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Selective inhibition of CA IX over CA XII in breast cancer cells using benzene sulfonamides: Disconnect between CA activity and growth inhibition

https://doi.org/10.1101/345298
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/bbrc.2001.5824openalex-snapshot
The Catalytic Properties of Human Carbonic Anhydrase IX
inferredcites →https://doi.org/10.1007/978-3-0348-8446-4_16openalex-snapshot
The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals
inferredcites →https://doi.org/10.1007/978-94-007-7359-2_1openalex-snapshot
Overview of the Carbonic Anhydrase Family
inferredcites →https://doi.org/10.1007/978-94-007-7359-2_2openalex-snapshot
Physiological Functions of the Alpha Class of Carbonic Anhydrases
inferredcites →https://doi.org/10.1007/s00109-017-1590-9openalex-snapshot
Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis
inferredcites →https://doi.org/10.1007/s004180000181openalex-snapshot
Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours
inferredcites →https://doi.org/10.1007/s10549-010-1113-7openalex-snapshot
Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study
inferredcites →https://doi.org/10.1007/s10555-007-9064-0openalex-snapshot
Regulation of tumor pH and the role of carbonic anhydrase 9
inferredcites →https://doi.org/10.1016/0042-6822(92)90464-zopenalex-snapshot
A novel quasi-viral agent, MaTu, is a two-component system
inferredcites →https://doi.org/10.1016/j.bbamcr.2010.09.018openalex-snapshot
Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells
inferredcites →https://doi.org/10.1016/j.bmc.2012.08.019openalex-snapshot
Insights towards sulfonamide drug specificity in α-carbonic anhydrases
inferredcites →https://doi.org/10.1016/j.bmc.2013.08.033openalex-snapshot
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases
inferredcites →https://doi.org/10.1016/j.bmc.2014.12.030openalex-snapshot
Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors
inferredcites →https://doi.org/10.1016/j.cbpa.2010.06.161openalex-snapshot
Perspectives on carbonic anhydrase
inferredcites →https://doi.org/10.1016/j.ejca.2005.09.011openalex-snapshot
The role of carbonic anhydrase IX overexpression in kidney cancer
inferredcites →https://doi.org/10.1016/j.ejmech.2017.03.026openalex-snapshot
Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides
inferredcites →https://doi.org/10.1016/j.semcancer.2008.03.011openalex-snapshot
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
inferredcites →https://doi.org/10.1016/j.tips.2012.01.005openalex-snapshot
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
inferredcites →https://doi.org/10.1016/s0002-9440(10)65569-1openalex-snapshot
Immunohistochemical Study of Colorectal Tumors for Expression of a Novel Transmembrane Carbonic Anhydrase, MN/CA IX, with Potential Value as a Marker of Cell Proliferation
inferredcites →https://doi.org/10.1016/s0065-2571(98)00018-1openalex-snapshot
Causes and consequences of acidic pH in tumors: a magnetic resonance study
inferredcites →https://doi.org/10.1016/s0076-6879(07)35015-5openalex-snapshot
Tumor Hypoxia in Cancer Therapy
inferredcites →https://doi.org/10.1016/s0076-6879(82)87037-7openalex-snapshot
[35] Carbonic anhydrase: Oxygen-18 exchange catalyzed by an enzyme with rate-contributing Proton-transfer steps
inferredcites →https://doi.org/10.1016/s0140-6736(05)66544-0openalex-snapshot
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
inferredcites →https://doi.org/10.1016/s0960-894x(03)00091-xopenalex-snapshot
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
inferredcites →https://doi.org/10.1016/s1357-4310(99)01615-9openalex-snapshot
Causes and consequences of tumour acidity and implications for treatment
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b01489openalex-snapshot
Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking
inferredcites →https://doi.org/10.1021/ar00145a005openalex-snapshot
The catalytic mechanism of carbonic anhydrase: implications of a rate-limiting protolysis of water
inferredcites →https://doi.org/10.1021/ja061574sopenalex-snapshot
Carbonic Anhydrase Inhibitors: X-ray and Molecular Modeling Study for the Interaction of a Fluorescent Antitumor Sulfonamide with Isozyme II and IX
inferredcites →https://doi.org/10.1021/ja3068098openalex-snapshot
Neutron Diffraction of Acetazolamide-Bound Human Carbonic Anhydrase II Reveals Atomic Details of Drug Binding
inferredcites →https://doi.org/10.1021/jm101541xopenalex-snapshot
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
inferredcites →https://doi.org/10.1021/jm200983eopenalex-snapshot
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors
inferredcites →https://doi.org/10.1021/jm400080copenalex-snapshot
Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design
inferredcites →https://doi.org/10.1038/227680a0openalex-snapshot
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
inferredcites →https://doi.org/10.1038/nchembio.2363openalex-snapshot
Selective degradation of splicing factor CAPERα by anticancer sulfonamides
inferredcites →https://doi.org/10.1038/nrc1478openalex-snapshot
Why do cancers have high aerobic glycolysis?
inferredcites →https://doi.org/10.1038/nrc2713openalex-snapshot
Biological determinants of endocrine resistance in breast cancer
inferredcites →https://doi.org/10.1038/nrd3554openalex-snapshot
Interfering with pH regulation in tumours as a therapeutic strategy
inferredcites →https://doi.org/10.1038/onc.2012.550openalex-snapshot
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
inferredcites →https://doi.org/10.1038/s41416-018-0216-5openalex-snapshot
Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo
inferredcites →https://doi.org/10.1038/sj.bjc.6600796openalex-snapshot
Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
inferredcites →https://doi.org/10.1039/c0cc02707copenalex-snapshot
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency
inferredcites →https://doi.org/10.1042/bcj20160115openalex-snapshot
Structure and function of carbonic anhydrases
inferredcites →https://doi.org/10.1042/bj1200797openalex-snapshot
The purification and properties of carbonic anhydrases from guinea-pig erythrocytes and the mucosae of the gastrointestinal tract
inferredcites →https://doi.org/10.1053/gast.1997.v112.pm9024293openalex-snapshot
Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
inferredcites →https://doi.org/10.1073/pnas.191367098openalex-snapshot
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
inferredcites →https://doi.org/10.1073/pnas.92.13.5965openalex-snapshot
Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.
