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Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cbic.200800291openalex-snapshot
Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders
inferredcites →https://doi.org/10.1002/cbic.200900172openalex-snapshot
Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities
inferredcites →https://doi.org/10.1002/cmdc.201100194openalex-snapshot
Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
inferredcites →https://doi.org/10.1002/ibd.20342openalex-snapshot
Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
inferredcites →https://doi.org/10.1002/ijc.25059openalex-snapshot
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP‐1 in human multiple myeloma cells
inferredcites →https://doi.org/10.1002/ijc.25416openalex-snapshot
STAT3 is essential for the maintenance of neurosphere‐initiating tumor cells in patients with glioblastomas: A potential for targeted therapy?
inferredcites →https://doi.org/10.1002/iub.283openalex-snapshot
Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells
inferredcites →https://doi.org/10.1002/jlb.64.5.675openalex-snapshot
Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils
inferredcites →https://doi.org/10.1002/pros.10079openalex-snapshot
Stat3 activation in prostatic carcinomas
inferredcites →https://doi.org/10.1002/pros.21409openalex-snapshot
Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion
inferredcites →https://doi.org/10.1006/bbrc.2000.3753openalex-snapshot
Protein Inhibitor of Activated STAT3 Regulates Androgen Receptor Signaling in Prostate Carcinoma Cells
inferredcites →https://doi.org/10.1007/s00204-010-0559-zopenalex-snapshot
IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary fibrosis
inferredcites →https://doi.org/10.1007/s00280-009-1109-3openalex-snapshot
LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate
inferredcites →https://doi.org/10.1007/s00384-006-0229-zopenalex-snapshot
Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis
inferredcites →https://doi.org/10.1007/s00395-007-0674-zopenalex-snapshot
Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis
inferredcites →https://doi.org/10.1016/0092-8674(94)90235-6openalex-snapshot
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2010.07.029openalex-snapshot
AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol
inferredcites →https://doi.org/10.1016/j.bbrc.2008.04.049openalex-snapshot
Crystal structure of unphosphorylated STAT3 core fragment
inferredcites →https://doi.org/10.1016/j.bbrc.2009.01.137openalex-snapshot
Novel high-throughput screening system for identifying STAT3–SH2 antagonists
inferredcites →https://doi.org/10.1016/j.bcp.2010.01.001openalex-snapshot
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
inferredcites →https://doi.org/10.1016/j.bmc.2010.12.010openalex-snapshot
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein
inferredcites →https://doi.org/10.1016/j.bmcl.2007.10.031openalex-snapshot
Design, synthesis, and studies of small molecule STAT3 inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2009.01.091openalex-snapshot
Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2011.06.056openalex-snapshot
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
inferredcites →https://doi.org/10.1016/j.cell.2006.12.036openalex-snapshot
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
inferredcites →https://doi.org/10.1016/j.chembiol.2006.09.018openalex-snapshot
Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization
inferredcites →https://doi.org/10.1016/j.cyto.2008.12.015openalex-snapshot
STAT3 induces muscle stem cell differentiation by interaction with myoD
inferredcites →https://doi.org/10.1016/j.gde.2006.08.009openalex-snapshot
Molecular control of pluripotency
inferredcites →https://doi.org/10.1016/j.immuni.2008.03.006openalex-snapshot
The STATs on Dendritic Cell Development
inferredcites →https://doi.org/10.1016/j.jdermsci.2007.05.016openalex-snapshot
Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases
inferredcites →https://doi.org/10.1016/j.lfs.2006.12.040openalex-snapshot
Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
inferredcites →https://doi.org/10.1016/j.lungcan.2008.05.025openalex-snapshot
Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease
inferredcites →https://doi.org/10.1016/j.pharmthera.2008.08.002openalex-snapshot
The myocardial JAK/STAT pathway: From protection to failure
inferredcites →https://doi.org/10.1016/j.stem.2010.06.022openalex-snapshot
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
inferredcites →https://doi.org/10.1016/s0006-291x(02)02291-xopenalex-snapshot
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
inferredcites →https://doi.org/10.1016/s0092-8674(03)00847-xopenalex-snapshot
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
inferredcites →https://doi.org/10.1016/s0960-894x(02)01050-8openalex-snapshot
Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3
inferredcites →https://doi.org/10.1016/s0960-9822(99)00268-7openalex-snapshot
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
inferredcites →https://doi.org/10.1016/s1359-6101(98)80005-1openalex-snapshot
Signaling mechanisms through gp130: A model of the cytokine system
inferredcites →https://doi.org/10.1021/cb7001973openalex-snapshot
An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects
inferredcites →https://doi.org/10.1021/jm050513mopenalex-snapshot
Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor
inferredcites →https://doi.org/10.1021/jm101330hopenalex-snapshot
Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand Simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)
inferredcites →https://doi.org/10.1021/jm701271yopenalex-snapshot
Inhibition of the Signal Transducer and Activator of Transcription-3 (STAT3) Signaling Pathway by 4-Oxo-1-Phenyl-1,4-Dihydroquinoline-3-Carboxylic Acid Esters
inferredcites →https://doi.org/10.1021/jm901105kopenalex-snapshot
Structure−Affinity Relationships of Glutamine Mimics Incorporated into Phosphopeptides Targeted to the SH2 Domain of Signal Transducer and Activator of Transcription 3
inferredcites →https://doi.org/10.1021/ml100010jopenalex-snapshot
Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors
