acid Derivatives

inferred← citeshttps://doi.org/10.1021/jm2010207openalex-snapshot

Toll-Like Receptor (TLR)-7 and -8 Modulatory Activities of Dimeric Imidazoquinolines

inferred← citeshttps://doi.org/10.1021/jm201071eopenalex-snapshot

Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides

inferred← citeshttps://doi.org/10.1021/jm3000533openalex-snapshot

Structure–Activity Relationships in Human Toll-like Receptor 2-Specific Monoacyl Lipopeptides

inferred← citeshttps://doi.org/10.1021/jm301066hopenalex-snapshot

Structure–Activity Relationships in Human Toll-like Receptor 8-Active 2,3-Diamino-furo[2,3- c ]pyridines

inferred← citeshttps://doi.org/10.1021/jm400620gopenalex-snapshot

Design and Development of Stable, Water-Soluble, Human Toll-like Receptor 2 Specific Monoacyl Lipopeptides as Candidate Vaccine Adjuvants

inferred← citeshttps://doi.org/10.1021/jm400694dopenalex-snapshot

Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3-c]quinolines

inferred← citeshttps://doi.org/10.1021/jm500701qopenalex-snapshot

Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1 H -benzimidazol-2-amines

inferred← citeshttps://doi.org/10.1021/jm500744fopenalex-snapshot

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

inferred← citeshttps://doi.org/10.1021/ml300079eopenalex-snapshot

Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction

inferred← citeshttps://doi.org/10.1038/nbt.3371openalex-snapshot

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

inferred← citeshttps://doi.org/10.1038/s41587-019-0390-xopenalex-snapshot

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

inferred← citeshttps://doi.org/10.1039/9781788016544-00339openalex-snapshot

Small Molecule Modulators of Endo-lysosomal Toll-like Receptors

inferred← citeshttps://doi.org/10.1039/c2ob26705eopenalex-snapshot

Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines

inferred← citeshttps://doi.org/10.1039/c3ob40816gopenalex-snapshot

Structure–activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines

inferred← citeshttps://doi.org/10.1039/c5ob01650aopenalex-snapshot

Synthesis and anti-cancer activity of 1,4-disubstituted imidazo[4,5-c]quinolines

inferred← citeshttps://doi.org/10.1039/d1md00031dopenalex-snapshot

Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles

inferred← citeshttps://doi.org/10.1039/d2ra06395fopenalex-snapshot

Synthesis and immunopharmacological evaluation of novel TLR7 agonistic triazole tethered imidazoquinolines

inferred← citeshttps://doi.org/10.1039/d6cs00494fopenalex-snapshot

Targeting toll-like receptors in the immunotherapy era: the chemistry behind TLR modulators

inferred← citeshttps://doi.org/10.1039/d6qo00608fopenalex-snapshot

Unexpected products in isocyanide-based multicomponent reactions

inferred← citeshttps://doi.org/10.1073/pnas.1600816113openalex-snapshot

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

inferred← citeshttps://doi.org/10.1080/00304948.2018.1433427openalex-snapshot

Synthesis and Applications of Imidazoquinolines: A Review

inferred← citeshttps://doi.org/10.1080/07391102.2018.1559098openalex-snapshot

Pharmacophore-based virtual screening approach for identification of potent natural modulatory compounds of human Toll-like receptor 7

inferred← citeshttps://doi.org/10.1080/21645515.2018.1480284openalex-snapshot

Transcriptomal signatures of vaccine adjuvants and accessory immunostimulation of sentinel cells by toll-like receptor 2/6 agonists

inferred← citeshttps://doi.org/10.1080/21645515.2019.1710409openalex-snapshot

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant

inferred← citeshttps://doi.org/10.1084/jem.20180595openalex-snapshot

Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses

inferred← citeshttps://doi.org/10.1093/jac/dkr588openalex-snapshot

Antiviral applications of Toll-like receptor agonists

inferred← citeshttps://doi.org/10.1093/nsr/nwad310openalex-snapshot

Modularized viromimetic polymer nanoparticle vaccines (VPNVaxs) to elicit durable and effective humoral immune responses

inferred← citeshttps://doi.org/10.1101/2023.03.23.533909openalex-snapshot

Cancer Immunotherapy through Tissue Adhering Polymers

inferred← citeshttps://doi.org/10.1101/793232openalex-snapshot

Further Exploration of the SAR of Imidazoquinolines; Identification of Potent C7 Substituted Imidazoquinolines

