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Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470508169.ch5openalex-snapshot
Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs
inferredcites →https://doi.org/10.1002/dvdy.21658openalex-snapshot
Epithelial–mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis
inferredcites →https://doi.org/10.1002/med.10025openalex-snapshot
Carbonic anhydrase inhibitors
inferredcites →https://doi.org/10.1002/path.1087openalex-snapshot
The glomerulo‐tubular junction: a target in renal diseases
inferredcites →https://doi.org/10.1002/path.1120openalex-snapshot
Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c‐erbB2
inferredcites →https://doi.org/10.1007/s004180000181openalex-snapshot
Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours
inferredcites →https://doi.org/10.1007/s00428-010-0938-0openalex-snapshot
Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX
inferredcites →https://doi.org/10.1016/j.bmc.2010.03.026openalex-snapshot
Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance
inferredcites →https://doi.org/10.1016/j.bmcl.2003.09.063openalex-snapshot
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-d-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits
inferredcites →https://doi.org/10.1016/j.bmcl.2006.11.046openalex-snapshot
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides
inferredcites →https://doi.org/10.1016/j.bmcl.2009.02.086openalex-snapshot
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties
inferredcites →https://doi.org/10.1016/j.bmcl.2009.06.022openalex-snapshot
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2010.05.009openalex-snapshot
Carbonic anhydrase inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2010.06.040openalex-snapshot
Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II
inferredcites →https://doi.org/10.1016/j.bmcl.2010.10.094openalex-snapshot
7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
inferredcites →https://doi.org/10.1016/j.febslet.2004.10.043openalex-snapshot
Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH
inferredcites →https://doi.org/10.1016/j.radonc.2009.06.019openalex-snapshot
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model
inferredcites →https://doi.org/10.1016/j.tips.2006.09.002openalex-snapshot
Targeting tumor-associated carbonic anhydrase IX in cancer therapy
inferredcites →https://doi.org/10.1016/s0021-9258(18)62326-9openalex-snapshot
The Carbon Dioxide Hydration Activity of Carbonic Anhydrase
inferredcites →https://doi.org/10.1021/cb1003477openalex-snapshot
Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds
inferredcites →https://doi.org/10.1021/ed079p1353openalex-snapshot
Synthesis of 4-Methylumbellifer-7-yl-alpha-D-Mannopyranoside: An Introduction to Modern Glycosylation Reactions
inferredcites →https://doi.org/10.1021/ja809683vopenalex-snapshot
Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors
inferredcites →https://doi.org/10.1021/jm0501073openalex-snapshot
Carbonic Anhydrase Inhibitors. Design of Fluorescent Sulfonamides as Probes of Tumor-Associated Carbonic Anhydrase IX That Inhibit Isozyme IX-Mediated Acidification of Hypoxic Tumors
inferredcites →https://doi.org/10.1021/jm060967zopenalex-snapshot
A Novel Class of Carbonic Anhydrase Inhibitors: Glycoconjugate Benzene Sulfonamides Prepared by “Click-Tailing”
inferredcites →https://doi.org/10.1021/jm061320hopenalex-snapshot
Carbonic Anhydrase Inhibitors: Inhibition of Isozymes I, II, and IX with Triazole-Linked O-Glycosides of Benzene Sulfonamides
inferredcites →https://doi.org/10.1021/jm1003667openalex-snapshot
Polyamines Inhibit Carbonic Anhydrases by Anchoring to the Zinc-Coordinated Water Molecule
inferredcites →https://doi.org/10.1021/jm101541xopenalex-snapshot
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
inferredcites →https://doi.org/10.1021/jm701426topenalex-snapshot
Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides
inferredcites →https://doi.org/10.1021/jm901287jopenalex-snapshot
Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins
inferredcites →https://doi.org/10.1021/jm901888xopenalex-snapshot
Sulfonamide Linked Neoglycoconjugates−A New Class of Inhibitors for Cancer-Associated Carbonic Anhydrases
inferredcites →https://doi.org/10.1038/nrd2467openalex-snapshot
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
inferredcites →https://doi.org/10.1038/nrd3554openalex-snapshot
Interfering with pH regulation in tumours as a therapeutic strategy
inferredcites →https://doi.org/10.1038/sj.bjc.6603530openalex-snapshot
Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
inferredcites →https://doi.org/10.1038/sj.bjc.6605702openalex-snapshot
Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype
inferredcites →https://doi.org/10.1073/pnas.0908301106openalex-snapshot
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
inferredcites →https://doi.org/10.1074/jbc.m801330200openalex-snapshot
Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths
inferredcites →https://doi.org/10.1080/14756360410001689540openalex-snapshot
Review Article