inferredcites →https://doi.org/10.1074/jbc.m110.188524openalex-snapshot
Catalysis and pH Control by Membrane-associated Carbonic Anhydrase IX in MDA-MB-231 Breast Cancer Cells
inferredcites →https://doi.org/10.1074/jbc.m801330200openalex-snapshot
Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths
inferredcites →https://doi.org/10.1080/07357900802653464openalex-snapshot
Expression and Activity of Carbonic Anhydrase IX Is Associated With Metabolic Dysfunction in MDA-MB-231 Breast Cancer Cells
inferredcites →https://doi.org/10.1080/15384047.2018.1449612openalex-snapshot
UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system
inferredcites →https://doi.org/10.1080/17460441.2017.1253677openalex-snapshot
Advances in structure-based drug discovery of carbonic anhydrase inhibitors
inferredcites →https://doi.org/10.1097/igc.0b013e318204c34fopenalex-snapshot
Serum Carbonic Anhydrase IX and Its Prognostic Relevance in Vulvar Cancer
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444912000200openalex-snapshot
Handling ligands with Coot
inferredcites →https://doi.org/10.1111/j.1464-410x.2008.07644.xopenalex-snapshot
Cancer‐associated, hypoxia‐inducible carbonic anhydrase IX facilitates CO 2 diffusion
inferredcites →https://doi.org/10.1111/j.1582-4934.2009.00994.xopenalex-snapshot
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
inferredcites →https://doi.org/10.1126/science.aal3755openalex-snapshot
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
inferredcites →https://doi.org/10.1155/2015/453543openalex-snapshot
Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors
inferredcites →https://doi.org/10.1158/0008-5472.can-05-4193openalex-snapshot
Acid-Mediated Tumor Invasion: a Multidisciplinary Study
inferredcites →https://doi.org/10.1158/0008-5472.can-07-6151openalex-snapshot
Estrogen Receptor Regulation of Carbonic Anhydrase XII through a Distal Enhancer in Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2470openalex-snapshot
Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
inferredcites →https://doi.org/10.1158/0008-5472.can-10-4261openalex-snapshot
Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-2019openalex-snapshot
Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1208openalex-snapshot
Triple-Negative Breast Cancer: Risk Factors to Potential Targets
inferredcites →https://doi.org/10.1172/jci27987openalex-snapshot
Estrogen receptors and human disease
inferredcites →https://doi.org/10.1186/1471-213x-9-22openalex-snapshot
Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development
inferredcites →https://doi.org/10.1186/1471-2407-11-12openalex-snapshot
Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
inferredcites →https://doi.org/10.1186/1471-2407-5-41openalex-snapshot
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
inferredcites →https://doi.org/10.1186/bcr2242openalex-snapshot
Triple-negative breast cancers are increased in black women regardless of age or body mass index
inferredcites →https://doi.org/10.1186/gb-2006-7-4-r28openalex-snapshot
Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivoin tumor xenografts and human breast tumors
inferredcites →https://doi.org/10.1200/jco.2007.12.1087openalex-snapshot
Carbonic Anhydrase IX Is Not an Independent Predictor of Outcome for Patients With Clear Cell Renal Cell Carcinoma
inferredcites →https://doi.org/10.1201/9780203475300.ch9openalex-snapshot
Cancer-Related Carbonic Anhydrase Isozymes and Their Inhibition
inferredcites →https://doi.org/10.1309/ajcpppr57hnjmslzopenalex-snapshot
Carbonic Anhydrase IX Expression in Renal Neoplasms
inferredcites →https://doi.org/10.1371/journal.pone.0120958openalex-snapshot
Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance
inferredcites →https://doi.org/10.1371/journal.pone.0199476openalex-snapshot
Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells
inferredcites →https://doi.org/10.1517/17460441.2015.1038235openalex-snapshot
Designing carbonic anhydrase inhibitors for the treatment of breast cancer
inferredcites →https://doi.org/10.1677/erc.1.01216openalex-snapshot
Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer
inferredcites →https://doi.org/10.2174/138161208783877884openalex-snapshot
Carbonic Anhydrases An Overview
inferredcites →https://doi.org/10.3109/10428194.2014.933218openalex-snapshot
Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models
inferredcites →https://doi.org/10.3109/14756366.2012.672983openalex-snapshot
Structure-based drug discovery of carbonic anhydrase inhibitors
inferredcites →https://doi.org/10.3109/14756366.2015.1122001openalex-snapshot
How many carbonic anhydrase inhibition mechanisms exist?
inferredcites →https://doi.org/10.3233/bd-2010-0307openalex-snapshot
Triple negative breast cancer cell lines: One tool in the search for better treatment of triple negative breast cancer
inferredcites →https://doi.org/10.4161/cc.3.2.618openalex-snapshot
Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3390/cancers12040899openalex-snapshot
Transport Metabolons and Acid/Base Balance in Tumor Cells
inferred← citeshttps://doi.org/10.3390/ijms21031110openalex-snapshot
A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics
inferred← citeshttps://doi.org/10.3390/ijms21155277openalex-snapshot
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
inferred← citeshttps://doi.org/10.3390/ijms21207475openalex-snapshot
Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era
inferred← citeshttps://doi.org/10.3390/ph13090252openalex-snapshot
The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme
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