inferredcites →https://doi.org/10.1021/ml1000273openalex-snapshot
Identification of a New Series of STAT3 Inhibitors by Virtual Screening
inferredcites →https://doi.org/10.1038/28101openalex-snapshot
Three-dimensional structure of the Stat3β homodimer bound to DNA
inferredcites →https://doi.org/10.1038/43219openalex-snapshot
Structure and function of a new STAT-induced STAT inhibitor
inferredcites →https://doi.org/10.1038/cr.2008.18openalex-snapshot
STAT3 as a target for inducing apoptosis in solid and hematological tumors
inferredcites →https://doi.org/10.1038/ki.2010.154openalex-snapshot
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
inferredcites →https://doi.org/10.1038/labinvest.2009.82openalex-snapshot
Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation of signal transducer and activator of transcription 3 signaling
inferredcites →https://doi.org/10.1038/nature01388openalex-snapshot
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
inferredcites →https://doi.org/10.1038/nature08113openalex-snapshot
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
inferredcites →https://doi.org/10.1038/ncb1680openalex-snapshot
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFκB and cooperating with Stat3
inferredcites →https://doi.org/10.1038/ni1052openalex-snapshot
The STAT3 isoforms α and β have unique and specific functions
inferredcites →https://doi.org/10.1038/nm1162openalex-snapshot
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
inferredcites →https://doi.org/10.1038/nm976openalex-snapshot
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
inferredcites →https://doi.org/10.1038/nrc1275openalex-snapshot
The STATs of cancer — new molecular targets come of age
inferredcites →https://doi.org/10.1038/nrc2734openalex-snapshot
STATs in cancer inflammation and immunity: a leading role for STAT3
inferredcites →https://doi.org/10.1038/nri1995openalex-snapshot
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
inferredcites →https://doi.org/10.1038/nrm1744openalex-snapshot
Regulatory networks in embryo-derived pluripotent stem cells
inferredcites →https://doi.org/10.1038/onc.2008.448openalex-snapshot
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
inferredcites →https://doi.org/10.1038/sj.bjc.6603597openalex-snapshot
Stat3 activation in human endometrial and cervical cancers
inferredcites →https://doi.org/10.1038/sj.bjc.6604793openalex-snapshot
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
inferredcites →https://doi.org/10.1038/sj.npp.1301591openalex-snapshot
Nasal Colivelin Treatment Ameliorates Memory Impairment Related to Alzheimer's Disease
inferredcites →https://doi.org/10.1038/sj.onc.1205152openalex-snapshot
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
inferredcites →https://doi.org/10.1038/sj.onc.1205263openalex-snapshot
Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
inferredcites →https://doi.org/10.1038/sj.onc.1206122openalex-snapshot
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
inferredcites →https://doi.org/10.1038/sj.onc.1208469openalex-snapshot
Stat3 regulates genes common to both wound healing and cancer
inferredcites →https://doi.org/10.1038/sj.onc.1208513openalex-snapshot
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
inferredcites →https://doi.org/10.1053/j.gastro.2010.02.049openalex-snapshot
Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis
inferredcites →https://doi.org/10.1073/pnas.0409894102openalex-snapshot
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
inferredcites →https://doi.org/10.1073/pnas.0609757104openalex-snapshot
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
inferredcites →https://doi.org/10.1073/pnas.0611665104openalex-snapshot
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
inferredcites →https://doi.org/10.1073/pnas.97.8.4227openalex-snapshot
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
inferredcites →https://doi.org/10.1074/jbc.271.22.13221openalex-snapshot
STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription
inferredcites →https://doi.org/10.1074/jbc.273.12.7072openalex-snapshot
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
inferredcites →https://doi.org/10.1074/jbc.m108233200openalex-snapshot
Regulation of Fas Expression by STAT3 and c-Jun Is Mediated by Phosphatidylinositol 3-Kinase-AKT Signaling
inferredcites →https://doi.org/10.1074/jbc.m110.158378openalex-snapshot
γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents
inferredcites →https://doi.org/10.1074/jbc.m111486200openalex-snapshot
Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a
inferredcites →https://doi.org/10.1074/jbc.m704267200openalex-snapshot
Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo
inferredcites →https://doi.org/10.1074/jbc.m707429200openalex-snapshot
Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function
inferredcites →https://doi.org/10.1091/mbc.12.10.3282openalex-snapshot
Simultaneous Tyrosine and Serine Phosphorylation of STAT3 Transcription Factor Is Involved in Rho A GTPase Oncogenic Transformation
inferredcites →https://doi.org/10.1093/carcin/bgm042openalex-snapshot
Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
inferredcites →https://doi.org/10.1093/intimm/dxm154openalex-snapshot
BART is essential for nuclear retention of STAT3
inferredcites →https://doi.org/10.1095/biolreprod.109.083352openalex-snapshot
Regulation of Mouse Spermatogonial Stem Cell Differentiation by STAT3 Signaling1
inferredcites →https://doi.org/10.1097/01.cji.0000211327.76266.65openalex-snapshot
Stat3 as a Potential Target for Cancer Immunotherapy
inferredcites →https://doi.org/10.1097/cad.0b013e3282f1a908openalex-snapshot
SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2
inferredcites →https://doi.org/10.1097/cad.0b013e32832afc04openalex-snapshot
Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells
inferredcites →https://doi.org/10.1111/j.1349-7006.2009.01220.xopenalex-snapshot
New curcumin analogues exhibit enhanced growth‐suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells
inferredcites →https://doi.org/10.1111/j.1365-2567.2007.02679.xopenalex-snapshot
Auranofin blocks interleukin‐6 signalling by inhibiting phosphorylation of JAK1 and STAT3
inferredcites →https://doi.org/10.1111/j.1440-1797.2007.00881.xopenalex-snapshot
Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction
inferredcites →https://doi.org/10.1124/mol.108.052548openalex-snapshot
Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1
inferredcites →https://doi.org/10.1126/science.1105166openalex-snapshot
Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue
inferredcites →https://doi.org/10.1126/science.8140422openalex-snapshot
Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6
inferredcites →https://doi.org/10.1128/mcb.19.10.7138openalex-snapshot
Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation
inferredcites →https://doi.org/10.1128/mcb.19.8.5326openalex-snapshot
Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2674openalex-snapshot
Activation of Stat3 in Human Melanoma Promotes Brain Metastasis
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3629openalex-snapshot
The Novel Triterpenoid C-28 Methyl Ester of 2-Cyano-3, 12-Dioxoolen-1, 9-Dien-28-Oic Acid Inhibits Metastatic Murine Breast Tumor Growth through Inactivation of STAT3 Signaling
inferredcites →https://doi.org/10.1158/0008-5472.can-07-6696openalex-snapshot
Guggulsterone, a Farnesoid X Receptor Antagonist, Inhibits Constitutive and Inducible STAT3 Activation through Induction of a Protein Tyrosine Phosphatase SHP-1
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2575openalex-snapshot
Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2468openalex-snapshot
Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-10-3852openalex-snapshot
6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-0215openalex-snapshot
The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-0861openalex-snapshot
Signal Transducers and Activators of Transcription 3 Pathway Activation in Drug-Resistant Ovarian Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-1330openalex-snapshot
SD-1029 Inhibits Signal Transducer and Activator of Transcription 3 Nuclear Translocation
inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-2575openalex-snapshot
Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6–Inducible STAT3 Activation
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1329openalex-snapshot
The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas
inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0605openalex-snapshot
Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
inferredcites →https://doi.org/10.1158/1535-7163.targ-11-b56openalex-snapshot
Abstract B56: A phase 1, open-label, dose escalation, nonrandomized study to assess the maximum tolerated dose, dose limiting toxicity, and pharmacokinetics of OPB-31121 in subjects with advanced solid tumors.
inferredcites →https://doi.org/10.1158/1541-7786.mcr-06-0348openalex-snapshot
Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells
inferredcites →https://doi.org/10.1158/1541-7786.mcr-09-0257openalex-snapshot
5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
inferredcites →https://doi.org/10.1161/circulationaha.109.893677openalex-snapshot
Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction
inferredcites →https://doi.org/10.1172/jci13568openalex-snapshot
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
inferredcites →https://doi.org/10.1172/jci7924openalex-snapshot
Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor
inferredcites →https://doi.org/10.1179/016164106x97982openalex-snapshot
Dobesilate inhibits the activation of signal transducer and activator of transcription 3, and the expression of cyclin D1 and bcl-XL in glioma cells
inferredcites →https://doi.org/10.1182/blood-2006-01-010199openalex-snapshot
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
inferredcites →https://doi.org/10.1182/blood-2006-05-024430openalex-snapshot
STAT3 positively regulates an early step in B-cell development
inferredcites →https://doi.org/10.1182/blood-2007-12-129718openalex-snapshot
Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
inferredcites →https://doi.org/10.1182/blood-2010-04-280123openalex-snapshot
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
inferredcites →https://doi.org/10.1182/blood.v95.12.3765openalex-snapshot
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
inferredcites →https://doi.org/10.1182/blood.v99.5.1627openalex-snapshot
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation
inferredcites →https://doi.org/10.1186/1476-4598-9-165openalex-snapshot
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
inferredcites →https://doi.org/10.1186/1476-4598-9-217openalex-snapshot
A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
inferredcites →https://doi.org/10.1186/gb-2009-10-11-r130openalex-snapshot
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources
inferredcites →https://doi.org/10.1200/jco.2008.26.15_suppl.3517openalex-snapshot
Phase I trial with a novel oral NF-κB/STAT3 inhibitor RTA 402 in patients with solid tumors and lymphoid malignancies
inferredcites →https://doi.org/10.1203/pdr.0b013e3181a9e7fdopenalex-snapshot
Exposure to Uteroplacental Insufficiency Reduces the Expression of Signal Transducer and Activator of Transcription 3 and Proopiomelanocortin in the Hypothalamus of Newborn Rats
inferredcites →https://doi.org/10.1242/jcs.03482openalex-snapshot
Nucleocytoplasmic shuttling of persistently activated STAT3
inferredcites →https://doi.org/10.1371/journal.pone.0004783openalex-snapshot
Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
inferredcites →https://doi.org/10.1371/journal.pone.0009701openalex-snapshot
Activation of PPARβ/δ Causes a Psoriasis-Like Skin Disease In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0013066openalex-snapshot
Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data
inferredcites →https://doi.org/10.1371/journal.pone.0018820openalex-snapshot
The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells
inferredcites →https://doi.org/10.1371/journal.pone.0027739openalex-snapshot
Capric Acid Inhibits NO Production and STAT3 Activation during LPS-Induced Osteoclastogenesis
inferredcites →https://doi.org/10.1517/13543776.2011.539205openalex-snapshot
Signal transducer and activator of transcription 3 inhibitors: a patent review
inferredcites →https://doi.org/10.1517/13543784.2011.601739openalex-snapshot
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors
inferredcites →https://doi.org/10.1517/14728222.11.7.869openalex-snapshot
STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses
inferredcites →https://doi.org/10.1517/14728222.8.5.409openalex-snapshot
STAT proteins as novel targets for cancer drug discovery
inferredcites →https://doi.org/10.1523/jneurosci.0519-10.2010openalex-snapshot
Tyk2/STAT3 Signaling Mediates β-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease
inferredcites →https://doi.org/10.1593/neo.04571openalex-snapshot
Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth
inferredcites →https://doi.org/10.1593/neo.91196openalex-snapshot
A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells
inferredcites →https://doi.org/10.1634/stemcells.22-4-522openalex-snapshot
Maintenance of Pluripotency in Human Embryonic Stem Cells Is STAT3 Independent
inferredcites →https://doi.org/10.1634/stemcells.22-5-770openalex-snapshot
LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells
inferredcites →https://doi.org/10.2119/molmed.2010.000134openalex-snapshot
Involvement of Leptin Receptor Long Isoform (LepRb)-STAT3 Signaling Pathway in Brain Fat Mass- and Obesity-Associated (FTO) Downregulation during Energy Restriction
inferredcites →https://doi.org/10.2174/092986711795843218openalex-snapshot
STAT-3 Inhibitors: State of the Art and New Horizons for Cancer Treatment
inferredcites →https://doi.org/10.2174/092986711796957284openalex-snapshot
Small Molecule Inhibitors of STAT3 for Cancer Therapy
inferredcites →https://doi.org/10.2174/156800907780006922openalex-snapshot
Small Molecule Inhibitors of Stat3 Signaling Pathway
inferredcites →https://doi.org/10.2174/1875036201004010005openalex-snapshot
Amazonia!: An Online Resource to Google and Visualize Public Human whole Genome Expression Data
inferredcites →https://doi.org/10.2183/pjab.86.717openalex-snapshot
Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir
inferredcites →https://doi.org/10.2353/ajpath.2008.071054openalex-snapshot
Stat3 Promotes Metastatic Progression of Prostate Cancer
inferredcites →https://doi.org/10.3109/10428199809057555openalex-snapshot
Stat3 and G-CSF-Induced Myeloid Differentiation
inferredcites →https://doi.org/10.3390/ijms9112253openalex-snapshot
Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
inferredcites →https://doi.org/10.3892/ijo.24.4.931openalex-snapshot
STAT3 and MAPK in human lung cancer tissues and suppression of oncogenic growth by JAB and dominant negative STAT3
inferredcites →https://doi.org/10.3892/ijo_00000249openalex-snapshot
Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer
inferredcites →https://doi.org/10.3892/ijo_00000658openalex-snapshot
Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells
inferredcites →https://doi.org/10.4049/jimmunol.169.11.6610openalex-snapshot
Rheumatoid Arthritis Synoviocyte Survival Is Dependent on Stat3
inferredcites →https://doi.org/10.4161/cc.7.1.5103openalex-snapshot
NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and mdulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts
inferredcites →https://doi.org/10.4161/cc.9.4.10615openalex-snapshot
Activation of epithelial STAT3 regulates intestinal homeostasis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4781594openalex-extracted
Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.2139/ssrn.4826555openalex-extracted
Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.1002/1873-3468.14040openalex-snapshot
15‐Deoxy‐Δ12,14‐prostaglandin J2 binds and inactivates STAT3 via covalent modification of cysteine 259 in H‐Ras‐transformed human breast epithelial cells
inferred← citeshttps://doi.org/10.1002/9781119819950.ch27openalex-snapshot
Strategies for Targeting the JAK ‐ STAT Pathway in Lymphoid Malignancies
inferred← citeshttps://doi.org/10.1002/cam4.70109openalex-snapshot
TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3 / STAT3 pathway
inferred← citeshttps://doi.org/10.1002/ptr.70245openalex-snapshot
Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer
inferred← citeshttps://doi.org/10.1002/stem.3345openalex-snapshot
LIF maintains mouse embryonic stem cells pluripotency by modulating TET1 and JMJD2 activity in a JAK2-dependent manner
inferred← citeshttps://doi.org/10.1007/s00044-015-1328-6openalex-snapshot
High-throughput virtual screening, identification and in vitro biological evaluation of novel inhibitors of signal transducer and activator of transcription 3
inferred← citeshttps://doi.org/10.1007/s00210-026-05103-4openalex-snapshot
Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma
inferred← citeshttps://doi.org/10.1007/s00395-021-00898-0openalex-snapshot
Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function
inferred← citeshttps://doi.org/10.1007/s00706-024-03220-5openalex-snapshot
Synthesis and pharmacological evaluation of polyamine-diarylidenyl piperidone derivatives as potent antitumor agents
inferred← citeshttps://doi.org/10.1007/s11010-021-04156-8openalex-snapshot
Targeting key transcriptional factor STAT3 in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s12272-016-0795-8openalex-snapshot
Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment
inferred← citeshttps://doi.org/10.1007/s13402-023-00817-6openalex-snapshot
Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
inferred← citeshttps://doi.org/10.1007/s13577-023-00923-5openalex-snapshot
Eight influenza virus cellular manipulations which can boost concurrent SARS-CoV-2 infections to severe outcomes
inferred← citeshttps://doi.org/10.1007/s43440-020-00156-5openalex-snapshot
STAT3 transcription factor as target for anti-cancer therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-816435-8.00005-5openalex-snapshot
STAT3 Inhibitors as Sensitizing Agents for Cancer Chemotherapy
inferred← citeshttps://doi.org/10.1016/bs.aihch.2015.04.002openalex-snapshot
The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103095openalex-snapshot
The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.bbcan.2013.12.005openalex-snapshot
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189727openalex-snapshot
Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy
inferred← citeshttps://doi.org/10.1016/j.bcp.2013.08.009openalex-snapshot
Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs
inferred← citeshttps://doi.org/10.1016/j.bcp.2017.10.009openalex-snapshot
Identification of new shikonin derivatives as STAT3 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.117076openalex-snapshot
The effects of STAT3 acetylation on the transcriptional activity and tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105169openalex-snapshot
Natural STAT3 inhibitors: A mini perspective
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106323openalex-snapshot
Discovery of two biotin-PEG4‑diarylidenyl piperidone prodrugs as potent antitumor agents with good efficacy, limited toxicity, and low resistance
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107617openalex-snapshot
Synthesis and biological evaluation of novel isoxazoloquinone derivatives as potent STAT3-targeting antipsoriasis agents
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107955openalex-snapshot
Design, synthesis, and biological evaluation of novel (E)-2-cyano-3-(4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-yl) derivatives as potent STAT3-targeting anticolorectal cancer agents
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108821openalex-snapshot
Scaffold-hopping strategy for pyrazolo[3,4-d]pyrimidines: In vitro and in silico studies of dual c-Met/STAT3 inhibition for enhanced antitumor activity
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110084openalex-snapshot
Design and synthesis of 1-Phenyl-2-thioaryl-4-benzyl-5-methylimidazoles as dual STAT3/NF-κB inhibitors for triple-negative breast Cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110525openalex-snapshot
Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.07.016openalex-snapshot
Antioxidant and apoptotic effects of Callistemon lanceolatus leaves and their compounds against human cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.09.070openalex-snapshot
4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.06.036openalex-snapshot
Identification of galiellalactone-based novel STAT3-selective inhibitors with cytotoxic activities against triple-negative breast cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.11.023openalex-snapshot
N-Arylsulfonylsubstituted-1H indole derivatives as small molecule dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and tubulin
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115347openalex-snapshot
STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae
inferred← citeshttps://doi.org/10.1016/j.bmc.2022.116757openalex-snapshot
Benzobis(imidazole) derivatives as STAT3 signal inhibitors with antitumor activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.09.001openalex-snapshot
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.07.063openalex-snapshot
Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.06.017openalex-snapshot
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.09.073openalex-snapshot
Screening and biological evaluation of a novel STAT3 signaling pathway inhibitor against cancer
inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127286openalex-snapshot
Synthesis and biological evaluation of novel isothiazoloquinoline quinone analogues
inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130777openalex-snapshot
Discovery of novel dual STAT3/TrxR1 inhibitors via pharmacophore fusion as potent lead compounds for colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.cclet.2024.110447openalex-snapshot
Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024)
inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216808openalex-snapshot
Recent advances in antitumor Pt(IV) complexes: Dual targeting and chemoimmunotherapy
inferred← citeshttps://doi.org/10.1016/j.cellsig.2019.109381openalex-snapshot
Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.09.007openalex-snapshot
Reply to “Revisiting the Specificity of Small Molecule Inhibitors: The Example of Stattic in Dendritic Cells”
inferred← citeshttps://doi.org/10.1016/j.ddmec.2013.03.001openalex-snapshot
STAT3 signaling in polycystic kidney disease
inferred← citeshttps://doi.org/10.1016/j.drup.2022.100884openalex-snapshot
Targeting feedback activation of signaling transduction pathways to overcome drug resistance in cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.01.023openalex-snapshot
Fragment-based drug design and identification of HJC0123 , a novel orally bioavailable STAT3 inhibitor for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.05.049openalex-snapshot
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.08.054openalex-snapshot
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.10.028openalex-snapshot
Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.03.053openalex-snapshot
Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.08.037openalex-snapshot
Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111922openalex-snapshot
Revisiting signal transducer and activator of transcription 3 (STAT3) as an anticancer target and its inhibitor discovery: Where are we and where should we go?
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112122openalex-snapshot
Allosteric inhibitors of the STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112428openalex-snapshot
Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112993openalex-snapshot
PROTACs to address the challenges facing small molecule inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113525openalex-snapshot
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114551openalex-snapshot
Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114858openalex-snapshot
Structural optimization of Imidazo[1, 2-a]pyridine derivatives for the treatment of gastric cancer via STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116448openalex-snapshot
Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118020openalex-snapshot
Discovery of potent and selective STAT3 inhibitors against triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.ejphar.2014.05.047openalex-snapshot
Comparative screening and validation as a novel tool to identify STAT-specific inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173107openalex-snapshot
Targeting STAT3 in cancer and autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.fct.2013.11.040openalex-snapshot
Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e18090openalex-snapshot
RETRACTED: Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.imbio.2014.02.012openalex-snapshot
STAT3-silenced human dendritic cells have an enhanced ability to prime IFNγ production by both αβ and γδ T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.imbio.2017.10.049openalex-snapshot
Dual requirement for STAT signaling in dendritic cell immunobiology
inferred← citeshttps://doi.org/10.1016/j.insi.2026.100372openalex-snapshot
Targeted protein degradation in the digital era: Computational challenges and opportunities for PROTACs
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.04.023openalex-snapshot
Inorganic kernel - Supported asymmetric hybrid vesicles for targeting delivery of STAT3-decoy oligonucleotides to overcome anti-HER2 therapeutic resistance of BT474R
inferred← citeshttps://doi.org/10.1016/j.jocs.2015.03.001openalex-snapshot
CAVS—Novel in silico selection strategy of specific STAT inhibitory compounds
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.117469openalex-snapshot
Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways
inferred← citeshttps://doi.org/10.1016/j.molonc.2015.02.012openalex-snapshot
Hitting the right spot: Mechanism of action of OPB‐31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2015.03.004openalex-snapshot
Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105637openalex-snapshot
Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility
inferred← citeshttps://doi.org/10.1016/j.semcancer.2015.08.006openalex-snapshot
The biological complexity of urothelial carcinoma: Insights into carcinogenesis, targets and biomarkers of response to therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.tips.2015.10.001openalex-snapshot
Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism
inferred← citeshttps://doi.org/10.1016/j.ydbio.2018.11.002openalex-snapshot
Molecular mechanism of mammary gland involution: An update
inferred← citeshttps://doi.org/10.1021/acs.accounts.5b00492openalex-snapshot
γ-AApeptides: Design, Structure, and Applications
inferred← citeshttps://doi.org/10.1021/acs.jcim.6b00198openalex-snapshot
Selective Inhibition of STAT3 with Respect to STAT1: Insights from Molecular Dynamics and Ensemble Docking Simulations
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01897openalex-snapshot
Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00136openalex-snapshot
Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00629openalex-snapshot
Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00940openalex-snapshot
Boronic Acid: A Novel Pharmacophore Targeting Src Homology 2 (SH2) Domain of STAT3
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01554openalex-snapshot
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00836openalex-snapshot
Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01055openalex-snapshot
Design, Synthesis, and Biological Activity of Novel Quinone Derivatives as Potent STAT3 Inhibitors for Psoriasis Treatment
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01814openalex-snapshot
Preclinical Characterization of 3β-(N-Acetyl l -cysteine methyl ester)-2aβ,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01704openalex-snapshot
Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01749openalex-snapshot
Allosteric Modulator Discovery: From Serendipity to Structure-Based Design
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01386openalex-snapshot
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00247openalex-snapshot
Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.joc.5b02121openalex-snapshot
Diastereoselective Total Synthesis of (−)-Galiellalactone
inferred← citeshttps://doi.org/10.1021/acs.orglett.7b00332openalex-snapshot
STAT3 Inhibitory Activity of Structurally Simplified Withaferin A Analogues
inferred← citeshttps://doi.org/10.1021/acschembio.5b00945openalex-snapshot
Strategies and Approaches of Targeting STAT3 for Cancer Treatment
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00228openalex-snapshot
Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00544openalex-snapshot
Linker Variation and Structure–Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors
inferred← citeshttps://doi.org/10.1021/bi501529xopenalex-snapshot
Molecular Determinants for Unphosphorylated STAT3 Dimerization Determined by Integrative Modeling
inferred← citeshttps://doi.org/10.1021/cb500071vopenalex-snapshot
A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion
inferred← citeshttps://doi.org/10.1021/jm4018042openalex-snapshot
Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6
inferred← citeshttps://doi.org/10.1021/jo500545dopenalex-snapshot
Synthetic and Biological Studies of Phaeosphaerides
inferred← citeshttps://doi.org/10.1021/ml3003082openalex-snapshot
Discovery of O-Alkylamino-Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents
inferred← citeshttps://doi.org/10.1038/bjc.2013.349openalex-snapshot
STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells
inferred← citeshttps://doi.org/10.1038/bjc.2014.349openalex-snapshot
Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
inferred← citeshttps://doi.org/10.1038/bjc.2015.228openalex-snapshot
Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer
inferred← citeshttps://doi.org/10.1038/ncomms7285openalex-snapshot
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
inferred← citeshttps://doi.org/10.1038/nrd4253openalex-snapshot
Tackling the cancer stem cells — what challenges do they pose?
inferred← citeshttps://doi.org/10.1038/nrurol.2014.129openalex-snapshot
Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer
inferred← citeshttps://doi.org/10.1038/onc.2015.215openalex-snapshot
Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo
inferred← citeshttps://doi.org/10.1038/s41598-018-20234-2openalex-snapshot
Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi
inferred← citeshttps://doi.org/10.1039/c3md00095hopenalex-snapshot
Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors
inferred← citeshttps://doi.org/10.1039/c4cc03909bopenalex-snapshot
Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library
inferred← citeshttps://doi.org/10.1039/c5an02397aopenalex-snapshot