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2010.00978.xopenalex-snapshot

Use of defined TLR ligands as adjuvants within human vaccines

inferred← citeshttps://doi.org/10.1128/spectrum.01695-21openalex-snapshot

High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

inferred← citeshttps://doi.org/10.1155/2016/1459394openalex-snapshot

Adjuvants: Classification, Modus Operandi , and Licensing

inferred← citeshttps://doi.org/10.1182/blood-2010-12-328138openalex-snapshot

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

inferred← citeshttps://doi.org/10.1186/s43094-026-00988-7openalex-snapshot

TLR7/8 agonist HYBRID2 as a dual-action compound against Leishmania donovani: antiparasitic and immunomodulatory effects

inferred← citeshttps://doi.org/10.1371/journal.pone.0043612openalex-snapshot

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer

inferred← citeshttps://doi.org/10.1371/journal.pone.0134640openalex-snapshot

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

inferred← citeshttps://doi.org/10.1371/journal.pone.0149848openalex-snapshot

Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen

inferred← citeshttps://doi.org/10.1371/journal.pone.0260565openalex-snapshot

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8

inferred← citeshttps://doi.org/10.1515/hc-2016-0059openalex-snapshot

A direct synthetic route to fused tricyclic quinolones from 2,3-diaminoquinolin-4(1 H )one

inferred← citeshttps://doi.org/10.15252/emmm.202012034openalex-snapshot

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

inferred← citeshttps://doi.org/10.2217/imt.11.112openalex-snapshot

Targeting the Tumor Microenvironment by Immunotherapy: Part 2

inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-20xp1openalex-snapshot

Structure−Activity Relationships Towards the Identification of High-Potency Selective Human Toll-Like Receptor-7 Agonist

inferred← citeshttps://doi.org/10.3389/fimmu.2017.00312openalex-snapshot

Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1168252openalex-snapshot

Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo

inferred← citeshttps://doi.org/10.3389/fimmu.2023.1217181openalex-snapshot

Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia

inferred← citeshttps://doi.org/10.3390/cells9071648openalex-snapshot

A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models

inferred← citeshttps://doi.org/10.3390/ijms242015417openalex-snapshot

Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses

inferred← citeshttps://doi.org/10.3390/molecules26051220openalex-snapshot

Polymeric Micelles in Cancer Immunotherapy

inferred← citeshttps://doi.org/10.3390/molecules27217567openalex-snapshot

Silver-Catalyzed Cascade Cyclization of Amino-NH-1,2,3-Triazoles with 2-Alkynylbenzaldehydes: An Access to Pentacyclic Fused Triazoles

inferred← citeshttps://doi.org/10.3390/ph14121292openalex-snapshot

Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

inferred← citeshttps://doi.org/10.3410/f.734913466.793557864openalex-snapshot

Faculty Opinions recommendation of Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.

inferred← citeshttps://doi.org/10.3987/rev-12-747openalex-snapshot

Imidazoquinolines as Diverse and Interesting Building Blocks: Review of Synthetic Methodologies

inferred← citeshttps://doi.org/10.4155/tde.12.52openalex-snapshot

Overview and Outlook of Toll-like Receptor ligand–antigen Conjugate Vaccines

inferred← citeshttps://doi.org/10.70675/a0a78f0dzb140z41bdz848ez080099d87366openalex-snapshot

Synthèse et développement de nouvelles molécules hétérocycliques tricycliques : étude de leurs propriétés immunomodulatrices

inferred← citeshttps://doi.org/10.7150/thno.37216openalex-snapshot

Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy

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