inferredcites →https://doi.org/10.1080/14756360902784425openalex-snapshot
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies
inferredcites →https://doi.org/10.1111/j.1464-410x.2008.07644.xopenalex-snapshot
Cancer‐associated, hypoxia‐inducible carbonic anhydrase IX facilitates CO 2 diffusion
inferredcites →https://doi.org/10.1158/0008-5472.can-10-4261openalex-snapshot
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
inferredcites →https://doi.org/10.1200/jco.2001.19.16.3660openalex-snapshot
Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma
inferredcites →https://doi.org/10.1517/13543784.12.2.283openalex-snapshot
Indisulam: an anticancer sulfonamide in clinical development
inferredcites →https://doi.org/10.2174/138161208783877910openalex-snapshot
Editorial [ Carbonic Anhydrases as Drug Targets Executive Editor: Claudiu T. Supuran ]
inferredcites →https://doi.org/10.4155/fmc.11.69openalex-snapshot
Carbonic Anhydrase Inhibitors and Activators for Novel Therapeutic Applications
inferredcites →https://doi.org/10.4324/9780203475300openalex-snapshot
Carbonic Anhydrase

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Phytoconstituents from Vernonia glaberrima Welw. Ex O. Hoffm. leaves and their cytotoxic activities on a panel of human cancer cell lines
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New 7‐hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies
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Design and Synthesis of New Multi‐Target Coumarin Analogues Acting as Carbonic Anhydrases IX/XII and Topoisomerase II Inhibitors With Apoptotic Potential
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Sulfocoumarin‐, Coumarin‐, 4‐Sulfamoylphenyl‐Bearing Indazole‐3‐carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor‐Associated Carbonic Anhydrase Isozymes IX and XII
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Synthesis and Biological Evaluation of 4‐Sulfamoylphenyl/Sulfocoumarin Carboxamides as Selective Inhibitors of Carbonic Anhydrase Isoforms hCA II, IX, and XII
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Coumarin‐Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action
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Exploring the potency of diazo‐coumarin containing hybrid molecules: Selective inhibition of tumor‐associated carbonic anhydrase isoforms IX and XII
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Synthesis of Mannosylglycerate Derivatives as Immunostimulating Agents
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Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?
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Isotopic splitting patterns in the 13C NMR spectra of some partially deuterated 1‐aryl‐2‐(phenyldiazenyl)butane‐1,3‐dione and 4‐hydroxy‐3‐(phenyldiazenyl)‐2H‐chromen‐2‐one: evidence for elucidation of tautomeric forms
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Convenient Synthesis of the Protein Thermal‐Stabilizer Mannosylglycerate
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Carbonic Anhydrase Inhibitors: Designing Isozyme-Specific Inhibitors as Therapeutic Agents
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Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-Induced Stress Response in Cancer Cells
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Carbonic Anhydrase Inhibitors Drug Design
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Anticancer activity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with two amino side chains
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Anti-tumour activity of a novel coumarin–chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio
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Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy
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In a search for selective inhibitors of carbonic anhydrases: coumarin and its bioisosteres – synthesis and derivatization
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Investigation of the effects of the proton transfer salts of 2-aminopyridine derivatives with 5-sulfosalicylic acid and their Cu(II) complexes on cancer-related carbonic anhydrases: CA IX and CA XII
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Synthesis of long chain fatty acids acylated coumarin glycoside esters with lipase as catalyst
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Tumor Microenvironment as Target in Cancer Therapy
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Carbonic anhydrases
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New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II
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Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins
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Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
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6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII
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inferred← citeshttps://doi.org/10.1016/j.cbpa.2015.02.005openalex-snapshot
Targeting carbonic anhydrase IX with small organic ligands