Tracking of STAT3 signaling for anticancer drug-discovery based on localized surface plasmon resonance
inferred← citeshttps://doi.org/10.1039/d5md00053jopenalex-snapshot
Discovery of novel STAT3 inhibitors with anti-breast cancer activity: structure-based virtual screening, molecular dynamics and biological evaluation
inferred← citeshttps://doi.org/10.1073/pnas.1615730114openalex-snapshot
Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells
inferred← citeshttps://doi.org/10.1074/jbc.ra119.009801openalex-snapshot
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3
inferred← citeshttps://doi.org/10.1074/jbc.ra120.016645openalex-snapshot
The STAT3 inhibitor Stattic acts independently of STAT3 to decrease histone acetylation and modulate gene expression
inferred← citeshttps://doi.org/10.1080/00207454.2020.1758088openalex-snapshot
BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells via the signal transducer and activator of transcription 3/fascin-1 pathway
inferred← citeshttps://doi.org/10.1080/1061186x.2018.1452244openalex-snapshot
Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer
inferred← citeshttps://doi.org/10.1080/14756366.2017.1350658openalex-snapshot
New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors
inferred← citeshttps://doi.org/10.1080/15384047.2021.1951573openalex-snapshot
STAT3 inhibitor in combination with irradiation significantly inhibits cell viability, cell migration, invasion and tumorsphere growth of human medulloblastoma cells
inferred← citeshttps://doi.org/10.1080/2162402x.2014.998529openalex-snapshot
MyeloidSTAT3promotes formation of colitis-associated colorectal cancer in mice
inferred← citeshttps://doi.org/10.1080/23723556.2015.1036199openalex-snapshot
Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis
inferred← citeshttps://doi.org/10.1096/fj.202002334ropenalex-snapshot
Advances in understanding the innate immune‐associated diabetic kidney disease
inferred← citeshttps://doi.org/10.1097/cad.0000000000000783openalex-snapshot
C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000079openalex-snapshot
JAK inhibition and progressive kidney disease
inferred← citeshttps://doi.org/10.1111/bph.12855openalex-snapshot
Mechanisms underlying the cytotoxicity of a novel quinazolinedione‐based redox modulator, QD 232, in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1111/bph.15435openalex-snapshot
The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
inferred← citeshttps://doi.org/10.1111/cbdd.13763openalex-snapshot
Novel anti‐cancer candidates from a combinatorial peptide library
inferred← citeshttps://doi.org/10.1111/cbdd.14593openalex-snapshot
Discovering novel derivatives of STAT3 and HDAC inhibitors with anti‐tumor activity
inferred← citeshttps://doi.org/10.1111/cbdd.70190openalex-snapshot
Antiproliferative Activity and Target Analysis of 18β‐Glycyrrhetinic Acid Derivatives Modified With α, β‐Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.1111/exd.12698openalex-snapshot
Anti‐angiogenic activity of thienopyridine derivative LCB 03‐0110 by targeting VEGFR ‐2 and JAK / STAT 3 Signalling
inferred← citeshttps://doi.org/10.1111/febs.13285openalex-snapshot
STAT 3 the oncogene – still eluding therapy?
inferred← citeshttps://doi.org/10.1134/s107042802411006xopenalex-snapshot
Approaches to the Formation of the Key 2-Oxabicyclo[3.3.0]octan-3-one Precursor of Galiellalactone
inferred← citeshttps://doi.org/10.1155/2015/272359openalex-snapshot
The Complex Role of STAT3 in Viral Infections
inferred← citeshttps://doi.org/10.1155/2022/8727566openalex-snapshot
The Bioinformatical Identification of Potential Biomarkers in Heart Failure Diagnosis and Treatment
inferred← citeshttps://doi.org/10.1158/0008-5472.can-12-3175openalex-snapshot
A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
inferred← citeshttps://doi.org/10.1158/0008-5472.can-13-2187openalex-snapshot
A Specific STAT3-Binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-16-0947openalex-snapshot
Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RET M918T Tumors
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-12-1082openalex-snapshot
Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-16-0606openalex-snapshot
Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152
inferred← citeshttps://doi.org/10.1172/jci.insight.136176openalex-snapshot
Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
inferred← citeshttps://doi.org/10.1186/s43556-022-00112-0openalex-snapshot
An overview of PROTACs: a promising drug discovery paradigm
inferred← citeshttps://doi.org/10.1194/jlr.m035576openalex-snapshot
Butein is a novel anti-adipogenic compound
inferred← citeshttps://doi.org/10.1371/journal.pone.0068391openalex-snapshot
Tagging of Genomic STAT3 and STAT1 with Fluorescent Proteins and Insertion of a Luciferase Reporter in the Cyclin D1 Gene Provides a Modified A549 Cell Line to Screen for Selective STAT3 Inhibitors
inferred← citeshttps://doi.org/10.1371/journal.pone.0116688openalex-snapshot
Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation
inferred← citeshttps://doi.org/10.1371/journal.pone.0136236openalex-snapshot
Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings
inferred← citeshttps://doi.org/10.1371/journal.pone.0170709openalex-snapshot
Inhibition of STAT3 by Anticancer Drug Bendamustine
inferred← citeshttps://doi.org/10.1371/journal.pone.0178844openalex-snapshot
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
inferred← citeshttps://doi.org/10.1517/14728222.2013.830105openalex-snapshot
gp130: a promising drug target for cancer therapy
inferred← citeshttps://doi.org/10.1634/theoncologist.2017-0325openalex-snapshot
A First-in-Human Phase I Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers
inferred← citeshttps://doi.org/10.1681/asn.2013091026openalex-snapshot
The Cleaved Cytoplasmic Tail of Polycystin-1 Regulates Src-Dependent STAT3 Activation
inferred← citeshttps://doi.org/10.17650/2313-805x-2025-12-4-8-23openalex-snapshot
Rearrangement of signaling pathways and adaptation of tumor cells to hypoxia
inferred← citeshttps://doi.org/10.18154/rwth-2017-01944openalex-snapshot
Die Rolle der STAT3 N-terminale Domäne und GAS-Sequenzerkennung bei der Signaltransduktion und der Wechselwirkung mit STAT1 und NF-κB
