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Plakilactones from the Marine SpongePlakinastrella mamillaris. Discovery of a New Class of Marine Ligands of Peroxisome Proliferator-Activated Receptor γ
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Long-term Risk of Cardiovascular Events With Rosiglitazone
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Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes
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The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2
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The Binding Mode of Petrosaspongiolide M to the Human Group IIA Phospholipase A2: Exploring the Role of Covalent and Noncovalent Interactions in the Inhibition Process
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Antimalarial Polyketide Cycloperoxides from the Marine SpongePlakortis simplex
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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
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PPARγ in human and mouse physiology
inferredcites →https://doi.org/10.1016/j.clinthera.2005.05.005openalex-snapshot
Metabolic effects of pioglitazone in combination with insulin in patients with type 2 diabetes mellitus whose disease is not adequately controlled with insulin therapy: Results of a six-month, randomized, double-blind, prospective, multicenter, parallel-group study
inferredcites →https://doi.org/10.1016/j.coph.2006.03.012openalex-snapshot
PPARs and other nuclear receptors in inflammation
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Sargaquinoic acid and sargahydroquinoic acid from Sargassum yezoense stimulate adipocyte differentiation through PPARα/γ activation in 3T3‐L1 cells
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Structural Insight into PPARγ Activation Through Covalent Modification with Endogenous Fatty Acids
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4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity
inferredcites →https://doi.org/10.1016/j.str.2011.10.018openalex-snapshot
Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism
inferredcites →https://doi.org/10.1016/j.tetlet.2005.09.011openalex-snapshot
Stereocontrolled synthesis of (±)-methyl 3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate, a major metabolite of Caribbean sponge, Plakortis halichondrioides, using reactions of alkylidenecarbenes in one pot
inferredcites →https://doi.org/10.1016/j.tetlet.2006.02.025openalex-snapshot
Total synthesis and absolute stereochemistry of plakortone E
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Amphiasterins: a new family of cytotoxic metabolites from the marine sponge Plakortis quasiamphiaster
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Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus
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Absolute configuration of methyl (2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate from the sponge Plakortis halichondrioides
inferredcites →https://doi.org/10.1021/ja00011a006openalex-snapshot
High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoids
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Solomonsterols A and B fromTheonella swinhoei. The First Example of C-24 and C-23 Sulfated Sterols from a Marine Source Endowed with a PXR Agonistic Activity
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Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor
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Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators
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Theonellasterols and Conicasterols from Theonella swinhoei. Novel Marine Natural Ligands for Human Nuclear Receptors
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Total Synthesis and Pharmacological Characterization of Solomonsterol A, a Potent Marine Pregnane-X-Receptor Agonist Endowed with Anti-Inflammatory Activity
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Conicasterol E, a Small Heterodimer Partner Sparing Farnesoid X Receptor Modulator Endowed with a Pregnane X Receptor Agonistic Activity, from the Marine Sponge Theonella swinhoei
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Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica
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Metabolites of three marine sponges of the genus Plakortis
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Quantitative NMR-Derived Interproton Distances Combined with Quantum Mechanical Calculations of 13C Chemical Shifts in the Stereochemical Determination of Conicasterol F, a Nuclear Receptor Ligand from Theonella swinhoei
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Gracilioethers A−C, Antimalarial Metabolites from the Marine Sponge Agelas gracilis
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Antiparasitic, Antineuroinflammatory, and Cytotoxic Polyketides from the Marine Sponge Plakortis angulospiculatus Collected in Brazil
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Manadoperoxides A−D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure−Activity Relationships of Simple 1,2-Dioxane Antimalarials
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Configurational Assignment of Cyclic Peroxy Metabolites Provides an Insight into Their Biosynthesis: Isolation of Plakortolides, seco-Plakortolides, and Plakortones from the Australian Marine Sponge Plakinastrella clathrata
inferredcites →https://doi.org/10.1021/np900535zopenalex-snapshot
Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
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Structural basis for the activation of PPARγ by oxidized fatty acids
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L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γ
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T0070907, a Selective Ligand for Peroxisome Proliferator-activated Receptor γ, Functions as an Antagonist of Biochemical and Cellular Activities
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α,β-Unsaturated Ketone Is a Core Moiety of Natural Ligands for Covalent Binding to Peroxisome Proliferator-activated Receptor γ
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Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex
inferredcites →https://doi.org/10.1096/fj.11-195701openalex-snapshot
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition
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Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis
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Unique Ability of Troglitazone to Up-Regulate Peroxisome Proliferator-Activated Receptor-γ Expression in Hepatocytes
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Fat and Beyond: The Diverse Biology of PPARγ
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Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis
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Update on Cardiovascular Safety of PPARgamma Agonists and Relevance to Medicinal Chemistry and Clinical Pharmacology
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Natural Ligands for Nuclear Receptors: Biology and Potential Therapeutic Applications
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Development of FXR, PXR and CAR Agonists and Antagonists for Treatment of Liver Disorders
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hPPARgamma Ligand binding domain in complex with 4-HDHA
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Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group.
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A Randomized Trial of Rosiglitazone Therapy in Patients With Inadequately Controlled Insulin-Treated Type 2 Diabetes
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Metabolites from Marine Sponges of the Genus Plakortis
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Uncertain Effects of Rosiglitazone on the Risk for Myocardial Infarction and Cardiovascular Death
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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New sciaphilic plakinids (Porifera, Homoscleromorpha) from the Central-Western Pacific
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inferred← citeshttps://doi.org/10.1002/anie.201911862openalex-snapshot
Searching for Small Molecules with an Atomic Sort
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Influence of alkene substituent in dictating the reaction course to form carbocycles or oxacycles during ring closing metathesis of acyclic trienes
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Marine-Derived Anti-diabetic Compounds: A Review of Potentials and Prospects
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Chemical and biological diversity of new natural products from marine sponges: a review (2009–2018)
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Protolichesterinic acid derivatives: α-Methylene-γ-lactones as potent dual activators of PPARγ and Nrf2 transcriptional factors
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How to nurture natural products to create new therapeutics: Strategic innovations and molecule-to-medicinal insights into therapeutic advancements
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.12.005openalex-snapshot
Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges
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Covalent ligands of nuclear receptors
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Leishmanicidal compounds and potent PPARγ activators from Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl.
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Nuclear receptors in cancer: Unveiling theranostic potentials and innovative therapeutic strategies
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Gracilioethers E–J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris
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New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands
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