inferred← citeshttps://doi.org/10.1016/j.cclet.2016.05.027openalex-snapshot
Anticancer activity and DNA binding property of the trimers of triphenylethylene–coumarin hybrids
inferred← citeshttps://doi.org/10.1016/j.chphi.2023.100329openalex-snapshot
Dynamics of an inhibitor at and away from an out-of-active site binding location in human carbonic anhydrase II
inferred← citeshttps://doi.org/10.1016/j.comptc.2017.08.034openalex-snapshot
Thermodynamic study on the mechanism of carbonic anhydrase XII inhibition with glycosyl coumarin as non-zinc mediated inhibitors: A quantum mechanical investigation
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2024.100131openalex-snapshot
Tumor associated carbonic anhydrase inhibitors: Rational approaches, design strategies, structure activity relationship and mechanistic insights
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2025.100321openalex-snapshot
Imidazole‒sulfonamide hybrid conjugate: A privilege scaffold with significant therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.09.059openalex-snapshot
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.072openalex-snapshot
5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112300openalex-snapshot
Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113589openalex-snapshot
Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide – A new caspase-activating proapoptotic agent
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113875openalex-snapshot
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116170openalex-snapshot
pH regulators and their inhibitors in tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176677openalex-snapshot
The potential of carbonic anhydrase enzymes as a novel target for anti-cancer treatment
inferred← citeshttps://doi.org/10.1016/j.ejps.2019.105012openalex-snapshot
Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.131548openalex-snapshot
Design, synthesis and in vitro evaluation of novel thiazole-coumarin hybrids as selective and potent human carbonic anhydrase IX and XII inhibitors
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.140462openalex-snapshot
Development of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity
inferred← citeshttps://doi.org/10.1016/j.jlumin.2016.11.037openalex-snapshot
Deciphering the perturbation effect of urea on the supramolecular host-guest interaction of biologically active hydrophobic molecule inside the nanocavity of cyclodextrins
inferred← citeshttps://doi.org/10.1016/j.jphotochem.2015.02.007openalex-snapshot
Intramolecular charge transfer in coumarin based donor-acceptor systems: Formation of a new product through planar intermediate
inferred← citeshttps://doi.org/10.1016/j.saa.2020.118641openalex-snapshot
Spectroscopic evaluation of Zn (II) complexes with drug analogues: Interactions with BSA and the pH effect on the drug-Zn (II) system
inferred← citeshttps://doi.org/10.1016/j.semcancer.2014.08.002openalex-snapshot
Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use
inferred← citeshttps://doi.org/10.1016/j.semcancer.2016.12.003openalex-snapshot
Value of pH regulators in the diagnosis, prognosis and treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.tips.2017.05.002openalex-snapshot
Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies
inferred← citeshttps://doi.org/10.1016/j.yexcr.2025.114421openalex-snapshot
Ethyl 2,2-difluoro-2-(2-oxo-2H-chromen-3-yl) acetate inhibits the malignant biological behaviors of colorectal cancer by restricting the phosphorylation and nuclear translocation of STAT3
inferred← citeshttps://doi.org/10.1017/s0033583518000082openalex-snapshot
Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00007openalex-snapshot
Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00523openalex-snapshot
6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01720openalex-snapshot
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01771openalex-snapshot
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00462openalex-snapshot
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00492openalex-snapshot
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01389openalex-snapshot
Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01607openalex-snapshot
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00770openalex-snapshot
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX
inferred← citeshttps://doi.org/10.1021/acs.organomet.7b00842openalex-snapshot
Anticancer Activity of Bifunctional Organometallic Ru(II) Arene Complexes Containing a 7-Hydroxycoumarin Group
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00175openalex-snapshot
Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5c00235openalex-snapshot
Selective Inhibition of Carbonic Anhydrase IX and XII by Natural Coumarin Coladonin and Its Derivatives: Promising Antimelanoma and Antiglioblastoma Agents
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.8b00170openalex-snapshot
Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors
inferred← citeshttps://doi.org/10.1021/co500092bopenalex-snapshot