inferred← citeshttps://doi.org/10.18632/oncotarget.12868openalex-snapshot
Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors
inferred← citeshttps://doi.org/10.18632/oncotarget.4054openalex-snapshot
Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
inferred← citeshttps://doi.org/10.18632/oncotarget.9195openalex-snapshot
Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
inferred← citeshttps://doi.org/10.21203/rs.3.rs-166478/v1openalex-snapshot
Identification of potential biomarkers and therapeutic targets in the chronic obstructive pulmonary disease and acute myocardial infarction
inferred← citeshttps://doi.org/10.21203/rs.3.rs-259286/v1openalex-snapshot
Identification of Common Mechanisms and Key Genes in the Chronic Obstructive Pulmonary Disease and Acute Myocardial Infarction
inferred← citeshttps://doi.org/10.2147/ott.s187777openalex-snapshot
Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
inferred← citeshttps://doi.org/10.2174/0929867324666171107095913openalex-snapshot
γ-AApeptides as a New Strategy for Therapeutic Development
inferred← citeshttps://doi.org/10.2174/0929867325666180719122729openalex-snapshot
Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents
inferred← citeshttps://doi.org/10.2174/1381612823666170616082125openalex-snapshot
Protein Tyrosine Signaling and its Potential Therapeutic Implications in Carcinogenesis
inferred← citeshttps://doi.org/10.2174/1568009619666181226094814openalex-snapshot
EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway
inferred← citeshttps://doi.org/10.2217/hep.13.7openalex-snapshot
STAT3 in hepatocellular carcinoma: new perspectives
inferred← citeshttps://doi.org/10.3109/08830185.2015.1027820openalex-snapshot
Primary Immunodeficiencies with Elevated IgE
inferred← citeshttps://doi.org/10.3109/1061186x.2016.1157882openalex-snapshot
Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells
inferred← citeshttps://doi.org/10.3109/14756366.2015.1079184openalex-snapshot
Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach
inferred← citeshttps://doi.org/10.3389/fchem.2020.00441openalex-snapshot
Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02141openalex-snapshot
Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs
inferred← citeshttps://doi.org/10.3389/fonc.2022.1021179openalex-snapshot
Role of STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy
inferred← citeshttps://doi.org/10.3389/fonc.2026.1802640openalex-snapshot
STAT3 inhibitor in oncology: a trial-based analysis of translational challenges and evolving therapeutic paradigms
inferred← citeshttps://doi.org/10.3389/fphar.2025.1507002openalex-snapshot
Elucidation of Callistemon lanceolatus-derived natural compounds in STAT 3 pathway against human cancer cells: in silico and in vitro studies
inferred← citeshttps://doi.org/10.3390/cancers11111711openalex-snapshot
STAT3 Dysregulation in Mature T and NK Cell Lymphomas
inferred← citeshttps://doi.org/10.3390/cancers13030437openalex-snapshot
The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma
inferred← citeshttps://doi.org/10.3390/cancers6010494openalex-snapshot
Genetic Interactions of STAT3 and Anticancer Drug Development
inferred← citeshttps://doi.org/10.3390/cancers6020926openalex-snapshot
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention
inferred← citeshttps://doi.org/10.3390/cancers6041986openalex-snapshot
STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy
inferred← citeshttps://doi.org/10.3390/ijms18122684openalex-snapshot
Molecular Mechanisms and Management of a Cutaneous Inflammatory Disorder: Psoriasis
inferred← citeshttps://doi.org/10.3390/ijms22020603openalex-snapshot
The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy
inferred← citeshttps://doi.org/10.3390/ijms22136669openalex-snapshot
Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control
inferred← citeshttps://doi.org/10.3390/ijms26136139openalex-snapshot
JAK2 Inhibition Augments the Anti-Proliferation Effects by AKT and MEK Inhibition in Triple-Negative Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/ijms27020942openalex-snapshot
LEM-Domain-Containing Inner Nuclear Membrane Proteins: Emerging Regulators of Intranuclear Signaling
inferred← citeshttps://doi.org/10.3390/molecules26206204openalex-snapshot
Acacetin Inhibits the Growth of STAT3-Activated DU145 Prostate Cancer Cells by Directly Binding to Signal Transducer and Activator of Transcription 3 (STAT3)
inferred← citeshttps://doi.org/10.3390/pharmaceutics14102104openalex-snapshot
SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity
inferred← citeshttps://doi.org/10.3390/v13060967openalex-snapshot
Influenza Virus-Induced Novel miRNAs Regulate the STAT Pathway
inferred← citeshttps://doi.org/10.35164/0554-2901-2022-1-2-20-23openalex-snapshot
(Meth)acrylic esters of betulin and their copolymers with hydrophilic methacrylic esters and amides
inferred← citeshttps://doi.org/10.3892/ol.2018.9262openalex-snapshot
A novel small inhibitor, LLL12, targets STAT3 in non‑small cell lung cancer in�vitro and in�vivo
inferred← citeshttps://doi.org/10.4062/biomolther.2023.210openalex-snapshot
Unraveling Stereochemical Structure-Activity Relationships of Sesquiterpene Lactones for Inhibitory Effects on STAT3 Activation
inferred← citeshttps://doi.org/10.4155/fmc-2019-0317openalex-snapshot
Triazolopyrimidinium Salts: Discovery of a New Class of Agents for Cancer Therapy
inferred← citeshttps://doi.org/10.4161/jkst.23650openalex-snapshot
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease
inferred← citeshttps://doi.org/10.5483/bmbrep.2019.52.7.152openalex-snapshot
Highlighted STAT3 as a potential drug target for cancer therapy
inferred← citeshttps://doi.org/10.7150/thno.21707openalex-snapshot
Inorganic Kernel-Reconstituted Lipoprotein Biomimetic Nanovehicles Enable Efficient Targeting “Trojan Horse” Delivery of STAT3-Decoy Oligonucleotide for Overcoming TRAIL Resistance
inferred← citeshttps://doi.org/10.7150/thno.33444openalex-snapshot
Multi-omics profiling reveals key signaling pathways in ovarian cancer controlled by STAT3
inferred← citeshttps://doi.org/10.7912/c2/310openalex-snapshot
Small molecule compounds targeting DNA binding domain of STAT3 for inhibition of tumor growth and metastasis
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