Ultrasound-Assisted Sequential Multicomponent Strategy for the Combinatorial Synthesis of Novel Coumarin Hybrids
inferred← citeshttps://doi.org/10.1021/jacs.5b02248openalex-snapshot
Influence of 4′-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin
inferred← citeshttps://doi.org/10.1021/jm300031jopenalex-snapshot
Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo
inferred← citeshttps://doi.org/10.1021/jm300878gopenalex-snapshot
Tricyclic Sulfonamides Incorporating Benzothiopyrano[4,3-c]pyrazole and Pyridothiopyrano[4,3-c]pyrazole Effectively Inhibit α- and β-Carbonic Anhydrase: X-ray Crystallography and Solution Investigations on 15 Isoforms
inferred← citeshttps://doi.org/10.1021/jm301625sopenalex-snapshot
Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases
inferred← citeshttps://doi.org/10.1021/jm4009532openalex-snapshot
Hypoxia-Targeting Carbonic Anhydrase IX Inhibitors by a New Series of Nitroimidazole-Sulfonamides/Sulfamides/Sulfamates
inferred← citeshttps://doi.org/10.1021/jm501003kopenalex-snapshot
Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX
inferred← citeshttps://doi.org/10.1021/jm501314copenalex-snapshot
Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups
inferred← citeshttps://doi.org/10.1021/jm501497mopenalex-snapshot
A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects
inferred← citeshttps://doi.org/10.1038/onc.2012.550openalex-snapshot
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
inferred← citeshttps://doi.org/10.1038/s41598-021-94809-xopenalex-snapshot
Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery
inferred← citeshttps://doi.org/10.1039/c4sc00685bopenalex-snapshot
A bivalent small molecule-drug conjugate directed against carbonic anhydrase IX can elicit complete tumour regression in mice
inferred← citeshttps://doi.org/10.1039/c4tb00334aopenalex-snapshot
Synthesis of an acid-cleavable and fluorescent amphiphilic block copolymer as a combined delivery vector of DNA and doxorubicin
inferred← citeshttps://doi.org/10.1039/c5ob00007fopenalex-snapshot
Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives
inferred← citeshttps://doi.org/10.1039/c5ra17907fopenalex-snapshot
Design, synthesis and biological evaluation of coumarin coupled nitroimidazoles as potential imaging agents
inferred← citeshttps://doi.org/10.1039/c7ra01025gopenalex-snapshot
In vitro apoptosis-inducing effect and gene expression profiles of mixed ligand Cu( ii ) complexes derived from 4-acyl pyrazolones on human lung cancer cells
inferred← citeshttps://doi.org/10.1039/d0ra00879fopenalex-snapshot
A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors
inferred← citeshttps://doi.org/10.1039/d3na01042bopenalex-snapshot
Shedding light on the use of graphene oxide-thiosemicarbazone hybrids towards the rapid immobilisation of methylene blue and functional coumarins
inferred← citeshttps://doi.org/10.1042/bcj20160115openalex-snapshot
Structure and function of carbonic anhydrases
inferred← citeshttps://doi.org/10.1042/cs20210040openalex-snapshot
Emerging role of carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1080/07391102.2022.2048075openalex-snapshot
In the footsteps of an inhibitor unbinding from the active site of human carbonic anhydrase II
inferred← citeshttps://doi.org/10.1080/10428194.2017.1339875openalex-snapshot
Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells
inferred← citeshttps://doi.org/10.1080/13543776.2016.1230202openalex-snapshot
CA IX stratification based on cancer treatment: a patent evaluation of US2016/0002350
inferred← citeshttps://doi.org/10.1080/13543784.2018.1548608openalex-snapshot
Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors
inferred← citeshttps://doi.org/10.1080/14728222.2026.2671683openalex-snapshot
Molecular understanding for therapeutic targeting of hypoxia in breast cancer
inferred← citeshttps://doi.org/10.1080/14756366.2016.1187143openalex-snapshot
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
inferred← citeshttps://doi.org/10.1080/14756366.2016.1214951openalex-snapshot
Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars
inferred← citeshttps://doi.org/10.1080/14756366.2017.1308928openalex-snapshot
Design, synthesis and evaluation of18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging
inferred← citeshttps://doi.org/10.1080/14756366.2017.1354857openalex-snapshot
Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2018.1445737openalex-snapshot
Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry
inferred← citeshttps://doi.org/10.1080/14756366.2020.1712596openalex-snapshot
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
inferred← citeshttps://doi.org/10.1080/14756366.2020.1722658openalex-snapshot
7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2020.1752201openalex-snapshot
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2020.1788009openalex-snapshot
Coumarin carbonic anhydrase inhibitors from natural sources
inferred← citeshttps://doi.org/10.1080/14756366.2020.1801674openalex-snapshot
Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents
inferred← citeshttps://doi.org/10.1080/14756366.2020.1825409openalex-snapshot
An overview of carbohydrate-based carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2021.1882453openalex-snapshot
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
inferred← citeshttps://doi.org/10.1080/14756366.2021.1998026openalex-snapshot
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
inferred← citeshttps://doi.org/10.1080/14756366.2021.2012174openalex-snapshot
Coumarins effectively inhibit bacterial α-carbonic anhydrases
inferred← citeshttps://doi.org/10.1080/14756366.2022.2036986openalex-snapshot
Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
inferred← citeshttps://doi.org/10.1080/14756366.2022.2080816openalex-snapshot
4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
inferred← citeshttps://doi.org/10.1080/17460441.2017.1253677openalex-snapshot
Advances in structure-based drug discovery of carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1080/17460441.2019.1651289openalex-snapshot
Advances in the structural annotation of human carbonic anhydrases and impact on future drug discovery
inferred← citeshttps://doi.org/10.1080/17460441.2020.1743676openalex-snapshot
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
inferred← citeshttps://doi.org/10.1093/jxb/ery075openalex-snapshot
Probing binding specificity of the sucrose transporter AtSUC2 with fluorescent coumarin glucosides
inferred← citeshttps://doi.org/10.1098/rstb.2013.0107openalex-snapshot
Targeting ion transport in cancer
inferred← citeshttps://doi.org/10.1101/345298openalex-snapshot
Selective inhibition of CA IX over CA XII in breast cancer cells using benzene sulfonamides: Disconnect between CA activity and growth inhibition
inferred← citeshttps://doi.org/10.1111/cbdd.14015openalex-snapshot
Some important inhibitors and mechanisms of rheumatoid arthritis
inferred← citeshttps://doi.org/10.1134/s0003683817010033openalex-snapshot
Glycosylation and sulfation of 4-methylumbelliferone by Gliocladium deliquescens NRRL 1086
inferred← citeshttps://doi.org/10.1134/s0006297917040010openalex-snapshot
Role of proton pumps in tumorigenesis
inferred← citeshttps://doi.org/10.1134/s1068162022060036openalex-snapshot
Thiazole- and Coumarin-Conjugated (β-Lactam Scaffold) Azetidinones Synthesis and Their Substitution Effect in In Silico, and In Vitro Cell Viability Studies
inferred← citeshttps://doi.org/10.1152/physrev.00018.2021openalex-snapshot
Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology
inferred← citeshttps://doi.org/10.1155/2015/425708openalex-snapshot
Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells
inferred← citeshttps://doi.org/10.1158/0008-5472.can-14-3000openalex-snapshot
Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production
inferred← citeshttps://doi.org/10.1371/journal.pone.0108068openalex-snapshot
Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model
inferred← citeshttps://doi.org/10.1371/journal.pone.0207417openalex-snapshot
Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition
inferred← citeshttps://doi.org/10.1371/journal.pone.0216132openalex-snapshot
Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design
inferred← citeshttps://doi.org/10.1371/journal.pone.0243327openalex-snapshot
PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide
inferred← citeshttps://doi.org/10.1515/hc-2022-0154openalex-snapshot
Study on effective synthesis of 7-hydroxy-4-substituted coumarins
inferred← citeshttps://doi.org/10.1517/13543776.2013.776041openalex-snapshot
Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1
inferred← citeshttps://doi.org/10.1517/13543776.2013.778245openalex-snapshot
Anti-infective carbonic anhydrase inhibitors: a patent and literature review
inferred← citeshttps://doi.org/10.1517/13543776.2013.794788openalex-snapshot
Antiglaucoma carbonic anhydrase inhibitors: a patent review
inferred← citeshttps://doi.org/10.1517/17425255.2016.1154534openalex-snapshot
Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1517/17460441.2013.795145openalex-snapshot
Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors
inferred← citeshttps://doi.org/10.1517/17460441.2015.1038235openalex-snapshot
Designing carbonic anhydrase inhibitors for the treatment of breast cancer
inferred← citeshttps://doi.org/10.18632/oncotarget.422openalex-snapshot
Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
inferred← citeshttps://doi.org/10.18632/oncotarget.7229openalex-snapshot
Targeting hypoxic response for cancer therapy
inferred← citeshttps://doi.org/10.2147/jep.s265620openalex-snapshot
Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors
inferred← citeshttps://doi.org/10.2174/0929867325666180719114150openalex-snapshot
Carbohydrates: Potential Sweet Tools Against Cancer
inferred← citeshttps://doi.org/10.2174/1381612811319210013openalex-snapshot
Current Developments of Coumarin Compounds in Medicinal Chemistry
inferred← citeshttps://doi.org/10.2174/1381612822666151211094235openalex-snapshot
An Update on Natural Products with Carbonic Anhydrase Inhibitory Activity
inferred← citeshttps://doi.org/10.2174/1871520618666180510113822openalex-snapshot
Indazole Derivatives: Promising Anti-tumor Agents
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